• KOL
    • Drug Discrimination
    • Robert J Barrett
    • Robert J Barrett: Influence Statistics

      Robert J Barrett

      Robert J Barrett

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      Veterans Administration Medical Center, 37232, Nashville, TN, USA | Veterans Administration Medical Center, Nashville, TN, USA | Veterans Administration Medical Center, ...

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      Robert J Barrett:Expert Impact

      Concepts for whichRobert J Barretthas direct influence:Drug discrimination,Training dose,Electroconvulsive shock,Stimulus properties,Chronic drug treatment,Discriminative stimulus,Serotonin 5,Avoidance acquisition.

      Robert J Barrett:KOL impact

      Concepts related to the work of other authors for whichfor which Robert J Barrett has influence:Animal models,Stimulus effects,Amphetamine withdrawal,Locomotor activity,Thiamine deficiency,Serotonin 5,Drug discrimination.

      KOL Resume for Robert J Barrett

      Year
      2005

      Veterans Administration Medical Center, 37232, Nashville, TN, USA

      2004

      Veterans Administration Medical Center, Departments of Psychology and Pharmacology, Vanderbilt University, Research Service (151), 1310 24th Avenue South, Nashville, TN 37212-2637, USA

      2002

      Veterans Administration Medical Center, Nashville, TN 37232, USA

      2001

      Research Service (151), Veterans Administration Medical Center, Departments of Psychology and Pharmacology, Vanderbilt University, 1310 24th Avenue South, Nashville, TN 37212-2637, USA

      1999

      Veterans Administration Medical Center, Departments of Psychology and Pharmacology, Vanderbilt University, 1310 24th Avenue South, Nashville, TN 37203, USA, US

      1998

      Department of Pharmacology, Vanderbilt University School of Medicine, Veterans Administration Medical Center, and John F. Kennedy Center and Department of Psychiatry, Vanderbilt University, Nashville, TN 37232 USA

      1997

      Veterans Administration Medical Center, Departments of Psychology and Pharmacology, Vanderbilt University, 1310 24th Avenue South, Nashville, TN 37203, USA, US

      1995

      Department of Psychology, Vanderbilt University, and Veterans Administration Medical Center, Nashville, TN37240 USA

      1994

      Veterans Administration Medical Center, Department of Psychology and Pharmacology, Vanderbilt University, 1310 24th Avenue South, 37203, Nashville, TN, USA

      1992

      Veterans Administration Medical Center, Departments of Psychology and Pharmacology, Vanderbilt University, 1310 24th Avenue South, 37203, Nashville, TN, USA

      1991

      Veterans Administration Medical Center Nashville, TN 37240, USA

      1989

      Vanderbilt University

      1988

      Veterans Administration Medical Center, Departments of Psychology and Pharmacology, Vanderbilt University, 1310 24th Avenue South, 37212, Nashville, TN, USA

      1985

      Department of Psychology, Vanderbilt University and Veterans Administration Hospital Nashville, TN 37240, USA

      1983

      Departments of Pharmacology and Physiology, Northwest Center for Medical Education Indiana University, Gary, IN 46408, USA

      1982

      Veterans Administration Medical Center and Departments Psychology and Pharmacology, Vanderbilt University, Nashville, TN, USA

      1981

      Veterans Administration Medical Center, Nashville, Tennessee, USA

      1980

      Psychology Research Laboratories, VA Hospital, 37232, Nashville, Tennessee, USA

      1978

      Tennessee Neuropsychiatric Institute and the Departments of Psychology and Pharmacology Vanderbilt University and the Veterans Administration Hospital, Nashville, TN 37217 USA

      Psychology Research Laboratories, VA Hospital, Nashville, Tenn. 37203 U.S.A.

      1977

      Tennessee Neuropsychiatrie Institute, Departments of Pharmacology and Psychology, Vanderbilt University School of Medicine, Veterans Administration Hospital, Nashville, TennesseeU.S.A.

      1976

      Department of Pharmacology, Vanderbilt University, Tennessee

      1975

      Psychology Research Laboratories, Veterans Administration Hospital and Vanderbilt University, Nashville, Tennessee 37203, USA

      Vanderbilt U, Medical School

      1974

      Tennessee Neuropsychiatric Institute, Department of Pharmacology Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA

      1973

      Veterans Administration Hosp., Psychology Research Lab., Nashville, Tenn.

      1972

      Department of Psychology, Vanderbilt University, Nashville, Tennessee, U.S.A.

