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    • Adrianna Vlachos
    • Adrianna Vlachos: Influence Statistics

      Adrianna Vlachos

      Adrianna Vlachos

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      Division of Hematology Oncology and Stem Cell Transplantation, Cohen Medical Center, Zucker School of Medicine at Hofstra Northwell, New Hyde Park, NY; | Feinstein Institutes ...

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      Adrianna Vlachos:Expert Impact

      Concepts for whichAdrianna Vlachoshas direct influence:Diamond blackfan,Blackfan anemia,Patients dba,Diamond blackfan anemia,Dba patients,Rp genes,Anemia dba,Osteogenic sarcoma.

      Adrianna Vlachos:KOL impact

      Concepts related to the work of other authors for whichfor which Adrianna Vlachos has influence:Blackfan anemia,Ribosomal proteins,Bone marrow,Ribosome biogenesis,Dyskeratosis congenita,Myelodysplastic syndrome,Stem cell.

      KOL Resume for Adrianna Vlachos

      Year
      2022

      Division of Hematology Oncology and Stem Cell Transplantation, Cohen Medical Center, Zucker School of Medicine at Hofstra Northwell, New Hyde Park, NY;

      Feinstein Institutes for Medical Research, Manhasset, New York, United States

      2021

      Division of Hematology/Oncology and Cellular Therapy, Cohen Children’s Medical Center of New York, New Hyde Park, NY USA

      Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York

      Feinstein Institute for Med Research/Cohen Children's Med Ctr, Northwell Health, Manhasset, NY

      2020

      Division of Hematology/Oncology and Cellular Therapy, Cohen Children's Medical Center, Northwell Health, New Hyde Park, New York

      Steven and Alexandra Cohen Children's Medical Center

      Feinstein Institutes for Medical Research, Manhasset, NY, USA

      2019

      The Feinstein Institute for Medical Research, Manhasset, NY, USA

      Hofstra Northwell School of Medicine, Hempstead, NY;

      2018

      The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY (A.V., D.S.O., E.A., J.K., M.L.L., D.G., K.O., J.M.L.)

      Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.

      Division of Hematology/Oncology and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, New York

      Feinstein Institute for Medical Research, Manhasset, NY

      2017

      The Feinstein Institute for Medical Research, Division of Hematology/Oncology and Stem Cell Transplantation, Cohen Children's Medical Center, New York, NY.

      Hofstra Northwell School of Medicine, Feinstein Institute for Medical Research, Cohen Children's Medical Center, Division of Hematology/Oncology and Stem Cell Transplantation, New Hyde Park, New York

      Cohen Children's Medical Center Hematology/Oncology and Stem Cell Transplantation New Hyde Park NY USA

      2016

      Professor, Elmezzi Graduate School of Medicine, Manhasset, New York

      Hofstra Northwell School of Medicine, Hempstead, NY

      2015

      CCMC Division of Hematology/Oncology and Stem Cell Transplantation New Hyde Park New York

      Hofstra North Shore-LIJ School of Medicine, Hempstead, NY;

      2014

      Cohen Children's Medical Center, New Hyde Park, NY

      Hofstra North Shore‐LIJ School of Medicine Departments of Pediatrics and Molecular Medicine Hempstead New York

      2013

      Feinstein Institute for Medical Research, Manhasset, NY;

      Division of Hematology/Oncology and Stem Cell Transplantation, Steven and Alexandra Cohen Children’s Medical Center, New Hyde Park, NY, USA

      Cohen Children's Medical Center of New York New Hyde Park New York

      2012

      The Feinstein Institute for Medical Research, Manhasset, NY;

      Division of Hematology/Oncology and Stem Cell Transplantation, Steven and Alexandra Cohen Children's Medical Center, New Hyde Park, New York

      2011

      Feinstein Institute for Medical Research, Patient-Oriented Research, Manhasset, NY;

      Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, NY

      Hofstra North Shore‐LIJ School of Medicine, Hempstead, New York

      2010

      Steven and Alexandra Cohen Children's Medical Center of New York, Albert Einstein College of Medicine, New Hyde Park, NY

