• Disease
  • Iga
  • Iga Nephropathy
  • Yasuhiko Tomino

    Prominent publications by Yasuhiko Tomino

    KOL Index score: 14597

    Selective modulation of the secretion of proteinases and their inhibitors by growth factors in cultured differentiated podocytes.

    BACKGROUND: Podocyte damage is considered to be an important factor in the development of glomerulosclerosis. Morphological studies on experimental models of progressive glomerular disease have identified the detachment of podocytes from the glomerular basement membrane (GBM) as a critical step in the development and progression of glomerulosclerosis. ...

    Also Ranks for: Growth Factor |  cathepsin cystatin |  matrix metalloproteinase |  extracellular inhibitor |  platelet derived
    KOL Index score: 14359

    We determined the relationship between levels of serum cystatin C or serum creatinine (s-Cr) and prognostic stages of type 2 diabetic nephropathy. Serum samples from 174 patients with type 2 diabetes were obtained from Juntendo University Hospital, Tokyo and Juntendo Urayasu Hospital, Chiba, Japan. They were classified into four groups according to the Report of the Ministry of Health and Welfare of Japan as follows: Stage I (normoalbuminuric stage), Stage II (microalbuminuric stage), ...

    Also Ranks for: Serum Cystatin |  2 diabetic |  prognostic stages |  renal dysfunction |  macroalbuminuric stage
    KOL Index score: 14095

    BackgroundTonsillectomy and steroid pulse (TSP) therapy was proposed as a curative treatment for IgA nephropathy by Hotta et al. (Am J Kidney Dis 38:736–742, 2001) based on data that about 50% of patients achieved clinical remission (CR) of urinary abnormalities.Materials and methodsAs a primary survey, we sent a questionnaire and letter to 848 hospitals in Japan, each of which employed a Fellow of the Japanese Society of Nephrology between October and December of 2006, in order to ...

    Also Ranks for: Tsp Therapy |  steroid pulse |  nationwide survey |  patients iga |  urinary abnormalities
    KOL Index score: 14030

    BACKGROUND: Estimation of glomerular filtration rate (GFR) is limited by differences in creatinine generation among ethnicities. Our previously reported GFR-estimating equations for Japanese had limitations because all participants had a GFR less than 90 mL/min/1.73 m2 and serum creatinine was assayed in different laboratories.

    STUDY DESIGN: Diagnostic test study using a prospective cross-sectional design. New equations were developed in 413 participants and validated in 350 ...

    Also Ranks for: Estimated Gfr |  serum creatinine |  japanese equation |  development data |  bias 173
    KOL Index score: 13642

    The detection of circulating immune complexes (CIC) in sera from patients with IgA nephropathy is described. A solid-phase anti-C3 Facb enzyme immunoassay (EIA) was employed for detection of IgA-, IgG- and IgM-CIC in sera. The C1q-binding enzyme assay was also used for the detection of CIC in sera from these patients and healthy adults. Twenty-two patients with IgA nephropathy, 14 patients with other glomerular diseases and 19 healthy adults were examined by anti-C3 Facb EIA. The levels ...

    Also Ranks for: Iga Nephropathy |  sera patients |  detection cic |  glomerular diseases |  circulating immune complexes
    KOL Index score: 13291

    Podocyte foot process effacement and disruption of the slit diaphragm are typically associated with glomerular proteinuria and can be induced in rats by the injection of puromycin aminonucleoside. Here, we show that the induction of puromycin aminonucleoside nephrosis involves podocyte migration conducted by a coordinated interplay between the cysteine protease cathepsin L and alpha(3) integrin. Puromycin aminonucleoside treatment up-regulates cathepsin L expression in podocytes in vivo ...

    Also Ranks for: Podocyte Migration |  nephrotic syndrome |  puromycin aminonucleoside |  cathepsin expression |  slit diaphragm
    KOL Index score: 12987

    It is well known that obesity and insulin resistance are closely related to the development of type 2 diabetes. However, the exact pathogenic mechanism underlying the insulin resistance in renal disease has not been clarified. The purpose of the present study was to clarify the contribution of abdominal (visceral and subcutaneous) fat accumulation to insulin resistance and various clinical parameters, including C-reactive protein (CRP), in hemodialysis (HD) patients. Visceral and ...

