• Disease
  • Differential
  • Differential Diagnosis
  • Mark R Wick

    Prominent publications by Mark R Wick

    KOL Index score: 14043

    Morphologic mimicry among human malignant neoplasms is a well-known phenomenon in surgical pathology; both undifferentiated and "committed" neoplasms may exhibit this trait. One particularly common group of histologic simulants includes ductal carcinomas of the breasts, the cutaneous appendages, and the salivary glands. One hundred three tumors in this structural cluster were analyzed microscopically and immunohistologically to codify points of potential pathologic similarity and ...

    Also Ranks for: Salivary Glands |  gland carcinoma |  estrogen receptors |  carcinoembryonic antigen |  breast neoplasms
    KOL Index score: 14014

    The distinction between squamoid basal cell carcinoma and basaloid squamous cell carcinoma (or between BCC and trichoepithelioma variants) is usually made readily on the basis of defined histological criteria. However, these differential diagnoses occasionally can pose difficult morphological problems. The stated distinctions are clinically important because the risk of progressive disease is significantly higher with squamous carcinoma of the skin than with basal cell carcinoma (BCC), ...

    Also Ranks for: Basal Cell Carcinoma |  squamous cell |  differential diagnosis |  monoclonal antigens |  bcc trichoepithelioma
    KOL Index score: 13777

    Neoplasms with rhabdoid features have been reported at many anatomic sites. In the kidney, rhabdoid tumors are typically found in children, whereas only rare examples have been reported in adults. Little is known of renal cell carcinomas (RCCs) that exhibit rhabdoid features. The objective of this study was to determine the incidence of RCC with rhabdoid attributes and characterize the histologic, immunophenotypic, and ultrastructural features by retrospective analysis of 480 ...

    Also Ranks for: Rhabdoid Features |  cell carcinoma |  grade presence |  rcc ema |  adult renal
    KOL Index score: 13234

    BACKGROUND: Some growth factors may promote tumor growth by affecting tumor angiogenesis. The angiogenic growth factor, pleiotrophin, was demonstrated previously in human breast carcinoma tissues; however, the pattern of pleiotrophin expression in normal breast tissues has not been established.

    METHODS: The expression of pleiotrophin and the related growth factor, midkine, was examined by polymerase chain reaction amplification of reverse transcriptase copies of RNA transcripts (RT-PCR) ...

    Also Ranks for: Pleiotrophin Expression |  growth factor midkine |  breast carcinoma |  northern blot analysis |  tumor angiogenesis
    KOL Index score: 13090

    CONTEXT: Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose.

    OBJECTIVE: To provide updated practical guidelines for the pathologic diagnosis of MM.

    DATA SOURCES: Pathologists involved in the International Mesothelioma Interest Group and others with an interest in the field contributed to this update. Reference material includes peer-reviewed publications and textbooks.

    CONCLUSIONS: There was consensus opinion regarding (1) distinction of benign from ...

    Also Ranks for: Pathologic Diagnosis |  malignant mesothelioma |  consensus statement |  immunohistochemical panels |  epithelioid mm carcinomas
    KOL Index score: 12782

    In an effort to shed light upon the nature of the colloid cyst, the immunohistochemical properties of 21 examples of this lesion were compared with those of other neuraxial cysts and choroid plexus epithelium. The neuraxial cysts included the following: eight Rathke's cleft cysts, 25 pituitaries containing follicular cysts of the pars intermedia, and four enterogenous cysts. Fifteen examples of normal choroid plexus and 12 choroid plexus papillomas were studied as well. These lesions ...

    Also Ranks for: Choroid Plexus |  colloid cyst |  s100 protein |  immunohistochemical study |  epithelial membrane antigen
    KOL Index score: 12514

    BACKGROUND: Although pathologic level of invasion and histologic grade are helpful in predicting the clinical outcome of transitional cell carcinoma of the bladder, they also create uncertainty. Immunohistochemical staining for p53, MIB-1, epidermal growth factor receptor (EGFR), c-erb B-2, and bcl-2 have shown promise as prognostic factors when evaluated singly, although multivariate analyses that include histologic grade and the interactive effects of these markers have not been ...

    Also Ranks for: Transitional Cell Carcinoma |  histologic grade |  bcl2 p53 |  immunohistochemical staining |  invasion bladder
    KOL Index score: 12009

    BACKGROUND: Atypical fibroxanthoma (AFX) is a pleomorphic spindle cell lesion of the skin; it is considered in the differential diagnosis with spindle cell malignant melanoma (MM) and sarcomatoid carcinoma/spindle cell squamous cell carcinoma (SCC). An optimum approach has yet to fully emerge with respect to the immunohistochemical discrimination of these lesions.

    METHODS: Departmental archives from 1978 onwards were searched for clinicopathologically confirmed cases of AFX, MM and SCC. ...

    Also Ranks for: Differential Diagnosis |  cell carcinoma |  desmoplastic melanoma |  cd10 p63 |  atypical fibroxanthoma
    KOL Index score: 11599

    GATA3 is a transcription factor, which is involved in the growth and differentiation of several human tissues. Immunohistochemical staining for this marker has proven to be useful in recognizing a number of tumors, most notably those in the urinary tract and breasts. To date, no study has specifically assessed the distribution of GATA3 among different histomorphologic subtypes of breast carcinoma. The surgical pathology archive at our institution was searched, to retrieve cases of breast ...