      Cohen Children's Medical Center of New York, Hofstra University School of Medicine, New Hyde Park, New York

      2009

      Pediatric Hematology/Oncology and Stem Cell Transplantation, Schneider Children's Hospital and The Feinstein Institute for Medical Research, New Hyde Park, NY, USA

      2008

      Division of Hematology/Oncology and Stem Cell Transplantation, Schneider Children's Hospital, New Hyde Park, NY; Feinstein Institute for Medical Research, Manhasset, NY; and

      Schneider Children's Hospital, Albert Einstein College of Medicine, New Hyde Park, NY, USA

      2007

      Albert Einstein College of Medicine, New Hyde Park, NY, USA

      2006

      Genetics Division and Program in Genomics, Division of Pediatric Hematology, Children’s Hospital Boston and Dana-Farber Cancer Institute, Boston, MA, USA

      Division of Pediatric Hematology/Oncology and Stem Cell Transplantation, Albert Einstein College of Medicine, Schneider Children's Hospital, New Hyde Park, NY

      2005

      Hematology/Oncology and Stem Cell Transplantation, Schneider Children’s Hospital, Albert Einstein College of Medicine, New Hyde Park, NY, USA

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      Sample of concepts for which Adrianna Vlachos is among the top experts in the world.
      Concept World rank
      dba heterogeneous #1
      rps malignancies #1
      cancers underexpression #1
      biology diamond #1
      treat diamond #1
      dba ribosomopathy #1
      disorders normal hematopoiesis #1
      dbar #1
      diamond blackfan #1
      dba diamond #1
      diseases diamond #1
      diamondblackfan dba #1
      somatic ribosomopathies variety #1
      dba #1
      dba cell failure #1
      dba future #1
      leukemia ribosomes anemia #1
      ribosomopathies acquired #1
      individuals dba #1
      hormones anemia diamondblackfan #1
      dependent dba #1
      marrow failure details #1
      ribosomopathies leukemia #1
      defects ribosomal proteins #1
      aplasia congenital #1
      severity wide differential #1
      dba patients #1
      acquired ribosomopathies #1
      inciting marrow failure #1
      presents infancy #1
      spontaneous ribosomal proteins #1
      registry dbar #1
      outcome publication anemia #1
      pathophysiology diamond #1
      dba defects #1
      rps19 rps19 haploinsufficiency #1
      background diamond #1
      understanding dba #1
      dba genes #1
      dba hormones anemia #1
      blackfan haploinsufficiency #1
      acquired ribosomopathies leukemia #1
      details adolescent female #1
      dba probands #2
      dba congenital #2
      mutations ribosomal protein #2
      update diamond #2
      blackfan #2
      dba registry #2
      Sign-in to see all concepts, it's free!

      Prominent publications by Adrianna Vlachos

      KOL-Index: 12063

      Diamond-Blackfan anemia (DBA), an inherited bone marrow failure syndrome characterized by anemia that usually presents before the first birthday or in early childhood, is associated with birth defects and an increased risk of cancer. Although anemia is the most prominent feature of DBA, the disease is also characterized by growth retardation and congenital malformations, in particular craniofacial, upper limb, heart, and urinary system defects that are present in approximately 30%-50% of ...

      Known for Ribosomal Protein | Blackfan Anemia | Rps10 Rps26 | Dba Mutations | Rp Genes
      KOL-Index: 11786

      Diamond-Blackfan anemia (DBA), a congenital bone-marrow-failure syndrome, is characterized by red blood cell aplasia, macrocytic anemia, clinical heterogeneity, and increased risk of malignancy. Although anemia is the most prominent feature of DBA, the disease is also characterized by growth retardation and congenital anomalies that are present in approximately 30%-50% of patients. The disease has been associated with mutations in four ribosomal protein (RP) genes, RPS19, RPS24, RPS17, ...

      Known for Cleft Palate | Anemia Patients | Rpl5 Rpl11 | Ribosomal Protein L5 | Rp Genes
      KOL-Index: 11700

      Dyskeratosis congenita (DC) is a rare inherited form of bone marrow failure (BMF) caused by mutations in telomere maintaining genes including TERC and TERT. Here we studied the prevalence of TERC and TERT gene mutations and of telomere shortening in an unselected population of patients with BMF at our medical center and in a selected group of patients referred from outside institutions. Less than 5% of patients with BMF had pathogenic mutations in TERC or TERT. In patients with BMF, ...

