• Disease
  • Knee
  • Knee Arthroplasty
  • Henrik Kehlet

    Prominent publications by Henrik Kehlet

    KOL Index score: 16658

    BACKGROUND: Quantitative reviews of postoperative pain management have demonstrated that the number of patients needed to treat for one patient to achieve at least 50% pain relief (NNT) is 2.7 for ibuprofen (400 mg) and 4.6 for paracetamol (1000 mg), both compared with placebo. However, direct comparisons between paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) have not been extensively reviewed. The aims of this review are (i) to compare the analgesic and adverse effects ...

    Also Ranks for: Paracetamol Nsaids |  postoperative pain management |  analgesic effects |  cochrane library |  direct comparisons
    KOL Index score: 15223

    BACKGROUND: Elderly patients are at risk of increased length of hospital stay (LOS), postoperative complications, readmission, and discharge to destinations other than home after elective total hip arthroplasty (THA) and total knee arthroplasty (TKA). Recent studies have found that enhanced recovery protocols or fast-track surgery can be safe for elderly patients undergoing these procedures and may result in reduced LOS. However, detailed studies on preoperative comorbidity and ...

    Also Ranks for: Postoperative Morbidity |  knee arthroplasty |  discharge destination |  track hip |  tka patients
    KOL Index score: 14733

    Background and purpose - Body mass index (BMI) outside the normal range possibly affects the perioperative morbidity and mortality following total hip arthroplasty (THA) and total knee arthroplasty (TKA) in traditional care programs. We determined perioperative morbidity and mortality in such patients who were operated with the fast-track methodology and compared the levels with those in patients with normal BMI. Patients and methods - This was a prospective observational study involving ...

    Also Ranks for: Tka Bmi |  hip arthroplasty |  replacement length |  obese patients |  knee body
    KOL Index score: 14654

    BackgroundRepair for a small (≤2 cm) umbilical and epigastric hernia is a minor surgical procedure. The most common surgical repair techniques are a sutured repair or a repair with mesh reinforcement. However, the optimal repair technique with regard to risk of reoperation for recurrence is not well documented. The aim of the present study was in a nationwide setup to investigate the reoperation rate for recurrence after small open umbilical and epigastric hernia repairs using either ...

    Also Ranks for: Epigastric Hernias |  small umbilical |  reoperation rate |  sutured repair |  mesh reinforcement
    KOL Index score: 14382

    The aim of the study was to examine the presence of hyperalgesia to heat stimuli within the zone of secondary hyperalgesia to punctate mechanical stimuli. A burn was produced on the medial part of the non-dominant crus in 15 healthy volunteers with a 50 x 25 mm thermode (47 degrees C, 7 min), and assessments were made 70 min and 40 min before, and 0, 1, and 2 h after the burn injury. Hyperalgesia to mechanical and heat stimuli were examined by von Frey hairs and contact thermodes (3.75 ...

    Also Ranks for: Secondary Hyperalgesia |  heat stimuli |  burn injury |  pain response |  15 healthy volunteers
    KOL Index score: 14089

    In recent years, there has been an increasing interest in local infiltration analgesia (LIA) as a technique to control postoperative pain. We conducted a systematic review of randomized clinical trials investigating LIA for total knee arthroplasty (TKA) and total hip arthroplasty (THA) to evaluate the analgesic efficacy of LIA for early postoperative pain treatment. In addition, the analgesic efficacy of wound catheters and implications for length of hospital stay (LOS) were evaluated. ...

    Also Ranks for: Analgesic Efficacy |  local infiltration analgesia |  replacement hip arthroplasty |  tha tka |  knee humans
    KOL Index score: 13819

    BACKGROUND: Preoperative anemia has been associated with increased risk of allogeneic blood transfusion and postoperative morbidity and mortality. The prevalence of preoperative anemia and its association with postoperative outcomes has not previously been reported in relation to fast-track elective total hip arthroplasty (THA) and total knee arthroplasty (TKA). We aimed to evaluate the prevalence of preoperative anemia in elective fast-track THA and TKA and its association with risk of ...

    Also Ranks for: Preoperative Anemia |  knee arthroplasty |  risk transfusion |  postoperative morbidity |  total hip
    KOL Index score: 13752

    BackgroundThis prospective study aimed to evaluate the impact of transabdominal preperitoneal patch plasty (TAPP) with implantation of a lightweight mesh (<50 g/m²) fixed by fibrin glue on the occurrence of chronic pain and sexual dysfunction in hernia patients.MethodsPatients were examined before TAPP, early and late postoperatively. The primary end point of the study was pain-related functional impairment 6 months after the operation as assessed by the validated assessment scale (AAS). ...

    Also Ranks for: Chronic Pain |  lightweight mesh |  hernia repair |  sexual dysfunction |  inguinal humans
    KOL Index score: 13735

    CONTEXT: Persistent pain and sensory disturbances following surgical treatment for breast cancer is a significant clinical problem. The pathogenic mechanisms are complex and may be related to patient characteristics, surgical technique, and adjuvant therapy.

    OBJECTIVE: To examine prevalence of and factors associated with persistent pain after surgical treatment for breast cancer.

    DESIGN, SETTING, AND PATIENTS: A nationwide cross-sectional questionnaire study of 3754 women aged 18 to 70 ...

    Also Ranks for: Persistent Pain |  cancer surgery |  sensory disturbances |  prevalence factors |  surgical treatment
    KOL Index score: 13673

    Objective: With the increasing societal awareness of the prevalence and impact of acute pain, there is a need to develop an acute pain classification system that both reflects contemporary mechanistic insights and helps guide future research and treatment. Existing classifications of acute pain conditions are limiting, with a predominant focus on the sensory experience (e.g., pain intensity) and pharmacologic consumption. Consequently, there is a need to more broadly characterize and ...

