Prominent publications by Guido Rindi

KOL Index score: 16987

BACKGROUND: Evidence suggests that metastatic colorectal carcinoma (mCRC) has a high level of intratumor heterogeneity. We carried out a quantitative assessment of tumor heterogeneity for KRAS, NRAS, BRAF and PIK3CA mutations, in order to assess potential clinical implications.

PATIENTS AND METHODS: Tumor samples (n = 182) from the CAPRI-GOIM trial of first-line cetuximab + FOLFIRI in KRAS exon-2 wild-type mCRC patients were assessed by next-generation sequencing that allows quantitative ...

Known for Pik3ca Mutations |  Neoplastic Cells |  Kras Nras |  Capri Goim |  Tumor Heterogeneity
KOL Index score: 15623

Gallium-68 somatostatin receptor (SMSR) positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) are valuable diagnostic tools for patients with neuroendocrine tumours (NETs). To date, a meta-analysis about the diagnostic accuracy of these imaging methods is lacking. Aim of our study is to meta-analyse published data about the diagnostic performance of SMSR PET or PET/CT in patients with thoracic and/or gastroenteropancreatic (GEP) NETs. A ...

Known for Diagnostic Performance |  Pet Patients |  Neuroendocrine Tumours |  Pooled Sensitivity |  Somatostatin Receptor
KOL Index score: 13889

BackgroundThe option of obtaining tissue samples for histological examination during endoscopic ultrasound (EUS) has theoretical and practical advantages over cytology alone. The aim of this study was to evaluate the feasibility, yield, and diagnostic accuracy of a new EUS 22-G fine-needle biopsy (FNB) device in patients with solid pancreatic masses in a multicenter, prospective study.MethodsAll consecutive patients who underwent EUS-guided fine-needle biopsy (EUS-FNB) using a newly ...

Known for Pancreatic Masses |  Eus Needle |  Multicenter Prospective |  Histological Examination |  Neoplasms Pancreatitis
KOL Index score: 13685

PURPOSE: Epidermal growth factor receptor (EGFR) gene copy number obtained by fluorescence in situ hybridization (FISH) has been recently found to predict treatment outcome in non-small cell lung cancer (NSCLC) patients receiving EGFR tyrosine kinase inhibitors. However, it is still unknown whether EGFR status differs in metastases compared with primary NSCLC. In all studies FISH have been performed on histologic material. The possibility to perform FISH analysis on cytologic material ...

Known for Cell Lung |  Primary Tumor |  Gene Expression |  Metastatic Site |  Situ Hybridization
KOL Index score: 13494

BACKGROUND: Gastro-oesophageal reflux disease has a chronic course, and often requires long-term treatment. Proton pump inhibitors are the treatment of choice for both acute and maintenance treatment, but little is known from randomized controlled trials of their effects beyond 1 year.

AIM: To compare the efficacy and safety of two doses of rabeprazole with 20 mg omeprazole in the maintenance treatment of erosive gastro-oesophageal reflux disease over 5 years.

METHODS: Two hundred and ...

Known for 5 Years |  Reflux Disease |  Treatment Rabeprazole |  Efficacy Safety |  20 Omeprazole
KOL Index score: 13342

BACKGROUND: Human papillomavirus 16 infection has been proven to be associated with oropharyngeal squamous cell carcinomas (SCCs) and is probably the main reason of the reported increase in the incidence. The role of high-risk (HR) HPV for carcinogenesis of other sites in the head and neck awaits confirmation. With the aim to evaluate the prevalence of HPV infection and the reliability of different diagnostic tools in SCCs of different sites, 109 consecutive untreated head and neck SCCs ...

Known for Hpv Infection |  P16 Immunohistochemistry |  Squamous Cell |  Human Papillomavirus |  Female Head
KOL Index score: 13332

PURPOSE: Human papillomavirus (HPV) 16 infection is associated with oropharyngeal carcinogenesis and is likely the cause of the reported increase in disease incidence. We evaluated the prevalence of HPV infection and the reliability of different diagnostic tools using primary tumor samples from a cohort of 50 patients.

