Prominent publications by Alberto Luini

KOL Index score: 21222

BACKGROUND: For patients with breast cancer and metastases in the sentinel nodes, axillary dissection has been standard treatment. However, for patients with limited sentinel-node involvement, axillary dissection might be overtreatment. We designed IBCSG trial 23-01 to determine whether no axillary dissection was non-inferior to axillary dissection in patients with one or more micrometastatic (≤2 mm) sentinel nodes and tumour of maximum 5 cm.

METHODS: In this multicentre, randomised, ...

Also Ranks for: Axillary Dissection |  sentinel nodes |  patients breast cancer |  phase 3 |  aged neoplasm
KOL Index score: 16538

BACKGROUND: In women with breast cancer, sentinel-lymph-node biopsy (SLNB) provides information that allows surgeons to avoid axillary-lymph-node dissection (ALND) if the SLN does not have metastasis, and has a favourable effect on quality of life. Results of our previous trial showed that SLNB accurately screens the ALN for metastasis in breast cancers of diameter 2 mm or less. We aimed to update this trial with results from longer follow-up.

METHODS: Women with breast tumours of ...

Also Ranks for: Breast Cancer |  alnd slnb |  node biopsy |  staging procedure |  negative slns
KOL Index score: 15843

BACKGROUND: Intraoperative radiotherapy with electrons allows the substitution of conventional postoperative whole breast irradiation with one session of radiotherapy with the same equivalent dose during surgery. However, its ability to control for recurrence of local disease required confirmation in a randomised controlled trial.

METHODS: This study was done at the European Institute of Oncology (Milan, Italy). Women aged 48-75 years with early breast cancer, a maximum tumour diameter ...

Also Ranks for: Intraoperative Radiotherapy |  equivalence trial |  rate ibtr |  breast carcinoma |  randomised controlled
KOL Index score: 14999

BACKGROUND: Sentinel node biopsy (SNB) has become a standard treatment in staging axillary lymph nodes in early breast cancer. SNB, however, is an invasive procedure and is time-consuming when the sentinel node is analysed intra-operatively. Breast cancer is frequently characterised by increased 2-fluoro-2-deoxy-D-glucose uptake and many studies have shown encouraging results in detecting axillary lymph node metastases. The aim of this study was to compare SNB and -positron emission ...

Also Ranks for: Node Biopsy |  axillary metastases |  alnd snb |  pet imaging |  sentinel lymph
KOL Index score: 14346

PURPOSE: The purpose of this research was to identify factors predicting response to preoperative chemotherapy.

EXPERIMENTAL DESIGN: In a large volume laboratory using standard immunohistochemical methods, we reviewed the pretreatment biopsies and histologic specimens at final surgery of 399 patients with large or locally advanced breast cancer (cT2-T4, N0-2, M0) who were treated with preoperative chemotherapy. The incidence of pathological complete remission and the incidence of ...

Also Ranks for: Preoperative Treatment |  estrogen receptor |  chemotherapy patients |  breast cancer |  pathological complete remission
KOL Index score: 14186

BACKGROUND: Routine histologic examination of axillary sentinel lymph nodes predicts axillary lymph node status and may spare patients with breast carcinoma axillary lymph node dissection. To avoid the need for two separate surgical sessions, the results of sentinel lymph node examination should be available intraoperatively. However, routine frozen-section examination of sentinel lymph nodes is liable to yield false-negative results. This study was conducted to ascertain whether ...

Also Ranks for: Intraoperative Examination |  axillary sentinel |  lymph nodes |  carcinoma patients |  node negative
KOL Index score: 14087

BACKGROUND: Sentinel lymph node (SLN) biopsy is used increasingly in patients with clinically lymph node negative, early-stage breast carcinoma, because it can spare axillary dissection when the sentinel lymph nodes are negative. The question arises, however, whether complete axillary lymph node dissection (ALND) also is necessary in patients with only micrometastases (< or = 2 mm in greatest dimension) in axillary SLNs. The authors carried out the current study to ascertain the risk of ...