    Also Ranks for: Acute Pain |  common features |  aps aapm |  modulating factors |  1 core criteria
    KOL Index score: 13558

    Pain is the dominant complaint after laparoscopic cholecystectomy. No study has examined the combined effects of a somato-visceral blockade during laparoscopic cholecystectomy. Therefore, we investigated the effects of a somato-visceral local anesthetic blockade on pain and nausea in patients undergoing elective laparoscopic cholecystectomy. In addition, all patients received multi-modal prophylactic analgesic treatment. Fifty-eight patients were randomized to receive a total of 286 mg ...

    Also Ranks for: Patients Laparoscopic Cholecystectomy |  local anesthetics |  pain nausea |  opioid anesthesia |  postoperative week
    KOL Index score: 13503

    IntroductionWith the implementation of fast-track surgery with optimization of both logistical and clinical features, the postoperative convalescence has been reduced as functional milestones have been achieved earlier and consequently length of stay (LOS) in hospital has been reduced. However, it has been speculated that a decrease in LOS may be associated with an increase in readmissions in general, including risk of dislocation after total hip arthroplasty (THA) or manipulation after ...

    Also Ranks for: Tha Tka |  knee arthroplasty |  track hip |  stay replacement |  increase readmissions
    KOL Index score: 13404

    OBJECTIVE: With the increasing societal awareness of the prevalence and impact of acute pain, there is a need to develop an acute pain classification system that both reflects contemporary mechanistic insights and helps guide future research and treatment. Existing classifications of acute pain conditions are limiting, with a predominant focus on the sensory experience (eg, pain intensity) and pharmacologic consumption. Consequently, there is a need to more broadly characterize and ...

    Also Ranks for: Acute Pain |  common features |  aps aapm |  modulating factors |  multidimensional approach
    KOL Index score: 13393

    BACKGROUND: Total knee arthroplasty (TKA) is associated with severe pain and inflammation despite an extensive multimodal analgesic approach, but the effect of high-dose glucocorticoid administration has not been studied.

    METHODS: Forty-eight patients undergoing unilateral TKA were included in a randomized, double-blind, placebo-controlled trial receiving preoperative methylprednisolone (MP) 125 mg i.v. or saline. All surgery was performed under lumbar spinal anaesthesia and patients ...

    Also Ranks for: Preoperative Methylprednisolone |  total knee arthroplasty |  opioid anesthesia |  24 surgery |  controlled trial


    Henrik Kehlet: Influence Statistics

    Sample of concepts for which Henrik Kehlet is among the top experts in the world.
    Concept World rank
    additional improvements physiotherapy #1
    preoperative dexamethasone 8 #1
    intraoperative nerve damage #1
    population norm hhs #1
    fasttrack protocol #1
    reduced pain fatigue #1
    modelflow sv svo2 #1
    hysterectomy chronic pain #1
    stay perioperative recovery #1
    preoperative methylprednisolone mp #1
    prospective studies replacement #1
    postoperative recovery mastectomy #1
    effects epidural analgesia #1
    knee humans pain #1
    study analgesic effects #1
    morphine mgml1 #1
    gch1 clinical factors #1
    fasttrack methodology #1
    pain lung #1
    severe persistent pain #1
    referral centers survival #1
    departments performed #1
    ongoing prophylaxis #1
    surgery saline administration #1
    conventional fasttrack #1
    cortisone plasma cortisol #1
    ambulatory hip #1
    pain preoperative #1
    ppbct alnd #1
    gch1 genes #1
    p004 pelvic pain #1
    prospective nationwide analysis #1
    postoperative anticoagulants risk #1
    inhibitory neural reflexes #1
    readmissions postoperative day #1
    common perioperative problem #1
    48h gastrointestinal recovery #1
    vomiting postanaesthesia unit #1
    3 postoperative patients #1
    oral carbohydrate beverage #1
    diagnostic process nact #1
    identical burn injuries #1
    thigh edema #1
    tha day #1
    matched tka tka #1
    digital drainage device #1
    mep trial outcome #1
    evaluated ketamine pregabalin #1
    injury infiltration #1
    ldgroup #1

    Key People For Knee Arthroplasty

    Top KOLs in the world
    John N Insall
    total knee arthroplasty knee prosthesis epidural anesthesia
    Michael Albert Mont
    total knee arthroplasty femoral head united states
    Parvizi Parvizi
    periprosthetic joint infection hip arthroplasty total knee
    Merrill A Ritter
    total knee arthroplasty ultraviolet lighting lateral release
    Steven M Kurtz
    united states knee arthroplasty medicare population
    Edmund C Lau
    united states knee arthroplasty medicare population

    Henrik Kehlet:Expert Impact

    Concepts for whichHenrik Kehlethas direct influence:Knee arthroplasty,  Chronic pain,  Epidural analgesia,  Postoperative pain,  Hip arthroplasty,  Persistent pain,  Hip fracture,  Hip arthroplasty replacement.

    Henrik Kehlet:KOL impact

    Concepts related to the work of other authors for whichfor which Henrik Kehlet has influence:Postoperative pain,  Enhanced recovery,  Epidural analgesia,  General anesthesia,  Hip fracture,  Colorectal surgery,  Total knee arthroplasty.



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    Surgical Pathophysiology Unit, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark | Section of Surgical Pathophysiology 7621, Rigshospitalet, Copenhagen | Section of Surgical Pathophysiology, Copenhagen University Hospital, Rigshospi