      Psychology Research Laboratories, Veterans Administration Hospital, and Vanderbilt University, 37203, Nashville, Tennessee, USA

      1971

      Psychology Research Laboratories, Veterans Administration Hospital, Nashville, Tennessee, U.S.A.

      1970

      Veterans Administration Hosp., Psychology Research Lab., Pittsburgh, Pa

      1969

      Veterans Administration Hosp., Leech Farm Rd., Pittsburgh, Pa

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      Sample of concepts for which Robert J Barrett is among the top experts in the world.
      Concept World rank
      suppression electroconvulsive shock #1
      reinforcement vi20 #1
      classical conditioning electroshock #1
      10 foot shock #1
      discriminate levers #1
      ecs classical conditioning #1
      manipulation heart rate #1
      data quantal view #2
      spiperone rebound increase #2
      continuum dopaminergic #2
      drug anorectic #2
      function ecstest interval #2
      retest intervals 8 #2
      rats cdp lever #2
      amphetamine training groups #2
      amph bidirectional #2
      cues cdp withdrawal #2
      cue amph #2
      dopamine mediated cues #2
      peripheral injections drugs #2
      002 quinpirole #2
      discriminate quipazine #2
      damphetamine lever #2
      saline injections transfer #2
      shock zm rats #2
      cues 030 #2
      rats amph lever #2
      implication animal studies #2
      tests 24 treatment #2
      original function tolerance #2
      amphetamines amph primary #2
      intervals proactive effects #2
      zm acute footshock #2
      ecs retest #2
      function punished #2
      continuous view subjects #2
      intensities ecs #2
      blocking discriminative #2
      quantal view animals #2
      interoceptive cues data #2
      performance drug termination #2
      training dosage drug #2
      shock nonshock effects #2
      subsequent diazepam #2
      testing haloperidol #2
      transfer nondrug state #2
      injection 5 ptz #2
      discriminate 025 #2
      amph primary #2
      withdrawal amph cue #2
      Sign-in to see all concepts, it's free!

      Prominent publications by Robert J Barrett

      KOL-Index: 13385

      Extensive behavioral and biochemical evidence suggests an agonist role at the 5-HT2A receptor, and perhaps the 5-HT2C receptor, in the mechanism of action of hallucinogenic drugs. However the published in vitro pharmacological properties of N,N-dimethyltryptamine (DMT), an hallucinogenic tryptamine analog, are not consistent with this hypothesis. We, therefore, undertook an extensive investigation into the properties of DMT at 5-HT2A and 5-HT2C receptors. In fibroblasts transfected with ...

      Known for Serotonin 5 | Ht2a Receptor | Dmt Rats | Hallucinogenic Drugs | Choroid Plexus
      KOL-Index: 10096

      Tolerance is defined as a decrease in responsiveness to a drug after repeated administration. Tolerance to the behavioral effects of hallucinogens occurs in humans and animals. In this study, we used drug discrimination to establish a behavioral model of lysergic acid diethylamide (LSD) tolerance and examined whether tolerance to the stimulus properties of LSD is related to altered serotonin receptor signaling. Rats were trained to discriminate 60 μg/kg LSD from saline in a two-lever ...

      Known for Lysergic Acid | Behavioral Tolerance | Serotonin 5 | Lsd Rats | Ht2a Receptor
      KOL-Index: 8681

      RationaleThe drug discrimination procedure is the most frequently used in vivo model of hallucinogen activity. Historically, most drug discrimination studies have been conducted in the rat. With the development of genetically modified mice, a powerful new tool has become available for investigating the mechanisms of drug-induced behavior. The current paper is part of an ongoing effort to determine the utility of the drug discrimination technique for evaluating hallucinogenic drugs in ...

      Known for Lysergic Acid Diethylamide | Lsd Mice | Stimulus Properties | Drug Discrimination | Serotonin 5
      KOL-Index: 7795

      Rats were trained to discriminate between 0.25 mg/kg amphetamine (AMPH) and 0.03 mg/kg haloperidol (HAL) in a two-lever drug discrimination task. In order to test for a drug-induced withdrawal state, animals were assigned to one of three chronic treatment groups and given injections of AMPH, HAL, or distilled water (DW) for 10 consecutive days. Subjects from each treatment condition were then tested at 24, 48, or 72 h after the final injection. At the 24 h retest interval, subjects ...

