Prominent publications by Ronald B Goldberg

KOL Index score: 18983

BACKGROUND: Effective prevention is needed to combat the worldwide epidemic of type 2 diabetes. We investigated the long-term extent of beneficial effects of lifestyle intervention and metformin on diabetes prevention, originally shown during the 3-year Diabetes Prevention Program (DPP), and assessed whether these interventions reduced diabetes-associated microvascular complications.

METHODS: The DPP (1996-2001) was a randomised trial comparing an intensive lifestyle intervention or ...

Known for Lifestyle Intervention |  Microvascular Complications |  Metformin Placebo |  Dpp Outcomes Study |  15 Years
KOL Index score: 17996

OBJECTIVE: Type 1 diabetes mellitus (T1D) patients have an increased risk of cardiovascular disease despite high levels of high-density lipoproteins (HDL). Apolipoprotein M (apoM) and its ligand sphingosine 1-phospate (S1P) exert many of the anti-inflammatory effects of HDL. We investigated whether apoM and S1P are altered in T1D and whether apoM and S1P are important for HDL functionality in T1D.

APPROACH AND RESULTS: ApoM and S1P were quantified in plasma from 42 healthy controls and ...

Known for Apom S1p |  Type 1 |  Hdl Particles |  Cardiovascular Disease |  Diabetes Mellitus
KOL Index score: 17261

BACKGROUND: In the 2.8 years of the Diabetes Prevention Program (DPP) randomised clinical trial, diabetes incidence in high-risk adults was reduced by 58% with intensive lifestyle intervention and by 31% with metformin, compared with placebo. We investigated the persistence of these effects in the long term.

METHODS: All active DPP participants were eligible for continued follow-up. 2766 of 3150 (88%) enrolled for a median additional follow-up of 5.7 years (IQR 5.5-5.8). 910 participants ...

Known for Diabetes Incidence |  Lifestyle Intervention Metformin |  Weight Loss |  10 Years |  Year Follow
KOL Index score: 16245

OBJECTIVE: Associated with insulin resistance in type 2 diabetes are increased serum triglycerides, decreased HDL cholesterol, and a predominance of large VLDL, small LDL, and small HDL particles. The comparative effects of thiazolidinedione insulin sensitizers on serum lipoprotein particle concentrations and sizes in type 2 diabetes are not known. We studied the effects of pioglitazone (PIO) and rosiglitazone (ROSI) treatments on serum lipoprotein particle concentrations and sizes in ...

Known for 2 Diabetes |  Hdl Lipoproteins |  Pio Treatment |  Insulin Resistance |  Humans Hypoglycemic Agents
KOL Index score: 15453

BACKGROUND: The metabolic syndrome is a high-risk state for diabetes and cardiovascular disease. Little is known about its prevalence and prevention in those with impaired glucose tolerance.

OBJECTIVE: To determine the prevalence of the metabolic syndrome at baseline in the Diabetes Prevention Program and the effect of intensive lifestyle intervention and metformin therapy on the syndrome's incidence and resolution.

DESIGN: Randomized, controlled clinical trial.

SETTING: Research and ...

Known for Diabetes Prevention Program |  Intensive Lifestyle Intervention |  Metabolic Syndrome |  Metformin Therapy |  Impaired Glucose Tolerance
KOL Index score: 15253

BACKGROUND: In people without diabetes, approximately 50% of daily insulin secretion is basal and the remainder is postprandial. Hence, it would be expected that insulin replacement therapy in a 50/50 ratio with each meal would mimic physiologic insulin secretion better than treatment with once-daily basal insulin in patients with diabetes mellitus. Using lispro mix (LM) 50/50 before meals may be a logical approach to achieving glycemic targets (glycosylated hemoglobin [HbA(lc)] and pre- ...

Known for 2 Diabetes |  Basal Insulin |  Blood Glucose |  Target Hba1c |  Mellitus Type
KOL Index score: 14433

CONTEXT: Vitamin B12 deficiency may occur with metformin treatment, but few studies have assessed risk with long-term use.

OBJECTIVE: To assess the risk of B12 deficiency with metformin use in the Diabetes Prevention Program (DPP)/DPP Outcomes Study (DPPOS).