      Known for Bone Marrow Failure | Telomere Length | Tert Gene | Patients Bmf | Dyskeratosis Congenita
      KOL-Index: 11053

      Severe congenital neutropenia (SCN) and Shwachman-Diamond syndrome (SDS) are congenital neutropenia syndromes with a high rate of leukemic transformation. Hematopoietic stressors may contribute to leukemic transformation by increasing the mutation rate in hematopoietic stem/progenitor cells (HSPCs) and/or by promoting clonal hematopoiesis. We sequenced the exome of individual hematopoietic colonies derived from 13 patients with congenital neutropenia to measure total mutation burden and ...

      Known for Congenital Neutropenia | Clonal Hematopoiesis | Patients Sds | Somatic Mutations | Leukemic Transformation
      KOL-Index: 10742

      Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome characterized by anemia, congenital abnormalities, and cancer predisposition. Small ribosomal subunit genes RPS19, RPS24, and RPS17 are mutated in approximately one-third of patients. We used a candidate gene strategy combining high-resolution genomic mapping and gene expression microarray in the analysis of 2 DBA patients with chromosome 3q deletions to identify RPL35A as a potential DBA gene. Sequence analysis ...

      Known for Ribosomal Subunit | Blackfan Anemia | Posttranscriptional Rna | Sequence Analysis | Cancer Predisposition
      KOL-Index: 10655

      Diamond Blackfan anemia (DBA) is an inherited bone marrow failure syndrome characterized by red cell aplasia and congenital anomalies. A predisposition to cancer has been suggested but not quantified by case reports. The DBA Registry of North America (DBAR) is the largest established DBA patient cohort, with prospective follow-up since 1991. This report presents the first quantitative assessment of cancer incidence in DBA. Among 608 patients with 9458 person-years of follow-up, 15 solid ...

      Known for Diamond Blackfan | Aplastic Anemia | Bone Marrow | Myelodysplastic Syndrome | Dyskeratosis Congenita
      KOL-Index: 10334

      Fanconi anemia (FA), dyskeratosis congenita (DC), and Diamond Blackfan anemia (DBA) are 3 of the most common inherited bone marrow failure syndromes (IBMFS), in which the hematologic manifestations can be cured with hematopoietic cell transplantation (HCT). Later in life, these patients face a variety of medical conditions, which may be a manifestation of underlying disease or due to pre-HCT therapy, the HCT, or a combination of all these elements. Very limited long-term follow-up data ...

      Known for Late Effects | Bone Marrow | Hematopoietic Cell | Consensus Statement | Aplastic Anemia
      KOL-Index: 10004

      This prospective study was designed to determine the safety and efficacy of cyclophosphamide, BCNU, and etoposide (CBV) conditioning and autologous peripheral blood stem cell transplant (PBSCT) in children with relapsed or refractory Hodgkin and non-Hodgkin lymphoma (HL and NHL). Patients achieving complete remission (CR) or partial remission (PR) after 2 to 4 courses of reinduction underwent a granulocyte-colony stimulating factor (G-CSF) mobilized PBSC apheresis with a target ...

      Known for Stem Cell | Hl Nhl | Peripheral Blood | 12 Months | Transplanted Patients
      KOL-Index: 9138

      Diamond-Blackfan anemia (DBA) is an inherited form of pure red cell aplasia that usually presents in infancy or early childhood and is associated with congenital malformations in ∼30-50% of patients. DBA has been associated with mutations in nine ribosomal protein (RP) genes in about 53% of patients. We completed a large-scale screen of 79 RP genes by sequencing 16 RP genes (RPL3, RPL7, RPL8, RPL10, RPL14, RPL17, RPL19, RPL23A, RPL26, RPL27, RPL35, RPL36A, RPL39, RPS4X, RPS4Y1, and ...

