• Disease
  • Anxiety
  • Anxiety Sensitivity
  • Jasper A J Smits

    Prominent publications by Jasper A J Smits

    KOL Index score: 15329

    OBJECTIVE: Cognitive-behavioral therapy (CBT) is frequently used for various adult anxiety disorders, but there has been no systematic review of the efficacy of CBT in randomized placebo-controlled trials. The present study meta-analytically reviewed the efficacy of CBT versus placebo for adult anxiety disorders.

    DATA SOURCES: We conducted a computerized search for treatment outcome studies of anxiety disorders from the first available date to March 1, 2007. We searched MEDLINE, ...

    Also Ranks for: Adult Anxiety Disorders |  randomized placebo |  response rates |  behavioral therapy |  efficacy cbt
    KOL Index score: 13236

    The purpose of this study was to examine the efficacy of cognitive behavioral therapy (CBT) for anxiety-related disorders based on randomized placebo-controlled trials. We included 41 studies that randomly assigned patients (N = 2,843) with acute stress disorder, generalized anxiety disorder (GAD), obsessive compulsive disorder (OCD), panic disorder (PD), posttraumatic stress disorder (PTSD), or social anxiety disorder (SAD) to CBT or a psychological or pill placebo condition. Findings ...

    Also Ranks for: Cognitive Behavioral Therapy |  cbt anxiety disorders |  stress disorder |  randomized placebo |  traumatic acute
    KOL Index score: 12286

    Importance: Whether and under which conditions D-cycloserine (DCS) augments the effects of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders is unclear.

    Objective: To clarify whether DCS is superior to placebo in augmenting the effects of cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders and to evaluate whether antidepressants interact with DCS and the effect of potential ...

    Also Ranks for: Stress Disorder |  behavior therapy |  based cognitive |  effects dcs |  cycloserine augmentation
    KOL Index score: 12106

    BACKGROUND: Although cigarette smoking is a leading cause of death and disability in the United States (US), over 40 million adults in the US currently smoke. Quitting smoking is particularly difficult for smokers with certain types of psychological vulnerability. Researchers have frequently called attention to the relation between smoking and anxiety-related states and disorders, and evidence suggests that panic and related anxiety vulnerability factors, specifically anxiety sensitivity ...

    Also Ranks for: Smoking Cessation |  anxiety sensitivity |  study protocol |  intensity exercise |  controlled trial
    KOL Index score: 11987

    OBJECTIVE: People with depressive symptoms report lower levels of exercise self-efficacy and are more likely to discontinue regular exercise than others, but it is unclear how depressive symptoms affect the relation between exercise and self-efficacy. We sought to clarify whether depressive symptoms moderate the relations between exercise and same-day self-efficacy, and between self-efficacy and next-day exercise.

    METHODS: Participants (n = 116) were physically inactive adults (35% ...

    Also Ranks for: Depressive Symptoms |  efficacy exercise
    KOL Index score: 11631

    OBJECTIVE: The evidence for the efficacy of D-cycloserine (DCS) for augmenting cognitive behavioral therapy (CBT) for anxiety disorders has been mixed. Guided by preclinical research and initial findings from a small-scale study involving humans, we tested the hypothesis that DCS enhancement of exposure therapy would be specific to successful exposure sessions.

    METHOD: Medication-free adults with generalized social anxiety disorder (N = 145) received 50 mg of DCS or placebo 1 h before ...

    Also Ranks for: Exposure Therapy |  social anxiety disorder |  patients dcs |  cycloserine enhancement |  cbt anxiety
    KOL Index score: 11558

    BACKGROUND: Sleep quality may be an important, yet relatively neglected, predictor of treatment outcome in cognitive-behavioral therapy (CBT) for anxiety disorders. Specifically, poor sleep quality may impair memory consolidation of in-session extinction learning. We therefore examined sleep quality as a predictor of treatment outcome in CBT for social anxiety disorder and the impact of d-cycloserine (DCS) on this relationship.

    METHODS: One hundred sixty-nine participants with a primary ...

    Also Ranks for: Sleep Quality |  social anxiety disorder |  cbt participants |  session symptoms |  slower improvement
    KOL Index score: 10712

    OBJECTIVES: High anxiety sensitivity predicts poor smoking cessation outcomes. Aerobic exercise reduces anxiety sensitivity and aspects of the risk conferred by anxiety sensitivity. In the current study, we examined whether exercise can aid smoking cessation in adults with high anxiety sensitivity.

    METHODS: Participants were sedentary and low-activity adult daily smokers (n = 136) with elevated prescreen anxiety sensitivity. Participants received 15 weeks of standard smoking cessation ...

    Also Ranks for: Anxiety Sensitivity |  smoking cessation |  15 weeks |  exercise therapy |  cognitive behavioral
    KOL Index score: 10530

    OBJECTIVE: Threat-related attention bias figures prominently in contemporary accounts of the maintenance of anxiety disorders, yet longitudinal intervention research relating attention bias to anxiety symptom severity is limited. Capitalizing on recent advances in the conceptualization and measurement of attention bias, we aimed to examine the relation between attention bias, indexed using trial-level bias scores (TLBSs) to quantify temporal dynamics reflecting dysregulation of ...

    Also Ranks for: Attention Bias |  social anxiety |  temporal dynamics |  therapy cbt |  cognitive behavioral
    KOL Index score: 10503

    CONTEXT: Social anxiety disorder (SAD) is common and debilitating. Although exposure therapy is one of the most effective forms of psychotherapy for this disorder, many patients remain symptomatic. Fear reduction in exposure therapy is similar to extinction learning, and early clinical data with specific phobias suggest that the treatment effects of exposure therapy for SAD may be enhanced with d-cycloserine, an agonist at the glutamatergic N-methyl-d-aspartate receptor.