DESIGN: Secondary analysis from the DPP/DPPOS. Participants were assigned to the placebo group (PLA) (n = 1082) or the metformin group (MET) (n = 1073) for 3.2 years; subjects in the metformin group received open-label metformin for ...

Known for B12 Deficiency |  Term Metformin |  Diabetes Prevention |  5 Years |  Program Outcomes
KOL Index score: 13790

OBJECTIVE: Published reports suggest that pioglitazone and rosiglitazone have different effects on lipids in patients with type 2 diabetes. However, these previous studies were either retrospective chart reviews or clinical trials not rigorously controlled for concomitant glucose- and lipid-lowering therapies. This study examines the lipid and glycemic effects of pioglitazone and rosiglitazone.

RESEARCH DESIGN AND METHODS: We enrolled subjects with a diagnosis of type 2 diabetes (treated ...

Known for Pioglitazone Rosiglitazone |  Hdl Cholesterol |  Type 2 Diabetes |  Glycemic Effects |  Ldl Particle Concentration
KOL Index score: 13540

OBJECTIVE: To compare the efficacy and safety of the recommended usual starting and next highest doses of ezetimibe/ simvastatin and atorvastatin in patients with type 2 diabetes mellitus and hypercholesterolemia.

PATIENTS AND METHODS: This double-blind, multicenter study (June 22 to December 7, 2005) consisted of adult patients randomized to the recommended usual starting (ezetimibe/simvastatin, 10/20 mg/d, vs atorvastatin, 10 or 20 mg/d) or next highest (ezetimibe/simvastatin, 10/40 ...

Known for Ezetimibe Simvastatin |  2 Diabetes |  Atorvastatin Patients |  Hdl Cholesterol |  Ldlc Levels
KOL Index score: 13134

OBJECTIVE: To evaluate the efficacy and safety of initial combination therapy with metformin plus colesevelam in patients with early type 2 diabetes.

METHODS: In this 16-week, randomized, double-blind, placebo-controlled study, adults with type 2 diabetes (hemoglobin A1c [A1C] values of 6.5% to 10.0%) and hypercholesterolemia (low-density lipoprotein cholesterol [LDL-C] levels > or =100 mg/dL) were randomly assigned (1:1) to colesevelam (3.75 g/d) or placebo in combination with ...

Known for 2 Diabetes |  Initial Combination Therapy |  Metformin Colesevelam |  Early Type |  Lipid Goals
KOL Index score: 12815

BACKGROUND: Bile acid sequestrants are a well-accepted class of cholesterol-lowering drugs. Over the last decade, small studies have indicated that these agents may also lower glucose levels in patients with type 2 diabetes mellitus (T2DM).

METHODS: This 26-week, randomized, double-blind, placebo-controlled, parallel-group study was conducted between August 2004 and July 2006 at 54 sites in the United States and 2 in Mexico to determine the effects of colesevelam hydrochloride, a bile ...

Known for Colesevelam Hydrochloride |  Diabetes Mellitus |  Type 2 |  Glucose Levels Patients |  Metformin Monotherapy
KOL Index score: 12335

OBJECTIVE: Restoration of normal glucose regulation (NGR) in people with prediabetes significantly decreases the risk of future diabetes. We sought to examine whether regression to NGR is also associated with a long-term decrease in cardiovascular disease (CVD) risk.

RESEARCH DESIGN AND METHODS: The Framingham (2008) score (as an estimate of the global 10-year CVD risk) and individual CVD risk factors were calculated annually for the Diabetes Prevention Program Outcomes Study years 1-10 ...

Known for Cardiovascular Risk |  Normal Glucose Regulation |  Diabetes Prevention Program |  Regression Ngr |  Blood Glucose
KOL Index score: 12227

OBJECTIVES: This study sought to examine the relationship between niacin treatment, lipoproteins, and cardiovascular (CV) outcomes in this secondary analysis of the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes) trial.

BACKGROUND: During a 3-year follow-up in 3,414 patients with established CV disease and low high-density lipoprotein cholesterol (HDL-C) levels, combined niacin + low-density lipoprotein ...

