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    • Andrew J M Boulton
    • Andrew J M Boulton: Influence Statistics

      Andrew J M Boulton

      Andrew J M Boulton

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      Diabetes Research Institute, University of Miami, Miami, FL 33136, USA | Diabetes Research Institute, University of Miami, Miami, FL, United States | Manchester Royal ...

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      Andrew J M Boulton:Expert Impact

      Concepts for whichAndrew J M Boultonhas direct influence:Diabetic foot,Foot ulceration,Diabetic patients,Diabetic neuropathy,Diabetes mellitus,Foot ulcers,Foot ulcer,Corneal confocal microscopy.

      Andrew J M Boulton:KOL impact

      Concepts related to the work of other authors for whichfor which Andrew J M Boulton has influence:Diabetic foot,Diabetes mellitus,Wound healing,Type 2,Peripheral neuropathy,Neuropathic pain,Plantar pressure.

      KOL Resume for Andrew J M Boulton

      Year
      2022

      Diabetes Research Institute, University of Miami, Miami, FL 33136, USA

      Manchester Royal Infirmary, Manchester, United Kingdom

      2021

      Faculty of Biology, Medicine and Health, University of Manchester and Manchester University Foundation Trust, Manchester, UK.

      Department of Medicine, Manchester Royal Infirmary, Manchester, UK; Diabetes Research Institute, University of Miami, Miami, FL, USA.

      University of Miami, Miami, Florida, USA

      International Diabetes Federation.

      2020

      University of Miami, Miami, FL, USA

      President, International Diabetes Federation 2020-21.

      Manchester Diabetes Centre, Manchester Royal Infirmary, Manchester, UK

      2019

      Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom

      Andrew JM Boulton MD DSc FRCP is a Professor of Medicine at the University of Manchester, UK and the University of Miami, USA, and Consultant Physician at Manchester Royal Infirmary, UK. Competing interests: none declared

      Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester and NIHR/Wellcome Trust Clinical Research Facility, Manchester, UK

      Diabetes Research Institute, University of Miami, Miami, Florida

      2018

      Faculty of Medical Human Sciences, University of Manchester, UK

      Manchester Diabetes Centre, Manchester Royal Infirmary, Manchester, United Kingdom

      2017

      University of Miami School of Medicine, Diabetes Research Institute, United States

      2016

      Manchester Diabetes Centre, University of Manchester, Manchester, U.K.

      Toronto, ON

      2015

      Andrew J M Boulton MD DSc FRCP is Professor of Medicine in the University of Manchester, UK, and the University of Miami, USA, and Consultant Physician at Manchester Royal Infirmary, Manchester, UK. Competing interests: none declared

      Visiting Professor, University of Miami, Miami, FL, USA

      Centre for Endocrinology and Diabetes, Institute of Human Development, University of Manchester and the Manchester Royal Infirmary, Central Manchester Hospital Foundation Trust, Manchester, U.K.

      Manchester Royal Infirmary, University of Manchester, 193 Hathersage Road, M13 0JE, Manchester, UK

      2014

      Centre for Endocrinology and Diabetes, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK

      Faculty of Medical & Human Sciences, University of Manchester, United Kingdom

      1st Department of Propaedeutic and Internal Medicine, Athens University Medical School, Laiko General Hospital, 17 Agiou Thoma Street, 11527, Athens, Greece.

      University of Manchester, Manchester, U.K

      2013

      Ipswich Hospital, Ipswich, UK

      Department of Medicine, University of Manchester, Manchester, U.K.

      European Association for the Study of Diabetes, Dusseldorf 40591, Germany

      University of Miami, Downtown, FL, USA

      Sign-in to see all concepts, it's free!
      Sample of concepts for which Andrew J M Boulton is among the top experts in the world.
      Concept World rank
      ulcer classification diagnosis #1
      nonrecurrent foot ulcers #1
      lowerextremity bypass ulceration #1
      filaments biothesiometry #1
      diabetic foot problems #1
      pressure pain relief #1
      ulceration amputation #1
      corneal sensitivity ccm #1
      participants lower speed #1
      neuropathic foot problems #1
      healthy control diabetes #1
      routine diabetic foot #1
      pin scales associations #1
      foot deformity article #1
      neuropathy 52 patients #1
      greater separations center #1
      fiber length cnfl #1
      deformities diabetic #1
      dialysis 150 patients #1
      survival rates amputation #1
      wound chronic wound #1
      jet lavage debridement #1
      indian asians asians #1
      qst electrophysiology #1
      ienfd 3 years #1
      challenges potential utility #1
      irremovable cast walkers #1
      osteomyelitis belowknee amputation #1
      method offloading compliance #1
      achilles capacity #1
      musgrave opg #1
      decreasing pncv #1
      century diabetic #1
      dsp 88 specificity #1
      fall risk stairs #1
      corneal sensitivity relates #1
      reliability occasions #1
      study peripheral neuropathies #1
      knee operating strengths #1
      macrovascular disease icam1 #1
      cnbd manual cnfd #1
      neuroqol factor analyses #1
      year amputation incidence #1
      averageanfl #1
      groups major amputations #1
      ivccm neuropathy #1
      type foot humans #1
      knee stair ascent #1
      oxide recurrent #1
      ulceration diabetic #1
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      Prominent publications by Andrew J M Boulton

      KOL-Index: 16643

      OBJECTIVE: Impaired glucose tolerance (IGT) through to type 2 diabetes is thought to confer a continuum of risk for neuropathy. Identification of subjects at high risk of developing type 2 diabetes and, hence, worsening neuropathy would allow identification and risk stratification for more aggressive management.

