• Disease
  • Gastroesophageal
  • Gastroesophageal Reflux
  • Donald O Castell

    Prominent publications by Donald O Castell

    KOL Index score: 17546

    AIM: Proton pump inhibitors taken twice daily before meals (proton pump inhibitor b.d. AC) effectively controls daytime gastric pH; however, nocturnal gastric acid breakthrough (NAB) occurs in more than 75% of patients. Adding an H2-blocker at bedtime decreases NAB in normal subjects. The efficacy of this regimen has not been evaluated in GERD patients. The aim of this study was to assess the effects of proton pump inhibitor b.d., both with and without bedtime H2-blocker on intragastric ...

    Also Ranks for: Gerd Patients |  proton pump |  gastric acid |  bedtime nab |  percentage time
    KOL Index score: 17303

    OBJECTIVES: Esomeprazole, the S isomer of omeprazole, has been shown to have higher healing rates of erosive esophagitis than omeprazole. This study compared esomeprazole with lansoprazole for the healing of erosive esophagitis and resolution of heartburn.

    METHODS: This United States multicenter, randomized, double blind, parallel group trial was performed in 5241 adult patients (intent-to-treat population) with endoscopically documented erosive esophagitis, which was graded by severity ...

    Also Ranks for: Erosive Esophagitis |  esomeprazole lansoprazole |  healing rates |  sustained resolution |  heartburn patients
    KOL Index score: 16506

    BACKGROUND AND AIMS: Empiric proton pump inhibitor (PPI) trials have become increasingly popular leading to gastroenterologists frequently evaluating gastro-oesophageal reflux disease (GORD) patients only after they have "failed" PPI therapy. Combined multichannel intraluminal impedance and pH (MII-pH) monitoring has the ability to detect gastro-oesophageal reflux (GOR) episodes independent of their pH and evaluate the relationship between symptoms and all types of GOR. Using this ...

    Also Ranks for: Acid Reflux |  persistent symptoms |  patients ppis |  ambulatory impedance |  ppi therapy
    KOL Index score: 16228

    BACKGROUND & AIMS: Proton pump inhibitors administered twice daily do not provide complete nocturnal acid suppression. Acid breakthrough, or decrease in intragastric pH to <4 for an hour or longer, occurs in three quarters of normal subjects and patients at night. We compared the effect of a third dose of omeprazole at bedtime with that of a dose of ranitidine at bedtime on residual nocturnal acid secretion in patients receiving omeprazole twice daily.

    METHODS: Twelve volunteers ...

    Also Ranks for: Acid Breakthrough |  ranitidine bedtime |  nocturnal gastric |  omeprazole placebo |  percentage time
    KOL Index score: 14694

    BACKGROUND: Nocturnal gastric acid breakthrough, defined as intragastric pH < 4 for more than 1 h in the overnight period, is observed in up to 70% of normal subjects on proton pump inhibitors taken twice daily. The frequency of this breakthrough in patients with gastro-oesophageal reflux and accompanying oesophageal reflux during this period has not been studied.

    AIM: To examine the frequency of nocturnal break-through and accompanying oesophageal acid exposure in patients with ...

    Also Ranks for: Oesophageal Reflux |  proton pump |  gastric acid |  barretts oesophagus |  breakthrough patients
    KOL Index score: 12769

    BACKGROUND: In patients with severe gastro-oesophageal reflux disease (GERD), proton pump inhibitors are being used increasingly in twice-daily regimens to improve control of gastric acidity. Few data exist to compare the ability of the most-often used proton pump inhibitors, omeprazole and lansoprazole, to control gastric acid at twice-daily dosage regimens. Nocturnal acid breakthrough, defined as gastric pH < 4.0 continuously for > 60 min, may compromise treatment goals in patients ...

    Also Ranks for: Gastric Acidity |  acid breakthrough |  omeprazole 20 |  patients gerd |  lansoprazole 30
    KOL Index score: 12451

    BACKGROUND: Persistent symptoms on acid suppressive therapy are due to either acid or nonacid gastroesophageal reflux (GER) episodes or are not related to reflux.

    AIM: To compare physical and chemical characteristics of GER episodes associated with symptoms in patients on acid suppressive therapy.

    METHODS: Patients with persistent symptoms on acid suppressive therapy underwent combined impedance-pH monitoring. Reflux episodes were classified as acid if nadir pH was <4.0, and nonacid if ...

    Also Ranks for: Reflux Episodes |  acid suppressive therapy |  symptoms patients |  proximal esophagus |  liquid mixed
    KOL Index score: 12129

    BACKGROUND & AIMS: Combined multichannel intraluminal impedance and manometry (MII-EM) assesses esophageal function by simultaneous measurement of both pressure and bolus transit. Normative data for this method have not been published. The aim of this study was to establish normative data for combined MII-EM and to correlate liquid and viscous bolus transit by impedance with esophageal contractions by manometry.

    METHODS: Forty-three normal volunteers recruited from 4 centers (15 women, ...

    Also Ranks for: Esophageal Function |  combined miiem |  complete bolus transit |  normative data |  intraluminal impedance
    KOL Index score: 12029

    BACKGROUND: In this multi-center study, the feasibility, safety, and efficacy of radiofrequency (RF) energy delivery to the gastroesophageal junction (GEJ) for the treatment of gastroesophageal reflux disease (GERD) were investigated.

    METHODS: Forty-seven patients with classic symptoms of GERD (heartburn and/or regurgitation), a daily anti-secretory medication requirement, and at least partial symptom response to drugs were enrolled. All patients had pathologic esophageal acid exposure ...

