Prominent publications by Hubert H M Van Tol

KOL Index score: 18381

The ability of dopamine D(4) and D(2) receptors to activate extracellular signal-regulated kinases (ERKs) 1 and 2 was compared using Chinese hamster ovary (CHO-K1) cells transfected with D(4.2), D(4.4), D(4.7), and D(2L) receptors. Dopamine stimulation of D(4) or D(2L) receptors produced a transient, dose-dependent increase in ERK1/2 activity. Receptor-specific activation of the ERK mitogen-activated protein kinase (MAPK) pathway was confirmed using the D(2)-like receptor-selective ...

Also Ranks for: Dopamine D4 |  activated protein |  d2l receptor |  derived growth |  erk1 2
KOL Index score: 13160

The dopamine D4 receptor is a G protein-coupled receptor (GPCR) that belongs to the dopamine D2-like receptor family. Functionally, the D2-like receptors are characterized by their ability to inhibit adenylyl cyclase. The dopamine D4 receptor as well as many other catecholaminergic receptors contain several putative SH3 binding domains. Most of these sites in the D4 receptor are located in a polymorphic repeat sequence and flanking sequences in the third intracellular loop. Here we ...

Also Ranks for: D4 Receptor |  sh3 domains |  binding proteins |  adenylyl cyclase |  intracellular loop
KOL Index score: 12874

To study the regulation of hypothalamic vasopressin (VP) and oxytocin (OT) gene expression in relation to the development of hypertension, levels of VP mRNA and OT mRNA were determined in spontaneously hypertensive rats (SHR). Differences in VP and OT mRNA content of the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of 4- and 10-week-old SHR and Wistar-Kyoto controls (WKY) were quantitated by dot-blot and Northern blot analysis. VP and OT pituitary content and VP plasma ...

Also Ranks for: Gene Expression |  shr wky |  spontaneously hypertensive |  messenger rats |  paraventricular nucleus pvn
KOL Index score: 12592

A large number of studies have demonstrated co-purification or co-immunoprecipitation of receptors with G proteins. We have begun to look for the presence of effector molecules in these receptor complexes. Co-expression of different channel and receptor permutations in COS-7 and HEK 293 cells in combination with co-immunoprecipitation experiments established that the dopamine D(2) and D(4), and beta(2)-adrenergic receptors (beta(2)-AR) form stable complexes with Kir3 channels. The ...

Also Ranks for: Adenylyl Cyclase |  stable complexes |  inwardly rectifying |  potassium channels |  coupled receptors
KOL Index score: 12409

For the past 20 years the most enduring explanation for schizophrenia has been the dopamine hypothesis, which proposes that the dopaminergic system is overactive in this widespread disease. Classically, the D2 receptor formed the core of the dopamine hypothesis since there was considerable evidence for elevations of D2 receptor levels in the brains of schizophrenic patients, and because these receptors served as the primary target in mediating antipsychotic effects of most neuroleptics. ...

Also Ranks for: D4 Receptor |  antipsychotic effects |  schizophrenic patients |  considerable evidence |  sideeffect profile
KOL Index score: 12356

Using the sequence homology approach for cloning related genes within the G-protein-coupled receptor gene family, we have cloned the gene for the rat beta 1-adrenergic receptor (beta 1-AR). The rat beta 1-adrenergic receptor gene was isolated from a lambda EMBL3 rat genomic DNA library using the hamster beta 2-adrenergic receptor (beta 2-AR) coding sequence as a probe under low stringency hybridization conditions. The rat beta 1-AR gene encodes a protein of 466 amino acids that contains ...

Also Ranks for: Beta 1 |  adrenergic receptor |  molecular cloning |  pineal gland |  transmembrane domains
KOL Index score: 12319

The purpose of this study was to determine whether dopamine D4 receptors could be detected in the human brain striatum by means of an indirect ligand-binding method, because no dopamine D4 receptor-selective ligand presently exists. The antipsychotic clozapine is more selective for the dopamine D4 receptor than for other dopamine receptors. Although most antipsychotic drugs act in the striatum to elicit Parkinson-like side-effects, clozapine is atypical in that it does not produce ...

Also Ranks for: Dopamine D4 Receptors |  low density |  receptor antagonists |  antipsychotic clozapine |  control brain
KOL Index score: 12314

DOPAMINE receptors belong to a superfamily of receptors that exert their biological effects through guanine nucleotide-binding (G) proteins. Two main dopamine receptor subtypes have been identified, D1 and D2, which differ in their pharmacological and biochemical characteristics. D1 stimulates adenylyl cyclase activity, whereas D2 inhibits it1–3. Both receptors are primary targets for drugs used to treat many psychomotor diseases, including Parkinson's disease and schizophrenia4,5. ...

