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    • Lawrence Joseph Wheat
    • Lawrence Joseph Wheat

      Lawrence Joseph Wheat

      MiraVista Diagnostics, Indianapolis, Indiana, USA | Miravista Diagnostics, LLC, Indianapolis, Indiana, USA. | MiraVista Diagnostics, Indianapolis, Indiana, USA. | MiraVista ...



      KOL Resume for Lawrence Joseph Wheat


      MiraVista Diagnostics, Indianapolis, Indiana, USA


      MiraVista Diagnostics, Indianapolis, Indiana, USA.


      MiraVista Diagnostics, Indianapolis, Indianapolis, Indiana


      Department of Medicine, Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

      From MiraVista Diagnostics, Indianapolis, Indiana.


      MiraVista Diagnostics, Indianapolis, IN, USA


      MiraVista Diagnostics, 4705 Decatur Boulevard, Indianapolis, IN 46241, USA


      MiraVista Laboratories, Indianapolis, IN, United States of America


      University of Michigan Health System, Division of Infectious Diseases (JR, CAK), Ann Arbor, Michigan; Veterans Affairs Ann Arbor Healthcare System (CAK), Ann Arbor, Michigan; University of Wisconsin, Division of Infectious Diseases (JAS), Madison, Wisconsin; University of Kansas School of Medicine (MA), Wichita, Kansas; Sawtooth Infectious Diseases (SB), Boise, Idaho; Idaho Falls Infectious Diseases (MIB), Idaho Falls, Idaho; Stanford University, Division of Infectious Diseases and Geographic Medicine (SD), Palo Alto, California; Vanderbilt University, Division of Infectious Diseases (PWW), Nashville, Tennessee; University of Oklahoma College of Medicine, Division of Infectious Diseases (DAD), Oklahoma City, Oklahoma; Community Infectious Disease (SAN), Indianapolis, Indiana; Mayo Clinic, Division of Infectious Diseases (HRV), Phoenix, Arizona; North Dakota State University, Master of Public Health Program (PJC), Fargo, North Dakota; Mayo Clinic, Division of Infectious Diseases (PV), Rochester, Minnesota; Scott and White Clinic (JC), Texas A&M University College of Medicine, Temple, Texas; Infectious Diseases Specialists (SMS), Dallas, Texas; and MiraVista Diagnostics (LJW), Indianapolis, Indiana.

      MiraVista Diagnostics, Indianapolis, Indianapolis, USA


      Aspergillus Technology Consortium (AsTeC), Würzburg, Germany

      Miravista Diagnostics, Indianapolis, Indiana


      MiraVista Diagnostics and MiraBella Technologies, Indianapolis, IN, USA

      From the Department of Pediatrics, Indiana University School of Medicine, and Mira Vista Diagnostics, Indianapolis, IN.


      MiraVista Diagnostics and MiraBella Technologies, Indianapolis, Indiana


      MiraVista Laboratories, Indianapolis, IN


      MiraVista Diagnostics/MiraBella Technologies, Indianapolis, IN, USA

      Miravista Labs, Indianapolis, Indiana


      Roudebush VA Medical Center, Indianapolis, Indiana

      Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee


      MiraVista Diagnostics
 4444 Decatur Blvd., Suite 300
 Indianapolis, Indiana 46241

      Mira Vista Diagnostics, Indianapolis, Indiana


      MiraVista Diagnostics
 Indianapolis, Indiana


      Dr. Mitchell Goldman, Indiana University School of Medicine, Div. of Infectious Diseases, Wishard Memorial Hospital, Rm. OPW-430, 1001 W. 10th St., Indianapolis, IN 46202

      Department of Medicine, Division of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, Indiana; Director, MiraVista Diagnostics, Indianapolis, Indiana; Department of Pathology and Laboratory Medicine, Division of Clinical Microbiology Indiana University School of Medicine and Clarian Health Partners, Inc. (Methodist-IU-Riley Hospitals), Indianapolis, Indiana; and Chief of Medicine, Roudebush VA Medical Center, Indianapolis, Indiana


      From the *Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, and the †Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA; ‡Shelby County Health Department, Shelbyville, IN; §Indiana State Department of Health and ∥MiraVista Diagnostics, Indianapolis, IN; and the ¶National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH

      Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana


      Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

      Associate Editor

      Histoplasmosis Reference Laboratory, Indianapolis and


      Department of Medicine, Indiana University School of MedicineIndianapolis, Indiana

      Histoplasmosis Reference Laboratory


      Division of Infectious Diseases, Indiana University School of Medicine, Richard L. Roudebush Department of Veterans' Affairs Hospital, Histoplasmosis Reference Laboratory, Indianapolis, IN 46202-28790, USA.

