• Disease
  • Mexico
  • Mexico City
  • Robert O Wright

    Prominent publications by Robert O Wright

    KOL Index score: 15165

    BACKGROUND: Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. Manganese is associated with cardiovascular dysfunction and hypotension in occupational cohorts.

    OBJECTIVES: We hypothesized that chronic arsenic, cadmium, mercury, and lead exposures elevate BP and that manganese lowers BP.

    METHODS: We conducted a cross-sectional analysis ...

    Also Ranks for: Toenail Arsenic |  normative aging study |  blood pressure |  mercury manganese |  cardiovascular disease
    KOL Index score: 14035

    OBJECTIVE: Increasing evidence suggests that 10 microg/dL, the current Centers for Disease Control and Prevention screening guideline for children's blood lead level, should not be interpreted as a level at which adverse effects do not occur. Using data from a prospective study conducted in Mexico City, Mexico, we evaluated the dose-effect relationship between blood lead levels and neurodevelopment at 12 and 24 months of age.

    METHODS: The study population consisted of 294 children whose ...

    Also Ranks for: Blood Lead |  mexico city |  24 months |  neurobehavioral development |  children levels
    KOL Index score: 13589

    BACKGROUND: Previous studies suggest that blood lead levels are positively associated with attention deficit/hyperactivity disorder (ADHD) and ADHD-symptoms in children. However, the associations between lead exposure and ADHD subtypes are inconsistent and understudied.

    OBJECTIVE: The objective of this study was to explore the association of low-level concurrent lead exposure with subtypes of ADHD symptoms in 578 Mexican children 6-13 years of age.

    METHODS: We measured concurrent blood ...

    Also Ranks for: Blood Lead |  mexican children |  attention deficit |  adhd symptoms |  hyperactivity disorder
    KOL Index score: 13500

    BACKGROUND: Limited epidemiologic data exist on prenatal arsenic exposure and fetal growth, particularly in the context of co-exposure to other toxic metals.

    OBJECTIVE: We examined whether prenatal arsenic exposure predicts birth outcomes among a rural U.S. population, while adjusting for exposure to lead and manganese.

    METHODS: We collected maternal and umbilical cord blood samples at delivery from 622 mother-infant pairs residing near a mining-related Superfund site in Northeast ...

    Also Ranks for: Birth Outcomes |  arsenic exposure |  gestational age |  fetal growth |  head circumference
    KOL Index score: 12933

    Prenatal smoke exposure, maternal obesity, aberrant fetal growth, and preterm birth are all risk factors for offspring metabolic syndrome. Cord blood aryl-hydrocarbon receptor repressor (AHRR) DNA methylation is responsive to maternal smoking during pregnancy. AHRR serves not only to inhibit aryl-hydrocarbon receptor (AHR) transcription, which is involved in mediating xenobiotic metabolism, but it is also involved in cell growth and differentiation. Other than maternal smoking, other ...

    Also Ranks for: Dna Methylation |  gestational age |  maternal bmi |  birth weight |  hydrocarbon receptor
    KOL Index score: 12833

    The extent of children's exposure to multiple toxic metals is not well described in many developing countries. We examined metal exposures in young children (6-37 months) from Montevideo, Uruguay and their mothers (15-47 years) participating in a community-based study. Hair samples collected from 180 children and their mothers were analyzed for: lead (Pb), cadmium (Cd), manganese (Mn), and arsenic (As) concentration using inductively coupled plasma-mass spectrometry (ICP-MS). Median ...

    Also Ranks for: Multiple Metals |  preschool children |  predictors exposure |  montevideo uruguay |  hair samples
    KOL Index score: 12661

    BACKGROUND: Brain growth and structural organization occurs in stages beginning prenatally. Toxicants may impact neurodevelopment differently dependent upon exposure timing and fetal sex.

    OBJECTIVES: We implemented innovative methodology to identify sensitive windows for the associations between prenatal particulate matter with diameter ≤ 2.5 μm (PM2.5) and children's neurodevelopment.

    METHODS: We assessed 267 full-term urban children's prenatal daily PM2.5 exposure using a validated ...

    Also Ranks for: Sensitive Windows |  urban children |  prenatal particulate |  specific associations |  pm25 exposure
    KOL Index score: 12480

    INTRODUCTION: Changes in mitochondrial DNA (mtDNA) can serve as a marker of cumulative oxidative stress (OS) due to the mitochondria's unique genome and relative lack of repair systems. In utero particulate matter ≤2.5μm (PM2.5) exposure can enhance oxidative stress. Our objective was to identify sensitive windows to predict mtDNA damage experienced in the prenatal period due to PM2.5 exposure using mtDNA content measured in cord blood.

    MATERIAL AND METHODS: Women affiliated with the ...

    Also Ranks for: Cord Blood |  mitochondrial dna |  sensitive windows |  prenatal particulate |  air pollution
    KOL Index score: 12171

    The balance of contaminant risk and nutritional benefit from maternal prenatal fish consumption for child cognitive development is not known. Using data from a prospective cohort study of 341 mother-child pairs in Massachusetts enrolled in 1999-2002, the authors studied associations of maternal second-trimester fish intake and erythrocyte mercury levels with children's scores on the Peabody Picture Vocabulary Test (PPVT) and Wide Range Assessment of Visual Motor Abilities (WRAVMA) at age ...

    Also Ranks for: Fish Intake |  mercury levels |  3 years |  2 servings |  child cognition
    KOL Index score: 12104

    RATIONALE: The influence of particulate air pollution on respiratory health starts in utero. Fetal lung growth and structural development occurs in stages; thus, effects on postnatal respiratory disorders may differ based on timing of exposure.