Known for Metabolic Syndrome |  Cardiovascular Events |  Atherothrombosis Intervention |  Low Hdl |  Global Health Outcomes
KOL Index score: 12082

Increases in subclinical inflammation (C-reactive protein [CRP]) and impaired coagulation have been associated with increased obesity and insulin resistance. Only a few small studies have examined the effect of lifestyle changes, such as weight loss, increased physical activity, and insulin-sensitizing intervention on inflammation and coagulation. The Diabetes Prevention Program (DPP) clinical trial studied the effect of an intensive lifestyle intervention or metformin on progression to ...

Known for Impaired Glucose Tolerance |  Lifestyle Metformin |  Crp Women |  Increased Physical Activity |  Blood Glucose
KOL Index score: 11998

OBJECTIVE: To determine whether baseline adiponectin levels or intervention-associated change in adiponectin levels were independently associated with progression to diabetes in the Diabetes Prevention Program (DPP).

RESEARCH DESIGN AND METHODS: Cox proportional hazards analysis was used to evaluate the contribution of adiponectin and treatment-related change in adiponectin to risk of progression to diabetes.

RESULTS: Baseline adiponectin was a strong independent predictor of incident ...

Known for Diabetes Prevention Program |  Adiponectin Levels |  Lifestyle Metformin |  Hazard Ratio |  Risk Progression


Ronald B Goldberg: Influence Statistics

Sample of concepts for which Ronald B Goldberg is among the top experts in the world.
Concept World rank
selectin retinopathy #1
diabetes lifestyle #1
vytal study #1
ils intervention #1
dppos coronary #1
mts women #1
apom s1p hdl #1
rivoglitazone thiazolidinedione #1
281–489 #1
placebo greater increases #1
mts prevalence #1
dyslipidemia glucose #1
carotid intima pioglitazone #1
t1d hyperadiponectinemia #1
age hispanic individuals #1
clinical context hdl #1
hdll #1
cvd diabetic subjects #1
homozygotes hdl #1
rosi 4 qd #1
niacin niacin therapy #1
adiponectin hdl #1
colesevelam vldl #1
patients rosi #1
marker therapeutic effectiveness #1
highest doses simvastatin #1
modern intervention strategies #1
improved hdl cholesterol #1
upperextremity fitness #1
atorva eze simva #1
values or126 #1
blood pressure tgs #1
hdlc lpl #1
presentation metabolic syndrome #1
bioelectric impedance techniques #1
patients low tgs #1
johannesburg obese #1
equal allocation schedule #1
bas chd risk #1
recommended usual starting #1
optional target level #1
venezuela hispanic americans #1
hypolipoproteinemias immunoglobulin #1
studyeligible conditions #1
hdlc atorva #1
day openlabel metformin #1
agents vasculoprotective effects #1
bas hypercholesterolemia #1
100 ≥26 mmol #1
bas therapy #1

Key People For Diabetes Prevention Program

Top KOLs in the world
William C Knowler
pima indians type 2 diabetes weight loss
Richard F Hamman
type 1 diabetes san luis valley insulin sensitivity
Elizabeth L Barrett‐Connor
rancho bernardo study postmenopausal women cognitive function
Sarah E Fowler
rheumatoid arthritis diabetes prevention program pulmonary embolism
David Matthew Nathan
type 2 diabetes insulin resistance cardiovascular disease
John M Lachin
type 1 diabetes cardiovascular disease complications trial

Ronald B Goldberg:Expert Impact

Concepts for whichRonald B Goldberghas direct influence:Diabetes prevention program,  Metabolic syndrome,  Insulin resistance,  Type 2 diabetes,  Lifestyle intervention,  2 diabetes,  Type 2,  Diabetes prevention.

Ronald B Goldberg:KOL impact

Concepts related to the work of other authors for whichfor which Ronald B Goldberg has influence:Metabolic syndrome,  Type 2 diabetes,  Cardiovascular disease,  Insulin resistance,  Weight loss,  Physical activity,  Statin therapy.



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University of Miami Miller School of Medicine, FL (R.B.G.). | Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL | University of Miami Miller School of Medicine, Miami, Florida, USA. | Division of Endocrinology, Dia

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