      Known for Ribosomal Rna | Blackfan Anemia | Frameshift Mutation | Patients Dba | Physical Abnormalities
      KOL-Index: 8823

      Current therapeutic strategies for sickle cell anemia are aimed at reactivating fetal hemoglobin. Pomalidomide, a third-generation immunomodulatory drug, was proposed to induce fetal hemoglobin production by an unknown mechanism. Here, we report that pomalidomide induced a fetal-like erythroid differentiation program, leading to a reversion of γ-globin silencing in adult human erythroblasts. Pomalidomide acted early by transiently delaying erythropoiesis at the burst-forming ...

      Known for Fetal Hemoglobin | Sickle Cell Anemia | Transcription Factors | Γ Globin | Terminal Differentiation
      KOL-Index: 8664

      Diamond–Blackfan anemia (DBA) is an inherited red blood cell aplasia that usually presents during the first year of life. The main features of the disease are normochromic and macrocytic anemia, reticulocytopenia, and nearly absent erythroid progenitors in the bone marrow. The patients also present with growth retardation and craniofacial, upper limb, heart and urinary system congenital malformations in ~30–50 % of cases. The disease has been associated with point mutations and large ...

      Known for Blackfan Anemia | Ribosomal Rna | Rp Genes | Comparative Genomic | Large Deletions
      KOL-Index: 8645

      Diamond-Blackfan anemia (DBA) is a heterogeneous genetic disorder characterized by red cell aplasia and congenital anomalies. One of what appears to be multiple DBA genes has been cloned. Affected individuals in the same family may vary dramatically as to the degree of anemia, response to corticosteroids, and the presence of congenital anomalies. The epidemiology of DBA has been gleaned largely from literature reviews. This approach is limited because of the two-fold disadvantage of the ...

      Known for Blackfan Anemia | Patients Dba | Congenital Anomalies | North America | Cell Aplasia
      KOL-Index: 8628

      The Diamond Blackfan Anemia (DBA) Registry of North America is a detailed database of patients with DBA from the United States and Canada. To date, 354 patients have been registered. From this database an analysis of the outcome of hematopoietic stem cell transplantation for DBA was undertaken. Of the 20 transplanted patients who met criteria for the diagnosis of DBA, eight underwent an allogeneic HLA-matched sibling hematopoietic stem cell transplant (SCT) and 12 an alternative donor ...

      Known for Diamond Blackfan | Cell Transplantation | Hematopoietic Stem | Patients Dba | Host Disease
      KOL-Index: 8270

      Diamond Blackfan anemia (DBA) is a heterogeneous genetic disorder characterized by red cell aplasia, congenital anomalies, and a predisposition to cancer. Although incompletely understood, the erythroid failure in DBA appears to result from the accelerated apoptosis of affected erythroid progenitors/precursors. One of what appears to be multiple DBA genes, coding for a ribosomal protein RPS 19, has been cloned. Even within multiplex families individuals may vary dramatically as to the ...

      Known for Diamond Blackfan | Patients Dba | Congenital Anomalies | Anemia Registry | Ribosomal Protein
      KOL-Index: 8090

      The genetic basis of Diamond-Blackfan anaemia (DBA), a congenital erythroid hypoplasia that shows marked clinical heterogeneity, remains obscure. However, the fact that nearly one-quarter of patients harbour a variety of mutations in RPS19, a ribosomal protein gene, provides an opportunity to examine whether haplo-insufficiency of RPS19 protein can be demonstrated in certain cases. To that end, we identified 19 of 81 DBA index cases, both familial and sporadic, with RPS19 mutations. We ...

      Known for Rps19 Mutations | Blackfan Anaemia | 10 Patients | Genetic Basis | Ribosomal Protein

      Key People For Diamond Blackfan

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      Adrianna Vlachos
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      Colin A Sieff
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      Hanna T Gazda
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      Ugo Ramenghi
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      Division of Hematology Oncology and Stem Cell Transplantation, Cohen Medical Center, Zucker School of Medicine at Hofstra Northwell, New Hyde Park, NY; | Feinstein Institutes for Medical Research, Manhasset, New York, United States | Division of Hema

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