Also Ranks for: Breast Carcinoma |  lymph nodes |  clinical implications |  patients micrometastases |  sln biopsy
KOL Index score: 13882

BackgroundBreast-conserving surgery has become the standard approach for about 80% of patients treated for primary breast cancer in most centres. However, mastectomy is still required in case of multicentric and/or large tumours or where recurrences occur after conservative treatment. When a total mastectomy is performed, the removal of the nipple areola complex (NAC) is a strongly debated issue. In fact, although removal of the NAC greatly increases the patient’s sensation of ...

Also Ranks for: Nac Patients |  situ carcinoma |  breast cancer treatment |  sparing mastectomy |  intra operative radiotherapy
KOL Index score: 12858

BACKGROUND: Axillary lymph-node dissection is an important staging procedure in the surgical treatment of breast cancer. However, early diagnosis has led to increasing numbers of dissections in which axillary nodes are free of disease. This raises questions about the need for the procedure. We carried out a study to assess, first, whether a single axillary lymph node (sentinel node) initially receives malignant cells from a breast carcinoma and, second, whether a clear sentinel node ...

Also Ranks for: Breast Cancer |  sentinel node |  axillary dissection |  frozen sections |  lymphatic metastasis tests
KOL Index score: 12795

BACKGROUND: There is limited knowledge about prognosis of selected breast cancer subtypes among very young women.

PATIENTS AND METHODS: We explored patterns of recurrence by age according to four immunohistochemically defined tumor subtypes: Luminal A and Luminal B (estrogen receptor positive and/or progesterone receptor positive and either human epidermal growth factor receptor 2 (HER2) positive and/or high Ki-67), HER2-positive (and) endocrine receptor absent and Triple Negative, in ...

Also Ranks for: 35 Years |  breast cancer |  young women |  triple negative |  estrogen receptors
KOL Index score: 12733

BACKGROUND: To assess the prognostic role of human epidermal growth factor receptor 2 (HER2) overexpression in patients with ductal carcinoma in situ (DCIS).

PATIENTS AND METHODS: We identified patients with HER2-positive DCIS among a population of 1667 cases, prospectively diagnosed and surgically treated at the European Institute of Oncology from 1996 to 2008. Rates of subsequent DCIS or invasive cancer in HER2-positive disease were estimated. We evaluated Cumulative Incidence of In ...

Also Ranks for: Breast Cancer |  ductal carcinoma |  estrogen receptors |  her2 positive |  neoplasm recurrence
KOL Index score: 12586

BACKGROUND: Axillary lymph node dissection is an established component of the surgical treatment of breast cancer, and is an important procedure in cancer staging; however, it is associated with unpleasant side effects. We have investigated a radioactive tracer-guided procedure that facilitates identification, removal, and pathologic examination of the sentinel lymph node (i.e., the lymph node first receiving lymphatic fluid from the area of the breast containing the tumor) to predict ...

Also Ranks for: Sentinel Lymph Node |  breast cancer |  axillary dissection |  large series |  staging predictive
KOL Index score: 12221

BackgroundNon-palpable breast lesions are diagnosed frequently posing the problem of localization and removal. When such lesions are malignant, axillary node status must be determined. We report our experience using radio-guided occult lesion localization (ROLL) for locating and removing non-palpable breast lesions together with sentinel node biopsy (SNB) to assess axillary status. We call the technique SNOLL.MethodsFrom March 1997 to April 2004, 1046 consecutive patients presented ...

Also Ranks for: Sentinel Node |  breast lesion |  noninfiltrating carcinoma |  imaging sensitivity |  conservative surgery

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Alberto Luini:Expert Impact

Concepts for whichAlberto Luinihas direct influence:Breast cancer,  Axillary dissection,  Node biopsy,  Breast carcinoma,  European institute,  Sentinel node,  Intraoperative radiotherapy,  Lymph node.

Alberto Luini:KOL impact

Concepts related to the work of other authors for whichfor which Alberto Luini has influence:Breast cancer,  Lymph node,  Neoadjuvant chemotherapy,  Radiation therapy,  Ductal carcinoma,  Axillary dissection.



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Division of Breast Surgery, IEO European Institute of Oncology IRCCS, Milan, Italy. | Department of Breast Surgery, IEO European Institute of Oncology IRCCS, Milan, Italy, | Division of Senology, European Institute of Oncology, 20141, Milan, Italy. |