METHODS AND MATERIALS: Formalin-fixed paraffin-embedded (FFPE) tumor samples were collected from all 50 consecutive primary oropharyngeal SCC patients who were enrolled in ...

Known for Hpv Dna |  Human Papillomavirus |  Squamous Cell |  P16 Immunohistochemistry |  Ffpe Samples
KOL Index score: 13119

BACKGROUND: Pulmonary carcinoids (PCs) are rare tumors. As there is a paucity of randomized studies, this expert consensus document represents an initiative by the European Neuroendocrine Tumor Society to provide guidance on their management.

PATIENTS AND METHODS: Bibliographical searches were carried out in PubMed for the terms 'pulmonary neuroendocrine tumors', 'bronchial neuroendocrine tumors', 'bronchial carcinoid tumors', 'pulmonary carcinoid', 'pulmonary typical/atypical ...

Known for Pulmonary Carcinoid |  Neuroendocrine Tumor |  Metastatic Disease |  Expert Consensus |  Relevant Literature
KOL Index score: 13010

BACKGROUND: Somatostatin analogues are commonly used to treat symptoms associated with hormone hypersecretion in neuroendocrine tumors; however, data on their antitumor effects are limited.

METHODS: We conducted a randomized, double-blind, placebo-controlled, multinational study of the somatostatin analogue lanreotide in patients with advanced, well-differentiated or moderately differentiated, nonfunctioning, somatostatin receptor-positive neuroendocrine tumors of grade 1 or 2 (a tumor ...

Known for Patients Lanreotide |  Neuroendocrine Tumors |  Quality Life |  Neoplasms Peptides |  Metastatic Enteropancreatic
KOL Index score: 12143

BACKGROUND: Both the European Neuroendocrine Tumor Society (ENETS) and the International Union for Cancer Control/American Joint Cancer Committee/World Health Organization (UICC/AJCC/WHO) have proposed TNM staging systems for pancreatic neuroendocrine neoplasms. This study aims to identify the most accurate and useful TNM system for pancreatic neuroendocrine neoplasms.

METHODS: The study included 1072 patients who had undergone previous surgery for their cancer and for which at least 2 ...

Known for Tnm Staging |  Stage Iii |  Endocrine Pancreas |  Uicc Ajcc |  Cox Analysis
KOL Index score: 11869

BACKGROUND: EUS-guided FNA is an efficacious technique for sampling intraintestinal and extraintestinal mass lesions. However, cytology has limitations to its final yield and accuracy, which may be overcome if histological specimens are provided to the pathologist.

OBJECTIVE: To evaluate feasibility, yield, and diagnostic accuracy of a newly developed 19-gauge, fine-needle biopsy (FNB) device.

DESIGN: Multicenter, pooled, cohort study.

SETTING: Five medical centers.

PATIENTS: This study ...

Known for Eus Fnb |  Accuracy Diagnosis |  Histology Needle |  Histological Evaluation |  Sample Quality
KOL Index score: 11814

BACKGROUND: Histological typing of non-small cell lung cancer (NSCLC) has an increasing clinical relevance due to the emerging differences in medical treatment between squamous and nonsquamous tumors. However, most NSCLCs are diagnosed in an advanced stage, and the diagnosis is often obtained exclusively by cytology either exfoliative or following fine needle aspiration. We investigated the accuracy of fine needle aspiration cytology (FNAC) in NSCLC typing as compared with ...

Known for Cell Lung |  Fine Needle |  Aspiration Cytology |  Nsclc Cases |  Adenosquamous Carcinoma
KOL Index score: 11674

BACKGROUND: Preoperative determination of Ki-67 expression, an important prognostic factor for grading nonfunctioning pancreatic endocrine tumors (NF-PETs), remains an important clinical challenge.

OBJECTIVE: To prospectively evaluate the feasibility, yield, and clinical impact of EUS-guided fine-needle tissue acquisition (EUS-FNTA) with a large-gauge needle to obtain tissue samples for histologic diagnosis and Ki-67 analysis in patients with suspected NF-PETs.

DESIGN: Prospective cohort ...

