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    • Katia Cortese
    • Katia Cortese

      Katia Cortese

      Cellular Electron Microscopy Laboratory, Department of Experimental Medicine (DIMES), University of Genoa, Via Antonio de Toni 14, 16132 Genova (GE), Italy;, ...



      KOL Resume for Katia Cortese


      Cellular Electron Microscopy Laboratory, Department of Experimental Medicine (DIMES), University of Genoa, Via Antonio de Toni 14, 16132 Genova (GE), Italy;, (M.C.G.);, (K.C.)


      DIMES, Department of Experimental Medicine, Cellular Electron Microscopy Lab, Università di Genova, Genova, Italy


      DIMES, Department of Experimental Medicine, Human Anatomy, University of Genoa, 16132 Genoa, Italy;, (K.C.);, (S.M.);, (M.C.G.)

      Department of Experimental Medicine, Human Anatomy, University of Genoa, Genova, Italy


      DIMES, Department of Experimental Medicine, Human Anatomy, University of Genoa, Genoa, Italy. Electronic address:

      Section of Anatomy, Department of Experimental Medicine, University of Genova, Genova, Italy


      DIMES, Dipartimento di Medicina Sperimentale, Anatomia Umana, Università di Genova, Genova, Italy,, View further author information

      Department of Experimental Medicine (DIMES), Human Anatomy Section, University of Genova, Via De Toni 14, 16132 Genova, Italy;, (K.C.);, (M.C.G.)

      Dept. of Experimental Medicine (DIMES), University of Genoa, Italy.


      DIMES, Department of Experimental Medicine, Human Anatomy, University of Genoa, Via Antonio de Toni 14, 16132, Genoa, Italy


      Department of Experimental Medicine – DIMES, University of Genoa, Italy


      DIMES, Dipartimento di Medicina Sperimentale, Università di Genova, Italy


      Dipartimento di Medicina Sperimentale – DIMES, Università di Genova, Genova, Italy


      These authors have equally contributed.

      Dipartimento di Medicina Sperimentale - DIMES, Università di Genova, Genova, Italy

      Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Queensland 4072, Australia


      Centro di Ricerca MicroSCoBio/IFOM Fondazione Istituto FIRC di Oncologia Molecolare, Dipartimento di Medicina Sperimentale, Università di Genova, Via de Toni 14, 16132, Genoa, Italy

      The Institute for Molecular Bioscience, and, The Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, Queensland 4072, Australia


      MicroSCoBiO Research Center, University of Genoa, 16146, Genoa, Italy


      Centro di Ricerca MicroSCoBio/IFOM, FIRC Institute of Molecular Oncology, Dipartimento di Medicina Sperimentale, Sezione di Anatomia Umana, Università di Genova, Genova, Italy


      MicroSCoBiO Research Center and IFOM Center of Cell Oncology and Ultrastructure, Department of Experimental Medicine, University of Genoa, Genoa, Italy; and


      Department of Experimental Medicine, Anatomy Section, University of Genoa, 16132 Genoa, Italy


      Department of Experimental Medicine, Anatomy Section, University of Genoa, 16132, Genoa



      Katia Cortese: Influence Statistics

      Sample of concepts for which Katia Cortese is among the top experts in the world.
      Concept World rank
      anatomy surgery teaching #1
      cis isomers fef77 #1
      surgery teaching #1
      feruloyl tertiary amides #1
      fef77 #1
      virus infections decades #1
      new settings anatomy #1
      peptoidlike derivative #1
      lipidlowering ferulic acid #1
      ferulic acid fef77 #1
      photoisomerization antioxidant activity #1
      imaging endocytosis dynamics #1
      antioxidant activity lipidlowering #1
      imaging endocytosis #1
      oleate palmitate ffa #2
      p185erbb2 polyubiquitination #2
      cooperative antitumor activities #2
      anatomy covid19 #2
      lipogenic pathway stimulation #2
      survival tz #2
      ros mediated mechanisms #2
      p116 erbb2 #2
      therapeutic hsp90 inhibitors #2
      complex cytotoxic activities #2
      tzresistant cells #2
      p116erbb2 #2
      carnosic acid trastuzumab #2
      treatment erbb2 cancers #2
      erbb2 p116erbb2 #2
      compound salvia corrugata #2
      feruloyl amides #2
      p185erbb2 cleavage #2
      ffa etoh #2
      p116erbb2 degradation #2
      dependent p116 #2
      survival erbb2 cells #2
      interestingly ethanol #2
      gadependent formation #2
      tz cell migration #2


      Prominent publications by Katia Cortese

      KOL-Index: 13149

      Macroautophagy/autophagy, a defense mechanism against aberrant stresses, in neurons counteracts aggregate-prone misfolded protein toxicity. Autophagy induction might be beneficial in neurodegenerative diseases (NDs). The natural compound trehalose promotes autophagy via TFEB (transcription factor EB), ameliorating disease phenotype in multiple ND models, but its mechanism is still obscure. We demonstrated that trehalose regulates autophagy by inducing rapid and transient lysosomal ...