    OBJECTIVES: We implemented an innovative method to identify sensitive windows for effects of prenatal exposure to particulate matter with a diameter less than or equal to 2.5 μm (PM2.5) on children's asthma development in an urban pregnancy ...

    Also Ranks for: Sensitive Windows |  urban children |  prenatal particulate |  air pollution |  pm25 exposure
    KOL Index score: 11946

    BACKGROUND: DNA methylation is an epigenetic mark that regulates gene expression. Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a marker of cumulative exposure, may therefore better predict DNA methylation than does blood lead.

    OBJECTIVE: In this study we compared associations between lead biomarkers and DNA methylation.

    METHODS: We measured global methylation in participants of the Normative Aging ...

    Also Ranks for: Dna Methylation |  lead exposure |  alu line1 |  long interspersed |  white blood cells
    KOL Index score: 11811

    BACKGROUND: The impact of prenatal ambient air pollution on child asthma may be modified by maternal stress, child sex, and exposure dose and timing.

    OBJECTIVE: We prospectively examined associations between coexposure to prenatal particulate matter with an aerodynamic diameter of less than 2.5 microns (PM2.5) and maternal stress and childhood asthma (n = 736).

    METHODS: Daily PM2.5 exposure during pregnancy was estimated using a validated satellite-based spatiotemporally resolved ...

    Also Ranks for: Maternal Stress |  fetal sex |  childhood asthma |  prenatal exposure |  sensitive windows
    KOL Index score: 11798

    BACKGROUND: Manganese is both an essential element and a known neurotoxicant to children. High manganese exposures have been associated with negative reproductive outcomes in animals, but few epidemiologic studies have examined the effects of human fetal manganese exposure.

    METHODS: We studied the association between maternal and umbilical cord blood manganese levels and birth weight in a cohort of 470 mother-infant pairs born at term (>or=37 weeks gestation) in Ottawa County, Oklahoma. ...

    Also Ranks for: Birth Weight |  manganese levels |  maternal blood |  nonlinear relationship |  essential element
    KOL Index score: 11732

    BACKGROUND: Evolving animal studies and limited epidemiological data show that prenatal air pollution exposure is associated with childhood obesity. Timing of exposure and child sex may play an important role in these associations. We applied an innovative method to examine sex-specific sensitive prenatal windows of exposure to PM2.5 on anthropometric measures in preschool-aged children.

    METHODS: Analyses included 239 children born ≥ 37 weeks gestation in an ethnically-mixed lower-income ...

    Also Ranks for: Body Composition |  sensitive windows |  prenatal particulate |  preschool children |  girls boys
    KOL Index score: 11726

    RATIONALE: Exposure to particulate air pollution has been related to increased hospitalization and death, particularly from cardiovascular disease. Lower blood DNA methylation content is found in processes related to cardiovascular outcomes, such as oxidative stress, aging, and atherosclerosis.

    OBJECTIVES: We evaluated whether particulate pollution modifies DNA methylation in heavily methylated sequences with high representation throughout the human genome.

    METHODS: We measured DNA ...

    Also Ranks for: Dna Methylation |  traffic particles |  black carbon |  genetic humans |  inhalation exposure


    Robert O Wright: Influence Statistics

    Sample of concepts for which Robert O Wright is among the top experts in the world.
    Concept World rank
    metals pregnant women #1
    slc30a10 slc39a8 influence #1
    illness nonparametric systole #1
    mexico city epds #1
    efa optimal fit #1
    delayed effects behavior #1
    95 hair #1
    metals epigenetics #1
    metabolism essential elements #1
    bwga #1
    relationship blls #1
    associations manganese #1
    studies early life #1
    early gestational periods #1
    stressors progress #1
    mixtures critical windows #1
    social stress progress #1
    key computational resource #1
    findings increased ifc #1
    tibia μg #1
    46 year children #1
    childhood fluoride #1
    modification stress #1
    females distinctive cws #1
    respiration severity illness #1
    essential elements findings #1
    postnatal week pm25 #1
    missed biological #1
    bisphenol female humans #1
    environmental health development #1
    manganese metal mixtures #1
    tremor sway #1
    pb childhood #1
    ccdb database #1
    child age sex #1
    environment anxiety symptoms #1
    evidence behavioral effects #1
    croup magnitude #1
    environment environmental influences #1
    metals rltl #1
    iron deficiency mcv #1
    βwqs #1
    susceptibility exposures #1
    60ml syringes #1
    severity wcs #1
    progress cohort #1
    humans osteopontin signal #1
    concentrations dentine #1
    rs12064812 rs13107325 #1
    neurodevelopment lead #1

    Key People For Mexico City

    Top KOLs in the world
    Luisa Tan Molina
    mexico city air quality guanzhong basin
    Mario J Molina
    mexico city air quality mobile laboratory
    Benjamin de Foy
    mexico city tibetan plateau air pollution
    Rainer M Volkamer
    mexico city methyl glyoxal hono sources
    José‐Luis Jiménez
    organic aerosol mexico city biomass burning
    Jerome D Fast
    mexico city trace gases north africa

    Robert O Wright:Expert Impact

    Concepts for whichRobert O Wrighthas direct influence:Mexico city,  Dna methylation,  Lead exposure,  Normative aging study,  Cord blood,  Prenatal exposure,  Blood pressure,  Blood lead.

    Robert O Wright:KOL impact

    Concepts related to the work of other authors for whichfor which Robert O Wright has influence:Dna methylation,  Air pollution,  Prenatal exposure,  Oxidative stress,  Particulate matter,  Heavy metals,  Blood pressure.



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    Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA | Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, USA; Department of Pediatrics, Icahn School of M