• Disease
  • Ewing
  • Ewing Sarcoma
  • Pancras C W Hogendoorn•

    Prominent publications by Pancras C W Hogendoorn•

    KOL Index score: 18213

    BACKGROUND: Effective targeted treatment is unavailable for most sarcomas and doxorubicin and ifosfamide-which have been used to treat soft-tissue sarcoma for more than 30 years-still have an important role. Whether doxorubicin alone or the combination of doxorubicin and ifosfamide should be used routinely is still controversial. We assessed whether dose intensification of doxorubicin with ifosfamide improves survival of patients with advanced soft-tissue sarcoma compared with ...

    Also Ranks for: Doxorubicin Ifosfamide |  3 trial |  tissue sarcoma |  metastatic soft |  controlled phase
    KOL Index score: 16023

    BACKGROUND: We designed the EURAMOS-1 trial to investigate whether intensified postoperative chemotherapy for patients whose tumour showed a poor response to preoperative chemotherapy (≥10% viable tumour) improved event-free survival in patients with high-grade osteosarcoma.

    METHODS: EURAMOS-1 was an open-label, international, phase 3 randomised, controlled trial. Consenting patients with newly diagnosed, resectable, high-grade osteosarcoma aged 40 years or younger were eligible for ...

    Also Ranks for: Poor Response |  preoperative chemotherapy |  grade osteosarcoma |  patients map |  eventfree survival
    KOL Index score: 15223

    PURPOSE: Angiomatoid fibrous histiocytoma (AFH) is a low-grade mesenchymal neoplasm which usually occurs in children and adolescents. Either FUS-ATF1 or EWSR1-ATF1 have been detected in the few cases published, pointing to the interchangeable role of FUS and EWSR1 in this entity. EWSR1-ATF1 also represents the most frequent genetic alteration in clear cell sarcoma, suggesting the existence of a molecular homology between these two histotypes. We investigated the presence of EWSR1-CREB1, ...

    Also Ranks for: Fibrous Histiocytoma |  ewsr1 atf1 |  situ hybridization |  clear cell sarcoma |  fusion genes
    KOL Index score: 15204

    INTRODUCTION: Ewing sarcoma (EWS) is a malignant bone-associated sarcoma, with poor prognosis in case of metastasis or relapse. To explore the feasibility of natural killer (NK) cell mediated immunotherapy and to identify molecular mechanisms involved, the susceptibility of EWS to NK cells was investigated.

    METHODS AND RESULTS: All EWS cell lines tested (n=7) were lysed by purified allogeneic NK cells from healthy donors, and the efficacy of lysis was increased by activating NK cells ...

    Also Ranks for: Nk Cells |  ewing sarcoma |  cell cytotoxicity |  dnam1 receptor |  healthy donors
    KOL Index score: 14478

    Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that can show overlapping features with benign neurofibromas as well as high-grade sarcomas. Additional diagnostic markers are needed to aid in this often challenging differential diagnosis. Recently mutations in two critical components of the polycomb repressor 2 (PRC2) complex, SUZ12 and EED, were reported to occur specifically in MPNSTs while such mutations are absent in neurofibromas, both in the setting of ...

    Also Ranks for: Inferior Survival |  mpnsts loss |  diagnostic marker |  h3k27me3 immunohistochemistry |  h3k27 trimethylation
    KOL Index score: 14423

    PURPOSE: EURAMOS-1, an international randomized controlled trial, investigated maintenance therapy with pegylated interferon alfa-2b (IFN-α-2b) in patients whose osteosarcoma showed good histologic response (good response) to induction chemotherapy.

    PATIENTS AND METHODS: At diagnosis, patients age ≤ 40 years with resectable high-grade osteosarcoma were registered. Eligibility after surgery for good response random assignment included ≥ two cycles of preoperative MAP (methotrexate, ...

    Also Ranks for: Histologic Response |  preoperative map |  adjuvant child child |  randomized controlled |  chemotherapy patients
    KOL Index score: 14048

    Large randomised trials are mandatory when one wants to examine the effects of different aspects (such as the treatment modality) of a pathological condition on the overall outcome. This is especially true when studying a disease in which there is a multifactorial influence on progression and outcome such as osteosarcoma. Data on 570 patients with biopsy-proven primary central osteosarcoma of an extremity included in two consecutive studies of the European Osteosarcoma Intergroup (EOI) ...

