William F Simonds: Influence Statistics

William F Simonds

William F Simonds

National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD | National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, ...

William F Simonds: Expert Impact

Concepts for which William F Simonds has direct influence: Multiple endocrine , Nuclear localization , Parathyroid cancer , Beta gamma , Adenylyl cyclase , Primary hyperparathyroidism , Lipid rafts .

William F Simonds: KOL impact

Concepts related to the work of other authors for which for which William F Simonds has influence: Protein kinase , Primary hyperparathyroidism , Parathyroid carcinoma , Multiple endocrine , Adenylyl cyclase , Muscarinic receptor , Signal transduction .

KOL Resume for William F Simonds

Year
2022

National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD

2021

Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

2020

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Disease (NIDDK)

2019

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA

2018

Metabolic Disease Branch, National Institutes of Digestive Disease and Kidney, National Institutes of Health, Bethesda, MD.

2017

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. Dr. Loshakov is now with the The Commonwealth Medical College, Scranton, PA, USA and Dr. Sholevar is now with the Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

The National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892

2016

National Institutes of HealthBethesda, Maryland, USA

2015

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD

2014

Metabolic Diseases Branch, National Institute of Digestive and Diabetes and Kidney Diseases, National Institutes of Health, Bethesda, MD

2012

Metabolic Diseases Branch (L.S.W., W.F.S., S.J.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892

2011

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA

2010

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 10 Room 8C-101, 10 Center Dr. MSC 1752 Bethesda, MD 20892-1752, USA

2009

Metabolic Diseases Branch, NIDDK, Bethesda, MD

2008

National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

2007

Metabolic Diseases Branch, 10/8C-101, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA

2006

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA

2005

Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, 20892, Bethesda, MD, USA

Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1802

2004

Metabolic Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 20892, Bethesda, MD, USA

2003

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892-1752, USA.

2002

From Metabolic Diseases Branch (WFS, LAJ-N, SKA, MCS, SJM), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, and Departments of Medicine, Physiology and Human Genetics (BY, GNH), McGill University, and Calcium Research Laboratory, Royal Victoria Hospital, Montreal, Quebec, Canada.

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA

2001

Metabolic Diseases Branch, NIDDK, Bethesda, Maryland 20892-1752

National Research Laboratory for the Study of Ginseng Signal Transduction and Department of Physiology, College of Veterinary Medicine, Chonnam National University, Kwangju 500-757 Korea

Bethesda, Md, New York, NY, San Francisco, Calif, and Philadelphia, Pa

2000

Metabolic Diseases Branch, Bldg. 10, Room 8C-101, 10 Center Dr., MSC 1752, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA

1999

Metabolic Diseases Branch/NIDDK National Institutes of Health Bldg 10/ Room 8C-101, 10 CENTER DR. MSC 1752, Bethesda, MD 20892-1752, USA.

1998

Department of Physiological Chemistry II, University of Düsseldorf, Düsseldorf, D‐40225, Germany

1997

MDB/NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1752

1996

Metabolic Diseases Branch, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, 20892, Bethesda, Maryland

1995

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA

1994

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 20892, Bethesda, Maryland, USA

1993

Molecular Pathophysiology Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, Bethesda, MD 20892.

1992

Molecular Pathophysiology Section, Metabolic Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 USA

1991

Molecular Pathophysiology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, USA

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

1990

Molecular Pathophysiology Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, 20892, Bethesda, Md., USA

Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892.

1989

Molecular Pathophysiology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.

1988

Molecular Pathophysiology Section, Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, Maryland 20892

1985

Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, MD 20205, U.S.A

1984

Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20205, USA

1982

Laboratory of General and Comparative Biochemistry, NIMH, National Institutes of Health, Bethesda, MD 20205, USA

