A double-blind study of the anticonvulsant and psychotropic properties of carbamazepine (Tegretol®) was undertaken in 37 hospitalized patients with intractable psychomotor epilepsy. Patients were first stabilized on diphenylhydantoin and phenobarbital, 10 to 15/xg/ml in serum, and then received for two 3-week periods identical capsules containing either carbamazepine first, then placebo, or vice versa. Telemetric EEGs were recorded during each period and routine EEGs weekly; routine ...

Electro-clinical correlations during Metrazolor Megimide-induced grand mal seizures were studied in a series of fifty-seven cats. It was found that conventional EEG tracings suggest that earliest and maximal seiaure activity occurs in the cerebral cortex or thalamus, but photographs of the animals' behavior failed to show consistent relationships between any aspect of the conventional EEG and the onset of the behavioral convulsion. When the conventional EEG was eliminated by filters ...

Photic evoked responses were studied by means of the computer of average transients during induced seizures in 10 epileptic patients and a series of 18 cats. Five patients had grand mal seizures, three “petit mal status”, one a symmetrical tonic seizure of both arms associated with unresponsiveness and one classical petit mal seizures. The visual evoked potential was clearly present in all patients during the non-grand mal seizures. It was suggestively present in three patients during ...

In an attempt to delineate the relative contribution of surface versus deep components in the EEG of patients with 3 per second generalized spike-wave discharges and clinical petit mal seizures, a mathematical method was devised which allows the splitting of the EEG into two major subsystems. It is based on the observation that broad electrical fields tend to represent activity at deeper structures while discrete narrow fields centered at one electrode position tend to be of more ...

Photic evoked responses were obtained in twenty normal male and twenty normal female subjects. It was demonstrated that females tend to have larger amplitude evoked responses than males. Intercorrelations of aspects of the evoked response curve with results of the frequency analysis of the EEG background showed highly significant correlations between amplitude of the photic response and energy amount of the EEG. Individuals with large amplitude evoked response curves showed a greater ...

An interdisciplinary research project was initiated for systematic, long-term study of employability prognosis of persons with epilepsy. Neurological, psychological, and occupational status variables were investigated in three groups of epileptics: Employed adults, Unemployed adults, and a Prevocational Group of young persons primarily in the 11th and 12th grades. Preliminary results reported showed significant differences between Unemployed and Employed adult epileptics on a substantial ...

The results of a study to elicit factors which are associated with an epileptic patient's gaining and keeping employment are presented. Eighty-seven employed patients were compared with 90 unemployed patients on a wide variety of variables. It was found that the employed patients had higher intelligence, less impairment on neuro-psychological tests, less neurological and electroencephalographic abnormalities, and their work history was considerably better than that of the unemployed ...

The effects of the reference electrode on field changes during generalized spike-wave complexes were studied. Linked ears reference, common average reference and source derivation were compared. Source derivation proved superior to the common average reference because it was not influenced by the 'dipole' effect when large transients are distributed over all the electrodes. Source derivation retained the midfrontal field maximum as previously reported but also showed more frequent ...

Intramuscular administration of penicillin G was carried out in a series of 27 chronic cat preparations. In addition to the EEG, the high frequency components of cerebral electrical activity were also recorded from cortical and deep structures. Videotape recordings using split-screen technique allowed correlations of the animal's clinical state with the EEG. The results showed that 'spike-wave' type activity occurred earliest in the cortex. The discharges were also best formed in ...

The electrical fields of spike-wave complexes were plotted with the aid of a microcomputer in patients suffering from petit mal absences. The maximum positivity as well as negativity of the individual complexes was mainly in the frontal areas. While this observation was quite constant among different patients and different seizures within the same patient, the way in which these maxima were reached varied markedly. Even in the most regular patterns, successive spike-wave complexes within ...