Neale R Towers: Influence Statistics

Neale R Towers

Neale R Towers

27 Mansel Avenue, Hamilton 3216, New ZealandView further author information | AgResearch Ruakura, Private Bag 3123, Hamilton 3240, New Zealand | AgResearch Ltd, Ruakura ...

Neale R Towers: Expert Impact

Concepts for which Neale R Towers has direct influence: New zealand , Facial eczema , Romney sheep , Sporidesmin metabolites , Catalase gene , Facial eczema fe , Dairy cattle .

Neale R Towers: KOL impact

Concepts related to the work of other authors for which for which Neale R Towers has influence: Domoic acid , New zealand , Marine toxins , Facial eczema , Ryegrass staggers , Liquid chromatography , Toxin production .

KOL Resume for Neale R Towers

Year
2017

27 Mansel Avenue, Hamilton 3216, New ZealandView further author information

2008

AgResearch Ruakura, Private Bag 3123, Hamilton 3240, New Zealand

2004

AgResearch Ltd, Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand

2003

Marine Biotoxins Program, Center for Coastal Environmental Health and Biomolecular Research, National Oceanic and Atmospheric Administration, National Ocean Service, Charleston, South Carolina 29412, USA.

2001

AgResearch Ruakura, Toxinology and Food Safety Group, Private Bag 3123, East St, Hamilton, New Zealand

1998

Toxinology and Food Safety Research, AgResearch Ruakura, Private Bag 3123, Hamilton, New Zealand

AgResearch , Ruakura Agricultural Research Centre , East Street, Private Bag 3123, Hamilton , 2001 ,

1997

New Zealand Pastoral Agricultural Research Institute Ltd, Ruakura Research Centre, Hamilton, New Zealand

1996

New Zealand Pastoral Agriculture Research Institute Ltd., Ruakura Agricultural Research Centre, Private Bag 3123, Hamilton, New Zealand, National Chemical Residues Analytical Laboratory, MAF, Wallaceville Animal Research Centre, Box 40063, Upper Hutt, New Zealand, and Chemistry Department, The University of Waikato, Private Bag 3105, Hamilton, New Zealand

1995

AgResearch, Ruakura Agricultural Research Centre, Private Bag 3123, Hamilton, New Zealand

1994

Mycotoxin Research Group, AgResearch, Ruakura Agricultural Research Centre, Hamilton, New Zealand

Fungal and Plant Toxin Group , AgResearch, Ruakura Agricultural Centre , Private Bag 3123, Hamilton,

1993

AgResearch, Ruakura Agricultural Centre, Hamilton, New Zealand

1992

Ministry of Agriculture and Fisheries. Ruakura Agricultural Research Centre, Hamilton New Zealand

