Jörg Wilting

Jörg Wilting

Department Of Anatomy And Cell Biology, University Medical Centre Of The Georg-August University Of Göttingen, Göttingen, Germany

Direct Impact

Concepts for which Jörg Wilting has direct influence:

endothelial cells
lymphatic vessels
chick embryos
chorioallantoic membrane
vertebral column
lung surface
burkitt lymphoma

External impact

Concepts related to the work of other authors for which Jörg Wilting has influence:

iron metabolism
major site
plasma transferrin
peptide hepcidin
normal circumstances
pathological situations
endothelial cells

Prominent publications by Jörg Wilting

KOL-Index: 270 AIM: To studied iron metabolism in liver, spleen, and serum after acute liver-damage, in relation to surrogate markers for liver-damage and repair. METHODS: Rats received intraperitoneal injection of the hepatotoxin thioacetamide (TAA), and were sacrificed regularly between 1 and 96 h thereafter. Serum levels of transaminases and iron were measured using conventional laboratory assays. Liver ...
Known for
Spleen Iron Concentrations | Taa | Fth Liver | Tissue Increased
KOL-Index: 57 Lymphedema (LE) affects millions of people worldwide. It is a chronic progressive disease with massive development of fibrosclerosis when untreated. There is no pharmacological treatment of lymphedema. The disease is associated with swelling of the interstitium of the affected organ, mostly arm or leg, impressive development of adipose tissue, fibrosis and sclerosis with accumulation of huge ...
KOL-Index: 49 After the intracranial venous-drainage route is switched from the vena capitis prima (VCP) to the transverse sinus, the cavernous sinus is considered to develop from a connecting part of the VCP with the ophthalmic vein (OPV). Observations of histological sections from 12 embryos and 47 fetuses (6-35 weeks) demonstrated that (1) at six weeks, a major tributary of the VCP ran inferiorly in ...
Known for
Histological Sections | Intracranial Venous-Drainage Route | 47 Fetuses | 12 Embryos
KOL-Index: 40 Although both alcohol and fructose are particularly steatogenic, their long-term effect in the development of a metabolic syndrome has not been studied in vivo. Consumption of fructose generally leads to obesity, whereas ethanol can induce liver damage in the absence of overweight. Here, Sprague-Dawley rats were fed ad libitum for 28 days on five diets: chow (control), liquid Lieber-DeCarli ...
Known for
Ldc Diet | Blood Liver | Ethanol Fructose
KOL-Index: 38 Classical Hodgkin lymphoma (cHL) has a typical clinical manifestation, with dissemination involving functionally neighboring lymph nodes. The factors involved in the spread of lymphoma cells are poorly understood. Here we show that cHL cell lines migrate with higher rates compared with non-Hodgkin lymphoma cell lines. cHL cell migration, invasion and adhesion depend on autocrine WNT ...
Known for
Wnt5a-Mediated Rhoa Activation | Functionally Neighboring Lymph Nodes | Porcupine Wnt5a | Primary Hl Cells

Vascular Embryology

KOL-Index: 35 In developed countries vascular diseases are the leading cause of mortality. With an incidence of up to 5 %, maldevelopment of vessels (mainly hemangiomas, but also lymphangiomas and vascular malformations) is the number one developmental failure observed in newborns and even more often in premature infants. In recent decades, our knowledge of the molecular genetic and epigenetic control of ...
Known for
Angiogenesis Lymphangiogenesis | Molecular Endothelial | Mural Cells
KOL-Index: 27 Purpose: Many reports have described anomalous connections of the superior rectus (SR) with other extraocular rectus muscles, in which additional heads of the other three rectus muscles likely provided the connections. We examined how these connections are established during fetal development. Methods: We analyzed paraffin-embedded horizontal sections from 25 late-stage fetuses. Horizontal ...
Known for
Published Diagram | Mediolateral Relationships | Orbital Apex | Muscle Origins
KOL-Index: 26 Amplification of the MYCN oncogene contributes to the malignant progression of human neuroblastomas, but the mechanisms have remained unclear. We have previously demonstrated that N-Myc facilitates angiogenesis by downregulating an angiogenesis inhibitor identified as the inhibin βA homodimer activin A. Here, we have sought to define the molecular, biological and clinical consequences of ...
Known for
Undifferentiated Neuroblastomas | N-Myc | Expression Suppresses Proliferation | Beneficial Role
KOL-Index: 26 Neuroblastoma (NB) is a tumor of the sympathoadrenal system arising in children under 15 years of age. In Germany, NB accounts for 7% of childhood cancer cases, but 11% of cancer deaths. It originates from highly migratory progenitor cells that leave the dorsal neural tube and contribute neurons and glial cells to sympathetic ganglia, and chromaffin and supportive cells to the adrenal ...
Known for
KOL-Index: 26 The mechanisms of radiation-induced liver damage are poorly understood. We investigated if tumour necrosis factor (TNF)-α acts synergistically with irradiation, and how its activity is influenced by platelet endothelial cell adhesion molecule-1 (PECAM-1). We studied murine models of selective single-dose (25 Gy) liver irradiation with and without TNF-α application (2 μg/mouse; i.p.). In ...
Known for
| Hepatic Damage Marker Aspartate | Pecam-1-Knock-Out-Mice | Sham-Irradiated

Department of Anatomy and Cell Biology, University Medical Centre of the Georg-August University of Göttingen, Göttingen, Germany

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