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    • HALLETT Hallett

      HALLETT Hallett

      Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA | Human Motor ...



      KOL Resume for HALLETT Hallett


      Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA


      Human Motor Control Section, NINDS, NIH, Bethesda, Maryland, USA

      Neuropsychiatry Research and Education Group, Institute of Psychiatry, Psychology and Neuroscience, King's College London (Butler, Pollak, Nicholson); Ashford St. Peter's National Health Service (NHS) Foundation Trust and St. George's NHS Foundation Trust, London (Coebergh);Division of Intramural Research, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Md. (Safavi, Hallett);Centre for Clinical Brain Sciences, University of Edinburgh, United Kingdom (Carson, Stone); and Department of Neurology, the Walton Centre NHS Foundation Trust, Liverpool, United Kingdom (Michael, Solomon).

      Government of the United States of America - National Institute of Neurological Disorders and Stroke (NINDS)


      National Institute of Neurological Disorders and Stroke, Human Motor Control Section, Bethesda, MD

      Human Motor Control Section, NINDS, NIH, Bethesda, USA


      Human Motor Control Section, NINDS, USA.

      National Institute of Neurological Disorders and Stroke, Bethesda, Maryland



      From the Human Motor Control Section, Medical Neurology Branch (C.W.M., K.L., G.S.L., G.C., M.H., S.G.H.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; Department of Neurology (C.W.M.), Stony Brook University School of Medicine, NY; Department of Neurology (K.L.), University of Louisville, KY; Experimental Therapeutics and Pathophysiology Branch (R.A.) and Office of the Clinical Director (S.S.), National Institute of Mental Health, NIH, Bethesda, MD; and Department of Psychiatry (S.A.E.), Georgetown University, Washington, DC.

      Human Motor Control Section, Medical Neurology Branch, NINDS, NIH, Bethesda, MD




      HALLETT Hallett: Influence Statistics

      Sample of concepts for which HALLETT Hallett is among the top experts in the world.
      Concept World rank
      distribution kinetic tremor #1
      peripheral movement disorders #1
      increase neural potential #1
      abobonta incobonta #1
      lai fdi #1
      hemisphere stimulation tms #1
      rs1182 #1
      groups grey matter #1
      mcc ventral striatum #1
      parietal erd #1
      force regulation patients #1
      cerebellum patients #1
      published studies inco #1
      chapter 44 explanation #1
      learning pinch force #1
      neuronal synapsin #1
      subacute phase mtbi #1
      dystonia disorder #1
      brain injury injury #1
      nogo eip #1
      fmzbp #1
      ecr postexercise depression #1
      tics urge #1
      ebcc psp patients #1
      paced movements #1
      10 normal subjects #1
      msa 7 patients #1
      csp duration adm #1
      arm dystonia #1
      site stimulation #1
      focal magnetic stimulation #1
      hfs supraorbital nerve #1
      blepharospasm study #1
      cranial nerves spt #1
      symptomatic palatal tremor #1
      chapter 15 chorea #1
      pathophysiology dystonia #1
      consensus tremor #1
      chapter 42 topics #1
      tasks gait #1
      people dystonia #1
      mcc findings #1
      eeg conjunction #1
      movements aged #1
      stimulation organization #1
      casl fmri #1
      sham sham tsdcs #1
      meps exercise #1
      corticomuscular coherence tricks #1
      motor cortex nf #1


      Prominent publications by HALLETT Hallett

      KOL-Index: 17475

      1. Using positron emission tomography and measurement of regional cerebral blood flow (rCBF) as an index of cerebral activity we investigated the central processing of motor preparation in 13 healthy volunteers. 2. We used a motor reaction time paradigm with visual cues as preparatory and response signals. A preparatory stimulus (PS) provided either full, partial, or no information regarding two variables of a forthcoming right finger movement: finger type (index or little finger) and ...

