Alan A Wanderer

Alan A Wanderer

From the Department of Medicine, Division of Allergy, University of California at San Diego Medical Center, San Diego, Calif., USA | From the Department of Pediatrics and ...

KOL Resume for Alan A Wanderer  (nasopharyngitis, common, cold, respiratory, upper respiratory tract, infection, upper, acute, tract, nasopharyngitis common cold, nasopharyngitis)


From the Department of Medicine, Division of Allergy, University of California at San Diego Medical Center, San Diego, Calif., USA


University of Colorado


Pediatric Allergy and Clinical Immunology Division, National Jewish Hospital and Research Center, Denver, Colo. USA


Prominent publications by Alan A Wanderer

KOL Index score: 6993

We investigated the possibility that the inflammatory reaction in primary acquired cold urticaria might be associated with the release of platelet-activating factor. Six patients with the disease and five normal controls were subjected to cold-water challenges during which blood samples were obtained for measurement of the release of possible mediators: i.e., histamine, neutrophilic chemotactic activity, and platelet-activating factor-like lipid (PAF-LL). Four of the patients had ...

Known for Cold Urticaria |  Activating Factor |  Primary Acquired |  Histamine Release |  Paf Patients
KOL Index score: 6869

The acquired cold urticaria (ACU) syndromes consists of nonfamilial heterogeneous disorders characterized by urticaria, angioedema, and occasionally symptoms of hypotension after cold exposure. In a study of 50 consecutive patients with ACU syndromes, it was observed that 70% experienced cold-induced systemic reactions, most frequently with aquatic activities. Patients with ACU syndromes were categorized by their response to an experimental cold-stimulation time test (CSTT) i.e., minimum ...

Known for Cold Urticaria |  Systemic Reactions |  Diagnostic Classification |  Patients Acu |  Aquatic Activities
KOL Index score: 4400

Serum factors from 2 patients with primary acquired cold urticaria have been characterised. These serum factors, which can passively transfer cold urticaria to normal recipients, are low in titer, have short skin-fixation times, and are relatively thermostable. Reduction with dithiothreitol or mercaptoethanol followed by alkylation with iodoacetamide destroyed the cold urticaria transfer activity. The passive transfer factor in both cases was recovered in Sephadex G-200 gel filtration ...

Known for Cold Urticaria |  Serum Igm |  Passive Transfer |  Chromatography Gel |  Immunoglobulin Immunoglobulins
KOL Index score: 3682

Eight subjects with primary-acquired cold urticaria were treated with chlorpheniramine maleate, cyproheptadine hydrochloride, and placebo in a double-blind clinical trial. During three separate seven-day treatment periods, each patient took 4 mg of either active drug or lactose placebo three times a day. Objective measurements were made at the beginning and end of each treatment period by establishing the minimum time (MT) of cold stimulus application required to provoke urtication. In ...

Known for Cold Urticaria |  Primary Acquired
KOL Index score: 3089

We have been able to effectively treat cold-induced urticaria with cyproheptadine. In 8 of 9 patients with primary acquired cold urticaria treated with this drug, there was a striking prolongation of the minimum time required for the induction of a wheal with a cold stimulus. Concomitant with this change there was a significant reduction or elimination of cold sensitivity following natural exposure. The one treatment failure occurred in a patient with an atypical familial form of cold ...

Known for Cold Urticaria |  Minimum Time |  Temperature Cyproheptadine |  Primary Acquired |  Required Induction

An ‘Allergy’ to Cold

KOL Index score: 692
Known for Cold Temperature
KOL Index score: 621

This study describes an 11-year-old Caucasian girl with a nonfamilial, late-onsetimmunologic disorder characterized by hypogammaglobulinemia, absent anamnestic responses to previously recognized antigens, and deficient cellular immunity. Evidence for impaired cellular immunity initially included lymphopenia, absent delayed skin responses to numerous antigens and failure to develop contact hypersensitivity to dinitrofluorobenzene (DNFB), delayed skin homograft rejection, and absent in ...

Known for Immunity Cellular |  Immune Deficiency
KOL Index score: 49

In Reply.— My reply to Dr Ramsay's comment is based primarily on the well-observed fact that acquired cold urticaria may induce serious anaphylactoid reactions. In one series, Horton et al1 described a 50% incidence of systemic reactions with syncope; 40% occurred while the persons were swimming and 18% of the persons had to be rescued during aquatic activities. Since cold urticaria must be viewed as a disorder with potential risk, it is imperative that the choice of treatment be ...


Alan A Wanderer: Influence Statistics

Sample of concepts for which Alan A Wanderer is among the top experts in the world.
Concept World rank
cyproheptadine suppressive action #1
urtication cold #1
addition spontaneous appearance #1
cold urticaria lesions #1
ineffectivearch #1
placebo ineffectivearch #1
chlorpheniramine dermatol 11313751377 #1
urtication cold stimulus #1
induction urtication #1
primaryacquired cold urticaria #1
urtication addition #1
demonstrated cyproheptadine #1
cold stimulus application #1
suppressive action placebo #1
cold urticaria cyproheptadine #2
patient active drug #2
cyproheptadine study #2
cyproheptadine coldinduced urticaria #2
elimination cold sensitivity #2
coldinduced urticaria cyproheptadine #2
drug striking prolongation #2
apparent effectiveness cyproheptadine #2
minimum time induction #2
wheal cold stimulus #2
induction wheal #2
urticaria cyproheptadine #3
patients acu syndromes #3
pafll patients #3
acu syndromes #3
hypotension cold exposure #3
coldwater challenges #3
positive cstts #3
patients cold challenges #3
coldinduced systemic reactions #3
cstt positive #3
mediators normal controls #3
acu syndromes doxepin #3
coalescent wheal #3
histamine neutrophilic #3
cold urticaria angioedema #3
inhibition pafll release #3
angioedema release #3
pafll release inhibition #3
aquatic activities patients #3
pafll release #3
natural cold exposure #3
test cstt #3
tritium urticaria #4
minimum time threshold #5
negative cstt #5

Key People For Cold Urticaria

Top KOLs in the world
Allen P Kaplan
factor xii chronic urticaria histamine release
Stephen I Wasserman
otitis media mast cells cold urticaria
Alan A Wanderer
cold urticaria serum factors diagnostic classification
Malcolm Watson Greaves
chronic urticaria human skin arachidonic acid
Michael A Beaven
mast cells protein kinase histamine release
Anne Kobza Black
human skin arachidonic acid delayed pressure urticaria

Alan A Wanderer:Expert Impact

Concepts for whichAlan A Wandererhas direct influence:Cold urticaria,  Diagnostic classification,  Systemic reactions,  Acquired cold,  Primary acquired,  Acu syndromes,  Urticaria syndromes,  Patients cold urticaria.

Alan A Wanderer:KOL impact

Concepts related to the work of other authors for whichfor which Alan A Wanderer has influence:Cold urticaria,  Activating factor,  Human skin,  Histamine release,  Epidermal cells,  Atopic dermatitis,  Cluster headache.



Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

From the Department of Medicine, Division of Allergy, University of California at San Diego Medical Center, San Diego, Calif., USA | From the Department of Pediatrics and Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denve

FREE Custom List