• Encephalopathy
  • Encephalopathy Kols

    Prominent publications by Peter Ott

    KOL Index score: 15184

    Excretion of conjugated bile acids into bile is an essential function of the liver, and impairment of canalicular bile acid secretion leads to cholestatic liver injury. However, hepatic excretory function cannot be quantified in vivo because of the lack of suitable methods. Cholylsarcosine is an analog of the endogenous bile acid conjugate cholylglycine and exhibits characteristics in vivo that led us to hypothesize that the (11)C-labeled form, that is, [N-methyl-(11)C]cholylsarcosine ...

    Also Ranks for: Bile Acid |  concept studies |  pet tracer |  11c cholylsarcosine |  liver function
    KOL Index score: 14577

    The clinical course of alcoholic cirrhosis, a condition with a high mortality, has not been well described. We examined prevalence, risk, chronology, and mortality associated with three complications of cirrhosis: ascites, variceal bleeding, and hepatic encephalopathy. We followed a population-based cohort of 466 Danish patients diagnosed with alcoholic cirrhosis in 1993-2005, starting from the date of hospital diagnosis and ending in August 2006. Data were extracted from medical charts ...

    Also Ranks for: Variceal Bleeding |  patients ascites |  complications hepatic encephalopathy |  risk mortality |  1 year
    KOL Index score: 14499

    The aim of this study was to develop a method for the quantification of hepatobiliary uptake and secretion of conjugated bile acids with PET and the (11)C-labeled conjugated bile acid analog [N-methyl-(11)C]cholylsarcosine ((11)C-CSar).

    METHODS: Six pigs (13 experiments) underwent dynamic (11)C-CSar PET of the liver with simultaneous measurements of hepatic blood perfusion and (11)C-CSar concentrations in arterial, portal, and hepatic venous blood. In 3 pigs (7 experiments), bile was ...

    Also Ranks for: Bile Acids |  hepatobiliary secretion |  blood hepatocytes |  11c csar |  pet liver
    KOL Index score: 13911

    Animal studies and results from 13N-ammonia positron emission tomography (PET) in patients with cirrhosis and minimal hepatic encephalopathy suggest that a disturbed brain ammonia metabolism plays a pivotal role in the pathogenesis of hepatic encephalopathy (HE). We studied brain ammonia kinetics in 8 patients with cirrhosis with an acute episode of clinically overt HE (I-IV), 7 patients with cirrhosis without HE, and 5 healthy subjects, using contemporary dynamic 13N-ammonia PET. Time ...

    Also Ranks for: Patients Cirrhosis |  brain metabolism |  hepatic encephalopathy |  positron emission |  ammonia blood
    KOL Index score: 13200

    Cerebral edema leading to cerebral herniation (CH) is a common cause of death in acute liver failure (ALF). Animal studies have related ammonia with this complication. During liver failure, hepatic ammonia removal can be expected to determine the arterial ammonia level. In patients with ALF, we examined the hypotheses that high arterial ammonia is related to later death by CH, and that impaired removal in the hepatic circulation is related to high arterial ammonia. Twenty-two patients ...

    Also Ranks for: Arterial Ammonia |  cerebral herniation |  patients alf |  liver failure |  encephalopathy humans
    KOL Index score: 13074

    BACKGROUND & AIMS: Hepatobiliary secretion of bile acids is an important liver function. Here, we quantified the hepatic transport kinetics of conjugated bile acids using the bile acid tracer [N-methyl-11C]cholylsarcosine (11C-CSar) and positron emission tomography (PET).

    METHODS: Nine healthy participants and eight patients with varying degrees of cholestasis were examined with 11C-CSar PET and measurement of arterial and hepatic venous blood concentrations of 11C-CSar.

    RESULTS: Results ...

