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    • Charles René Leemans
    • Charles René Leemans

      Charles René Leemans

      Cancer Center Amsterdam, Department of Otolaryngology—Head and Neck Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The ...



      KOL Resume for Charles René Leemans


      Cancer Center Amsterdam, Department of Otolaryngology—Head and Neck Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands;,

      Department of Otolaryngology and Head and Neck Surgery, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands


      Department of Otolaryngology-Head and Neck Surgery, Cancer Center Amsterdam, Amsterdam University Medical Centers, Location VUmc, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands


      Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, Amsterdam, the Netherlands


      Cancer Center Amsterdam (CCA), Amsterdam UMC, location VUmc, Amsterdam, The Netherlands


      Department of Otolaryngology‐Head and Neck Surgery, VU University Medical Center, Cancer Center Amsterdam, The Netherlands


      VU University Medical Center Department of Otorhinolaryngology – Head and Neck Surgery Amsterdam the Netherlands



      Charles René Leemans: Influence Statistics

      Sample of concepts for which Charles René Leemans is among the top experts in the world.
      Concept World rank
      level emotional distress #1
      recurrent locoregional disease #1
      enucleation remaining patients #1
      shi carcinoma #1
      neoplasms humans hnc #1
      ottrt 8 weeks #1
      hpv status oscc #1
      pretreatment images #1
      89zrdn30 #1
      survival hpvprevalence #1
      hbaac median #1
      sticky saliva risk #1
      pet residualising radionuclide #1
      causal inference analyses #1
      margins local relapse #1
      validated test #1
      rfs combined models #1
      psychiatric disorder anxiety #1
      surgery ipsilateral neck #1
      thoracic duct cyst #1
      surgery pharmacokinetic analysis #1
      radiotherapy energy expenditure #1
      fieldwork component patients #1
      oscc dna aneuploidy #1
      100 loh #1
      mripositive nodes mri #1
      prognosis human papillomavirus #1
      hnc patients 70 #1
      questionnairehead #1
      ptln sensitivity #1
      purpose amsterdam #1
      95 hnc patients #1
      mat wst #1
      functional genomics patients #1
      mri criteria detection #1
      treatment d∗ #1
      recurrences 105 years #1
      glt16 #1
      p001 anteflexion #1
      selfcare education program #1
      endocrine dysfunction treatment #1
      risd neck neoplasms #1
      18fdgpet strategy patients #1
      recurrence prediction hpvstatus #1
      ptln metastasis #1
      swalm6 female head #1
      hazard ratio class #1
      field preneoplastic cells #1
      nasogastric feeding studies #1


      Prominent publications by Charles René Leemans

      KOL-Index: 15168

      BACKGROUND: Transcriptionally active high-risk human papilloma viruses (HPVs), particularly HPV type 16 (HPV16), are found in a subset of head and neck squamous-cell carcinomas (HNSCCs). HPV16-associated carcinogenesis is mediated by expression of the viral E6 and E7 oncoproteins, which cause deregulation of the cell cycle by inactivating p53 and pRb, respectively. We tested the hypothesis that HPV-associated HNSCCs display a pattern of genetic alterations different from those of HNSCCs ...

      Known for Hpv Dna | Transcriptionally Active | Viral E6 | Genetic Alterations | Neoplastic Genes
      KOL-Index: 14676

      BackgroundCancer survivors have to deal with a wide range of physical symptoms, psychological, social and existential concerns, and lifestyle issues related to cancer and its treatment. Therefore, it is essential that they have access to optimal supportive care services. The eHealth self-management application Oncokompas was developed to support cancer survivors with where they need to turn to for advice and guidance, as well as to increase their knowledge on the availability of optimal ...

