 | Christian N Gluud |
Prominent publications by Christian N Gluud
BACKGROUND: Available evidence on the effects of vitamin D on mortality has been inconclusive. In a recent systematic review, we found evidence that vitamin D3 may decrease mortality in mostly elderly women. The present systematic review updates and reassesses the benefits and harms of vitamin D supplementation used in primary and secondary prophylaxis of mortality.
OBJECTIVES: To assess the beneficial and harmful effects of vitamin D supplementation for prevention of mortality in ...
| Also Ranks for: Vitamin D3 | trials risk | participants compared | aged mortality | calcitriol data |
Transient elastography for diagnosis of stages of hepatic fibrosis and cirrhosis in people with alcoholic liver disease
[ PUBLICATION ]
BACKGROUND: The presence and progression of hepatic (liver) fibrosis into cirrhosis is a prognostic variable having impact on survival in people with alcoholic liver disease. Liver biopsy, although an invasive method, is the recommended 'reference standard' for diagnosis and staging of hepatic fibrosis in people with liver diseases. Transient elastography is a non-invasive method for assessing and staging hepatic fibrosis.
OBJECTIVES: To determine the diagnostic accuracy of transient ...
| Also Ranks for: Transient Elastography | hepatic fibrosis | alcoholic liver disease | liver biopsy | cirrhosis people |
Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
[ PUBLICATION ]
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed and treated psychiatric disorders in childhood. Typically, children with ADHD find it difficult to pay attention, they are hyperactive and impulsive.Methylphenidate is the drug most often prescribed to treat children and adolescents with ADHD but, despite its widespread use, this is the first comprehensive systematic review of its benefits and harms.
OBJECTIVES: To assess the beneficial and ...
| Also Ranks for: Children Adhd | evidence methylphenidate | attention deficit | risk bias | adverse events 95 |
BACKGROUND: Alcoholic hepatitis is a form of alcoholic liver disease, characterised by steatosis, necroinflammation, fibrosis, and potential complications to the liver disease. Typically, alcoholic hepatitis presents in people between 40 and 50 years of age. Alcoholic hepatitis can be resolved if people abstain from drinking, but the risk of death will depend on the severity of the liver damage and abstinence from alcohol. Glucocorticosteroids are used as anti-inflammatory drugs for ...
| Also Ranks for: Alcoholic Hepatitis | glucocorticosteroids people | life adverse events | participants trials | placebo intervention |
BACKGROUND: Millions of people worldwide suffer from hepatitis C, which can lead to severe liver disease, liver cancer, and death. Direct-acting antivirals (DAAs) are relatively new and expensive interventions for chronic hepatitis C, and preliminary results suggest that DAAs may eradicate hepatitis C virus (HCV) from the blood (sustained virological response). However, it is still questionable if eradication of hepatitis C virus in the blood eliminates hepatitis C in the body, and ...
| Also Ranks for: Chronic Hepatitis | trial sequential analysis | daas market | risk adverse events | allcause mortality |
Peginterferon plus ribavirin versus interferon plus ribavirin for chronic hepatitis C
[ PUBLICATION ]
BACKGROUND: Pegylated interferon (peginterferon) plus ribavirin is the recommended treatment for patients with chronic hepatitis C, but systematic assessment of the effect of this treatment compared with interferon plus ribavirin is needed.
OBJECTIVES: To systematically evaluate the benefits and harms of peginterferon plus ribavirin versus interferon plus ribavirin for patients with chronic hepatitis C.
SEARCH METHODS: We searched the Cochrane Hepato-Biliary Group Controlled Trials ...
| Also Ranks for: Interferon Ribavirin | trials risk | patients chronic hepatitis | sustained virological response | allcause mortality |
Antibody induction versus placebo, no induction, or another type of antibody induction for liver transplant recipients
[ PUBLICATION ]
BACKGROUND: Liver transplantation is an established treatment option for end-stage liver failure. To date, no consensus has been reached on the use of immunosuppressive T-cell antibody induction for preventing rejection after liver transplantation.
OBJECTIVES: To assess the benefits and harms of immunosuppressive T-cell specific antibody induction compared with placebo, no induction, or another type of T-cell specific antibody induction for prevention of acute rejection in liver ...
| Also Ranks for: Antibody Induction | liver transplant recipients | acute rejection | risk bias | randomised clinical trials |
BACKGROUND: Heart transplantation has become a valuable and well-accepted treatment option for end-stage heart failure. Rejection of the transplanted heart by the recipient's body is a risk to the success of the procedure, and life-long immunosuppression is necessary to avoid this. Clear evidence is required to identify the best, safest and most effective immunosuppressive treatment strategy for heart transplant recipients. To date, there is no consensus on the use of immunosuppressive ...
| Also Ranks for: Antibody Induction | heart transplant recipients | acute rejection | trials risk | monoclonal antibodies |
BACKGROUND: Vitamin D deficiency is often reported in people with chronic liver diseases. Therefore, improving vitamin D status could have a beneficial effect on people with chronic liver diseases.
OBJECTIVES: To assess the beneficial and harmful effects of vitamin D supplementation in people with chronic liver diseases.
SEARCH METHODS: We searched The Cochrane Hepato-Biliary Group Controlled Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, ...
| Also Ranks for: Chronic Liver Diseases | trials vitamin | participants liver | allcause mortality | risk bias |
BACKGROUND: The evidence on whether vitamin D supplementation is effective in decreasing cancers is contradictory.
OBJECTIVES: To assess the beneficial and harmful effects of vitamin D supplementation for prevention of cancer in adults.
SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, LILACS, Science Citation Index Expanded, and the Conference Proceedings Citation Index-Science to February 2014. We scanned bibliographies of ...
| Also Ranks for: Trials Vitamin | risk bias | intervention adults | moderate quality evidence | supplementation cancer |
BACKGROUND: Liver transplantation is an established treatment option for end-stage liver failure. To date, no consensus has been reached on the use of immunosuppressive T-cell specific antibody induction compared with corticosteroid induction of immunosuppression after liver transplantation.
OBJECTIVES: To assess the benefits and harms of T-cell specific antibody induction versus corticosteroid induction for prevention of acute rejection in liver transplant recipients.
SEARCH METHODS: We ...
| Also Ranks for: Antibody Induction | liver transplant | lowquality evidence | trials risk | cell specific |
Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus
[ PUBLICATION ]
BACKGROUND: Patients with type 2 diabetes mellitus (T2D) exhibit an increased risk of cardiovascular disease and mortality compared to the background population. Observational studies report a relationship between reduced blood glucose and reduced risk of both micro- and macrovascular complications in patients with T2D.
OBJECTIVES: To assess the effects of targeting intensive versus conventional glycaemic control in T2D patients.
SEARCH STRATEGY: Trials were obtained from searches of ...
| Also Ranks for: Intensive Glycaemic Control | conventional glycaemic | type 2 | diabetes mellitus | cardiovascular mortality 95 |
BACKGROUND: Foot ulcers are a major complication of diabetes mellitus, often leading to amputation. Growth factors derived from blood platelets, endothelium, or macrophages could potentially be an important treatment for these wounds but they may also confer risks.
OBJECTIVES: To assess the benefits and harms of growth factors for foot ulcers in patients with type 1 or type 2 diabetes mellitus.
SEARCH METHODS: In March 2015 we searched the Cochrane Wounds Group Specialised Register, The ...
| Also Ranks for: Growth Factor | foot ulcers | complete healing | risk bias | recombinant human |
BACKGROUND: The viral hepatitides are common causes of liver diseases globally. Trials have assessed bile acids for patients with viral hepatitis, but no consensus was reached regarding their usefulness.
OBJECTIVES: To assess the beneficial and harmful effects of bile acids for viral hepatitis.
SEARCH STRATEGY: Searches were performed of the trial registers of The Cochrane Hepato-Biliary Group (September 2002), The Cochrane Library (Issue 2, 2002), MEDLINE (September 2002), EMBASE ...
| Also Ranks for: Bile Acids | viral hepatitis | placebo intervention | methodological quality | treatment 95 |
BACKGROUND: Ursodeoxycholic acid is administered to patients with primary biliary cirrhosis, a chronic progressive inflammatory autoimmune-mediated liver disease with unknown aetiology. Despite its controversial effects, the U.S. Food and Drug Administration has approved its usage for primary biliary cirrhosis.
OBJECTIVES: To assess the beneficial and harmful effects of ursodeoxycholic acid in patients with primary biliary cirrhosis.
SEARCH METHODS: We searched for eligible randomised ...
| Also Ranks for: Ursodeoxycholic Acid | primary biliary cirrhosis | biliary liver | bias risk | intervention patients |
Christian N Gluud: Influence Statistics
| Concept | World rank |
|---|---|
| p005 boundaries | #1 |
| monoclonal antibody induction | #1 |
| intervention adult participants | #1 |
| alcoholic sensitivity | #1 |
| methylphenidate work | #1 |
| teens feasibility trial | #1 |
| patients phyllanthus species | #1 |
| early spc danpact | #1 |
| ribavirin intervention | #1 |
| anesthesiologic interventions tsa | #1 |
| quetiapineer 50 day | #1 |
| active placebo | #1 |
| i² 95 | #1 |
| placebo clarithromycin patients | #1 |
| alcoholic steatosis cirrhosis | #1 |
| assessment imprecision | #1 |
| trial unit | #1 |
| anesthesiologic interventions risk | #1 |
| hyperlipidaemia gingival hyperplasia | #1 |
| antibody trials | #1 |
| antibody induction trials | #1 |
| hospital cerebrovascular morbidity | #1 |
| liver disease 95 | #1 |
| alcoholic disease prognosis | #1 |
| serum tbg levels | #1 |
| hepatitis search | #1 |
| iss knowledge | #1 |
| outpatient visits treatment | #1 |
| backgroundcooling | #1 |
| propylthiouracil beneficial effects | #1 |
| adverse events tsaadjusted | #1 |
| 12 weeks quetiapineer | #1 |
| interventions paracetamol | #1 |
| risk profit bias | #1 |
| size meta | #1 |
| onpump cabg patients | #1 |
| glucocorticosteroids chronic hepatitis | #1 |
| risks random errors | #1 |
| 18 months tbs | #1 |
| evidence glucocorticosteroids | #1 |
| periodontal treatment risk | #1 |
| trial sequential analyses | #1 |
| primary outcomes 98 | #1 |
| intervention pediatric ocd | #1 |
| 95 milk thistle | #1 |
| groups cus | #1 |
| trials total | #1 |
| placebo body bone | #1 |
Key People For Trial Sequential Analysis
Christian N Gluud:Expert Impact
Concepts for whichChristian N Gluudhas direct influence:Trial sequential analysis, Chronic hepatitis, Primary biliary cirrhosis, Hepatic encephalopathy, Antioxidant supplements, Randomised clinical trials, Alcoholic liver disease, Atrial fibrillation.
Christian N Gluud:KOL impact
Concepts related to the work of other authors for whichfor which Christian N Gluud has influence:Liver disease, Oxidative stress, Randomized controlled trials, Hepatocellular carcinoma, Hepatic encephalopathy, Type 2 diabetes, Chronic hepatitis.
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