Prominent publications by Neale R Towers

KOL-Index: 9232 . Genetic selection foror against resistance to the mycotoxicosis, facial eczema (FE), was begun in a Romney flock in 1975. Randomly selected ewes were mated with rams which had been previously identified by progeny testing as resistant (R) or susceptible (S) to FE. In subsequent years (until 1982), the same ewes and their daughters were again mated within flock to progeny-tested rams. From ...
Known for Facial Eczema | Performance Testing | Romney Flock | Liver Damage
KOL-Index: 8088 . The acute toxicity of the phycotoxin gymnodimine to female Swiss mice by intraperitoneal injection and by oral administration has been determined. Gymnodimine was highly toxic by injection, the LD50 being only 96 microg/kg. Animals either died within 10 min of injection or made a full recovery with no perceptible long-term effects. Gymnodimine was also toxic after oral administration by ...
Known for Acute Toxicity | Oral Administration | 3ring Hydrocarbons | Intraperitoneal Injection
KOL-Index: 8060 . Genetic selection for or against susceptibility to facial eczema (FE) was begun in Romney sheep in 1975, with the establishment of a resistant (R) selection flock, a susceptible (S) selection flock, and later a control (C) flock. For all but the initial years, rams were identified by performance testing with a sporidesmin challenge, ranking them on relative elevation of the liver enzyme, ...
Known for Romney Sheep | Facial Eczema | Dose Rate | Liver Enzyme
KOL-Index: 7424 . We have developed a simple and effective method for isolating pectenotoxin-2 (PTX-2) from Dinophysis cells collected from a natural bloom. A two-step extraction procedure followed by two column chromatography steps produced PTX-2 in high purity suitable for use as an analytical standard and for toxicological studies. Incubation of purified PTX-2 with the supernatant from ultracentrifuged ...
Known for Seco Acid | Dinophysis Acuta | 5000 Microg | Pectenotoxin2 Ptx2
KOL-Index: 7107 . We developed a radioimmunoassay (RIA) using a sheep anti-brevetoxin antiserum to evaluate detection of brevetoxin on blood collection cards from mice treated with the brevetoxin congener PbTx-3. The RIA has high affinity for PbTx-3 [half-maximal effective concentration (EC(50)) +/- SE = 1.2 +/- 0.2 nM; n = 10] and recognizes both type 1 and type 2 brevetoxins, but not ciguatoxin. Direct ...
Known for Blood Collection Cards | Brevetoxin Levels | Exposure Mice | Radioimmunoassay Ria
KOL-Index: 7088 . Cyanobacteria (blue-green algae) (e.g., Microcystis and Nodularia spp.) capable of producing toxic peptides are found in fresh and brackish water worldwide. These toxins include the microcystin (MC) heptapeptides (>60 congeners) and the nodularin pentapeptides (ca. 5 congeners). Cyanobacterial cyclic peptide toxins are harmful to man, other mammals, birds, and fish. Acute exposure to high ...
Known for Detection Microcystins | Drinking Water | Toxic Peptides | Acute Exposure
KOL-Index: 6739 . Five Finnish Landrace (F) rams and 10 Romney (R) rams were mated with F and R ewes to generate F × F, F? × R?, and R × R lambs. These lambs were compared for their susceptibility to an oral challenge with sporidesmin, the toxin causing facial eczema. All lambs of 17.0 kg or above were dosed at 4 months of age with sporidesmin (0.15 mg/kg liveweight). Resistance or susceptibility was ...
Known for × × Lambs | Sporidesmin Challenge | Facial Eczema | Liver Injury
KOL-Index: 6513 . Polyclonal antibodies were produced for the development of competitive enzyme-linked immunoassays for use in quantifying yessotoxins in shellfish, algal cells, and culture supernatants. Immunizing and plate coating antigens were prepared by derivatization of yessotoxin either by ozonolysis or bromination and conjugation to proteins. Two assays that were the most sensitive for yessotoxin ...
Known for Linked Immunosorbent | Yessotoxin Analogues | European Commission | Broad Specificity
KOL-Index: 6400 . Ovine antibodies raised against conjugates linked through the secondary amino group of domoic acid (1) were used, together with activated-ester-derived conjugates of domoic acid (DA) as the plate coater, to develop a robust indirect competitive enzyme-linked immunosorbent assay (cELISA) for DA in shellfish and seawater. The ELISA was used to analyze shellfish samples for DA, and was ...
Known for Domoic Acid | Seawater Elisa | Shellfish Samples | Polyclonal Antibodies
KOL-Index: 5841 . Mating and lambing data from the Romney facial eczema (FE) selection flocks at Ruakura were collated in order to study the effects of FE susceptibility on subsequent reproduction. The data analysed were ewe fertility (numbers of ewes lambing, as a % of those joined), litter size at birth, and postnatal lamb survival. Two of the flocks, selected for resistance (R) or susceptibility (S) to ...
Known for Romney Sheep | Facial Eczema | Resistance Susceptibility | Litter Size
KOL-Index: 5829 . Facial eczema (FE) is a hepatogenous photosensitization disease of ruminant animals, particularly in sheep which vary widely in their susceptibility to the disease. The liver damage is caused by the mycotoxin, sporidesmin. There is evidence that the toxicity of sporidesmin is due to its ability to generate 'active oxygen' species. We evaluated the catalase gene, which encodes an enzyme ...
Known for Facial Eczema | Differences Allele Frequencies | Liver Damage | Genetic Lines
KOL-Index: 5574 . Facial eczema (FE) is a secondary photosensitization disease arising from liver cirrhosis caused by the mycotoxin sporidesmin. The disease affects sheep, cattle, deer and goats, and costs the New Zealand sheep industry alone an estimated NZ$63M annually. A long-term sustainable solution to this century-old FE problem is to breed for disease-resistant animals by marker-assisted selection. ...
Known for Facial Eczema | Quantitative Trait Loci | Mycotoxin Sporidesmin | Romney Sheep
KOL-Index: 5545 . Mycotoxicoses are some of the most important diseases of animals grazing pastures in New Zealand, especially in northern areas where the disease, facial eczema, occurs. New Zealand scientists have led the world in research on facial eczema and endophyte-related diseases associated with tremoring. Facial eczema (pithomycotoxicosis) was one of the first mycotoxicoses to be studied ...
Known for New Zealand | Grazing Animals | Facial Eczema | Fusarium Spp
KOL-Index: 5080 . Ten East Friesian (EF), eight Romney Control (RC), and two Romney Facial Eczema Resistant (RR) rams were mated with Romney (R) ewes to generate EF × R, RC × R, and RR × R lambs. These lambs were compared for their susceptibility to an oral challenge with sporidesmin, the toxin causing facial eczema. All lambs of 16.0 kg or above (average weight 21.3 kg) were dosed after weaning with ...
Known for Facial Eczema | Lambs Sired | Liver Injury | Clinical Cases

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27 Mansel Avenue, Hamilton 3216, New ZealandView further author information | AgResearch Ruakura, Private Bag 3123, Hamilton 3240, New Zealand | AgResearch Ltd, Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand | AgResearch Ltd., Ruaku