• Disease
  • Dna
  • Dna Synthesis
  • Eeva Therman

    Prominent publications by Eeva Therman

    KOL Index score: 9918

    The anatomy and cytology of the crown gall in Vicia faba L. have been studied during its development. The galls have been fixed at the following dates after inoculation with Agrobacterium tumefaciens: 2, 4, 6, 9, 16, 19, 23, 29, 35, 69, and 81 days. As controls normal stems as well as 23-day-old galls induced by indole-3-acetic acid have been examined.The first visible reaction of the cells to the bacterial inoculation is the inflation and increased stainability of the nuclei, and an ...

    Also Ranks for: Crown Gall |  vicia faba |  diploid cells |  growth substances |  agrobacterium tumefaciens
    KOL Index score: 7785

    We have collected from the literature adult nonmosaic women with the following aberrant X chromosomes: Xp- (52), Xq- (67), idic(Xp-)(10), idic(Xq-)(9), and interstitial deletions (12). Lack of Xp, and especially Xcen-Xp11 (b region), may cause full-blown Turner syndrome. However, individual Turner symptoms, including gonadal dysgenesis, otherwise seem to be randomly distributed with respect to the different Xp and Xq deletions, although breakpoints distal to Xq25 do not give rise to any ...

    Also Ranks for: Xq Deletions |  human female |  phenotypic effects |  short stature |  deleted chromosomes
    KOL Index score: 7504

    The correlations of abnormal X chromosome constitutions and the resulting phenotypes in the human female are reviewed. The following hypotheses put forward to explain these correlations are discussed in detail: (1) The damage is done before X inactivation; (2) An effect is exerted between reactivation of the X chromosome(s) and meiosis in oocytes; (3) A recessive gene(s) in hemizygous condition might be expressed in the cases in which the same X is active in all cells; (4) A change in ...

    Also Ranks for: Chromosomes Human |  chromosome constitution |  phenotypic effects |  inactivation patterns |  normal development
    KOL Index score: 7490

    Abnormal human X chromosomes, their origin, phenotypic effects, and especially their inactivation are reviewed. In cases of balanced reciprocal X-autosomal translocations (Table 2), almost always the normal X is inactivated. Most of such patients suffer from gonadal dysgenesis, which might be caused either by functional hemizygosity for a recessive gene or by a position effect resulting from a rearrangement involving a certain region of Xq. In cases with 46 chromosomes and an unbalanced ...

    Also Ranks for: Inactivation Center |  translocation chromosome |  phenotypic effects |  xp xq |  autosomal segment
    KOL Index score: 7474

    The behavior of individual allocyclic chromosomes has been analyzed in lymphocytes of a sister and a brother with Bloom's syndrome. Of 4,633 diploid cells, 115 showed allocyclic chromosomes, and 74 of these had 44, 45 or 46 normal metaphase chromosomes accompanied by one or two allocyclic chromosomes. Of 56 tetraploid cells, 9 contained such chromosomes. The allocyclic chromosomes appeared “pulverized” or extended corresponding to S or G2 PCC. We have proposed the hypothesis that ...

    Also Ranks for: Allocyclic Chromosomes |  blooms syndrome |  chromosome arm |  metaphase plate |  hypothetical coiling center
    KOL Index score: 6570

    The origin and behavior of human dicentric chromosomes are reviewed. Most dicentrics between two non-homologous or two homologous chromosomes (isodicentrics), which are permanent members of a chromosome complement, probably originate from segregation of an adjacent quadriradial; such configurations are the result of a chromatid translocation between two nonhomologous chromosomes, or they represent an adjacent counterpart of a mitotic chiasma. The segregation of such a quadriradial may ...