      Known for Neurodegenerative Diseases | Tfeb Activation | Autophagy Lysosomal | Protein 1 | Nuclear Translocation
      KOL-Index: 10946

      Marine bivalves can accumulate large numbers of bacteria, in particular Vibrio species, whose persistence in bivalve tissues largely depends on their sensitivity to the bactericidal activity of circulating hemocytes and hemolymph soluble factors. The interactions between vibrios and hemolymph have been investigated, in particular in bivalve species susceptible to infection by certain Vibrio spp. and strains. In this work, the effects of two bivalve pathogens, Vibrio splendidus LGP32 ...

      Known for Mytilus Galloprovincialis | Vibrio Aestuarianus | Bactericidal Activity | Splendidus Lgp32 | Bivalve Species
      KOL-Index: 10551

      PURPOSE: The authors took advantage of the Oa1 mutant mouse in combination with other albinism mouse models (i.e., Tyrosinase and membrane-associated transporter protein [Matp]) to study the function of Oa1, the gene mutated in ocular albinism type 1, in the RPE during development and after birth.

      METHODS: Enzyme activity and protein localization were analyzed by immunohistochemistry of tyrosinase (Tyr) in Oa1-null mice. Ultrastructural analysis and morphometry were performed by electron ...

      Known for Ocular Albinism Type | Melanosome Maturation | Function Oa1 | Eye Receptors | Inbred C57bl Mice
      KOL-Index: 10462

      The potential toxicity of engineered nanoparticles (NPs) for humans and the environment represents an emerging issue. Since the aquatic environment represents the ultimate sink for NP deposition, the development of suitable assays is needed to evaluate the potential impact of NPs on aquatic biota. The immune system is a sensitive target for NPs, and conservation of innate immunity represents an useful basis for studying common biological responses to NPs. Suspension-feeding ...

      Known for Bivalve Mytilus | Effects Nps | Aquatic Organisms | Engineered Nanoparticles | Functional Parameters
      KOL-Index: 10247

      Due to the increasing production of nanoparticles (NPs) and their potential release in the aquatic environment, evaluation of their biological impact on aquatic organisms represents a major concern. Suspension feeding invertebrates, in particular bivalve mollusks, may play a role in NP biotransformation and transfer through food webs and may represent a significant target for NP toxicity. In this work, the in vivo effects of titanium dioxide (n-TiO2), one of the most widespread NPs in ...

      Known for Digestive Gland | Vivo Effects | Bivalve Mytilus | Exposure Tio2 | Immune Cells
      KOL-Index: 10136

      The bivalve Mytilus galloprovincialis has proven as a suitable model invertebrate for evaluating the potential impact of nanoparticles (NPs) in the marine environment. In particular, in mussels, the immune system represents a sensitive target for different types of NPs. In environmental conditions, both NP intrinsic properties and those of the receiving medium will affect particle behavior and consequent bioavailability/uptake/toxicity. However, the evaluation of the biological effects ...

      Known for Marine Bivalve | Effects Nps | Polystyrene Nanoparticles | Aquatic Organisms | Mytilus Hemocytes
      KOL-Index: 8924

      Evidence indicates that endosomal entry promotes signaling by the Notch receptor, but the mechanisms involved are not clear. In a search for factors that regulate Notch activation in endosomes, we isolated mutants in Drosophila genes that encode subunits of the vacuolar ATPase (V-ATPase) proton pump. Cells lacking V-ATPase function display impaired acidification of the endosomal compartment and a correlated failure to degrade endocytic cargoes. V-ATPase mutant cells internalize Notch and ...

      Known for Vacuolar Atpase | Notch Receptor | Drosophila Genes | Early Endosomes | Endosomal Compartment
      KOL-Index: 8258

      Clathrin-independent endocytosis is an umbrella term for a variety of endocytic pathways that internalize numerous cargoes independently of the canonical coat protein Clathrin [1, 2]. Electron-microscopy studies have defined the pleiomorphic CLathrin-Independent Carriers (CLICs) and GPI-Enriched Endocytic Compartments (GEECs) as related major players in such uptake [3, 4]. This CLIC/GEEC pathway relies upon cellular signaling and activation through small G proteins, but mechanistic ...