    Also Ranks for: Positron Emission Tomography |  healthy humans |  bile acids |  transport kinetics |  hepatobiliary secretion
    KOL Index score: 12225

    Liver failure represents a major therapeutic challenge, and yet basic pathophysiological questions about hepatic perfusion and oxygenation in this condition have been poorly investigated. In this study, hepatic blood flow (HBF) and splanchnic oxygen delivery (DO2, sp) and oxygen consumption (VO2,sp) were assessed in patients with liver failure defined as hepatic encephalopathy grade II or more. Measurements were repeated after high-volume plasmapheresis (HVP) with exchange of 8 to 10 L ...

    Also Ranks for: Blood Flow |  oxygen consumption |  liver failure |  patients alf |  splanchnic circulation
    KOL Index score: 11456

    OBJECTIVES: In patients with multiple trauma, actin released from damaged cells may cause severe circulatory disturbance due to thrombi formation. The aim of this study was to evaluate serum concentrations of the actin scavenger, Gc-globulin, in relation to the severity of injury and outcome.

    DESIGN: Prospective, longitudinal, observational study.

    SETTING: Trauma center at a university hospital.

    PATIENTS: Twelve patients with multiple trauma, consecutively included, according to defined ...

    Also Ranks for: Multiple Trauma |  gc globulin |  serum concentrations |  actin scavenger |  injury severity
    KOL Index score: 11439

    Heat shock protein (Hsp) 72 is a cytosolic stress protein that is highly inducible by several factors including exercise. Hsp60 is primarily mitochondrial in cellular location, plays a key role in the intracellular protein translocation and cytoprotection, is increased in skeletal muscle by exercise, and is found in the peripheral circulation of healthy humans. Glucose deprivation increases Hsp72 in cultured cells, whereas reduced glycogen availability elevates Hsp72 in contracting human ...

    Also Ranks for: Glucose Ingestion |  heat shock |  protein 60 |  skeletal muscle |  serum hsp72
    KOL Index score: 11211

    Cerebral hyperammonemia is a hallmark of hepatic encephalopathy, a debilitating condition arising secondary to liver disease. Pyruvate oxidation including tricarboxylic acid (TCA) cycle metabolism has been suggested to be inhibited by hyperammonemia at the pyruvate and alpha-ketoglutarate dehydrogenase steps. Catabolism of the branched-chain amino acid isoleucine provides both acetyl-CoA and succinyl-CoA, thus by-passing both the pyruvate dehydrogenase and the alpha-ketoglutarate ...

    Also Ranks for: Neurons Astrocytes |  tca cycle |  glutamate dehydrogenase |  hepatic encephalopathy |  glutamine synthetase
    KOL Index score: 11045

    It has been previously demonstrated that ammonia exposure of neurons and astrocytes in co-culture leads to net synthesis not only of glutamine but also of alanine. The latter process involves the concerted action of glutamate dehydrogenase (GDH) and alanine aminotransferase (ALAT). In the present study it was investigated if the glutamine synthetase (GS) inhibitor methionine sulfoximine (MSO) would enhance alanine synthesis by blocking the GS-dependent ammonia scavenging process. Hence, ...

    Also Ranks for: Glutamine Synthesis |  glutamate dehydrogenase |  ammonia fixation |  astrocytes neurons |  presence mso
    KOL Index score: 10957

    Branched-chain amino acids (BCAA) are used in attempts to reduce blood ammonia in patients with cirrhosis and intermittent hepatic encephalopathy based on the hypothesis that BCAA stimulate muscle ammonia detoxification. We studied the effects of an oral dose of BCAA on the skeletal muscle metabolism of ammonia and amino acids in 14 patients with cirrhosis and in 7 healthy subjects by combining [(13)N]ammonia positron emission tomography (PET) of the thigh muscle with measurements of ...

    Also Ranks for: Ammonia Metabolism |  amino acids |  patients cirrhosis |  branched chain |  oral dose
    KOL Index score: 10775

    BACKGROUND & AIMS: It is unclear whether patients with hepatic encephalopathy (HE) have disturbed brain oxygen metabolism and blood flow.