    Also Ranks for: Dicentric Chromosomes |  centromere chromosome |  bloom syndrome |  sister chromatids |  translocation genetic
    KOL Index score: 6539

    The following hypothesis is put forward: X chromatin in man condenses around a center which is situated on Xq at a short distance from the centromere. The hypothesis is based on, and explains, two classes of observations. (1) Abnormal X chromosomes that have the assumed center in duplicate form bipartite Barr bodies in part of the cells. The frequency of bipartite bodies and the distance between the two parts seem to be determined by the distance between the postulated centers. (2) A ...

    Also Ranks for: Barr Body |  female humans labeling |  bipartite bodies |  sex chromosome |  short distance
    KOL Index score: 6419

    The present study explores the origin of human Robertsonian translocations (RT) and the causes of the nonrandom participation of the different acrocentrics in them. Satellite associations have been analysed in 966 cells from 8 persons, and 1266 RT with ascertainment have been collected from the literature. The observation that the chromosomes preferentially taking part in satellite associations vary between individuals is confirmed. However, since a preferred chromosome appears to ...

    Also Ranks for: Chromosomes Human |  pair 21 |  robertsonian translocations |  praderwilli syndrome |  translocation genetic
    KOL Index score: 6334

    The behavior of a translocation chromosome t(6; 19) in the lymphocytes of a mentally retarded woman with other anomalies has been analyzed. The two chromosomes were attached at the telomeres of their short arms without any apparent deletion. The centromere of chromosome 19 was marked by a primary constriction and the site of the centromere of chromosome 6 by a C-band, but no constriction. The translocation chromosome showed two primary constrictions once in 8,800 metaphases, probably ...

    Also Ranks for: Fusion Point |  chromosomes human |  centromere chromosome |  translocation genetic |  intellectual disability
    KOL Index score: 6256

    Although clear genetic evidence of mitotic crossing-over is lacking in man, observations of mitotic chiasmata in normal cells (0.1–1 per 1000) and in Bloom's syndrome (BS) cells (5–150 per 1000) demonstrate its occurrence. That mitotic chiasmata are true exchanges is concluded from the occurrence of heteromorphic “bivalents” and the pattern of sister chromatid exchanges in mitotic “bivalents”. Several observations demonstrate that chiasmata are different in principle from chromatid ...

    Also Ranks for: Mitotic Chiasmata |  chromatid translocations |  crossing genetic |  adjacent exchanges |  chromosomes chromosome
    KOL Index score: 5946

    Enamel thickness of the maxillary permanent central incisors and canines in seven Finnish 47,XXX females, their first-degree male and female relatives, and control males and females from the general population were determined from radiographs. The results showed that enamel in the teeth of 47,XXX females was clearly thicker than that of normal controls. On the other hand, the thickness of “dentin” (distance between mesial and distal dentinoenamel junctions) in 47,XXX females' teeth was ...

    Also Ranks for: Sex Chromosomes |  47xxx females |  control males |  enamel thickness |  tooth crown
    KOL Index score: 5901

    The syndrome caused by partial trisomy for 11q is reviewed on the basis of a patient of our own and 20 cases (including a stillbirth) from the literature. The main symptoms are presented in Tables 1 and 2. The syndrome can be suspected when, in addition to mental retardation, the following characteristics are present: short nose, long philtrum, micrognathia, retracted lower lip, and micropenis in males. In 15 families, the mother was a balanced translocation carrier and in four the ...

    Also Ranks for: 11q Trisomy |  female heterozygote humans |  mental retardation |  20 cases |  short nose
    KOL Index score: 5452

    Mitotic recombination in satellite stalks — a phenomenon often difficult to distinguish from satellite association — was studied in a sister and a brother with Bloom's syndrome. Segregation after recombination was analyzed in the lymphocytes of the sister who had Q-bright satellites. Her cells varied greatly both in regard to the acrocentrics which displayed Q-bright satellites and the number of such satellites per cell. In 58 cells a total of 31 different patterns were seen. In 83 cells ...