      Department of Medicine, Indiana University School of Medicine

      Veterans' Affairs Medical Center,

      Histoplasmosis Reference Laboratory, and


      Departments of Internal Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA

      Department of Pathology and Laboratory Medicine , Indianapolis, Indiana

      Roudebusch Veterans' Affairs Medical Center3 and


      Division of Infectious Diseases, Indiana University Medical Center, Indianapolis, Indiana


      Department of Medicine, Indiana University School of Medicine, Indianapolis 46262, USA.


      Division of Infectious Diseases, Department of Medicine, Indiana University Medical Center, Indianapolis, Indiana, USA



      Lawrence Joseph Wheat: Influence Statistics

      Sample of concepts for which Lawrence Joseph Wheat is among the top experts in the world.
      Concept World rank
      reactivity coccidioides #1
      greater numbers lymphocytes #1
      histoplasma antigen test #1
      502 aureus strain #1
      histoplasma urine antigen #1
      histoplasma capsulatum diagnosis #1
      specific antigens urine #1
      mvista histoplasma #1
      detection staphylococcal antigen #1
      latin america class #1
      common endemic mycosis #1
      patients baseline isolates #1
      antigen excretion #1
      27 diabetes mellitus #1
      central indiana indianapolis #1
      model histoplasmosis #1
      identical molecules study #1
      fungitell publication antigens #1
      immy alpha #1
      mvista histoplasma lfa #1
      clearance fungemia #1
      fungemia itraconazole #1
      progressive dissemination diagnosis #1
      conclusion hpa detection #1
      infliximab control antibody #1
      fungal conflict #1
      histoplasmosis occurring #1
      76 complement fixation #1
      major highway construction #1
      range ≤0007 #1
      characterized assays #1
      capsulatum igg #1
      histoplasma initial diagnosis #1
      recurrence triazoles histoplasma #1
      mhpa capsulatum antigen #1
      blastomycosis 13 dogs #1
      threephase bone scans #1
      detection antigen #1
      sensitivity mvista #1
      100 control specimens #1
      progressive disseminated disease #1
      histoplasmosis sarcoidosis #1
      concurrent testing antigen #1
      80 percent studies #1
      histoplasmosis cases #1
      4 pneumophila urinary #1
      fungal antigens specificity #1
      histoplasma immunoglobulin #1
      central indiana rise #1
      histoplasmosis antibodies #1


      Prominent publications by Lawrence Joseph Wheat

      KOL-Index: 16038

      The effects of prolonged itraconazole exposure on the susceptibility of Candida albicans isolates to itraconazole and fluconazole have not been well characterized. A recent placebo-controlled study of long-term itraconazole antifungal prophylaxis in persons with advanced human immunodeficiency virus infection afforded the opportunity to address this question. Mucosal Candida sp. isolates were obtained from subjects who developed oropharyngeal or esophageal candidiasis, and in vitro ...

      Known for Candida Albicans | Itraconazole Fluconazole | Vitro Azole Resistance | Immunodeficiency Virus | Mucosal Candidiasis
      KOL-Index: 12790

      We review the experience at our institution with galactomannan (GM) testing of bronchoalveolar lavage (BAL) fluid in the diagnosis of invasive pulmonary aspergillosis (IPA) among solid-organ transplant recipients. Among 81 patients for whom BAL GM testing was ordered (heart, 24; kidney, 22; liver, 19; lung, 16), there were five cases of proven or probable IPA. All five patients had BAL GM of > or = 2.1 and survived following antifungal therapy. The sensitivity, specificity, and positive ...

