• Disease
  • Temporal
  • Temporal Lobe
  • Christian Erich Elger

    Prominent publications by Christian Erich Elger

    KOL Index score: 19931

    PURPOSE: To study the efficacy and safety of eslicarbazepine acetate (ESL) as adjunctive therapy for refractory partial seizures in adults with >or=4 partial-onset seizures (simple or complex, with or without secondary generalization) per 4 weeks despite treatment with 1-2 antiepileptic drugs (AEDs).

    METHODS: This multicenter, parallel-group study had an 8-week, single-blind, placebo baseline phase, after which patients were randomized to placebo (n = 102) or once-daily ESL 400 mg (n = ...

    Also Ranks for: Adjunctive Treatment |  placebo patients |  refractory partial |  eslicarbazepine acetate |  1200 aes
    KOL Index score: 14365

    Focal cortical dysplasias (FCD) with Taylor-type balloon cells (FCDIIb) are frequently observed in biopsy specimens of patients with pharmacoresistant focal epilepsies. The molecular pathogenesis of FCDIIb, which lack familial inheritance, is only poorly understood. Due to their highly differentiated, malformative nature and glioneuronal phenotype, FCDIIb share neuropathological characteristics with lesions observed in familial disorders such as cortical tubers present in patients with ...

    Also Ranks for: Focal Cortical |  ctmp akt |  somatic mutation |  tsc1 tsc2 |  pathway activation
    KOL Index score: 13465

    Focal cortical dysplasias type II (FCD II) are highly epileptogenic lesions frequently causing pharmacoresistant epilepsy. Detection of these lesions on MRI is still challenging as FCDs may be very subtle in appearance and might escape conventional visual analysis. Morphometric MRI analysis is a voxel-based post-processing method based on algorithms of the statistical parametric mapping software (SPM5). It creates three dimensional feature maps highlighting brain areas with blurred ...

    Also Ranks for: Morphometric Mri |  conventional visual analysis |  cortical development |  fcd iia |  experienced neuroradiologist
    KOL Index score: 13436

    PURPOSE: To evaluate the long-term efficacy and safety of once daily eslicarbazepine acetate (ESL) as adjunctive therapy for partial-onset seizures in adults with epilepsy.

    METHODS: One-year open-label treatment extension with ESL in patients who completed a placebo-controlled pivotal study (Epilepsia 2009; 50: 454-463). Starting dose was 800 mg once daily, for 4 weeks; thereafter, dose could be titrated up or down. Doses of concomitant antiepileptic drugs were to be kept ...

    Also Ranks for: Partial‐onset Seizures |  quality life |  long‐term efficacy |  eslicarbazepine acetate |  esl patients
    KOL Index score: 13249

    It is a fundamental question whether the medial temporal lobe (MTL) supports only long-term memory encoding, or contributes to working memory (WM) processes as well. Recent data suggest that the MTL is activated whenever multiple items or item features are being maintained in WM. This may rely on interactions between the MTL or the prefrontal cortex (PFC) and content-specific areas in the inferior temporal (IT) cortex. Here, we investigated the neural mechanism through which the MTL, ...

    Also Ranks for: Prefrontal Cortex |  medial temporal lobe |  magnetic resonance |  functional connectivity |  intracranial eeg
    KOL Index score: 13120

    BACKGROUND: There is evidence that the sudden unexpected death in epilepsy (SUDEP) risk can be reduced by good seizure control, nocturnal supervision, and by early cardiopulmonary resuscitation if cardiorespiratory arrest occurs in the aftermaths of generalized tonic-clonic seizures (GTCS). These measures, however, may critically depend on the knowledge of patients and relatives on SUDEP. Here, we assessed the basic knowledge on SUDEP of people with epilepsy at a tertiary epilepsy center ...