      Known for Cancer Survivors | Optimal Supportive | Randomised Controlled Trial | Management Application | Costutility Oncokompas
      KOL-Index: 14464

      BACKGROUND: The incidence of human papillomavirus (HPV)-positive oropharyngeal cancer, a disease affecting younger patients, is rapidly increasing. Cetuximab, an epidermal growth factor receptor inhibitor, has been proposed for treatment de-escalation in this setting to reduce the toxicity of standard cisplatin treatment, but no randomised evidence exists for the efficacy of this strategy.

      METHODS: We did an open-label randomised controlled phase 3 trial at 32 head and neck treatment ...

      Known for Cisplatin Cetuximab | 3 Trial | Positive Oropharyngeal | Human Papillomavirus | 24 Months
      KOL-Index: 14288

      OBJECTIVES: The detection of distant metastases at initial evaluation may alter the selection of therapy in patients with head and neck squamous cell carcinoma (HNSCC). In this study the value of screening for distant metastases is evaluated.

      STUDY DESIGN: Retrospective analysis.

      METHODS: The results of screening for distant metastases were retrospectively analyzed in 101 consecutive HNSCC patients with high-risk factors who were scheduled for major surgery. All patients had computed ...

      Known for Distant Metastases | Local Neoplasms | Female Head | Bone Scintigraphy | Scan Thorax
      KOL-Index: 14272

      PURPOSE: Immuno-positron emission tomography (PET), the combination of PET with monoclonal antibodies (mAb), is an attractive option to improve tumor detection and to guide mAb-based therapy. The long-lived positron emitter zirconium-89 ((89)Zr) has ideal physical characteristics for immuno-PET with intact mAbs but has never been used in a clinical setting. In the present feasibility study, we aimed to evaluate the diagnostic imaging performance of immuno-PET with (89)Zr-labeled-chimeric ...

      Known for Lymph Node | Positron Emission | Immuno Pet | Monoclonal Carcinoma | Tumor Detection
      KOL-Index: 14175

      Recent studies have reported that p16 protein overexpression qualifies as a surrogate marker identifying an oncogenic human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC). However, there is still a percentage of OPSCCs that are positive for p16 immunohistochemistry (p16 IHC) but lack HPV DNA. The objective of this study was to characterize this group at the molecular level by performing sensitive HPV DNA- and RNA-based PCR methods and genetic profiling. ...

      Known for Hpv Dna | P16 Ihc | Neoplasms Papillomavirus | Proteins Viral | Surrogate Marker
      KOL-Index: 13826

      AIMS AND OBJECTIVES: To gain insight into cancer survivors' needs towards an eHealth application monitoring quality of life and targeting personalised access to supportive care.

      BACKGROUND: Supportive care in cancer addresses survivors' concerns and needs. However, many survivors are not taking advantage of supportive care provided. To enable cancer survivors to benefit, survivors' needs must be identified timely and effectively. An eHealth application could be a solution to meet ...

      Known for Cancer Survivors | Ehealth Application | Breast Neoplasms | Female Head | Health Patient
      KOL-Index: 13672

      BACKGROUND: Incidence and survival trends of head and neck squamous cell carcinoma (HNSCC) are essential knowledge for guiding policy making and research.

      METHODS: The total population of the Netherlands was studied covering 1989-2011. Two-and five-year survival and age-standardized incidence rates of HNSCC were assessed in relation to site, gender and age (15 years-of-age categories).

      RESULTS: We recorded a statistically significant increase of oral, oropharyngeal and hypopharyngeal ...

      Known for Squamous Cell | Incidence Survival | Laryngeal Carcinoma | Mouth Neoplasms | Netherlands Oropharyngeal
      KOL-Index: 13660

      BACKGROUND: Knowledge about the efficacy of behavioural intervention technologies that can be used by cancer survivors independently from a health-care provider is scarce. We aimed to assess the efficacy, reach, and usage of Oncokompas, a web-based eHealth application that supports survivors in self-management by monitoring health-related quality of life (HRQOL) and cancer-generic and tumour-specific symptoms and obtaining tailored feedback with a personalised overview of supportive care ...