    Also Ranks for: Mitotic Recombination |  blooms syndrome |  qbright satellites |  satellite stalks |  lymphocytes sister
    KOL Index score: 5383

    Adult female carriers of balanced X; autosome translocations (118 cases) and of balanced X inversions (31 cases) have been collected from the literature. Forty-five of the 118 translocation carriers in whom the break was in the critical region (Xq13–q22, Xq22–q26, separated by a narrow region within Xq22) showed gonadal dysgenesis. Seven of the 31 inversion carriers in whom the break was in the same region also had gonadal dysgenesis, whereas the remaining 24 were normal in this respect. ...

    Also Ranks for: Critical Region |  gonadal dysgenesis |  genetic chromosome |  autosome translocations |  female carriers
    KOL Index score: 5319

    Quadriradial (QR) configurations from four different human lymphocyte metaphase samples have been analyzed: a patient with Fanconi's anemia; normal female cells X-irradiated with 150 or 200 R in S or G2; spontaneous QRs occurring in 13,584 metaphases; and cells from two sibs with Bloom's syndrome. That mitotic chiasmata are caused by crossing-over rather than by random breakage and reunion was concluded from the following observations: (1) In the spontaneous sample, mitotic chiasmata are ...

    Also Ranks for: Mitotic Crossing |  chromatid translocations |  genetic abnormalities |  break points |  blooms syndrome


    Eeva Therman: Influence Statistics

    Sample of concepts for which Eeva Therman is among the top experts in the world.
    Concept World rank
    premeiotic mitosis leptotene #1
    octoploid metaphases sibs #1
    stem segments wound #1
    dentin calculations #1
    trisomy lethals #1
    vicia faba t37 #1
    abnormal human chromosomes #1
    wounds dna #1
    phe­ nomena #1
    qbright satellites satellites #1
    sterile wounds control #1
    break critical #1
    chromosomes satellite associations #1
    wound agrobacterium tumefaciens #1
    metaphase anaphase groups #1
    “ pulverized #1
    origin phenotypic effects #1
    qbright material #1
    synthesis mitoses #1
    definite position interphase #1
    fingers anomalous feet #1
    fragment functional centromere #1
    gonadal dysgenesis sisters #1
    b6 2 hours #1
    mitosis tapetal #1
    satellites blooms syndrome #1
    amenorrhea chromosome #1
    translocation chromosome patients #1
    chromosomes inuvularia #1
    human xq #1
    control vicia faba #1
    inactive chromosome meiosis #1
    metric enamel growth #1
    lassi alvesalo #1
    chromosome dental #1
    8c divisions #1
    qdark region distal #1
    chromosomebreakage syndrome #1
    typical zygotene #1
    molecular bacterial genetics #1
    wound washing #1
    ofuvularia grandiflora #1

    Key People For Dna Synthesis

    Top KOLs in the world
    quantitative histochemistry glucuronidase hydrolysis brain iii
    folin phenol reagent protein measurement tungsten compounds
    OliverH LOWRY
    folin phenol reagent protein measurement tungsten compounds
    RoseJ Randall
    protein measurement folin phenol reagent tungsten compounds
    K Burton
    deoxyribonucleic acid concomitant medications phylogenetic analysis
    Enrique Rozengurt
    protein kinase swiss 3t3 cells dna synthesis

    Eeva Therman:Expert Impact

    Concepts for whichEeva Thermanhas direct influence:Dna synthesis,  Mitotic chiasmata,  Crown gall,  Allocyclic chromosomes,  Translocation chromosome,  Human chromosomes,  Vicia faba,  Critical region.

    Eeva Therman:KOL impact

    Concepts related to the work of other authors for whichfor which Eeva Therman has influence:Situ hybridization,  Premature ovarian failure,  Human pair,  Turner syndrome,  Chromosome aberrations,  Trisomy 13,  Robertsonian translocations.



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    Laboratory of Genetics, University of Wisconsin, Genetics Building, 53706, Madison, WI, USA | Department of Medical Genetics, University of Wisconsin, Madison 53706, USA. | Department of Medical Genetics, University of Wisconsin, 53706, Madison, WI,