      Known for Bronchoalveolar Lavage | Transplant Recipients | Bal Gm | Specificity Positive Predictive | Invasive Pulmonary
      KOL-Index: 12666

      CONTEXT: Management of antiretroviral treatment failure in patients receiving protease inhibitor (PI)-containing regimens is a therapeutic challenge.

      OBJECTIVE: To assess whether adding a second PI improves antiviral efficacy of a 4-drug combination in patients with virologic failure while taking a PI-containing regimen.

      DESIGN: Multicenter, randomized, 4-arm trial, double-blind and placebo-controlled for second PI, conducted between October 1998 and April 2000, for which there was a ...

      Known for Viral Load | Protease Inhibitor | 24 Weeks | Saquinavir Indinavir | Prior Exposure
      KOL-Index: 12483

      Pulmonary aspergillosis in nonimmunocompromised hosts, although rare, is being increasingly recognized. The diagnosis of pulmonary aspergillosis is difficult, since the recovery of Aspergillus from respiratory samples cannot differentiate colonization from invasion. We assessed the role of bronchoalveolar lavage (BAL) in detecting galactomannan (GM) for diagnosing pulmonary aspergillosis in 73 nonimmunocompromised patients with pulmonary infiltrates for whom the test was ordered. Six ...

      Known for Pulmonary Aspergillosis | Bronchoalveolar Lavage | Sensitivity Specificity | Galactomannan Diagnosis | Bal Gm
      KOL-Index: 12354

      A randomized, open-label, comparative study was conducted in 30 male patients with moderately advanced human immunodeficiency virus (HIV) infection to examine the pharmacokinetics of an investigational intravenous preparation of itraconazole compared with pharmacokinetics after administration of itraconazole capsules. The study also assessed whether adequate plasma concentrations of itraconazole could be rapidly achieved with the intravenous formulation and then maintained after ...

      Known for Intravenous Itraconazole | Plasma Concentrations | Oral Administration | Virus Infection | Capsules Patients
      KOL-Index: 11720

      BACKGROUND: Detection of antigen in BAL is useful for diagnosis of histoplasmosis. The MVista Histoplasma antigen enzyme immunoassay has been modified to permit quantification. The purpose of this study is to compare the sensitivity of the quantitative antigen detection assay with cytopathology and culture of BAL specimens.

      METHODS: BAL from patients with histoplasmosis who were evaluated at the Indiana University Medical Center and controls without histoplasmosis were studied. BAL fluid ...

      Known for Antigen Detection | Patients Histoplasmosis | Bal Fluid | Serum Urine | Diagnosis Sensitivity
      KOL-Index: 11559

      PURPOSE: Oropharyngeal candidasis (thrush) is the most common opportunistic infection in individuals who are positive for the human immunodeficiency virus (HIV) and those who have progressed to AIDS. Itraconazole has a broad in vitro spectrum of activity, including a wide variety of Candida species. Our study determined the relative efficacy of a new oral solution formulation of itraconazole and fluconazole tablets in the treatment of oropharyngeal candidiasis.


      Known for Itraconazole Oral Solution | Oropharyngeal Candidiasis | Aids Patients | Fluconazole Treatment | 7 14
      KOL-Index: 11384

      The diagnosis of Histoplasma capsulatum infection by serologic testing for the presence of antibodies is limited by a high rate of false positive and false negative results and by the requirement that the patient have a normal immune response. We have developed a radioimmunoassay for the detection of H. capsulatum antigen in urine and serum specimens. Antigenuria was noted in 20 of 22 episodes of disseminated histoplasmosis that occurred in 16 patients, in 6 of 32 patients with ...

      Known for Capsulatum Antigen | Disseminated Histoplasmosis | Urine Specimens | 16 Patients | Serologic Testing
      KOL-Index: 10708

      Background: Central nervous system (CNS) histoplasmosis is a life-threatening condition and represents a diagnostic and therapeutic challenge. Isolation of Histoplasma capsulatum from cerebrospinal fluid (CSF) or brain tissue is diagnostic; however, culture is insensitive and slow growth may result in significant treatment delay. We performed a retrospective multicenter study to evaluate the sensitivity and specificity of a new anti-Histoplasma antibody enzyme immunoassay (EIA) for the ...