    Also Ranks for: Histological Subtype |  570 patients |  consecutive trials |  chemotherapy survival |  central osteosarcoma
    KOL Index score: 13891

    Clear cell sarcoma of soft tissue (CCSST), also known as malignant melanoma of soft parts, represents a rare lesion of the musculoskeletal system usually affecting adolescents and young adults. CCSST is typified by a chromosomal t(12;22)(q13;q12) translocation resulting in a fusion between the Ewing sarcoma gene (EWSR1) and activating transcription factor 1 (ATF1), of which the activity in nontransformed cells is regulated by cyclic AMP. Our aim was to identify critical differentially ...

    Also Ranks for: Clear Cell Sarcoma |  soft tissue |  cell lines |  erbb3 ccsst |  expression regulation
    KOL Index score: 13862

    Chondrosarcomas are malignant cartilage-forming tumors arising centrally in bone (central chondrosarcoma) or within the cartilaginous cap of osteochondroma (peripheral chondrosarcoma). For hereditary multiple osteochondromas, two responsible genes, EXT1 and EXT2, have been cloned. Their recently elucidated role in heparan sulfate biosynthesis and Hedgehog diffusion leads to the hypothesis that EXT inactivation affects fibroblast growth factor (FGF) and Indian Hedgehog (IHh)/parathyroid ...

    Also Ranks for: Central Chondrosarcoma |  fibroblast growth factor |  neoplastic genes |  type 1 receptors |  pthrp fgf
    KOL Index score: 13556

    AIMS: The histopathological diagnosis of gastrointestinal stromal tumours (GIST) is typically made based on a combination of clinical and morphological features supported by immunohistochemistry studies. The aim of this study was to examine the staining quality, sensitivity, specificity and utility of antibodies used commonly in GIST diagnosis.

    METHODS AND RESULTS: Immunohistochemistry with a panel of antibodies [CD117, DOG1, protein kinase C (PKC)-theta, nestin, CD34, smooth muscle ...

    Also Ranks for: Gastrointestinal Stromal Tumours |  diagnosis gist |  dog1 cd117 |  sma desmin |  neoplasm proteins
    KOL Index score: 13395

    Osteosarcoma is the most common malignant bone tumour, with a peak incidence in children and young adolescents, suggesting a role of rapid bone growth in its pathogenesis. The Wnt/beta-catenin pathway plays a crucial role in skeletal development and is indispensable for osteoblasts' lineage determination. Previous studies suggesting an oncogenic role for the Wnt/beta-catenin pathway in osteosarcoma were based on cytoplasmic staining of beta-catenin or the detection of one component of ...

    Also Ranks for: Catenin Pathway |  osteosarcoma cell |  wnt proteins |  oncogenic role |  osteogenic differentiation
    KOL Index score: 13350

    BACKGROUND: The effect of adjuvant chemotherapy on survival for resected soft-tissue sarcoma remains unknown. We investigated the effect of intensive adjuvant chemotherapy on survival in patients after resection of high-risk soft-tissue sarcomas.

    METHODS: In this multicentre randomised trial, patients with macroscopically resected, Trojani grade II-III soft-tissue sarcomas at any site, no metastases, performance status lower than 2 and aged between 16 and 70 years were eligible within 4 ...

    Also Ranks for: Adjuvant Chemotherapy |  doxorubicin ifosfamide |  tissue sarcoma |  patients resection |  resected soft
    KOL Index score: 13039

    BACKGROUND: Previous randomized controlled trials that used the two-drug chemotherapy regimen of cisplatin and doxorubicin as the conventional arm showed no evidence of benefit from an increase in the number of agents or the length of treatment. It was then proposed that survival could be improved by increasing the planned dose intensity of cisplatin and doxorubicin.

    METHODS: Previously untreated patients with nonmetastatic, high-grade, central osteosarcoma of an extremity were randomly ...

    Also Ranks for: Histologic Response |  osteosarcoma patients |  cisplatin doxorubicin |  intensified chemotherapy |  survival dose
    KOL Index score: 12755

    BACKGROUND: A common treatment of low-grade cartilaginous lesions of bone is intralesional curettage with local adjuvant therapy. Because of the wide variety of different diagnoses and treatments, there is still a lack of knowledge about the effectiveness of the use of phenol as local adjuvant therapy in patients with grade-I central chondrosarcoma of a long bone.