      Known for Motor Preparation | Parietal Cortex | Emission Tomography | Reaction Time | Rest Condition
      KOL-Index: 15723

      We studied the activation and interaction of cortical motor regions during simple, internally paced and externally paced right-hand finger extensions in healthy volunteers. We recorded EEGs from 28 scalp electrodes and analysed task-related coherence, task-related power and movement-related cortical potentials. Task-related coherence reflects inter-regional functional coupling of oscillatory neuronal activity, task-related power reflects regional oscillatory activity of neuronal ...

      Known for Regional Activation | Functional Coupling | Motor Areas | Finger Movements | Externally Paced
      KOL-Index: 14212

      Patients with Parkinson's disease (PD) have difficulty in performing self-initiated movements. The neural mechanism of this deficiency remains unclear. In the current study, we used functional MRI (fMRI) and psychophysiological interaction (PPI) methods to investigate the changes in effective connectivity of the brain networks during performance of self-initiated movement in PD patients. Effective connectivity is defined as the influence one neuronal system exerts over another. fMRIs ...

      Known for Brain Networks | Effective Connectivity | Initiated Movement | M1 Sma | Cerebellum Patients
      KOL-Index: 13785

      In patients with focal hand dystonia (FHD), pathological overflow activation occurs in muscles not involved in the movement. Surround inhibition is a neural mechanism that can sharpen desired movement by inhibiting unwanted movement in adjacent muscles. To further establish the phenomenon of surround inhibition and to determine whether short intracortical inhibition (SICI) reflecting inhibition from the local interneurons in primary motor cortex (M1), might play a role in its genesis, ...

      Known for Movement Initiation | Surround Inhibition | Focal Hand Dystonia | Patients Fhd | Neural Mechanism
      KOL-Index: 13348

      OBJECTIVES: To test to which extent the increase in ipsilateral motor cortex excitability during unimanual motor tasks shows hemispheric asymmetry.

      METHODS: Six right-handed healthy subjects performed one of several motor tasks of different complexity (including rest) with one hand (task hand) while the other hand (non-task hand) was relaxed. Focal transcranial magnetic stimulation was applied to the motor cortex ipsilateral to the task hand and the amplitude of the motor evoked ...

      Known for Motor Cortex | Hemispheric Asymmetry | Task Hand | Mep Amplitude | Spinal Motoneuron Excitability
      KOL-Index: 13308

      Deep brain stimulation therapy is an effective symptomatic treatment for Parkinson's disease, yet the precise mechanisms responsible for its therapeutic effects remain unclear. Although the targets of deep brain stimulation are grey matter structures, axonal modulation is known to play an important role in deep brain stimulation's therapeutic mechanism. Several white matter structures in proximity to the subthalamic nucleus have been implicated in the clinical benefits of deep brain ...

      Known for Subthalamic Nucleus | Brain Stimulation | Tractography Patterns | Parkinsons Disease | Superior Frontal Gyrus
      KOL-Index: 13299

      Motor practice may lead to expansion of trained representations in the motor cortex, but it is unknown whether this practice-dependent plasticity can be purposefully enhanced or depressed. Evidence, mainly based on animal experiments, indicates that the activity of GABA-related cortical inhibition is important in controlling the extent to which plasticity may occur. We tested the role of GABA in modulating practice-dependent plasticity in the human motor cortex. A decrease in ...

      Known for Human Motor Cortex | Dependent Plasticity | Motor Practice | Peak Acceleration | Animal Experiments
      KOL-Index: 12813

      OBJECTIVE: To explore effective combinations of computational methods for the prediction of movement intention preceding the production of self-paced right and left hand movements from single trial scalp electroencephalogram (EEG).

      METHODS: Twelve naïve subjects performed self-paced movements consisting of three key strokes with either hand. EEG was recorded from 128 channels. The exploration was performed offline on single trial EEG data. We proposed that a successful computational ...

