Direct Impact

Concepts for which Mariko Dawn DeWire has direct influence:

diffuse intrinsic pontine glioma
bmi-1 modulation
diagnostic biopsy
spatial genomic heterogeneity
radiation therapy
fanconi anemia
female survivors

External impact

Concepts related to the work of other authors for which Mariko Dawn DeWire has influence:

imaging features
diffuse intrinsic pontine glioma
international dipg registry
diagnostic biopsy
spatial genomic heterogeneity
widespread inter-
tb-25limited autopsy

Prominent publications by Mariko Dawn DeWire

KOL-Index: 48 An adequate understanding of the relationships between radiographic and genomic features in diffuse intrinsic pontine glioma (DIPG) is essential, especially in the absence of universal biopsy, to further characterize the molecular heterogeneity of this disease and determine which patients are most likely to respond to biologically-driven therapies. Here, a radiogenomics analytic approach was ...
KOL-Index: 41 INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) and midline high-grade glioma (mHGG) are lethal childhood brain tumors. Spatial genomic heterogeneity has been well-described in adult HGG but has not been comprehensively characterized in pediatric HGG. We performed whole exome sequencing on 38-matched primary, contiguous, and metastatic tumor sites from eight children with DIPG (n = 7) ...
Known for
Spatial Conservation | Mutations Dipg
KOL-Index: 39 BACKGROUND: DIPG generally occurs in young school-age children, although can occur in adolescents and young adults. The purpose of this study was to describe clinical, radiological, pathologic, and molecular characteristics in patients ≥10 years of age with DIPG enrolled in the International DIPG Registry (IDIPGR). METHODS: Patients ≥10 years of age at diagnosis enrolled in the IDIPGR with ...
Known for
Dipg Survival | Autopsy | Short-Term Survivors | Atrx Mutation Rates
KOL-Index: 30 PurposeCyclin-dependent kinase-retinoblastoma (CDK-RB) pathway is dysregulated in some diffuse intrinsic pontine gliomas (DIPG). We evaluated safety, feasibility, and early efficacy of the CDK4/6-inhibitor ribociclib, administered following radiotherapy in newly-diagnosed DIPG patients.MethodsFollowing radiotherapy, eligible patients received ribociclib in 28-day cycles (350 mg/m2; 21 days ...
Known for
Dipg Months | Early Year | Increased Tumor | Ribociclib Administered
KOL-Index: 29 PURPOSE: Diffuse intrinsic pontine glioma (DIPG) is a devastating pediatric disease, with a median survival of <1 year. Here, we review our institution's DIPG experience over an 8-year interval and perform a systematic review of the literature, specifically evaluating reports of reirradiation (reRT) for DIPG. METHODS AND MATERIALS: We retrospectively reviewed the medical records of 26 ...
Known for
Concurrent Adjuvant | Radiation Select | Institution Dipg | Pontine
KOL-Index: 26 Genomic sequencing studies have uncovered alterations of checkpoint cell cycle regulators (CDK4/6, CDK2NA) in diffuse intrinsic pontine gliomas (DIPG) and high-grade gliomas (HGG). Ribociclib (LEE011) is an orally bioavailable, small molecule inhibitor of CDK4/CyclinD1 and CDK6/CyclinD3 complexes resulting in hypophosphorylation of RB and cell cycle arrest. In a feasibility, phase II study, ...
Known for
Diffuse Pontine | Tolerated Grade | Biopsied Dipg | Ribociclib Lee011
KOL-Index: 25 BACKGROUND: Female survivors of central nervous system (CNS) tumors are at an increased risk for gonadal damage and variations in the timing of puberty following radiotherapy and alkylating agent-based chemotherapy. PROCEDURE: Clinical and laboratory data were obtained from 30 evaluable female patients with newly diagnosed embryonal CNS tumors treated on a prospective protocol (SJMB 96) at ...
Known for
Agent-Based Chemotherapy | Primary Cns | Follow-Up Post Completion | Tanner Stage I-Ii
KOL-Index: 22 Although bevacizumab has not proven effective in adults with newly diagnosed high-grade gliomas (HGG), feasibility in newly diagnosed children with diffuse intrinsic pontine gliomas (DIPG) or HGG has not been reported in a prospective study. In a safety and feasibility study, children and young adults with newly diagnosed HGG received radiotherapy (RT) with bevacizumab (10 mg/kg: days 22, ...
Known for
Adults Hgg | Grade 3 Hepatotoxicity | Lymphopenia | Diagnosed Children
KOL-Index: 22 There is a paucity of data regarding patterns of progression in children with high-grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG) treated with bevacizumab (BVZ) at diagnosis. We performed a retrospective study of 20 children with HGG or DIPG who received BVZ-based therapy at diagnosis on, or according to, a bi-institutional study. Magnetic resonance imaging (MRI) ...
Known for
Local Diffuse | Glioma Dipg

Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

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