• Disease
  • Functional
  • Functional Dyspepsia
  • Nicholas Joseph Talley

    Prominent publications by Nicholas Joseph Talley

    KOL Index score: 20171

    OBJECTIVES: Helicobacter pylori is a carcinogen; gastric carcinoma involves a multistep process from chronic gastritis to atrophy, intestinal metaplasia, and dysplasia. The aims of this study were to determine the types of mucosa at different gastric sites in H. pylori-infected and uninfected patients, and whether the presence of antral-type mucosa in the incisura, body, and fundus is associated with gastric atrophy and intestinal metaplasia.

    METHODS: Two hundred and sixty-eight patients ...

    Also Ranks for: Intestinal Metaplasia |  gastric incisura |  helicobacter pylori |  atrophic gastritis |  type mucosa
    KOL Index score: 16390

    OBJECTIVES: Helicobacter pylori is an identified carcinogen for gastric cancer, however, the underlying mechanisms remain to be defined. In this review, we sought to elucidate the role of apoptosis in gastric carcinogenesis, to determine the influence of H. pylori infection on apoptosis, and finally to provide insights into the mechanisms by which H. pylori may lead to gastric carcinogenesis.

    METHODS: A broad-based MEDLINE and Current Contents literature search was performed to identify ...

    Also Ranks for: Gastric Carcinogenesis |  pylori infection |  cell proliferation |  intestinal metaplasia |  underlying mechanisms
    KOL Index score: 16214

    Background: Patient-rated symptom assessments are needed for evaluating the effectiveness of medical treatments and for monitoring outcomes in gastroparesis. Objective: This paper summarizes the development and psychometric evaluation of a new instrument, the Gastroparesis Cardinal Symptom Index (GCSI), for assessing severity of symptoms associated with gastroparesis. Methods: The GCSI was based on reviews of the medical literature, patient focus groups, and interviews with clinicians. A ...

    Also Ranks for: Gastroparesis Symptoms |  patients gcsi |  symptom severity |  united states |  total score
    KOL Index score: 15761

    OBJECTIVES: Helicobacter pylori (H. pylon) infection seems to induce antralization (ie., gastric mucosal transformation from transitional or body type to antral type), which is strongly associated with gastric atrophy and intestinal metaplasia. The aim of this study was to determine the topographic associations of Ki-67 (a protein expressed in proliferative cells), Bax (a pro-apoptotic protein), and Bcl-2 (an antiapoptotic protein) expression with antralization.

    METHODS: In each of 104 ...

    Also Ranks for: Gastric Incisura |  pylori infection |  bax bcl2 |  epithelial expression |  intestinal metaplasia
    KOL Index score: 15453

    OBJECTIVE: To assess the prevalence of combined fecal and urinary incontinence.

    DESIGN: A cross-sectional, community-based study.

    SETTING: Olmsted County, Minnesota.

    PARTICIPANTS: Men (n = 778) and women (n = 762), aged 50 years or older, selected randomly from the population.

    MEASUREMENTS: Participants completed a previously validated self-administered questionnaire that assessed the occurrence of fecal and urinary incontinence in the previous year.

    RESULTS: The age-adjusted prevalence ...

    Also Ranks for: Urinary Incontinence |  women prevalence |  combined fecal |  crosssectional studies |  previous year
    KOL Index score: 15221

    INTRODUCTION: We conducted a systematic review and meta-analysis to compare the prevalence of small intestinal bacterial overgrowth (SIBO) in patients with irritable bowel syndrome (IBS) and controls.

    METHODS: Electronic databases were searched up to December 2018 for studies reporting SIBO prevalence in patients with IBS. Prevalence rates, odds ratios (ORs), and 95% confidence intervals (CIs) of SIBO in patients with IBS and controls were calculated.

    RESULTS: We included 25 studies with ...

    Also Ranks for: Patients Ibs |  irritable bowel syndrome |  sibo prevalence |  controls 95 |  bacterial overgrowth
    KOL Index score: 15214

    BACKGROUND: On-demand therapy may offer an effective approach to the long-term management of gastro-oesophageal reflux disease (GORD) without oesophagitis.

    AIM: To examine the efficacy of the novel proton pump inhibitor esomeprazole as on-demand therapy in endoscopy-negative GORD.

