Prominent publications by David R Sibley

KOL Index score: 15782

Angiotensin II type 1 (AT1) receptor and D1 and D3 dopamine receptors directly interact in renal proximal tubule (RPT) cells from normotensive Wistar-Kyoto rats (WKY). There is indirect evidence for a D5 and AT1 receptor interaction in WKY and spontaneously hypertensive rats (SHR). Therefore, we sought direct evidence of an interaction between AT1 and D5 receptors in RPT cells. D5 and AT1 receptors colocalized in WKY cells. Angiotensin II decreased D5 receptors in WKY cells in a time- ...

Also Ranks for: Dopamine Receptors |  type 1 |  wky shr |  d5 receptor |  proximal tubule
KOL Index score: 14391

Previously, D2 dopamine receptors (D2 DARs) have been shown to undergo G-protein-coupled receptor kinase phosphorylation in an agonist-specific fashion. We have now investigated the ability of the second messenger-activated protein kinases, protein kinase A (PKA) and protein kinase C (PKC), to mediate phosphorylation and desensitization of the D2 DAR. HEK293T cells were transiently transfected with the D2 DAR and then treated with intracellular activators and inhibitors of PKA or PKC. ...

Also Ranks for: Dopamine Receptor |  protein kinase |  pkc phosphorylation |  dominant humans |  hek293t cells
KOL Index score: 14145

We have used a recently developed cell-free system (cell lysate) derived from turkey erythrocytes to explore the potential role of cAMP-activated and other protein kinase systems in desensitizing the adenylate cyclase-coupled beta-adrenergic receptor. Desensitization by the agonist isoproterenol required more than simple occupancy of the receptor by the agonist since under conditions where adenylate cyclase was not activated, no desensitization occurred. As in whole cells, addition of ...

Also Ranks for: Adrenergic Receptor |  protein kinase |  desensitization adenylate cyclase |  turkey erythrocyte |  phosphorylation beta
KOL Index score: 13997

Preincubation of turkey erythrocytes with beta-adrenergic agonists leads to an attenuation of the responsiveness of adenylate cyclase to subsequent hormonal stimulation. Recently, our laboratory has shown (Stadel, J. M., Nambi, P., Shorr, R. G. L., Sawyer, D. D., Caron, M. G., and Lefkowitz, R. J. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 3173-3177) using 32Pi incorporation that phosphorylation of the beta-adrenergic receptor accompanies this desensitization process. We now report that, ...

Also Ranks for: Receptor Phosphorylation |  adenylate cyclase |  turkey erythrocytes |  adrenergic beta |  01 mol
KOL Index score: 13974

RationaleDopamine D1-like antagonists block several effects of cocaine, including its locomotor-stimulant and discriminative-stimulus effects. Because these compounds generally lack selectivity among the dopamine D1 and D5 receptors, the specific roles of the subtypes have not been determined.ObjectivesDopamine D5 receptor knockout (DA D5R KO), heterozygous (HET) and wild-type (WT) mice were used to study the role of D5 dopamine receptors in the effects of cocaine. In addition, effects ...

Also Ranks for: Dopamine D5 |  effects cocaine |  knockout mice |  d1 receptors |  discriminative stimulus
KOL Index score: 13745

We recently demonstrated that heterologous desensitization of adenylate cyclase in turkey erythrocytes is highly correlated with phosphorylation of the beta-adrenergic receptor. In contrast, little is known of the biochemical mechanisms underlying the homologous form of beta-adrenergic receptor desensitization, which is agonist-specific and not cAMP-mediated. Accordingly, the present studies were undertaken to examine if phosphorylation of the beta-adrenergic receptor is also associated ...

Also Ranks for: Adenylate Cyclase |  adrenergic receptor |  homologous desensitization |  prostaglandin e1 |  phosphorylation beta
KOL Index score: 13536

Atypical antipsychotic drugs have revolutionized the treatment of schizophrenia and related disorders. The current clinically approved atypical antipsychotic drugs are characterized by having relatively low affinities for D2-dopamine receptors and relatively high affinities for 5-HT2A serotonin receptors (5-HT, 5-hydroxytryptamine (serotonin)). Aripiprazole (OPC-14597) is a novel atypical antipsychotic drug that is reported to be a high-affinity D2-dopamine receptor partial agonist. We ...

Also Ranks for: Atypical Antipsychotic |  receptors 5 |  aripiprazole affinity |  drug humans |  functional actions
KOL Index score: 12956

A hormone responsive adenylate cyclase has been reconstituted in phosphatidylcholine vesicles from its isolated protein components. The proteins used were the affinity chromatography purified (500-2000-fold) or pure Mr = 64,000 beta-adrenergic receptors (beta AR) isolated from hamster and guinea pig lung membranes, the pure heterotrimeric (Mr: alpha = 42,000; beta = 35,000; gamma approximately equal to 5,000) guanine nucleotide regulatory protein (Ns) isolated from human erythrocyte ...