    OBJECTIVE: To ...

    Also Ranks for: Exposure Therapy |  social anxiety |  treatment session |  extinction learning |  specific phobias
    KOL Index score: 10437

    BACKGROUND: Exposure therapy is an established learning-based intervention for the treatment of anxiety disorders with an average response rate of nearly 50%, leaving room for improvement. Emerging strategies to enhance exposure therapy in humans and fear extinction retention in animal models are primarily pharmacological. These approaches are limited as many patients report preferring non-pharmacological approaches in therapy. With general cognitive enhancement effects, exercise has ...

    Also Ranks for: Fear Extinction |  exposure therapy |  acute exercise |  anxiety disorders |  animal rats
    KOL Index score: 10260

    Pharmacotherapy is an effective treatment for generalized anxiety disorder (GAD), but few studies have examined the nature of decline of anxiety and depression during pharmacotherapy for GAD and even fewer studies have examined predictors of symptom decline. This study examined the decline in symptoms of anxiety and depression in patients with GAD during a 6-week open trial of fluoxetine. Growth curve analyses indicated that pharmacotherapy with fluoxetine led to significant declines in ...

    Also Ranks for: Anxiety Sensitivity |  disorder gad |  depressive symptoms |  longitudinal studies |  uptake inhibitors
    KOL Index score: 10102

    BACKGROUND: Evidence suggests that comorbid depression influences the outcome of cognitive-behavioral treatment for patients presenting with social phobia. Little is known, however, about the influence of comorbid social phobia on the response to cognitive therapy (CT) for depression among adults presenting with recurrent major depressive disorder (MDD). These analyses seek to clarify this relationship.

    METHODS: Patients (N=156) with recurrent DSM-IV MDD entered CT (20% also met DSM-IV ...

    Also Ranks for: Social Phobia |  cognitive therapy |  depressive symptoms |  depression anxiety |  patients mdd
    KOL Index score: 10037

    OBJECTIVE: Preclinical studies have shown that low-dose methylene blue increases mitochondrial cytochrome oxidase activity in the brain and improves memory retention after learning tasks, including fear extinction. The authors report on the first controlled experiment to examine the memory-enhancing effects of posttraining methylene blue administration on retention of fear extinction and contextual memory following fear extinction training.

    METHOD: Adult participants displaying marked ...

    Also Ranks for: Methylene Blue |  fear extinction |  memory retention |  adult participants |  exposure session
    KOL Index score: 9902

    OBJECTIVE: Among people living with HIV, cigarette smoking rates are higher than among the general population, and anxiety, depression, and their disorders are common and associated with smoking and poorer outcomes during cessation. This study evaluated the efficacy of an integrated smoking cessation intervention, developed to target anxiety, depression, and smoking cessation concurrently among people living with HIV.

    METHOD: Smokers living with HIV who reported at least moderate ...

    Also Ranks for: Smoking Cessation |  integrated treatment |  people living |  anxiety depression |  cognitive behavioral therapy


    Jasper A J Smits: Influence Statistics

    Sample of concepts for which Jasper A J Smits is among the top experts in the world.
    Concept World rank
    aggregated bias scores #1
    cbt size #1
    participants 39 adults #1
    retention fear extinction #1
    qidssr hrsd scores #1
    prescriptive variables conscientiousness #1
    positivityapproach training #1
    degree extinction learning #1
    week sham abmt #1
    gad trial #1
    blue fear #1
    gad potential #1
    recurrent dsmiv mdd #1
    imagined feared stimulus #1
    assignment ptsd #1
    symptom severity cbt #1
    169 participants #1
    efficacy depressed adults #1
    agoraphobia community #1
    nextday exercise #1
    cognitive mechanisms links #1
    antimetabolites cycloserine #1
    exposure therapy outcomes #1
    qidssr secondary outcomes #1
    advantage exercise #1
    attention bias cbt #1
    reinforcement maladaptive behaviors #1
    active imaginal #1
    participant chapter #1
    fear reduction reduction #1
    role hpgaxis #1
    ocd inpatient treatment #1
    theories constructivism #1
    dissemination cbt #1
    dcs effects degree #1
    hedges cbt #1
    socially avoidant behavior #1
    imaginal treatment #1
    15min post stressor #1
    response growing support #1
    studies hedgess #1
    improvements eatingdisorder symptoms #1
    selfefficacy depressive symptoms #1
    nontraining chamber #1
    disorders combined #1
    social psychometrics severity #1
    enhance cognitive #1
    perceived stress stressor #1
    posttraining methylene #1
    psychologic fear feedback #1

    Key People For Anxiety Sensitivity

    Top KOLs in the world
    Richard J McNally
    anxiety sensitivity panic disorder childhood sexual abuse
    S Martin Taylor
    anxiety sensitivity panic disorder dysfunctional beliefs
    Norman Bradley Schmidt
    anxiety sensitivity panic disorder emotion dysregulation
    Sherry H Stewart H Stewart
    anxiety sensitivity drinking motives alcohol problems
    Rolf A Peterson
    anxiety sensitivity social support behavioral compliance
    Brian James Cox
    anxiety disorders panic disorder social phobia

    Jasper A J Smits:Expert Impact

    Concepts for whichJasper A J Smitshas direct influence:Anxiety sensitivity,  Exposure therapy,  Panic disorder,  Anxiety disorders,  Smoking cessation,  Depressive symptoms,  Social anxiety disorder,  Physical activity.

    Jasper A J Smits:KOL impact

    Concepts related to the work of other authors for whichfor which Jasper A J Smits has influence:Anxiety disorders,  Physical activity,  Panic disorder,  Mental health,  Exposure therapy,  Depressive symptoms,  Fear extinction.



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