Also Ranks for: Higher Affinity |  dopamine receptor |  competitive blotting |  adenylyl cyclase |  d5 sequence
KOL Index score: 12257

BACKGROUND: Among the different dopamine receptors, the D4 dopamine receptor is of particular interest in schizophrenia because of its high affinity for the atypical neuroleptic clozapine. Recently, the gene for the D4 dopamine receptor has been cloned and a new and intriguing polymorphism has been described. Different versions of the receptor have varying affinity for clozapine, and thus variant froms of D4 with differing pharmacologic activity exist in the human population. Our ...

Also Ranks for: Receptor Gene |  d4 dopamine |  linkage schizophrenia |  psychotic illness |  polymerase chain
KOL Index score: 12102

G protein-coupled receptors comprise a family of genes that share significant sequence similarity. We have screened a rat genomic library under low stringency hybridization conditions with the coding portion of the hamster beta 2-adrenergic receptor gene to isolate new members of this gene family. We show that one of these clones, clone D, codes for a 5-hydroxytryptamine1A (5-HT1A) binding site since: 1) it possesses an intronless open reading frame encoding a protein with seven putative ...

Also Ranks for: Receptor Gene |  functional expression |  tissue distribution |  sequence binding |  rat brain
KOL Index score: 11777

here is considerable evidence that dopamine D2 receptors can modulate AMPA receptor-mediated neurotoxicity. However, the molecular mechanism underlying this process remains essentially unclear. Here we report that D2 receptors inhibit AMPA-mediated neurotoxicity through two pathways: the activation of phosphoinositide-3 kinase (PI-3K) and downregulation of AMPA receptor plasma membrane expression, both involving a series of protein-protein coupling/uncoupling events. Agonist stimulation ...

Also Ranks for: Ampa Receptor |  protein coupling |  nsf interaction |  intracellular loop |  dopamine agonists
KOL Index score: 11238

DOPAMINE receptors belong to the family of G protein-coupled receptors. On the basis of the homology between these receptors, three different dopamine receptors (D1,D2,D3) have been cloned1–7. Dopamine receptors are primary targets for drugs used in the treatment of psychomotor disorders such as Parkinson's disease and schizophrenia8,9. In the management of socially withdrawn and treatment-resistant schizophrenics, clozapine10 is one of the most favoured antipsychotics because it does ...

Also Ranks for: Human Dopamine |  antipsychotic clozapine |  competitive blotting |  messenger rats receptors |  d4 receptor
KOL Index score: 11015

NMDA receptor function is modulated by both G-protein-coupled receptors and receptor tyrosine kinases. In acutely isolated rat hippocampal neurons, direct activation of the platelet-derived growth factor (PDGF) receptor or transactivation of the PDGF receptor by D4 dopamine receptors inhibits NMDA-evoked currents in a phospholipase C (PLC)-dependent manner. We have investigated further the ability of D2-class dopamine receptors to modulate NMDA-evoked currents in isolated rat prefrontal ...

Also Ranks for: Dopamine Receptor |  growth factor |  nmda currents |  hippocampal neurons |  platelet derived
KOL Index score: 10788

OBJECTIVE: The alpha7-nicotinic receptor subunit gene (CHRNA7) is located at chromosome 15q13-14, a region previously linked with schizophrenia. Genetic association and mRNA expression studies also implicate CHRNA7 in schizophrenia. The CHRNA7 gene has a partial duplication that constitutes the alpha7-like nicotinic receptor gene (CHRFAM7A). We hypothesized that major psychoses could affect the expression of both CHRNA7 and CHRFAM7A.

METHOD: CHRNA7 and CHRFAM7A mRNA levels were measured ...

Also Ranks for: Bipolar Disorder |  gene expression |  prefrontal cortex |  chrna7 schizophrenia |  nicotinic receptor

Key People For Dopamine Receptors

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Hubert H M Van Tol:Expert Impact

Concepts for whichHubert H M Van Tolhas direct influence:Dopamine receptors,  D4 receptor,  Dopamine d4,  Dopamine d4 receptor,  Dopamine receptor,  D4 receptors,  Dopamine d4 receptors,  Receptors dopamine.

Hubert H M Van Tol:KOL impact

Concepts related to the work of other authors for whichfor which Hubert H M Van Tol has influence:Dopamine receptors,  D4 receptor,  Gene expression,  Antipsychotic drugs,  Prefrontal cortex,  Caenorhabditis elegans,  Bipolar disorder.



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University of Toronto | Department of Psychiatry, University of Toronto, Toronto, Canada | Laboratory of Molecular Neurobiology, Centre for Addiction and Mental Health, Toronto, Ontario, Canada | Department of Pharmacology, University of Toronto, Tor