      RESEARCH DESIGN AND METHODS: Thirty subjects with IGT and 17 age-matched control subjects underwent an oral glucose tolerance test, assessment of neuropathic symptoms and ...

      Known for Type 2 Diabetes | Glucose Tolerance | Corneal Confocal Microscopy | Fiber Neuropathy | Skin Biopsy
      KOL-Index: 14746

      OBJECTIVE: The receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL), and osteoprotegerin (OPG) signaling pathway (RANKL/RANK/OPG signaling) is implicated in the osteolysis associated with diabetic Charcot neuroarthropathy (CN); however, the links with medial arterial calcification (MAC) seen in people with CN are unclear. This study aimed to investigate the role of RANKL/OPG in MAC in patients with CN.

      RESEARCH DESIGN AND METHODS: Enzyme-linked immunosorbent assay and ...

      Known for Opg Rankl | Diabetic Charcot | Arterial Calcification | Signaling Pathway | Receptor Activator
      KOL-Index: 13637

      OBJECTIVE: To report the incidence of diabetes-related lower-extremity complications in a cohort of patients enrolled in a diabetes disease management program.

      RESEARCH DESIGN AND METHODS: We evaluated screening results and clinical outcomes for the first 1,666 patients enrolled in a disease management program for a period of 24 months (50.3% men, aged 69.1 +/- 11.1 years).

      RESULTS: The incidence of ulceration, infection, amputation, and lower-extremity bypass was 68.4, 36.5, 5.9, and ...

      Known for Mexican Americans | Incidence Amputation | Nonhispanic Whites | Diabetic Foot Syndrome | Ulceration Infection
      KOL-Index: 13621

      The Achilles tendon (AT) has the capacity to store and release elastic energy during walking, contributing to metabolic energy savings. In diabetes patients, it is hypothesized that a stiffer Achilles tendon may reduce the capacity for energy saving through this mechanism, thereby contributing to an increased metabolic cost of walking (CoW). The aim of this study was to investigate the effects of diabetes and diabetic peripheral neuropathy (DPN) on the Achilles tendon and plantarflexor ...

      Known for Achilles Tendon | Dm Dpn | People Diabetes | Diabetic Patients | Controls Ctrl
      KOL-Index: 13313

      OBJECTIVE: To assess the diagnostic utility of corneal confocal microscopy (CCM) for diabetic peripheral neuropathy (DPN) and the risk factors for corneal nerve loss.

      RESEARCH DESIGN AND METHODS: A total of 490 participants, including 72 healthy control subjects, 149 with type 1 diabetes, and 269 with type 2 diabetes, underwent detailed assessment of peripheral neuropathy and CCM in relation to risk factors.

      RESULTS: Corneal nerve fiber density (CNFD) (P < 0.0001 and P < 0.0001), corneal ...

      Known for Type 2 Diabetes | Corneal Nerve | Confocal Microscopy | Diagnosis Dpn | Cnbd Cnfl
      KOL-Index: 12800

      The onset of diabetic neuropathy, a complication of diabetes mellitus, has been linked to poor glycemic control. We tested the hypothesis that the mitogen-activated protein kinases (MAPK) form transducers for the damaging effects of high glucose. In cultures of adult rat sensory neurons, high glucose activated JNK and p38 MAPK but did not result in cell damage. However, oxidative stress activated ERK and p38 MAPKs and resulted in cellular damage. In the dorsal root ganglia of ...

      Known for Activated Protein | P38 Jnk | Diabetes Mellitus | Diabetic Neuropathy | Kinases Mitogen
      KOL-Index: 12667

      OBJECTIVE: To investigate the role of limited joint mobility (LJM) in causing abnormal foot pressures and foot ulceration.

      RESEARCH DESIGN AND METHODS: The subjects were recruited from a general diabetes clinic where patients were screened for neuropathy, retinopathy, and elevated plantar foot pressure. Sixty-four patients in five groups were matched by age and sex in the following groups: group 1, patients with LJM and neuropathy; group 2, nonneuropathic diabetic patients with LJM; ...

      Known for Joint Mobility | Foot Ulceration | Patients Ljm | Pressures Diabetic | 2 5
      KOL-Index: 12631

      OBJECTIVE: Muscle weakness and atrophy of the lower limbs may develop in patients with diabetes, increasing their risk of falls. The underlying basis of these abnormalities has not been fully explained. The aim of this study was to objectively quantify muscle strength and size in patients with type 2 diabetes mellitus (T2DM) in relation to the severity of neuropathy, intramuscular noncontractile tissue (IMNCT), and vitamin D deficiency.