Prominent publications by William F Simonds

KOL-Index: 14166 . While positive regulation of c-Akt (also known as protein kinase B) by receptor tyrosine kinases is well documented, compounds acting through G protein-coupled receptors can also activate Akt and its downstream targets. We therefore explored the role of G protein subunits in the regulation of Akt in cultured mammalian cells. In HEK-293 and COS-7 cells transiently transfected with ...
Known for Protein Kinase | Activation Akt | Muscarinic Receptors | Gtp Binding
KOL-Index: 12779 . The role that Gbeta(5) regulator of G protein signaling (RGS) complexes play in signal transduction in brain remains unknown. The subcellular localization of Gbeta(5) and RGS7 was examined in rat PC12 pheochromocytoma cells and mouse brain. Both nuclear and cytosolic localization of Gbeta(5) and RGS7 was evident in PC12 cells by immunocytochemical staining. Subcellular fractionation of ...
Known for Nuclear Localization | Protein Β5 | Gbeta5 Rgs7 | Pc12 Cells
KOL-Index: 12295 . NHE3 activity is regulated by phosphorylation/dephosphorylation processes and membrane recycling in intact cells. However, the Na(+)/H(+) exchanger (NHE) can also be regulated by G proteins independent of cytoplasmic second messengers, but the G protein subunits involved in this regulation are not known. Therefore, we studied G protein subunit regulation of NHE3 activity in renal ...
Known for Nhe3 Activity | Protein Subunits | Gtp Binding | Inbred Wky Receptors
KOL-Index: 12254 . Familial hyperparathyroid syndromes involving mutations of HRPT2 (also CDC73), a tumor suppressor, are important to identify because the relatively high incidence of parathyroid malignancy associated with such mutations warrants a specific surveillance strategy. However, there is a dearth of reports describing experience with surveillance and early detection informed by genetic insight ...
Known for Hrpt2 Mutation | Atypical Adenoma | Primary Hyperparathyroidism | Familial Isolated
KOL-Index: 11746 . Genetic evidence suggests that the yeast STE4 and STE18 genes encode G beta and G gamma subunits, respectively, that the G betagamma complex plays a positive role in the pheromone response pathway, and that its activity is subject to negative regulation by the G alpha subunit (product of the GPA1 gene) and to positive regulation by cell-surface pheromone receptors. However, as yet there is ...
Known for Plasma Membrane | Pheromone Response | Binding Protein | Ste4p Ste18p
KOL-Index: 11716 . Stimulation of a variety of cell surface receptors enhances the enzymatic activity of mitogen-activated protein kinases (MAPKs). MAPKs have been classified in three subfamilies: extracellular signal-regulated kinases (ERKs), stress-activated protein kinases or c-Jun NH2-terminal kinases (SAPKs/JNKs), and p38 kinase. Whereas the pathway linking cell surface receptors to ERKs has been ...
Known for Coupled Receptors | Jnk Stimulation | Heterotrimeric Proteins | Jun Kinase
KOL-Index: 10945 . CONTEXT: One variant of multiple endocrine neoplasia type 1 (MEN1) is defined by sporadic tumors of both the parathyroids and pituitary. The prevalence of identified MEN1 mutations in this variant is lower than in familial MEN1 (7% vs. 90%), suggesting different causes. Recently, one case of this variant had a germline mutation of p27(Kip1)/CDKN1B. OBJECTIVE: The objective was to test p27 ...
Known for Multiple Endocrine | Neoplasia Type | Germline Mutation | P27 Gene
KOL-Index: 10441 . BACKGROUND: Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins), composed of G alpha, G beta, and G gamma subunits, are positioned at the inner face of the plasma membrane and relay signals from activated G protein-coupled cell surface receptors to various signaling pathways. G beta 5 is the most structurally divergent G beta isoform and forms tight heterodimers with ...
Known for Lipid Rafts | Binding Protein | R7 Rgs | Neurons Brain
KOL-Index: 10283 . Abstract MITOGEN-ACTIVATED protein kinases, MAP kinases or ERKs (extracellular signal-regulated kinases) are rapidly stimulated by growth-promoting factors acting on a variety of cell-surface receptors1,2. In turn, ERKs phosphorylate and regulate key intra-cellular enzymes and transcription factors involved in the control of cellular proliferation3,4. The tyrosine-kinase class of ...
Known for Map Kinase Pathway | Erk Activation | Protein Βγ | Muscarinic Receptors
KOL-Index: 10015 . The expression and assembly of particular combinations of beta and gamma subunit isoforms into beta gamma heterodimers may contribute to the specificity of signal transduction mediated by heterotrimeric guanine nucleotide binding regulatory proteins. Using a transient transfection paradigm to examine selectivity in beta gamma heterodimer formation, we find that gamma 1 interacts with beta ...
Known for Beta Gamma | Multiple Domains | Signal Transduction | Heterotrimeric Guanine
KOL-Index: 9869 . We report here the identification of a gene associated with the hyperparathyroidism–jaw tumor (HPT–JT) syndrome. A single locus associated with HPT–JT (HRPT2) was previously mapped to chromosomal region 1q25–q32. We refined this region to a critical interval of 12 cM by genotyping in 26 affected kindreds. Using a positional candidate approach, we identified thirteen different heterozygous, ...
Known for Jaw Tumor | Encoding Parafibromin | Suppressor Proteins | Gene Hyperparathyroidism
KOL-Index: 9783 . While multiple G protein beta and gamma subunit isoforms have been identified, the implications of this potential diversity of betagamma heterodimers for signaling through betagamma-regulated effector pathways remains unclear. Furthermore the molecular mechanism(s) by which the betagamma complex modulates diverse mammalian effector molecules is unknown. Effector signaling by the ...
Known for Effector Pathways | Cos Cells | Beta5 Gamma2 | Gtp Binding
KOL-Index: 9712 . Parafibromin is the 531-amino-acid protein product encoded by HRPT2, a putative tumor suppressor gene recently implicated in the autosomal dominant hyperparathyroidism–jaw tumor familial cancer syndrome, sporadic parathyroid cancer, and a minority of families with isolated hyperparathyroidism. Parafibromin contains no identified functional domains but bears sequence homology to Cdc73p, a ...
Known for Cyclin D1 | Expression Parafibromin | Jaw Tumor | Parathyroid Cancer
KOL-Index: 9657 . We transfected COS cells with cDNAs for the alpha subunits of stimulatory and inhibitory GTP-binding proteins, alpha s and alpha i1, respectively, and immunoprecipitated the metabolically labeled products with specific peptide antibodies. Cells were separated into particulate and soluble fractions before immunoprecipitation; [35S]methionine-labeled alpha s and alpha i were both found ...
Known for Membrane Attachment | Protein Alpha | Cos Cells | Particulate Fraction

Key People For Multiple Endocrine

Top KOLs in the world
#1
Stephen J Marx∘∘
multiple endocrine men1 gene primary hyperparathyroidism
#2
Samuel A Wells
multiple endocrine parathyroid glands carcinoembryonic antigen
#3
Rajesh V Thakker
multiple endocrine neoplasia type mutational analysis
#4
Britt M Skogseid
multiple endocrine men1 gene neoplasia type
#5
Maria Luisa Brandi
multiple endocrine estrogen receptor postmenopausal women
#6
Bruce Anthony John Ponder
breast cancer multiple endocrine neoplasia type

National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD | National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA;, bills@niddk.nih.gov | Metabolic Diseases Branch, Metabolic Diseases Bran