      Known for Movement Intention | Single Trial | Spatial Filtering | Eeg Data | Pattern Classification
      KOL-Index: 12600

      To explore the neural networks used for Braille reading, we measured regional cerebral blood flow with PET during tactile tasks performed both by Braille readers blinded early in life and by sighted subjects. Eight proficient Braille readers were studied during Braille reading with both right and left index fingers. Eight-character, non-contracted Braille-letter strings were used, and subjects were asked to discriminate between words and non-words. To compare the behaviour of the brain ...

      Known for Braille Reading | Neural Networks | Blind Subjects | Secondary Somatosensory Area | Discrimination Tasks
      KOL-Index: 12519

      Clinical recovery after stroke can be significant and has been attributed to plastic reorganization and recruitment of novel areas previously not engaged in a given task. As equivocal results have been reported in studies using single imaging or electrophysiological methods, here we applied an integrative multimodal approach to a group of well-recovered chronic stroke patients (n = 11; aged 50-81 years) with left capsular lesions. Focal activation during recovered hand movements was ...

      Known for Contralesional Hemisphere | Recovered Patients | Motor Areas | Capsular Stroke | Brain Reorganization
      KOL-Index: 12431

      We used high-frequency repetitive transcranial magnetic stimulation (rTMS) to study the role of the mesial frontocentral cortex (including the supplementary motor area) in the organization of sequential finger movements of different complexity in humans. In 15 subjects, rTMS was randomly applied to the scalp overlying the region of the supplementary motor area and over other positions, including the contralateral primary motor cortex (hand area) during the performance of three ...

      Known for Supplementary Motor Area | Motor Sequences | Complex Sequence | Female Fingers | Stimulation Rtms
      KOL-Index: 12377

      The human frontomesial cortex reportedly contains at least four cortical areas that are involved in motor control: the anterior supplementary motor area (pre-SMA), the posterior SMA (SMA proper, or SMA), and, in the anterior cingulate cortex, the rostral cingulate zone (RCZ) and the caudal cingulate zone (CCZ). We used functional magnetic resonance imaging (fMRI) to examine the role of each of these mesial motor areas in self-initiated and visually triggered movements. Healthy subjects ...

      Known for Motor Areas | Activation Sma | Triggered Movements | Functional Laterality Humans | Cortex Movement
      KOL-Index: 12262

      Patients with Parkinson's disease have great difficulty in performing bimanual movements; this problem is more obvious when they perform bimanual anti-phase movements. The underlying mechanism of this problem remains unclear. In the current study, we used functional magnetic resonance imaging to study the bimanual coordination associated changes of brain activity and inter-regional interactions in Parkinson's disease. Subjects were asked to perform right-handed, bimanual in-phase and ...

      Known for Phase Movements | Parkinsons Disease | Supplementary Motor Area | Basal Ganglia | Magnetic Resonance
      KOL-Index: 12252

      We used proton magnetic resonance spectroscopic imaging (1H-MRSI) to assess the in vivo cortical and subcortical neuronal involvement in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration. This technique permitted the simultaneous measurement of compounds containing N-acetylaspartate (NA), choline (Cho), creatine-phosphocreatine (Cre) and lactate, from four 15-mm slices divided into 0.84-ml single-volume elements. The study included 12 patients with ...

      Known for Corticobasal Degeneration | Progressive Supranuclear | Magnetic Resonance | Parkinsons Disease | Lentiform Nucleus

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      HALLETT Hallett:Expert Impact

      Concepts for whichHALLETT Halletthas direct influence:Essential tremor,  Motor cortex,  Magnetic stimulation,  Movement disorders,  Parkinson disease,  Focal hand dystonia,  Transcranial magnetic,  Basal ganglia.

      HALLETT Hallett:KOL impact

      Concepts related to the work of other authors for whichfor which HALLETT Hallett has influence:Motor cortex,  Magnetic stimulation,  Parkinson disease,  Essential tremor,  Movement disorders,  Basal ganglia,  Functional connectivity.



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      Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA | Human Motor Control Section, National Institute of Neurological Disorders and Stroke, N

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