Yukisato Kitamura

Yukisato Kitamura

Division Of Molecular Pathology, Department Of Microbiology And Pathology, Tottori University, Departments Of

Direct Impact

Concepts for which Yukisato Kitamura has direct influence:

endocrine cells
cd1a expression
situ hybridization
simian virus
hepatocellular carcinoma
proliferative activity
fusion genes

External impact

Concepts related to the work of other authors for which Yukisato Kitamura has influence:

protein expression
molecular diagnosis
duchenne muscular dystrophy
central nervous
growth factor
breast carcinomas
liver cirrhosis

Prominent publications by Yukisato Kitamura

KOL-Index: 36 Background: Recent rapid advances in molecular biology have led the discovery of disease-specific novel fusion genes in a variety of soft tissue tumors. In this study, we attempted to detect these fusion genes using formalin-fixed paraffin-embedded (FFPE) tumor tissues and investigated their clinical utility and factors that affect the results of examination. Methods: Reverse transcription ...
Known for
Histological Soft | Detect Fusion | Diagnostic Rates | Embedded Ffpe
KOL-Index: 23 We have earlier shown that dystroglycan (DG) is a lamininbinding protein and as such is a cell adhesion molecule. DG is a heterodimer of alpha and beta DG subunits. beta-dystroglycan (betaDG) is the membrane spanning subunit, whereas the alpha subunit is bound to the extracellular domain of betaDG. To study physiological function of the protein, we expressed full-length DG (FL-DG) and the ...
Known for
Serum-Deprived Quiescent Cells | Dystroglycan Dg | Physiological Function | Heterodimer
KOL-Index: 22 A practical mouse astrocyte cell line (A640-IG) was established by transformation with a temperature-sensitive mutant of simian virus 40 (SV40) and the relationship between the function of SV40 large T antigen and the growth and differentiation of A640-IG cells, which are most clearly dependent on temperature that ever established, was reported. A640-IG cells proliferated actively with ...
Known for
Growth Differentiation | Unique Practical Astrocyte | Fibroblast-Like Appearance | 39 Degrees
KOL-Index: 22 Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer that mostly occurs in the elderly. Merkel cell polyomavirus (MCPyV) is detected in approximately 80% of MCCs and is associated with carcinogenesis. Hedgehog signaling pathway plays a role in human embryogenesis and organogenesis. In addition, reactivation of this pathway later in life can cause tumors. ...
Known for
Mutation Gli1 | Mccs Mcpyv | Merkel Polyomavirus | Japanese Ethnicity
KOL-Index: 21 Abstract The endocrine cells in intraductal papillary-mucinous neoplasms (IPN) of the pancreas have rarely been investigated. In the normal pancreatic ducts of normal pancreases (n=5) there were a few endocrine cells: argyrophil in 5 (100%), chromogranin A in (100%), pancreatic polypeptide (PP) in 3 (60%), and insulin in 7 (20%). These endocrine cells were scattered, and located in the basal ...
Known for
Normal Pancreatic Ducts | Cells Ipn | Pancreas Endocrine | Basal Portions
KOL-Index: 20 Immunolocalization of E-cadherin (E-cad), alpha-catenin, beta-catenin, and CD44 has rarely been investigated in human cholangiocarcinoma (CC). We, therefore, immunohistochemically examined the expression of E-cad, alpha-catenin, beta-catenin, CD44 standard (CD44s), and CD44 variants (CD44v) including CD44v5, CD44v6, CD44v7-8, and CD44v10 in normal adult livers and in 47 cases of CC; and the ...
Known for
Cd44v5 Cd44s | Expression Cad | C-Erbb2 Down-Regulation | Catenin Regulation
KOL-Index: 20 AIMS: The c-erbB-2 proto-oncogene encodes a transmembrane protein which is highly homologous to epidermal growth factor receptor. Overexpression of this c-erbB-2 protein has been reported in many human carcinomas, including breast carcinoma. However, there have been few studies of the expression of c-erbB-2 in cholangiocarcinoma and hepatolithiasis, a condition occasionally associated with ...
Known for
Livers Expression | Protein Cholangiocarcinoma | Biliary Proliferation | Membranous Pattern
KOL-Index: 18 BACKGROUND: Merkel cell carcinomas (MCCs), clinically aggressive neuroendocrine skin cancers, are divided into Merkel cell polyomavirus (MCPyV)-positive and -negative tumors, which show different clinicopathological features and may develop through different mechanisms of carcinogenesis. Aberrant expression of activation-induced cytidine deaminase (AID) as a genomic modulator was ...
Known for
Merkel Carcinomas | Expression Higher | Pax5 | Phospho S536
KOL-Index: 18 It has recently been shown that approximately 80% of Merkel cell carcinomas harbor a novel polyomavirus named Merkel cell polyomavirus (MCPyV). MCPyV has been detected in human tissue samples. However, detailed distribution of MCPyV in non-neoplastic Japanese human tissues remains unclear. To address this, we used single or real-time quantitative polymerase chain reaction (PCR) for 41 ...
Known for
Tissues Japanese | Mcpyv-Related | Non-Neoplastic | Valuable Insights
KOL-Index: 16 Transforming growth factor (TGF)-beta 1 is an important cytokine involved in the pathobiology of tissue fibrosis through its stimulation of the production of, and inhibition of the degradation of, extracellular matrix proteins. We examined the clinical usefulness of plasma TGF-beta 1 concentration as a marker of fibrogenesis in patients with chronic viral hepatitis. Thirty-five patients, 11 ...
Known for
Marker Fibrogenesis | Concentrations Chronic | Hepatitis Mild | Fibrosis Plasma

Division of Molecular Pathology, Department of Microbiology and Pathology, Tottori University, Departments of

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