      RESEARCH DESIGN AND METHODS: Twenty patients with ...

      Known for Muscle Strength | Type 2 | Ankle Plantar | Knee Extensor | Vitamin Deficiency
      KOL-Index: 12505

      Human serum paraoxonase (PON1) is located on high density lipoprotein and has been implicated in the detoxification of organophosphates and possibly in the prevention of low density lipoprotein lipid peroxidation. PON1 has two genetic polymorphisms both due to amino acid substitution, one involving glutamine (A genotype) and arginine (B genotype) at position 192 and the other leucine (L genotype) and methionine (M genotype) at position 55. We investigated the effect of these ...

      Known for 192 Polymorphism | Serum Paraoxonase | Diabetes Mellitus | Insulin Dependent | Activity Concentration
      KOL-Index: 12357

      OBJECTIVE: To determine whether dialysis treatment is an independent risk factor for foot ulceration in patients with diabetes and renal impairment.

      RESEARCH DESIGN AND METHODS: We performed a cross-sectional study of consecutive patients with diabetes and stage 4 or 5 chronic kidney disease (CKD) attending clinics in Manchester (U.K.). Patients were classified as either receiving dialysis therapy (dialysis) or not (no dialysis). Foot assessment included diabetic peripheral neuropathy ...

      Known for Dialysis Treatment | Foot Ulceration | Chronic Kidney | Independent Risk Factor | 64 Years
      KOL-Index: 11809

      OBJECTIVE: To determine 1) foot ulcer rates for European, South-Asian, and African-Caribbean diabetic patients in the U.K and 2) the contribution of neuropathy and peripheral arterial disease (PAD) differences to altered ulcer risk between the groups.

      RESEARCH DESIGN AND METHODS: In this U.K. population-based study, we screened 15,692 type 1 and type 2 diabetic patients in the community health care setting for foot ulcers, foot deformities, neuropathy, and PAD plus other characteristics. ...

      Known for Foot Ulcer | South Asians | Diabetic Patients | Continental Ancestry | Type 1
      KOL-Index: 11726

      Human serum paraoxonase is physically associated with HDL and has been implicated in the detoxification of organophosphates and possibly in the prevention of LDL lipid peroxidation. We investigated the serum activity and concentration of paraoxonase in 78 patients with type 1 diabetes mellitus, 92 with type 2 diabetes, and 82 nondiabetic control subjects. Paraoxonase activity was generally lower in diabetics than in control subjects. This decrease was unrelated to differences in ...

      Known for Diabetes Mellitus | Paraoxonase Activity | Serum Lipids | Phenotype Distribution | Diabetics Control Subjects
      KOL-Index: 11702

      Surrogate markers of diabetic neuropathy are being actively sought to facilitate the diagnosis, measure the progression, and assess the benefits of therapeutic intervention in patients with diabetic neuropathy. We have quantified small nerve fiber pathological changes using the technique of intraepidermal nerve fiber (IENF) assessment and the novel in vivo technique of corneal confocal microscopy (CCM). Fifty-four diabetic patients stratified for neuropathy, using neurological ...

      Known for Small Fiber Damage | Diabetic Neuropathy | Patients Ccm | Surrogate Markers | Branch Density
      KOL-Index: 11409

      OBJECTIVES: Corneal confocal microscopy (CCM) is a rapid, non-invasive, reproducible technique that quantifies small nerve fibres. We have compared the diagnostic capability of CCM against a range of established measures of nerve damage in patients with diabetic neuropathy.

      METHODS: In this cross sectional study, thirty subjects with Type 1 diabetes without neuropathy (T1DM), thirty one T1DM subjects with neuropathy (DSPN) and twenty seven non-diabetic healthy control subjects underwent ...

      Known for Diabetic Neuropathy | Corneal Confocal Microscopy | Diagnostic Utility | Fibre Density | Patients Dspn
      KOL-Index: 11372

      OBJECTIVE: Corneal confocal microscopy (CCM) is a rapid, noninvasive, clinical examination technique that quantifies small nerve fiber pathology. We have used it to assess the neurological benefits of pancreas transplantation in type 1 diabetic patients.

      RESEARCH DESIGN AND METHODS: In 20 patients with type 1 diabetes undergoing simultaneous pancreas and kidney transplantation (SPK) and 15 control subjects, corneal sensitivity was evaluated using noncontact corneal esthesiometry, and ...

      Known for Type 1 Diabetes | Pancreas Transplantation | Confocal Microscopy | Nerve Regeneration | Diabetic Patients

      Key People For Diabetic Foot

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      Diabetes Research Institute, University of Miami, Miami, FL 33136, USA | Diabetes Research Institute, University of Miami, Miami, FL, United States | Manchester Royal Infirmary, Manchester, United Kingdom | Division of Endocrinology, Diabetes and Gas

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