      Known for Endocytic Pathway | Protein Graf1 | Clic Geec | Signal Transduction | Membrane Carriers
      KOL-Index: 8082

      Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity and mortality. Oxidative stress and release of pro-inflammatory cytokines, such as tumor necrosis factor α (TNFα), are major consequences of hepatic lipid overload, which can contribute to progression of NAFLD to non-alcoholic steatohepatitis (NASH). Also, mitochondria are involved in the NAFLD pathogenesis for their role in hepatic lipid metabolism. Definitive treatments for NAFLD/NASH are lacking so ...

      Known for Oxidative Stress | Fatty Liver | Progression Nafld | Lipid Accumulation | Nonalcoholic Steatohepatitis
      KOL-Index: 8055

      BACKGROUND: The urokinase receptor (uPAR/CD87) is highly expressed in malignant tumours. uPAR, as a GPI anchored protein, is preferentially located at the cell surface, where it interacts with its ligands urokinase (uPA) and the extracellular matrix protein vitronectin, thus promoting plasmin generation, cell-matrix interactions and intracellular signalling events. Interaction with a complex formed by uPA and its inhibitor PAI-1 induces cell surface down regulation and recycling of the ...

      Known for Cell Surface | Urokinase Receptor | Lrp1 Upar | Plasminogen Activator | Lipid Rafts
      KOL-Index: 7891

      Although the importance of clathrin- and caveolin-independent endocytic pathways has recently emerged, key aspects of these routes remain unknown. Using quantitative ultrastructural approaches, we show that clathrin-independent carriers (CLICs) account for approximately three times the volume internalized by the clathrin-mediated endocytic pathway, forming the major pathway involved in uptake of fluid and bulk membrane in fibroblasts. Electron tomographic analysis of the 3D morphology of ...

      Known for Leading Edge | Migrating Cells | Independent Carriers | Mice Mice | Clathrin Caveolin
      KOL-Index: 7513

      Bisphenol A (BPA), used in the manufacture of polycarbonate plastic and epoxy resin, is one of the most abundant endocrine disruptors in the environment, considered as a xenoestrogen. BPA has recently become of additional public health concern because of increasing evidence of deleterious effects on metabolism. Dietary intake seems the most important route for BPA exposure, followed by rapid biotransformation in the gut and liver and elimination in the urine. Although hepatocytes can ...

      Known for Lipid Homeostasis | Effects Bpa | Hepatoma Cells | Cellular Level | Estrogen Receptor
      KOL-Index: 7366

      Vibrio coralliilyticus has emerged as a coral pathogen of concern throughout the Indo-Pacific reef. The interest towards understanding its ecology and pathogenic potential has increased since V. coralliilyticus was shown to be strongly virulent also for other species; in particular, it represents a serious threat for bivalve aquaculture, being one of the most important emerging pathogen responsible for oyster larval mortalities worldwide. V. coralliilyticus has a tightly regulated ...

      Known for Mytilus Galloprovincialis | Vibrio Coralliilyticus | Lysosomal Membrane Stability | Responses Mussel | Hemocytes Immunity
      KOL-Index: 7053

      X-linked recessive ocular albinism type I (OA1) is due to mutations in the OA1 gene (approved gene symbol GPR143), which is expressed in the retinal pigment epithelium (RPE). The Oa1 (Gpr143) knockout mouse (Oa1(-/-)) model recapitulates many of the OA1 retinal morphological anomalies, including a lower number of melanosomes of increased size in the RPE. The Oa1(-/-) mouse also displays some of the retinal developmental abnormalities observed in albino patients such as misrouting of the ...

      Known for Gene Transfer | Ocular Albinism | Retina Mouse | Albino Patients | Mice Knockout

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      Katia Cortese:Expert Impact

      Concepts for whichKatia Cortesehas direct influence:Electron microscopy,  Extracellular vesicles,  Digestive gland,  Amyotrophic lateral sclerosis,  Carnosic acid,  Ferulic acid,  Ocular albinism type,  Gbm cells.

      Katia Cortese:KOL impact

      Concepts related to the work of other authors for whichfor which Katia Cortese has influence:Electron microscopy,  Plasma membrane,  Mytilus galloprovincialis,  Ocular albinism,  Extracellular vesicles,  Cell surface,  Neurodegenerative diseases.



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      Cellular Electron Microscopy Laboratory, Department of Experimental Medicine (DIMES), University of Genoa, Via Antonio de Toni 14, 16132 Genova (GE), Italy;,, (M.C.G.);,, (K.C.) | Cellular Electron Microscopy

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