Alan A Wanderer
From the Department of Medicine, Division of Allergy, University of California at San Diego Medical Center, San Diego, Calif., USA | From the Department of Pediatrics and ...
KOL Resume for Alan A Wanderer (nasopharyngitis, common, cold, respiratory, upper respiratory tract, infection, upper, acute, tract, nasopharyngitis common cold, nasopharyngitis)
From the Department of Medicine, Division of Allergy, University of California at San Diego Medical Center, San Diego, Calif., USA
University of Colorado
Pediatric Allergy and Clinical Immunology Division, National Jewish Hospital and Research Center, Denver, Colo. USA
Prominent publications by Alan A Wanderer
We investigated the possibility that the inflammatory reaction in primary acquired cold urticaria might be associated with the release of platelet-activating factor. Six patients with the disease and five normal controls were subjected to cold-water challenges during which blood samples were obtained for measurement of the release of possible mediators: i.e., histamine, neutrophilic chemotactic activity, and platelet-activating factor-like lipid (PAF-LL). Four of the patients had ...
|Known for Cold Urticaria | Activating Factor | Primary Acquired | Histamine Release | Paf Patients|
Clinical characteristics of cold-induced systemic reactions in acquired cold urticaria syndromes: Recommendations for prevention of this complication and a proposal for a diagnostic classification of
[ PUBLICATION ]
The acquired cold urticaria (ACU) syndromes consists of nonfamilial heterogeneous disorders characterized by urticaria, angioedema, and occasionally symptoms of hypotension after cold exposure. In a study of 50 consecutive patients with ACU syndromes, it was observed that 70% experienced cold-induced systemic reactions, most frequently with aquatic activities. Patients with ACU syndromes were categorized by their response to an experimental cold-stimulation time test (CSTT) i.e., minimum ...
|Known for Cold Urticaria | Systemic Reactions | Diagnostic Classification | Patients Acu | Aquatic Activities|
Serum factors from 2 patients with primary acquired cold urticaria have been characterised. These serum factors, which can passively transfer cold urticaria to normal recipients, are low in titer, have short skin-fixation times, and are relatively thermostable. Reduction with dithiothreitol or mercaptoethanol followed by alkylation with iodoacetamide destroyed the cold urticaria transfer activity. The passive transfer factor in both cases was recovered in Sephadex G-200 gel filtration ...
|Known for Cold Urticaria | Serum Igm | Passive Transfer | Chromatography Gel | Immunoglobulin Immunoglobulins|
Primary Acquired Cold Urticaria: Double-Blind Comparative Study of Treatment With Cyproheptadine, Chlorpheniramine, and Placebo
[ PUBLICATION ]
Eight subjects with primary-acquired cold urticaria were treated with chlorpheniramine maleate, cyproheptadine hydrochloride, and placebo in a double-blind clinical trial. During three separate seven-day treatment periods, each patient took 4 mg of either active drug or lactose placebo three times a day. Objective measurements were made at the beginning and end of each treatment period by establishing the minimum time (MT) of cold stimulus application required to provoke urtication. In ...
|Known for Cold Urticaria | Primary Acquired|
Treatment of cold urticaria with cyproheptadine
[ PUBLICATION ]
We have been able to effectively treat cold-induced urticaria with cyproheptadine. In 8 of 9 patients with primary acquired cold urticaria treated with this drug, there was a striking prolongation of the minimum time required for the induction of a wheal with a cold stimulus. Concomitant with this change there was a significant reduction or elimination of cold sensitivity following natural exposure. The one treatment failure occurred in a patient with an atypical familial form of cold ...
|Known for Cold Urticaria | Minimum Time | Temperature Cyproheptadine | Primary Acquired | Required Induction|
An ‘Allergy’ to Cold
[ PUBLICATION ]
|Known for Cold Temperature|
This study describes an 11-year-old Caucasian girl with a nonfamilial, late-onsetimmunologic disorder characterized by hypogammaglobulinemia, absent anamnestic responses to previously recognized antigens, and deficient cellular immunity. Evidence for impaired cellular immunity initially included lymphopenia, absent delayed skin responses to numerous antigens and failure to develop contact hypersensitivity to dinitrofluorobenzene (DNFB), delayed skin homograft rejection, and absent in ...
|Known for Immunity Cellular | Immune Deficiency|
Primary Acquired Cold Urticaria-Reply
[ PUBLICATION ]
In Reply.— My reply to Dr Ramsay's comment is based primarily on the well-observed fact that acquired cold urticaria may induce serious anaphylactoid reactions. In one series, Horton et al1 described a 50% incidence of systemic reactions with syncope; 40% occurred while the persons were swimming and 18% of the persons had to be rescued during aquatic activities. Since cold urticaria must be viewed as a disorder with potential risk, it is imperative that the choice of treatment be ...
Alan A Wanderer: Influence Statistics
|cyproheptadine suppressive action||#1|
|addition spontaneous appearance||#1|
|cold urticaria lesions||#1|
|chlorpheniramine dermatol 11313751377||#1|
|urtication cold stimulus||#1|
|primaryacquired cold urticaria||#1|
|cold stimulus application||#1|
|suppressive action placebo||#1|
|cold urticaria cyproheptadine||#2|
|patient active drug||#2|
|cyproheptadine coldinduced urticaria||#2|
|elimination cold sensitivity||#2|
|coldinduced urticaria cyproheptadine||#2|
|drug striking prolongation||#2|
|apparent effectiveness cyproheptadine||#2|
|minimum time induction||#2|
|wheal cold stimulus||#2|
|patients acu syndromes||#3|
|hypotension cold exposure||#3|
|patients cold challenges||#3|
|coldinduced systemic reactions||#3|
|mediators normal controls||#3|
|acu syndromes doxepin||#3|
|cold urticaria angioedema||#3|
|inhibition pafll release||#3|
|pafll release inhibition||#3|
|aquatic activities patients||#3|
|natural cold exposure||#3|
|minimum time threshold||#5|
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Key People For Cold Urticaria
Alan A Wanderer:Expert Impact
Concepts for whichAlan A Wandererhas direct influence:Cold urticaria, Diagnostic classification, Systemic reactions, Acquired cold, Primary acquired, Acu syndromes, Urticaria syndromes, Patients cold urticaria.
Alan A Wanderer:KOL impact
Concepts related to the work of other authors for whichfor which Alan A Wanderer has influence:Cold urticaria, Activating factor, Human skin, Histamine release, Epidermal cells, Atopic dermatitis, Cluster headache.
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