    PATIENTS AND METHODS: Endoscopy-negative GORD patients who achieved complete resolution of heartburn after short-term esomeprazole or omeprazole treatment (n = 721) were randomized to esomeprazole 20 mg (n = ...

    Also Ranks for: 6 Months |  esomeprazole 40 |  demand therapy |  oesophageal reflux disease |  term management
    KOL Index score: 14942

    BACKGROUND: Disturbed bowel habit, diarrhoea or constipation is a key manifestation of irritable bowel syndrome (IBS). In some patients, diarrhoea and constipation alternate, giving rise to the so-called alternating subtype.

    AIMS: To assess IBS subtype breakdown (constipation (C-IBS), diarrhoea (D-IBS) or alternating (A-IBS)) according to the Rome II criteria and patients' self-assessment, the predominance in the alternating subtype (i.e. constipation, diarrhoea or neither), and the ...

    Also Ranks for: Rome Criteria |  ibs subtypes |  bowel habit |  constipation diarrhoea |  health quality life
    KOL Index score: 14898

    OBJECTIVES: Proton pump inhibitors reduce ulcer recurrence in non-steroidal anti-inflammatory drug (NSAID) users, but their impact in at-risk ulcer-free patients using the current spectrum of prescribed agents has not been clearly defined. We assessed esomeprazole for ulcer prevention in at-risk patients (> or = 60 yr and/or ulcer history) taking NSAIDs, including COX-2 inhibitors. Such studies are particularly relevant, given that concerns regarding adverse cardiovascular outcomes among ...

    Also Ranks for: 2 Inhibitors |  placebo esomeprazole |  6 months |  nonselective nsaids |  risk ulcer
    KOL Index score: 14484

    OBJECTIVE: Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder. Evidence for treatment of the condition with antidepressants and psychological therapies is conflicting.

    DESIGN: Systematic review and meta-analysis of randomised controlled trials (RCTs). MEDLINE, EMBASE and the Cochrane Controlled Trials Register were searched (up to May 2008).

    SETTING: RCTs based in primary, secondary and tertiary care.

    PATIENTS: Adults with IBS.

    INTERVENTIONS: Antidepressants ...

    Also Ranks for: Psychological Therapies |  antidepressants placebo |  treatment ibs |  irritable bowel |  control therapy
    KOL Index score: 14385

    INTRODUCTION: Motilin-receptor agonists are prokinetics; whether they relieve the symptoms of functional dyspepsia is unknown. We aimed to test the efficacy of the motilin agonist ABT-229 in functional dyspepsia patients with and without delayed gastric emptying.

    METHODS: Patients were randomized with postprandial symptoms and documented functional dyspepsia by endoscopy (n=589 in intention-to-treat analysis). Patients were assigned to either the delayed or normal gastric emptying ...

    Also Ranks for: Delayed Gastric |  functional dyspepsia |  patients placebo |  motilin receptor agonist |  4 weeks
    KOL Index score: 14289

    OBJECTIVE: The diagnostic value of the addition of alarm symptoms in distinguishing functional from organic gastrointestinal disease remains uncertain. We aimed to establish the value of alarm features in differentiating between organic disease and irritable bowel syndrome (IBS) and functional dyspepsia (FD).

    METHODS: A total of 568 consecutive patients (63% female; mean age 44.7 years) completed a detailed symptom questionnaire and then received a complete diagnostic workup, as ...

    Also Ranks for: Alarm Features |  diagnostic yield |  bowel syndrome |  diagnosis ibs |  organic disease
    KOL Index score: 14254

    OBJECTIVE: To determine the effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome.

    DESIGN: Systematic review and meta-analysis of randomised controlled trials.

    DATA SOURCES: Medline, Embase, and the Cochrane controlled trials register up to April 2008. Review methods Randomised controlled trials comparing fibre, antispasmodics, and peppermint oil with placebo or no treatment in adults with irritable bowel syndrome were eligible for inclusion. ...