    Also Ranks for: Breast Carcinoma |  gata3 expression |  tissue microarrays |  cystic disease |  fluid protein
    KOL Index score: 11491

    The immunoprofiles of 121 germ cell and trophoblastic neoplasms were defined, using a battery of antibodies against cytokeratin (CK), vimentin (VIM), epithelial membrane antigen (EMA), placental alkaline phosphatase (PLAP), S-100 protein, leukocyte common antigen (LCA), UCHL-1, LN-2, carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), chromogranin A, Leu-7, alpha-fetoprotein (AFP), alpha-1-antitrypsin (AAT), and the beta subunit of human chorionic gonadotropin (BHCG). In ...

    Also Ranks for: Germ Cell |  trophoblastic neoplasms |  beta subunit |  monoclonal antigens |  placental alkaline phosphatase
    KOL Index score: 11006

    The identification of metastatic carcinoma of the breast may be difficult in the absence of a previous history of breast cancer. Various immunophenotypic markers have been introduced to aid in this process. A monoclonal antibody directed at a 15-kilodalton (kd) gross cystic disease fluid protein (GCDFP-15) was applied immunohistochemically to paraffin sections of 105 breast cancers and 585 nonmammary malignancies in order to assess its value in this context. In addition, GCDFP-15 was ...

    Also Ranks for: Breast Cancer |  immunohistochemical analysis |  metastatic carcinoma |  cystic disease |  sensitivity specificity
    KOL Index score: 10983

    Most prior studies of primary diagnosis in surgical pathology using whole slide imaging (WSI) versus microscopy have focused on specific organ systems or included relatively few cases. The objective of this study was to demonstrate that WSI is noninferior to microscopy for primary diagnosis in surgical pathology. A blinded randomized noninferiority study was conducted across the entire range of surgical pathology cases (biopsies and resections, including hematoxylin and eosin, ...

    Also Ranks for: Primary Diagnosis |  surgical pathology |  slide imaging |  reference standard |  hematoxylin eosin


    Mark R Wick: Influence Statistics

    Sample of concepts for which Mark R Wick is among the top experts in the world.
    Concept World rank
    skin adenoid #1
    cutaneous granular #1
    mbcs mbc #1
    59 bclp #1
    dfsp manifests #1
    tufts proliferation #1
    fbc mbcs #1
    uel cutaneous lesions #1
    scc cd99 #1
    afx mm #1
    0 synovial sarcomas #1
    mesenchymal profile #1
    flow cytometric comparison #1
    m1 ln2 #1
    causation assessment #1
    cd20 cd43 #1
    biomarkers differential education #1
    authors ocots #1
    matrical sclerosis #1
    f8rag uea #1
    bgi epithelial antigens #1
    tumors histologically #1
    male carcinoembryonic ductal #1
    lesional glands #1
    bclp mls #1
    spindlecell carcinomas #1
    histopathologic prognosis #1
    jawbones osteofibrous dysplasia #1
    causation mm #1
    nonsecretory state #1
    lymphomas lymphoid #1
    lyso ptcl #1
    s100 stains #1
    mae rae #1
    histologi #1
    lung concepts #1
    selected benign lesions #1
    nevi epithelioid histiocytoma #1
    dendriticcell sarcoma #1
    ocots glandular differentiation #1
    histopathologic considerations management #1
    uel lca #1
    authors intrathoracic neoplasms #1
    pseudoneoplastic #1
    b723 antibodies #1
    differentiated enteric #1
    myofibroblastic tumor heart #1
    evidencebased principles pathology #1
    breast carrier #1
    neuroendocrine neoplasms lung #1

    Key People For Differential Diagnosis

    Top KOLs in the world
    Christopher D M FLETCHER†
    soft tissue situ hybridization fibrous histiocytoma
    Dennis, W Dickson
    lewy bodies alzheimer disease frontotemporal dementia
    Markku M A Miettinen
    gastrointestinal stromal tumors differential diagnosis epithelioid sarcoma
    John Q Trojanowski
    alzheimer disease lewy bodies tau pathology
    Andrew John Andrew
    parkinsons disease progressive supranuclear motor fluctuations
    Juan Rosai
    papillary carcinoma lymph nodes sinus histiocytosis

    Mark R Wick:Expert Impact

    Concepts for whichMark R Wickhas direct influence:Differential diagnosis,  Cell carcinoma,  Paraffin sections,  Germ cell,  Juan rosai,  Pathologic diagnosis,  Malignant mesothelioma,  Diagnostic immunohistochemistry.

    Mark R Wick:KOL impact

    Concepts related to the work of other authors for whichfor which Mark R Wick has influence:Cell carcinoma,  Differential diagnosis,  Malignant mesothelioma,  Urinary bladder,  Synovial sarcoma,  Neuroendocrine tumors,  Situ hybridization.



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    The University of Virginia, Virginia, USA | Department of Pathology, University of Virginia, Charlottesville, VA, USA | Department of Pathology, University of Virginia, PO Box 800214, 1215 Lee Street, Hospital Expansion Building Room 3020, Charlottes