Known for Pancreatic Neuroendocrine |  Guided Fine |  Needle Tissue |  Ki67 Determination |  G1 G2
KOL Index score: 11619

The hormone peptide YY is produced by endocrine cells in the pancreas, ileum and colon. We have previously shown that peptide YY is coexpressed in all four islet cell types in the murine pancreas when they first appear, suggesting a common peptide YY-producing progenitor. In the colon, peptide YY has been frequently identified in glucagon-expressing L-type endocrine cells. Characterization of colonic endocrine tumors in transgenic mice expressing simian virus 40 large T antigen under the ...

Known for Peptide Yy |  Transgenic Mice |  Endocrine Cell |  Animals Antigens Viral |  Embryonic Day
KOL Index score: 11230

The four cell types of gut epithelium, enteroendocrine cells, enterocytes, Paneth cells and goblet cells, arise from a common totipotent stem cell located in the mid portion of the intestinal gland. The secretin-producing (S) cell is one of at least ten cell types belonging to the diffuse neuroendocrine system of the gut. We have examined the developmental relationship between secretin cells and other enteroendocrine cell types by conditional ablation of secretin cells in transgenic mice ...

Known for Transgenic Mice |  Enteroendocrine Cell |  Small Intestine |  Secretin Cholecystokinin |  Intestinal Endocrine


Guido Rindi: Influence Statistics

Sample of concepts for which Guido Rindi is among the top experts in the world.
Concept World rank
imaging body insulinoma #1
patients highgrade progression #1
loh malignant pets #1
1151 months #1
neurog3crerosatdtom mice #1
metastases neoplasms #1
30 incubation deenergization #1
nf3b #1
chromogranin anionic proteins #1
involvement metastasis proteins #1
eusfnta diagnosis #1
multidirectional carcinoma #1
specific classifications schemes #1
foregut presence #1
conventional ssas #1
familial pdgfra #1
3hthiamin monophosphate #1
sstr5 ki67 #1
loh malignant carcinoids #1
differentiated carcinomas p0002 #1
carcinosarcoma metastatic #1
ileal enterochromaffin #1
cells secretin #1
thiamin intestinal #1
suvmax values sstrpet #1
sv40 transgenic #1
issues health organization #1
secretin serotoninergic neurons #1
sstrpet ihc #1
thiamine intestinal transport #1
transport 3htmp #1
condition inf nf3b #1
consecutive patients sels #1
men1 men1− #1
notch cell fate #1
87 ldr #1
adenoma pdec #1
macroscopical description #1
secretin gene development #1
pericolic lymph node #1
chromogranin endocrine markers #1
lev tpkase #1
ghrelin gastroprotection pge2 #1
pure nens #1
microallelotyping analysis #1
normal mice e14 #1
90 ldr #1
nodule lower lobe #1
ncam cdx2 #1
men1 men1− patients #1

Key People For Neuroendocrine Tumors

Top KOLs in the world
Kjell E Öberg
neuroendocrine tumors carcinoid syndrome telotristat ethyl
James C Yao
neuroendocrine tumors gastric cancer carcinoid syndrome
Martyn Evan Caplin
neuroendocrine tumors telotristat ethyl carcinoid syndrome
Wouter W de Herder
neuroendocrine tumors somatostatin analogs carcinoid syndrome
Guido Rindi
neuroendocrine tumors endocrine cells transgenic mice
Philippe B Ruszniewski
neuroendocrine tumors chronic pancreatitis liver metastases

Guido Rindi:Expert Impact

Concepts for whichGuido Rindihas direct influence:Neuroendocrine tumors,  Neuroendocrine neoplasms,  Endocrine cells,  Transgenic mice,  Endocrine tumors,  Endocrine tumours,  5 years,  Adenomatous polyposis.

Guido Rindi:KOL impact

Concepts related to the work of other authors for whichfor which Guido Rindi has influence:Neuroendocrine tumors,  Gastrointestinal tract,  Endocrine cells,  Liver metastases,  Lung cancer,  Pancreatic neoplasms,  Endoscopic ultrasound.



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Section of Anatomic Pathology, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 00100, Rome, Italy | Department of Life Sciences, Section of Anatomic Pathology, Università Cattolica del Sacro Cuore, Rome, Italy | E

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