    Also Ranks for: Epilepsy Sudep |  sudden unexpected death |  patients relatives |  nocturnal supervision |  health knowledge
    KOL Index score: 13083

    PURPOSE: To evaluate pregabalin as add-on therapy for patients with partial seizures administered as fixed dose or as flexible dose adjusted to optimal seizure reduction and tolerability.

    METHODS: Patients receiving antiepileptic drugs (98.8% between 1 and 3 AEDs; 1.2% on more than 3 AEDs) and experiencing > or =4 partial seizures during the 6-week baseline period and no 4-week seizure-free interval were randomized (1:2:2) to placebo (n = 73), pregabalin fixed dose (600 mg/day BID; n = ...

    Also Ranks for: Partial Seizures |  patients pregabalin |  flexible dose |  combination epilepsies |  600 day
    KOL Index score: 12652

    PURPOSE: The anticonvulsants phenytoin (PHT), carbamazepine (CBZ), and gabapentin (GBP) are commonly used in the treatment of temporal lobe epilepsy. Ca2+ current modulation has been proposed to contribute to the antiepileptic activity of these drugs. The purpose of this study was to determine the effects of these anticonvulsants on voltage-dependent calcium channels in pathologically altered neurons from patients with chronic temporal lobe epilepsy.

    METHODS: Acutely isolated human ...

    Also Ranks for: Calcium Channels |  temporal lobe epilepsy |  carbamazepine cbz |  granule cells |  gabapentin gbp
    KOL Index score: 12543

    The present study investigated the effect of frontal lobe surgery on "cognitive functions", which have previously been shown to be discriminative in the evaluation of non-resected patients with frontal lobe epilepsy (FLE). The cognitive outcome was evaluated with particular consideration of the side (left/right), the site (lateral, orbital, mesial, premotor/SMA), the type of surgery (resections vs. resections plus multiple subpial transections; MST), and seizure outcome. The evaluation ...

    Also Ranks for: Frontal Lobe |  epilepsy surgery |  cognitive outcome |  term memory |  patients temporal
    KOL Index score: 12495

    PURPOSE: Cardiac asystole provoked by epileptic seizures is a rare but important complication in epilepsy and is supposed to be relevant to the pathogenesis of sudden unexplained death in epilepsy (SUDEP). We sought to determine the frequency of this complication in a population of patients with medically intractable epilepsy and to analyze the correlation between EEG, electrocardiogram (ECG), and clinical features obtained from long-term video-EEG monitoring.

    METHODS: Retrospective ...

    Also Ranks for: Cardiac Asystole |  partial epilepsy |  epileptic seizures |  temporal lobe |  sudden unexplained death
    KOL Index score: 12436

    Oxcarbazepine (OXC, Trileptal) is a modern antiepileptic drug (AED) used as both monotherapy and adjunctive therapy for the treatment of partial seizures with or without secondary generalization in adults and children above 4 years (USA) or 6 years (Europe) of age. Although OXC has been developed through structural variation of carbamazepine (CBZ) with the intent to avoid metabolites causing side effects, significant differences have emerged between the two drugs. The mechanism of action ...

    Also Ranks for: Cbz Oxc |  antiepileptic drug |  partial seizures |  adults children |  reductive metabolism
    KOL Index score: 11880

    The present study evaluates results of language testing during intracarotid amobarbital procedures in 167 patients with either left (LHE, n = 81) or right hemisphere epilepsies (RHE, n = 86). In both groups there was a high rate of deviance from complete left hemisphere dominance of 24 and 31%, respectively. Whilst complete right hemisphere or incomplete left hemisphere language dominance were the prominent atypical patterns in LHE, RHE was associated with either bilateral dominance or ...

    Also Ranks for: Language Dominance |  hemisphere epilepsies |  mri findings |  age onset |  atypical patterns
    KOL Index score: 11604

    PURPOSE: Surgical treatment of refractory temporal lobe epilepsy (TLE) is promising for selected patients, but only little experience has been acquired in operating on older patients, especially with limited resections. We intend to delineate clinical and surgical factors influencing outcome in patients older than 50 years at operation and to compare the results with those of a younger patient cohort.

