• KOLs
  • Dna Ploidy
  • Peter Roger Morgan
Peter Roger Morgan

Peter Roger Morgan

Authors' Affiliations: Clinical And Diagnostic Sciences, King's College London; Oral Pathology, Guy's And St Thomas' Nhs Foundation Trust, Floor 28 Tower Wing, Guy's Hospital; ...

Direct Impact

Concepts for which Peter Roger Morgan has direct influence:

dna ploidy
malignant transformation
gene expression
salivary gland
oral lichen planus
plasma cells
odontogenic keratocysts

External impact

Concepts related to the work of other authors for which Peter Roger Morgan has influence:

early stage
mouse model
cytokeratin expression
basement membranes
adp-ribosylation factor-like 4c
predictive biomarker
increased circulating

Prominent publications by Peter Roger Morgan

KOL-Index: 29 Keratin 76 (Krt76) is expressed in the differentiated epithelial layers of skin, oral cavity and squamous stomach. Krt76 downregulation in human oral squamous cell carcinomas (OSCC) correlates with poor prognosis. We show that genetic ablation of Krt76 in mice leads to spleen and lymph node enlargement, an increase in regulatory T cells (Tregs) and high levels of pro-inflammatory cytokines. ...
Known for
Carcinogen-Induced Tumours | Carcinogenesis Increased | Lymph Node Enlargement | Differentiated Epithelial Layers
KOL-Index: 26 Normal oral keratinocytes (NOKs), and a Simian virus 40 T-antigen-immortalised oral keratinocyte line termed SVpgC2a, were cultured in an effort to model the human oral epithelium in vitro, including normal and dysplastic tissue. Monolayer and organotypic cultures of NOKs and SVpgC2a were successfully established in a standardised serum-free medium with high levels of amino acids, by using ...
Known for
Tissue Terminal | Expression Xenobiotic | Normal Premalignant | Cultures Svpgc2a
KOL-Index: 24 Ameloblastoma is a benign but locally infiltrative odontogenic neoplasm. Although ameloblastomas rarely metastasise, recurrences together with radical surgery often result in facial deformity and significant morbidity. Development of non-invasive therapies has been precluded by a lack of understanding of the molecular background of ameloblastoma pathogenesis. When addressing the role of ERBB ...
Known for
Molecular Ameloblastoma | Frequency Braf | Sanger Sequencing
KOL-Index: 23 The major value of intermediate filaments (IFs) in biological and applied research lies in their high order of cell and tissue specificity. This is particularly well illustrated in keratin (K) expression in various oral epithelia. Although the original class of IF is usually conserved in tissues after neoplastic transformation, epithelia show a tendency to shift their pattern of keratin ...
Known for
Anti-Keratin Antibodies | Concomitant Disordered Expression | Occasional K7 | Moderate Severe Dysplasias
KOL-Index: 23 BACKGROUND: Primary adenocarcinomas of the parotid gland are rare and account for less than 5% of all head and neck malignant neoplasms. There is considerable variation in biological behaviour within this group; low-grade tumours exhibit slow growth rates with minimal or no local invasion. High-grade tumours, however, show a high incidence of local recurrence and distant metastasis. AIM: The ...
Known for
Survival Adjuvant | Radiotherapy Tumours | High-Grade Advanced Parotid Cancers | 5 Year
KOL-Index: 21 The distribution of two cellular fibronectins (cFn), tenascin, laminin, as well as type VII collagen was studied in 14 benign odontogenic tumours of epithelial (ameloblastoma) and epithelial-ectomesenchymal (ameloblastic fibroma) origins, as well as in developing human teeth by immunocytochemical means using monoclonal antibodies (Mabs). An extradomain sequence-A-containing form of cFn ...
Known for
Cfn Extracellular | Ameloblastic | Tenascin Laminin | Collagen Ameloblastomas
KOL-Index: 21 Ameloblastoma is an odontogenic neoplasm characterized by slow intraosseous growth with progressive jaw resorption. Recent reports have revealed that ameloblastoma harbours an oncogenic BRAFV600E mutation with mitogen-activated protein kinase (MAPK) pathway activation and described cases of ameloblastoma harbouring a BRAFV600E mutation in which patients were successfully treated with a BRAF ...
Known for
Brafv600e | Primary Osteoblasts | Arl4c Elevation | Mapk Pathway
KOL-Index: 20 Little is known about the genetic background of keratocystic odontogenic tumors (KCOT, odontogenic keratocysts). Our aim was to characterize genomic aberrations in sporadic KCOT using cDNA-expression arrays and array-comparative genomic hybridization. For cDNA-expression arrays, 10 KCOT specimens and 20 fetal tooth germs were studied. Quantitative real-time reverse-transcription/polymerase ...
Known for
Over-Expressed Amplified Genes | Leukocyte Adhesion Molecule | 10 Kcot | Glioma-Associated Oncogene Homologue
KOL-Index: 19 The current study was undertaken to analyse growth and differentiation-related functions of normal keratinocytes (NOK) and an SV40T-immortalized keratinocyte line (SVpgC2a) from buccal mucosa, viewing the latter cell line as a model of a dysplastic epithelium. Morphological and immunohistochemical assessments of organotypic epithelia generated from 10 or 17 d of culture showed three- to ...
Known for
Svpgc2a Proliferative | K2a Hair Keratins | Normal Immortalized | Basal Lamina
KOL-Index: 18 The aim of the study was to investigate the differentiation-specific keratins (K4, K13, K1 and K10) in oral epithelial dysplasia and squamous cell carcinoma (SCC). Alterations in keratin gene expression were determined by in situ hybridization using 35S-labeled riboprobes and immunohistochemistry with monoclonal antibodies. In mild dysplasia, both sets of differentiation keratins were ...
Known for
Keratins | Differentiated Carcinomas | Moderate Lesions | Tumor Islands

Authors' Affiliations: Clinical and Diagnostic Sciences, King's College London; Oral Pathology, Guy's and St Thomas' NHS Foundation Trust, Floor 28 Tower Wing, Guy's Hospital; Thames Cancer Registry, Division of Cancer Studies, King's College London;

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