    Also Ranks for: Peppermint Oil |  irritable bowel syndrome |  antispasmodics placebo |  persistent symptoms |  randomized controlled trials
    KOL Index score: 13969

    BACKGROUND: Irritable bowel syndrome (IBS) prevalence estimates are essential for measuring the importance of the problem and the burden of the illness. However, IBS diagnosis is based on clinical criteria which have changed over time. The aim of this study was to assess how the use of different diagnostic criteria influences estimated IBS prevalence and, in particular, to compare how this prevalence varies using the new Rome II criteria and previous diagnostic criteria.

    METHODS: An ...

    Also Ranks for: Ibs Rome |  manning criteria |  irritable bowel |  epidemiological survey |  prevalence varies
    KOL Index score: 13938

    BACKGROUND & AIMS: Empirical therapy has been proposed for initial management of dyspepsia. The aim of this study was to evaluate initial endoscopy, empirical therapy, and testing for Helicobacter pylori in the management of patients with a new onset of dyspepsia.

    METHODS: Decision analysis was used to compare the direct medical charges in the first year after the onset of dyspepsia for patients managed by initial endoscopy or empirical therapy, with or without initial testing for H. ...

    Also Ranks for: Initial Endoscopy |  empirical therapy |  helicobacter pylori |  patients dyspepsia |  decision analysis


    Nicholas Joseph Talley: Influence Statistics

    Sample of concepts for which Nicholas Joseph Talley is among the top experts in the world.
    Concept World rank
    fgids psychological disorders #1
    specificity statistical models #1
    model childhood abuse #1
    chronic dyspepsia presence #1
    prevalence abdominal pain #1
    fd sleep #1
    antacids alginates #1
    vomiting67 #1
    goetschalckx #1
    diagnosis erosive gerd #1
    imt medical therapy #1
    potential etiological factor #1
    neuroticism psychological morbidity #1
    functional disorders community #1
    hiatal hernias length #1
    prevalence upper gastrointestinal #1
    constipation physical activity #1
    symptoms diabetic subjects #1
    65195ci #1
    dyspepsia management #1
    i29669 #1
    ibs childhood factors #1
    gastric function stomach #1
    95 dysmotility symptoms #1
    gastric sites #1
    studies constipation #1
    fd patients eps #1
    ci212 #1
    eoe cases adults #1
    food intake fd #1
    trials antispasmodics #1
    definitions dyspepsia #1
    subjects questionnaire #1
    gors obesity #1
    continued chest pain #1
    ibs cognitivebehaviour therapy #1
    time clinical assessment #1
    trpm8 polymorphisms #1
    rap childhood #1
    non‐cardiac chest pain #1
    baseline duodenal eosinophilia #1
    gastrointestinal symptoms sleep #1
    ibs investigation #1
    unknown origin constipation #1
    bowel syndrome #1
    dyspeptics #1
    animals semf procedure #1
    mechanisms fd #1
    children duodenal eosinophilia #1
    finnish asq #1

    Key People For Functional Dyspepsia

    Top KOLs in the world
    Nicholas Joseph Talley
    functional dyspepsia irritable bowel syndrome emergency action
    Vincenzo Stanghellini
    irritable bowel syndrome functional dyspepsia gastric emptying
    Jan F Tack
    functional dyspepsia irritable bowel syndrome chronic constipation
    Camilleri Camilleri
    irritable bowel syndrome colonic transit gastric emptying
    Gerald J Holtmann
    functional dyspepsia irritable bowel syndrome inflammatory bowel disease
    Juan‐R Malagelada
    functional dyspepsia abdominal bloating intestinal gas

    Nicholas Joseph Talley:Expert Impact

    Concepts for whichNicholas Joseph Talleyhas direct influence:Functional dyspepsia,  Irritable bowel syndrome,  Helicobacter pylori,  Bowel syndrome,  Irritable bowel,  Gastrointestinal symptoms,  Nonulcer dyspepsia,  Celiac disease.

    Nicholas Joseph Talley:KOL impact

    Concepts related to the work of other authors for whichfor which Nicholas Joseph Talley has influence:Irritable bowel syndrome,  Helicobacter pylori,  Functional dyspepsia,  Gastric cancer,  Eosinophilic esophagitis,  Gastroesophageal reflux disease,  Abdominal pain.



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    School of Medicine and Public Health, University of Newcastle, Newcastle, Australia; National Health and Medical Research Council Centre of Research Excellence on Digestive Health, Newcastle, Australia; Hunter Medical Research Institute, New Lambton