    METHODS: A retrospective study was done to assess the clinical and oncological outcomes after intralesional curettage, ...

    Also Ranks for: Intralesional Curettage |  long bone |  grade chondrosarcoma |  phenol ethanol |  recurrence rate
    KOL Index score: 12391

    Osteochondromas occur as sporadic solitary lesions or as multiple lesions, characterizing the hereditary multiple exostoses syndrome (EXT). Approximately 15% of all chondrosarcomas arise within the cartilaginous cap of an osteochondroma. EXT is genetically heterogeneous, and two genes, EXT1 and EXT2, located on 8q24 and 11p11-p12, respectively, have been cloned. It is still unclear whether osteochondroma is a developmental disorder or a true neoplasm. Furthermore, it is unclear whether ...

    Also Ranks for: Mutation Analysis |  loss heterozygosity |  secondary chondrosarcomas |  multiple osteochondromas |  ext gene


    Pancras C W Hogendoorn•: Influence Statistics

    Sample of concepts for which Pancras C W Hogendoorn• is among the top experts in the world.
    Concept World rank
    sporadic osteochondromas cells #1
    fields improvements #1
    worrisome clinical features #1
    growth factor paragangliomas #1
    127 inhabitants incidence #1
    adamantinoma long #1
    chondroma #1
    osteosarcoma driver #1
    preschool chondrosarcoma cloning #1
    autoantibodies model #1
    fish suspension #1
    biopsy specimen subtype #1
    cd51 expression osteoclasts #1
    repeat surgery lesion #1
    telomere‐associated proteins #1
    sma gctb #1
    ethanol adjuvant therapy #1
    dedifferentiated chondrosarcoma l2975 #1
    mrc bo06 #1
    weak reactivity fli1 #1
    osteolytic tumour tibia #1
    cdk4 cdkn2a p16 #1
    prognostic significance osteosarcoma #1
    pei staining #1
    osteosarcoma zebrafish model #1
    sdc2 wnt #1
    inhibited cells effects #1
    erg antibody ewsr1erg #1
    osteochondroma cartilage cap #1
    pattern initial enhancement #1
    mlpa analysis ext1 #1
    update musculoskeletal tumors #1
    central chondrosarcomas #1
    srd5a1 gene expression #1
    variable growth rate #1
    trocar biopsy #1
    tumours adamantinoma #1
    mdr1 dox #1
    mpsnt #1
    ifosfamide mapifo #1
    cytometry data study #1
    fibroma cmf #1
    central cartilaginous tumours #1
    central chondrosarcomas hspgs #1
    trisomies ofd #1
    fam86d #1
    lysis ews cells #1
    macrophage activating agents #1
    chondromyxoid fibroma molecules #1
    bcl2 fgfr1 #1

    Key People For Ewing Sarcoma

    Top KOLs in the world
    Olivier Delattre
    ewing sarcoma situ hybridization human pair
    Heinrich Kovar
    ewing sarcoma oncogene proteins ews fli1
    Piero Picci
    neoadjuvant chemotherapy ewing sarcoma bone neoplasms
    Stephen L Lessnick
    ewing sarcoma ews fli oncogene proteins
    Timothy Junius Triche
    cell lines ewing sarcoma gene expression
    Uta Dirksen
    ewing sarcoma fertility impairment local treatment

    Pancras C W Hogendoorn•:Expert Impact

    Concepts for whichPancras C W Hogendoorn•has direct influence:Ewing sarcoma,  Cell lines,  Soft tissue,  Central chondrosarcoma,  Osteosarcoma patients,  Situ hybridization,  Cartilaginous tumors,  Multiple osteochondromas.

    Pancras C W Hogendoorn•:KOL impact

    Concepts related to the work of other authors for whichfor which Pancras C W Hogendoorn• has influence:Ewing sarcoma,  Soft tissue,  Gastrointestinal stromal,  Stem cells,  Cell tumor,  Neoadjuvant chemotherapy,  Situ hybridization.



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    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. | Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and Centre for Statistics in Medicine (CSM), University of Oxford, Botnar Research Ce