Katia Cortese

Katia Cortese

Centro Di Ricerca Microscobio/ifom, Firc Institute Of Molecular Oncology, Dipartimento Di Medicina Sperimentale, Sezione Di Anatomia Umana, Università Di Genova, Genova, Italy

Direct Impact

Concepts for which Katia Cortese has direct influence:

electron microscopy
extracellular vesicles
ocular albinism
tumor suppression
amyotrophic lateral sclerosis
gbm cells
mytilus galloprovincialis

External impact

Concepts related to the work of other authors for which Katia Cortese has influence:

spinal cord
autophagic flux
amyotrophic lateral sclerosis
rna viruses
oxidative stress
extracellular vesicles
bone marrow

Prominent publications by Katia Cortese

KOL-Index: 783 In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. ...
KOL-Index: 120 We previously reported that c-KIT+ human amniotic-fluid derived stem cells obtained from leftover samples of routine II trimester prenatal diagnosis (fetal hAFS) are endowed with regenerative paracrine potential driving pro-survival, anti-fibrotic and proliferative effects. hAFS may also be isolated from III trimester clinical waste samples during scheduled C-sections (perinatal hAFS), thus ...
Known for
Paracrine Cargo | Formulations Fetal- | Hypoxic Preconditioning | Fetal Perinatal
KOL-Index: 50 Breast cancers (BCa) with ERBB2 amplification show rapid tumor growth, increased disease progression, and lower survival rate. Deregulated intracellular trafficking and extracellular vesicle (EVs) release are mechanisms that support cancer progression and resistance to treatments. Neratinib (NE) is a Food and Drug Administration-approved pan-ERBB inhibitor employed for the treatment of ...
Known for
Cd63 Mvb Compartment | Evs Release | Bca Erbb2 | Distant Target Cells
KOL-Index: 45 Recent studies reported that the uptake of [18F]-fluorodeoxyglucose (FDG) is increased in the spinal cord (SC) and decreased in the motor cortex (MC) of patients with ALS, suggesting that the disease might differently affect the two nervous districts with different time sequence or with different mechanisms. Here we show that MC and SC astrocytes harvested from newborn B6SJL-Tg (SOD1G93A) ...
Known for
Mitochondria Respiratory Uncoupling | Fdg Uptake | Impressive Ultrastructural Enlargement | Spectrophotometric Cytofluorimetric
KOL-Index: 37 The chromodomain helicase DNA-binding 4 (CHD4), a member of the nucleosome remodeling and deacetylases (NuRD) complex, has been identified as an oncogene that modulates proliferation and migration of breast cancers (BC). ERBB2 is an oncogenic driver in 20-30% of BC in which its overexpression leads to increased chemoresistance. Here we investigated whether CHD4 depletion affects the ERBB2 ...
Known for
Tz Proliferation | Therapeutic Anti-Erbb2 Antibody | Erbb2 Pi3k | Impairs
KOL-Index: 32 Whether exosomes can be actively released from presynaptic nerve terminals is a matter of debate. To address the point, mouse cortical synaptosomes were incubated under basal and depolarizing (25 mM KCl-enriched medium) conditions, and extracellular vesicles were isolated from the synaptosomal supernatants to be characterized by dynamic light scattering, transmission electron microscopy, ...
Known for
Nerve Terminals | High-Kcl Stimulus | Presynaptic Release | Ca2-Dependent Exocytosis
KOL-Index: 31 According to the “gain-of-toxicity mechanism”, neuronal loss during cerebral proteinopathies is caused by accumulation of aggregation-prone conformers of misfolded cellular proteins, although it is still debated which aggregation state actually corresponds to the neurotoxic entity. Autophagy, originally described as a variant of programmed cell death, is now emerging as a crucial mechanism ...
Known for
Prp90 231 | Intracellular Accumulation | Misfolded Proteins | Cerebral Proteinopathies
KOL-Index: 30 Colorectal cancer (CRC) is one of the main causes of cancer-related death in developed countries. Targeted therapies and conventional chemotherapeutics have been developed to help treat this type of aggressive cancer. Among these, the monoclonal antibodies cetuximab (Cxm) and panitumumab specifically target and inactivate the signaling of ERBB1 (EGF receptor), a key player in the development ...
Known for
Llnle-Immunoliposomes | Llnle Effective | Crc Cancer | Small Fraction
KOL-Index: 27 Extracellular vesicles (EVs) play a central role in neurodegenerative diseases (NDs) since they may either spread the pathology or contribute to the intracellular protein quality control (PQC) system for the cellular clearance of NDs-associated proteins. Here, we investigated the crosstalk between large (LVs) and small (SVs) EVs and PQC in the disposal of TDP-43 and its FTLD and ...
Known for
Extracellularly Secreted | Intracellular Protein | Evs Pqc | Nsc-34 Cells
KOL-Index: 26 AIMS: The aim of this study was the characterization of the in vitro cytotoxic properties of a recently isolated diterpene compound, 7β-acetoxy-20-hydroxy-19,20-epoxyroyleanone (compound 1), extracted from Salvia corrugata, versus human cell lines. MAIN METHODS: We used as model study immortalized breast epithelial cells MCF10A and two ERBB2+ breast cancer (BCa) cell lines, SKBR-3 and BT474. ...
Known for
Isolated Diterpene Compound | Vitro Cytotoxic Properties | Growth-Arrest Proapoptotic Activity | Salvia Corrugata Vahl

Centro di Ricerca MicroSCoBio/IFOM, FIRC Institute of Molecular Oncology, Dipartimento di Medicina Sperimentale, Sezione di Anatomia Umana, Università di Genova, Genova, Italy

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