      Known for Cancer Survivors | Intervention Control | Patient Activation | Application Oncokompas | Skills Confidence
      KOL-Index: 13362

      BACKGROUND: The clinical results of radiotherapy and endoscopic cordectomy for T1a glottic carcinoma are reported to be similar, but costs of both treatments may differ. Therefore, we retrospectively evaluated the costs, voice quality, quality of life, and clinical results of both treatments.

      METHODS: Costs and effects from the first visit up to 2 years of follow-up were calculated, based on chart data of 35 and 54 patients who were treated with curative intent for T1a glottic carcinoma ...

      Known for Voice Quality | Glottic Carcinoma | Local Control | Co2 Laser | Life Radiotherapy
      KOL-Index: 13200

      PURPOSE: The purpose of this multicentre prospective study was to investigate the significance of the radiation dose in the major and minor salivary glands, and other pre-treatment and treatment factors, with regard to the development of patient-rated xerostomia and sticky saliva among head and neck cancer (HNC) patients treated with primary (chemo-) radiotherapy ((CH)RT).

      METHODS AND MATERIALS: The study population was composed of 167 consecutive HNC patients treated with ...

      Known for Sticky Saliva | Ntcp Models | Conformal Radiotherapy | Neck Cancer | 6 Months
      KOL-Index: 13115

      BACKGROUND: Both induction chemotherapy followed by irradiation and concurrent chemotherapy and radiotherapy have been reported as valuable alternatives to total laryngectomy in patients with advanced larynx or hypopharynx cancer. We report results of the randomized phase 3 trial 24954 from the European Organization for Research and Treatment of Cancer.

      METHODS: Patients with resectable advanced squamous cell carcinoma of the larynx (tumor stage T3-T4) or hypopharynx (T2-T4), with ...

      Known for Larynx Preservation | Sequential Arm | Total Laryngectomy Patients | Chemotherapy Radiotherapy | Phase 3
      KOL-Index: 13099

      Human papillomavirus type 16 (HPV16) plays a role in the development of a subgroup of head and neck squamous cell carcinomas (HNSCC). However, uncertainty exists about the true impact of HPV in this tumor type as conflicting reports have been published with prevalence rates from 0 to 100%. We aimed to find a detection algorithm of a biologically and thus clinically meaningful infection, applicable for high-throughput screening of frozen and formalin-fixed paraffin embedded (FFPE) ...

      Known for Human Papillomavirus | Reliable Detection | Female Head | Gp5 6 | Neck Cancer
      KOL-Index: 13076

      The aim of the study was to define the cost-effectiveness of whole-body (18)F-FDG PET, as compared with chest CT, in screening for distant metastases in patients with head and neck squamous cell carcinoma (HNSCC).

      METHODS: In a multicenter prospective study, 145 consecutive patients with high risk factors for distant metastases and scheduled for extensive treatment underwent chest CT and whole-body (18)F-FDG PET for screening of distant metastases. The cost data of 80 patients in whom ...

      Known for Distant Metastases | Fdg Pet | Neck Neoplasms | Pretreatment Screening | Positive Predictive

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      Charles René Leemans:Expert Impact

      Concepts for whichCharles René Leemanshas direct influence:Distant metastases,  Neck cancer,  Squamous cell,  Head neck,  Cell carcinoma,  Neck neoplasms humans,  Female head,  Sticky saliva.

      Charles René Leemans:KOL impact

      Concepts related to the work of other authors for whichfor which Charles René Leemans has influence:Squamous cell,  Neck cancer,  Human papillomavirus,  Oral cavity,  Nasopharyngeal carcinoma,  Radiomic features,  Radiation therapy.



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      Cancer Center Amsterdam, Department of Otolaryngology—Head and Neck Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands;, cr.leemans@amsterdamumc.nl | Amsterdam UMC, Vrije Universiteit Amsterdam

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