    METHODS: Fifty-two patients older than 50 years were operated on for intractable mesial ...

    Also Ranks for: Surgical Treatment |  seizure outcome |  temporal lobe |  younger cohort |  50 years
    KOL Index score: 11469

    PURPOSE: The objective of this study was to correlate health-related quality of life (HRQOL) after surgery for mesial temporal lobe epilepsy, as revealed by a postoperative screening tool, to different modalities of seizure outcome classification (Engel, International League Against Epilepsy (ILAE)).

    METHOD: One hundred twenty-eight of one hundred forty consecutive patients returned a HRQOL questionnaire at a mean of 36 months after selective amygdalohippocampectomy. Patients answered in ...

    Also Ranks for: Seizure Outcome |  temporal lobe |  hrqol surgery |  healthrelated quality |  ilae 1


    Christian Erich Elger: Influence Statistics

    Sample of concepts for which Christian Erich Elger is among the top experts in the world.
    Concept World rank
    rhinal process #1
    satscom mri #1
    impaired verbal fluency #1
    atypical dominant patients #1
    findings wm maintenance #1
    amf motor compensation #1
    deltaband #1
    tsc2 2 protein #1
    interictal fdg‐pet #1
    familial febrile convulsions #1
    intracranial ecog #1
    cyclinb1 gangliogliomas #1
    multitask electrical stimulation #1
    antibodyassociated #1
    entire hippocampus #1
    stronger activations recognition #1
    carbamazepinecr protocol #1
    cardiac asystole epilepsy #1
    cognitive performance vns #1
    seizure duration patient #1
    postoperative verbal #1
    tests seizures eeg #1
    erster epileptischer anfall #1
    risks implantation #1
    hippocampal p600 #1
    7991 #1
    tpm maintenance phase #1
    functionally cortex combination #1
    berichtete #1
    selective amobarbital test #1
    tle immunohistochemistry #1
    surgery language performance #1
    epilepsypatients #1
    brain abnormality pnes #1
    nonlinear deterministic dynamics #1
    ftbtcs #1
    subsequent hippocampal #1
    homocysteine plasma level #1
    variance anticonvulsants #1
    deactivations items #1
    condition vv session #1
    human dab1 p35 #1
    epileptogenic vascular lesions #1
    cd34 nfm #1
    method excitable media #1
    epilepsiediagnostik #1
    evoked gba #1
    patients gadtle #1
    tbf cues electrodes #1
    dynorphin effects patients #1

    Key People For Temporal Lobe

    Top KOLs in the world
    Christian Erich Elger
    temporal lobe epilepsy surgery limbic encephalitis
    Dennis D Spencer†
    temporal lobe magnetic resonance hippocampal sclerosis
    Jerome Jr Engel
    temporal lobe epilepsy surgery surgical treatment
    Frederick Andermann
    temporal lobe partial epilepsy magnetic resonance
    John Sidney Duncan
    temporal lobe epilepsy surgery hippocampal sclerosis
    Susan Soloway Spencer
    temporal lobe epilepsy surgery seizure onset

    Christian Erich Elger:Expert Impact

    Concepts for whichChristian Erich Elgerhas direct influence:Temporal lobe,  Temporal lobe epilepsy,  Lobe epilepsy,  Epilepsy surgery,  Epilepsy patients,  Limbic encephalitis,  Epileptic seizures,  Status epilepticus.

    Christian Erich Elger:KOL impact

    Concepts related to the work of other authors for whichfor which Christian Erich Elger has influence:Temporal lobe,  Epilepsy surgery,  Epileptic seizures,  Eeg signals,  Hippocampal sclerosis,  Magnetic resonance,  Functional connectivity.



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    Department of Pediatric Neurology, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin 13353, Germany; Center for Chronically Sick Children, Augustenburger Platz 1, Berlin, Germany; Beta Neurologie - Kompetenzzentrum für Epilepsie, B