    Also Ranks for: Insulin Resistance |  hemodialysis patients |  vfa sfa |  abdominal fat |  body mass bmi
    KOL Index score: 12673

    BACKGROUND: Upregulation of local monocyte chemoattractant protein-1 (MCP-1) production is involved in glomerular damage through macrophage recruitment and activation in diabetic nephropathy. Treatment of db/db mice with soluble receptor for advanced glycation end-products (RAGE) prevented recruitment of macrophages to the glomeruli and reduced albuminuria, suggesting that binding of ligands and RAGE may be involved in MCP-1 expression. Therefore, we investigated the role of advanced ...

    Also Ranks for: Advanced Glycation |  mcp1 expression |  podocytes cml |  monocyte chemoattractant |  products rage
    KOL Index score: 12656

    AIMS/OBJECTIVE: Nephropathy, a major complication of diabetes, is the leading cause of end-stage renal disease. Recent studies have demonstrated that podocyte injury is involved in the onset of and progression to renal insufficiency. Here, we describe a novel, highly sensitive ELISA for detecting urinary podocalyxin, a glycoconjugate on the podocyte apical surface that indicates podocyte injury, particularly in the early phase of diabetic nephropathy.

    METHODS: Urine samples from patients ...

    Also Ranks for: Urinary Podocalyxin |  podocyte injury |  early marker |  western blotting |  urine samples
    KOL Index score: 12581

    OBJECTIVES: Clinical studies have indicated the beneficial effect of an L/N-type calcium channel blocker (CCB), cilnidipine, on the progression of proteinuria in hypertensive patients compared with an L-type CCB, amlodipine. In the present study, we examined the effects of cilnidipine and amlodipine on the renal injury in spontaneously hypertensive rat/ND mcr-cp (SHR/ND) and their underlying mechanism.

    METHODS AND RESULTS: SHR/ND were treated with vehicle (nU10), cilnidipine [33 mg/kg ...

    Also Ranks for: Podocyte Injury |  type calcium |  cilnidipine amlodipine |  shr rats |  metabolic syndrome
    KOL Index score: 12495

    The actin-based foot processes of kidney podocytes and the interposed slit diaphragm form the final barrier to proteinuria. Mutations affecting several podocyte proteins cause disruption of the filtration barrier and rearrangement of the highly dynamic podocyte actin cytoskeleton. Proteins regulating the plasticity of the podocyte actin cytoskeleton are therefore of critical importance for sustained kidney barrier function. Synaptopodin is an actin-associated protein essential for the ...

    Also Ranks for: Kidney Podocytes |  irsp53 cdc42 |  binding proteins |  podocyte actin cytoskeleton |  actin protein
    KOL Index score: 12356

    BACKGROUND: Simple sclerosis consisted of a thin layer of submesothelial sclerotic tissue in peritoneal dialysis patients. Encapsulated peritoneal sclerosis (EPS) was characterized by thick sclerotic tissue involving vascular alterations in peritoneal dialysis patients. The objective of the present study is to evaluate serial morphologic changes and expressions of angiogenic factors [i.e., vascular endothelial growth factor (VEGF), angiopietin-1 (Ang-1), and angiopoietin-2 (Ang-2)] in ...

    Also Ranks for: Rat Model |  vegf ang2 |  peritoneal sclerosis |  endothelial growth |  dialysis patients
    KOL Index score: 12266

    BACKGROUND: Angiotensin-II induces nitro-oxidative stress in patients with diabetic nephropathy. Peroxynitrite and reactive oxide species can accelerate formation of advanced glycation end-products (AGEs). We investigated the effects of candesartan, an angiotensin-II type 1 receptor blocker (ARB), on the formation of AGEs and nitro-oxidative stress in type 2 diabetic KK/Ta mouse kidneys.