Also Ranks for: Regulatory Protein |  catalytic unit |  guanine nucleotide |  adenylate cyclase |  beta receptors
KOL Index score: 12607

Though D1-like dopamine receptors [D1A/B] are defined in terms of linkage to the stimulation of adenylyl cyclase, with D1A assumed to be the functionally prepotent subtype, evidence suggests the existence of another, novel D1-like receptor without such coupling. To investigate these issues we challenged mutant mice having targeted gene deletion of the D1A receptor with selective agonists and used an ethologically-based assessment technique to resolve resultant behavioural topography. ...

Also Ranks for: Adenylyl Cyclase |  dopamine d1 |  mutant mice |  behavioural topography |  receptor agonists
KOL Index score: 12373

Prolonged exposure of cells or tissues to drugs or hormones such as catecholamines leads to a state of refractoriness to further stimulation by that agent, known as homologous desensitization. In the case of the beta-adrenergic receptor coupled to adenylate cyclase, this process has been shown to be intimately associated with the sequestration of the receptors from the cell surface through a cAMP-independent process. Recently, we have shown that homologous desensitization in the frog ...

Also Ranks for: Adenylate Cyclase |  adrenergic receptor |  cell surface |  functional coupling |  phosphorylation beta
KOL Index score: 12329

We have synthesized and characterized a series of novel fluorescently labeled ligands with high affinity and specificity for D1 and D2 dopamine receptors. D1-selective probes were synthesized using (R,S)-5-(4'-aminophenyl)-8-chloro-2,3,4,5-tetrahydro-3-methyl- [1H]-3-benzazepin-7-ol, the 4'-amino derivative of the high-affinity, D1-selective antagonist SCH-23390, whereas D2-selective probes were synthesized using the high-affinity, D2-selective antagonist N-(p-aminophenethyl)spiperone ...

Also Ranks for: Fluorescent Ligands |  dopamine receptors |  affinity d1 |  benzazepines binding |  4amino derivative
KOL Index score: 12243

The role of D1 dopamine (DA) receptors in mediating the ability of DA to modulate responses attributable to activation of NMDA receptors was examined in mice lacking D1A dopamine receptors. Specifically, experiments were designed to test the hypothesis that the ability of DA to potentiate responses mediated by activation of NMDA receptors was attributable to activation of D1 receptors. Based on this hypothesis, we would predict that in the D1A mutant mouse, either DA would not induce ...

Also Ranks for: Mutant Mice |  nmda receptors |  d1 dopamine |  mediated responses |  receptor agonists
KOL Index score: 12219

Converging lines of evidence indicate that elevations in synaptic dopamine levels play a pivotal role in the reinforcing effects of cocaine, which are associated with its abuse liability. This evidence has led to the exploration of dopamine receptor blockers as pharmacotherapy for cocaine addiction. While neither D1 nor D2 receptor antagonists have proven effective, medications acting at two other potential targets, D3 and D4 receptors, have yet to be explored for this indication in the ...

Also Ranks for: Dopamine Receptors |  buspirone cocaine |  reinforcing effects |  receptor antagonists |  d3 d4

Key People For Dopamine Receptors

Top KOLs in the world
Philip ******
dopamine receptors antipsychotic drugs rat brain
David * ******
dopamine receptors adenylate cyclase receptor phosphorylation
Jean‐Charles ********
histamine receptors d3 receptor rat brain
Marc * *****
adrenergic receptors adenylate cyclase dopamine transporter
Pierre ********
d3 receptor nucleus accumbens drug addiction
Marie‐Pascale *******
dopamine receptors d3 receptor rat brain

David R Sibley:Expert Impact

Concepts for whichDavid R Sibleyhas direct influence:Dopamine receptors,  Dopamine receptor,  Receptors dopamine,  Dopamine d1,  Adenylate cyclase,  Dopamine d5,  D1 dopamine,  Lipid rafts.

David R Sibley:KOL impact

Concepts related to the work of other authors for whichfor which David R Sibley has influence:Dopamine receptors,  Protein kinase,  Basal ganglia,  Nucleus accumbens,  D1 receptor,  Adenylate cyclase,  Gene expression.



Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

Molecular Neuropharmacology Section, NINDS/NIH, Bethesda, MD | Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD | Molecular Neuropharmacology Section, National Institute of Neurological D