      Known for Histoplasma Meningitis | Cerebrospinal Fluid | Cns Histoplasmosis | Antibody Csf | Central Nervous
      KOL-Index: 10429

      PURPOSE: Disseminated histoplasmosis is a serious and often rapidly progressive, opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS), supporting the importance of rapid diagnostic tests. We investigated Histoplasma capsulatum polysaccharide antigen (HPA) detection, a promising new method for rapid diagnosis of histoplasmosis.

      PATIENTS AND METHODS: Sixty-one cases of disseminated histoplasmosis in patients with AIDS form the basis of this report. Control ...

      Known for Disseminated Histoplasmosis | Patients Aids | Immunodeficiency Syndrome | Hpa Urine | Antigen Detection
      KOL-Index: 10221

      PURPOSE: The purpose of this study was to establish the effect of induction and maintenance treatment with amphotericin B on levels of Histoplasma capsulatum var. capsulatum polysaccharide antigen (HPA) in the urine and blood of patients with acquired immunodeficiency syndrome (AIDS) and disseminated histoplasmosis.

      PATIENTS AND METHODS: This was a retrospective study of the effect of amphotericin B treatment on levels of HPA in the urine or serum from 70 patients with AIDS and ...

      Known for Histoplasma Capsulatum | Urine Serum | Successful Treatment | Patients Amphotericin | Disseminated Histoplasmosis
      KOL-Index: 10175

      BACKGROUND: Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have been of immense value to researchers who conduct clinical trials of antifungals, assess diagnostic tests, and undertake epidemiologic studies. However, their utility has not extended beyond patients with cancer or recipients of stem cell ...

      Known for Consensus Definitions | European Organization | Mycoses Study | Invasive Fungal | Patients Cancer
      KOL-Index: 9565

      We have evaluated the Platelia Aspergillus enzyme immunoassay for detection of galactomannan in bronchoalveolar lavage (BAL) specimens in solid organ transplant patients with aspergillosis. The precision and reproducibility in serum or BAL to which galactomannan was added were similar. Sensitivity was 81.8% in patients with aspergillosis, and specificity was 95.8% in lung transplant patients who underwent BAL for surveillance for infection or rejection. Among transplant controls, ...

      Known for Bronchoalveolar Lavage | Aspergillus Galactomannan | Performance Characteristics | Sensitivity Specificity | Patients Aspergillosis

      Key People For Disseminated Histoplasmosis

      Top KOLs in the world
      Lawrence Joseph Wheat
      disseminated histoplasmosis histoplasma capsulatum antigen detection
      Carol A Kauffman
      fungal infections zoster vaccine endemic mycoses
      David S McKinsey
      fluconazole therapy hiv treatment histoplasmosis patients
      George A Sarosi
      disseminated histoplasmosis fungal infections pulmonary blastomycosis
      James E Loyd
      pulmonary hypertension bmpr2 mutation mediastinal fibrosis
      Roger M Des Prez
      bacterial endotoxin mediastinal fibrosis apical localization

      Lawrence Joseph Wheat:Expert Impact

      Concepts for whichLawrence Joseph Wheathas direct influence:Disseminated histoplasmosis,  Histoplasma antigen,  Capsulatum antigen,  Histoplasma capsulatum,  Fungal antigens,  Antigen detection,  Rapid diagnosis,  Enzyme immunoassay.

      Lawrence Joseph Wheat:KOL impact

      Concepts related to the work of other authors for whichfor which Lawrence Joseph Wheat has influence:Fungal infections,  Disseminated histoplasmosis,  Histoplasma capsulatum,  Invasive aspergillosis,  Central nervous,  Immunocompromised patients,  Diabetic foot.



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      MiraVista Diagnostics, Indianapolis, Indiana, USA | Miravista Diagnostics, LLC, Indianapolis, Indiana, USA. | MiraVista Diagnostics, Indianapolis, Indiana, USA. | MiraVista Diagnostics | MiraVista Diagnostics, Indianapolis, Indiana USA

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