      Known for Drug Discrimination | 24 Treatment | Tolerance Withdrawal | Dopamine Mediated | Distilled Water
      KOL-Index: 7735

      d-Lysergic acid diethylamide (LSD), an indoleamine hallucinogen, produces profound alterations in mood, thought, and perception in humans. The brain site(s) that mediates the effects of LSD is currently unknown. In this study, we combine the drug discrimination paradigm with intracerebral microinjections to investigate the anatomical localization of the discriminative stimulus of LSD in rats. Based on our previous findings, we targeted the anterior cingulate cortex (ACC) to test its ...

      Known for Discriminative Stimulus | Lsd Rats | Lysergic Acid | Spraguedawley Receptor | 5 Ht2a
      KOL-Index: 7128

      The purpose of this study was to determine if animals trained to discriminate a serotonin2A (5-HT2A) receptor agonist from a 5-HT2A receptor antagonist would also be sensitive to alterations in serotonin neurotransmission brought about by 5-HT reuptake inhibitors and releasers. Previous work from our laboratory has shown that the quipazine-ketanserin discrimination is mediated solely by the 5-HT2A receptor, thus providing a behavioral continuum of 5-HT2A receptor function. Rats were ...

      Known for Serotonin 5 | Quipazine Rats | Ht2a Receptor | Ketanserin Male | Trained Discriminate
      KOL-Index: 6882

      Existing reports of tolerance to the behavioral effects of d-amphetamine are most parsimoniously interpreted as reflecting behavioral adaptation to the disruptive effects of the drug rather than physiological tolerance. The present study shows that physiological tolerance does develop to the facilitation of self-stimulation behavior which the drug produces. Rats were trained to bar-press for electrical stimulation of the medial forebrain bundle and tested for facilitation of responding ...

      Known for Drug Tolerance | Male Rats | Behavioral Effects | Reward Stimulation | Medial Forebrain Bundle
      KOL-Index: 6805

      Rats responding for food reinforcement were trained in a 2-lever drug discrimination task. Groups of rats were trained to discriminate one of four doses of amphetamine (0.0, 0.1, 0.3, or 0.5 mg/kg) from haloperidol (0.02 mg/kg). Both the rate of acquisition and level of discrimination at asymptote were a function of amphetamine training dose. Following acquisition of this discrimination, choice behavior was assessed in the absence of drug during two test sessions. Twenty-four hours ...

      Known for Chronic Drug Treatment | Choice Behavior | Amphetamine Haloperidol | Drug Discrimination | 10 Consecutive
      KOL-Index: 6264

      In one experiment three intensities of ECS were given to rats shortly after passive avoidance training. Separate groups were tested 1, 24 or 42 days later. Retrograde amnesia was observed at all ECS to test intervals for the highest intensity ECS. For the two lower intensities retrograde amnesia was not observed one day after ECS but appeared as an increasing function of the ECS to test interval. A second experiment replicated these results and demonstrated that a similar function ...

      Known for Retrograde Amnesia | Ecs Intensity | Animals Avoidance | Male Memory | Reaction Time
      KOL-Index: 6155

      Two groups of male Sprague-Dawley rats were trained to discriminate which of two levers to press for milk reinforcement on a VI-20 sec schedule of reinforcement on the basis of whether they were injected intraperitoneally with d-amphetamine (0.50 mg/kg or 1.50 mg/kg) or saline 15 min prior to daily 30 min training sessions. Following acquisition of the discrimination, dose-response functions were generated for both training-dose groups during 5 min test sessions. All subjects were then ...

      Known for Drug Discrimination | Chronic Haloperidol | Training Dose | Cue State | Male Rats
      KOL-Index: 6078

      Rats were trained to discriminate the stimulus properties of l-5-hydroxytryptophan (l-5-HTP) (30 mg/kg SC), the immediate precursor of serotonin (5-HT). The peripheral decarboxylase inhibitor R04-4602, administered prior to l-5-HTP, greatly attenuated the disruptive effects observed on responding when l-5-HTP alone was injected. Following acquisition, the discrimination was dosedependent and generalized to fenfluramine, a 5-HT-releasing drug, but not to amphetamine, a ...

      Known for Stimulus Properties | Serotonin Receptors | 5 Ht | Discrimination Learning | Response Relationship

      Key People For Drug Discrimination

      Top KOLs in the world
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      Francis C Colpaert
      ht1a receptor drug discrimination serotonin 5
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      Veterans Administration Medical Center, 37232, Nashville, TN, USA | Veterans Administration Medical Center, Nashville, TN, USA | Veterans Administration Medical Center, Departments of Psychology and Pharmacology, Vanderbilt University | Veterans Admi

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