    METHODS: We measured cerebral oxygen metabolism rate (CMRO(2)) by using (15)O-oxygen positron emission tomography (PET); and cerebral blood flow (CBF) by using (15)O-water PET in 6 patients with liver cirrhosis and an acute episode of overt HE, 6 cirrhotic patients without HE, and 7 healthy subjects.

    RESULTS: Neither whole-brain CMRO(2) nor CBF ...

    Also Ranks for: Blood Flow |  acute episode |  hepatic encephalopathy |  oxygen consumption |  cirrhotic patients
    KOL Index score: 10549

    Physical exercise results in the appearance of heat shock protein (HSP) 72 in the circulation that precedes any increase in gene or protein expression in contracting skeletal muscle. In rodents, exercise increases liver HSP72 expression and the hepatosplanchnic viscera are known to release many acute phase proteins. In the present study, we tested the hypothesis that the splanchnic tissue beds release HSP72 during exercise. Seven male subjects performed 120 min of semi-recumbent cycling ...

    Also Ranks for: Heat Shock Protein |  hsp72 exercise |  femoral vein |  skeletal muscle |  blood flow


    Peter Ott: Influence Statistics

    Sample of concepts for which Peter Ott is among the top experts in the world.
    Concept World rank
    gctotal gcglobulin #1
    higher prevalence europe #1
    nonsurvivors 56 micromol #1
    jindal journal #1
    sinusoidal binding #1
    globulin survival #1
    increased ammonia #1
    140000–160000 #1
    predictive ability gc #1
    47 micromol #1
    improved diagnostic awareness #1
    wilson populations #1
    study jindal #1
    editorial comments findings #1
    gec 10 #1
    early stage ultrasound #1
    icg sorbitol #1
    return editorial comments #1
    gastroenterology weaknesses #1
    detoxification ammonia #1
    overlooked cases #1
    prothrombin gc #1
    gcfree survivors #1
    gcglobulin predicts #1
    levels gctotal #1
    trauma stimulates #1
    fraction icg #1
    muscle cells circulation #1
    absence splanchnic hypoxia #1
    concentrations gctotal #1
    gctotal gcfree #1
    gccomplexed #1
    encephalopathy gec #1
    patient groups recommendations #1
    frequent firstcousin marriages #1
    mutations danish patients #1
    actin circulation #1
    programmes effective treatments #1
    temporal profile gc #1
    reported crude prevalence #1
    elevated hepatic flow #1
    country based surveillance #1
    astrocytes ammonia treatment #1
    sildenafil citrate hvpg #1
    binding disequilibrium #1
    groups prothrombin levels #1
    oxygen consumption hvpg #1
    albumin preoperative values #1

    Key People For Hepatic Encephalopathy

    Top KOLs in the world
    Peter Ferenci
    chronic hepatitis hepatic encephalopathy wilson disease
    Kevin Daniel Mullen
    hepatic encephalopathy chronic hepatitis portacaval shunt
    Juan Córdoba
    hepatic encephalopathy liver transplantation brain edema
    Roger F Butterworth∗
    hepatic encephalopathy acute liver failure thiamine deficiency
    Karin Weissenborn
    hepatic encephalopathy liver transplantation ischemic stroke
    Andrés T Blei
    brain edema hepatic encephalopathy acute liver failure

    Peter Ott:Expert Impact

    Concepts for whichPeter Otthas direct influence:Hepatic encephalopathy,  Acute liver failure,  Indocyanine green,  Wilson disease,  Liver failure,  Alcoholic cirrhosis,  Liver disease,  Patients cirrhosis.

    Peter Ott:KOL impact

    Concepts related to the work of other authors for whichfor which Peter Ott has influence:Hepatic encephalopathy,  Acute liver failure,  Liver disease,  Skeletal muscle,  Cirrhotic patients,  Brain edema,  Indocyanine green.



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    Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark | Aarhus University Hospital, Medical Dept LMT Hepatology and Gastroenterology, Aarhus, Denmark | Department of Hepatology and Gastroenterology, Aarhus Univers