    METHODS: KK/Ta mice were divided into three treatment groups: an early treatment group receiving 4 ...

    Also Ranks for: Oxidative Stress |  type 2 |  diabetic kk |  advanced glycation |  rage expression
    KOL Index score: 12060

    Evaluations of glomerular mRNA levels encoding for PCNA, TNF-alpha, PDGF-A and -B chains, TGF-beta, IGF-I, bFGF, and EGF were made at 4, 12, and 24 wk after injection of STZ in Sprague-Dawley rats. The mRNA levels for PCNA, TNF-alpha, PDGF-B chain, TGF-beta, and bFGF increased with age in STZ-induced diabetic rats. At 24 wk after STZ injection, mRNA levels for PCNA, TNF-alpha, PDGF-B chain, TGF-beta, and bFGF were increased 3.8-fold, (P < 0.01), 4.2-fold (P < 0.01), 4.0-fold (P < 0.01), ...

    Also Ranks for: Diabetic Rats |  mrna expression |  growth factors |  insulin kidney |  pdgfb chain


    Yasuhiko Tomino: Influence Statistics

    Sample of concepts for which Yasuhiko Tomino is among the top experts in the world.
    Concept World rank
    pathogenesis iga nephropathy #1
    presternal catheter #1
    initiation dialysis period #1
    stage p000001 #1
    measured ccr #1
    onset renal prognosis #1
    cml pravastatin #1
    dendrin podocyte nucleus #1
    inflamed kidneys glomeruli #1
    healthy adults fibroblasts #1
    onset hae #1
    urinary podocytes levels #1
    fcgammar polymorphisms susceptibility #1
    bmt igan #1
    cultured mouse ccb #1
    mesangium glomerulonephritis #1
    region syntenic #1
    ddy mouse #1
    ccr blood pressure #1
    iga nephropathy presence #1
    oral astaxanthin #1
    double immunofluorescence patients #1
    icam1 expression glomeruli #1
    peritoneum bm cells #1
    lficolin masp2 #1
    utweak patients #1
    hematuria iga humans #1
    wielisakit #1
    urinary sediments patients #1
    development segmental sclerosis #1
    groups mip8a #1
    iga nephorpathy #1
    h2o2 production patients #1
    immunological abnormalities sera #1
    macroalbuminuric stage #1
    eps patients patients #1
    mctconclusion #1
    podocytes pravastatin #1
    kidneys pyridoxamine #1
    pan injected #1
    dendrin podocyte nuclei #1
    nephropathy ddy mice #1
    disease onset model #1
    circulating iga antibodies #1
    healthy individuals dmn #1
    ckd patients dyslipidemia #1
    week ddy #1
    imn srns #1
    apr proteins patients #1
    sprotein patients #1

    Key People For Iga Nephropathy

    Top KOLs in the world
    Bruce A Julian
    iga nephropathy african americans renal transplantation
    Yasuhiko Tomino
    iga nephropathy diabetic rats chronic kidney disease
    John Feehally
    iga nephropathy renal function acute kidney injury
    Rosanna Coppo
    iga nephropathy glomerular disease oxford classification
    F Paolo Principal discussant: Schena
    iga nephropathy renal damage growth factor
    Robert J Wyatt
    iga nephropathy complement activation serum levels

    Yasuhiko Tomino:Expert Impact

    Concepts for whichYasuhiko Tominohas direct influence:Iga nephropathy,  Diabetic nephropathy,  Patients iga,  Patients iga nephropathy,  Diabetic rats,  Chronic kidney disease,  Ddy mice,  Renal tissues.

    Yasuhiko Tomino:KOL impact

    Concepts related to the work of other authors for whichfor which Yasuhiko Tomino has influence:Iga nephropathy,  Chronic kidney disease,  Renal function,  Type 2 diabetes,  Blood pressure,  Japanese patients,  Oxidative stress.



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    Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan. | Progressive Renal Diseases Research, Research on Intractable Disease, from the Ministry of Health, Labour and Welfare of Japan, Tokyo, Japan | Medical Corporation SHOW