    Also Ranks for: Gastroesophageal Junction |  energy delivery |  6 months |  treatment gerd |  quality life
    KOL Index score: 12021

    OBJECTIVE: The association of gastroesophageal reflux disease (GERD) and respiratory symptoms is well known. The coexistence of ineffective esophageal motility (IEM, low-amplitude [< 30 mm Hg] or nontransmitted contractions in > or = 30% of 10 wet swallows in the distal esophagus) in patients with GERD has recently been demonstrated. Our aim was to determine the prevalence of IEM in patients with GERD-associated respiratory symptoms.

    METHODS: Manometry and pH studies of 98 consecutive ...

    Also Ranks for: Respiratory Symptoms |  ineffective esophageal motility |  iem patients |  chronic cough asthma |  abnormal reflux
    KOL Index score: 11794

    BACKGROUND & AIMS: Combined multichannel intraluminal impedance (MII) and manometry (MII-EM) recently became available as an esophageal function test. Initial studies in healthy volunteers have shown that a proportion of ineffective contractions actually have complete bolus transit. The aim of our study is to evaluate esophageal bolus transit in patients with manometric patterns of ineffective esophageal motility (IEM).

    METHODS: All patients referred for esophageal function testing ...

    Also Ranks for: Esophageal Function |  combined impedance |  viscous swallows |  manometric diagnosis |  transit patients
    KOL Index score: 11511

    BACKGROUND: On chronic intake of omeprazole, most healthy volunteers and patients still have nocturnal acid breakthrough (NAB), defined as night-time periods with gastric pH < 4.0 lasting for longer than 1 h. Gastro-oesophageal reflux during NAB may be particularly injurious to the oesophageal mucosa, contributing to the chronic lesions complicating the condition.

    AIM: To compare the effect of three different dosing regimens of omeprazole 40 mg daily with regard to suppressing nocturnal ...

    Also Ranks for: Gastric Acidity |  acid breakthrough |  breakfast dinner |  percentage time |  regimens omeprazole
    KOL Index score: 11389

    BACKGROUND: Achalasia is defined manometrically by an aperistaltic esophagus. Variations in the manometric findings occur in achalasia suggesting that all manometric features should not be required to diagnose achalasia. Combined multichannel intraluminal impedance and esophageal manometry (MII-EM) allows both a functional and a manometric evaluation of esophageal motility and identifies chronic fluid retention.

    AIM: To compare manometric and MII characteristics in patients with ...

    Also Ranks for: Achalasia Patients |  esophageal manometry |  mm hg |  aged pressure |  manometric evaluation


    Donald O Castell: Influence Statistics

    Sample of concepts for which Donald O Castell is among the top experts in the world.
    Concept World rank
    impedancemanometry postprandial reflux #1
    abnormal ger patients #1
    gastroesophageal reflux heartburn #1
    mii ger #1
    esophageal transit abnormalities #1
    mbss miiem #1
    adverse chocolate #1
    1 general approach #1
    response balloon distention #1
    iem female humans #1
    incompetent lower #1
    methods 64 patients #1
    manometric abnormalities patients #1
    patients gastric nab #1
    dysphagia chest pain #1
    lansoprazole gastric acid #1
    progressively larger volumes #1
    precordial radioactivity #1
    antireflux therapies #1
    recumbency bmi groups #1
    esophageal origin esophagus #1
    time acidity #1
    esophagus gastrointestinal #1
    diagnosis incomplete transit #1
    reflux combined #1
    total monitoring 2hour #1
    hiatal hernia life #1
    normal values manometry #1
    orangejuice #1
    onsets ues relaxations #1
    achalasia manometry #1
    time sleeping position #1
    scleroderma iem #1
    parkinsons disease achalasia #1
    inhibition semicarbazide #1
    42 episode #1
    quantity comparison #1
    esophageal inflammation cats #1
    viscous distal #1
    preventing symptoms #1
    miiom swallows #1
    esophageal balloon #1
    impedance transit defects #1
    spontaneous reflux #1
    cmf transducers #1
    9961011–9 #1
    lidocaine inhibition pressure #1
    50 nar #1
    percent time reflux #1
    achalasia bolus #1

    Key People For Gastroesophageal Reflux

    Top KOLs in the world
    John Dent
    reflux disease gastric emptying pyloric motility
    Donald O Castell
    gastroesophageal reflux chest pain esophageal manometry
    Peter James Kahrilas
    esophagogastric junction chicago classification gastroesophageal reflux disease
    Tom R DeMeester
    gastroesophageal reflux intestinal metaplasia esophageal adenocarcinoma
    Joel E Richter
    chest pain gastroesophageal reflux eosinophilic esophagitis
    Hashem B EL‐SERAG
    united states hepatocellular carcinoma veterans affairs

    Donald O Castell:Expert Impact

    Concepts for whichDonald O Castellhas direct influence:Gastroesophageal reflux,  Chest pain,  Gastroesophageal reflux disease,  Esophageal manometry,  Nutcracker esophagus,  Esophageal motility,  Acid reflux,  Lower esophageal sphincter.

    Donald O Castell:KOL impact

    Concepts related to the work of other authors for whichfor which Donald O Castell has influence:Gastroesophageal reflux,  Chest pain,  Esophageal motility,  Proton pump,  Chronic cough,  Gerd patients,  Hiatal hernia.



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    Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina, USA | Medical University of South Carolina, Charleston, South Carolina, USA | Department of Internal Medicine, Medical University of South