Sin H Phua: Influence Statistics

Sin H Phua

Sin H Phua

153 Evans Street, Dunedin 9010, New ZealandView further author information | AgResearch Invermay, Private Bag 50034, Mosgiel 9053, New Zealand | AgResearch Invermay Mosgiel ...

Sin H Phua: Expert Impact

Concepts for which Sin H Phua has direct influence: New zealand , Facial eczema , Zinc protection , Sporidesmin toxicity , Abcg2 gene , Sheep chromosome , Xenobiotic exposure .

Sin H Phua: KOL impact

Concepts related to the work of other authors for which for which Sin H Phua has influence: Mitochondrial dna , Domestic sheep , Ovis aries , Facial eczema , Control region , New zealand , Molecular ecology .

KOL Resume for Sin H Phua


153 Evans Street, Dunedin 9010, New ZealandView further author information


AgResearch Invermay, Private Bag 50034, Mosgiel 9053, New Zealand


AgResearch Invermay Mosgiel New Zealand


AgResearch Ltd., New Zealand


AgResearch Molecular Biology Unit, Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand


AgResearch Molecular Biology Unit, Department of Biochemistry, University of Otago, P.O. Box 56, Dunedin, New Zealand


AgResearch Molecular Biology Unit, Department of Biochemistry, University of Otago, Dunedin, New Zealand


Department of Biochemistry, University of Otago, Dunedin, New Zealand.


AgResearch Molecular Biology Unit, Department of Biochemistry , University of Otago , Dunedin


AqResearch, Grasslands Research Centre, Private Bag 11008, Palmerston North, New Zealand


Gene Mapping Unit, AgResearch Grasslands, Private Bag 11008, Palmerston North, New Zealand.

AgResearch Grasslands Research Centre, Private Bag 11008, Palmerston North, New Zealand


DSIR Grasslands, Private Bag, Palmerston North, New Zealand

Prominent publications by Sin H Phua

KOL-Index: 7689 . Facial eczema (FE) is a hepatogenous mycotoxicosis in sheep caused by the fungal toxin sporidesmin. Resistance to FE is a multigenic trait. To identify QTL associated with this trait, a scan of ovine chromosomes was implemented. In addition, ABCG2 was investigated as a possible positional candidate gene because of its sequence homology to the yeast PDR5 protein and its functional role as a ...
Known for Abcg2 Gene | Facial Eczema | Quantitative Trait | Sheep Diseases
KOL-Index: 6369 . AIM: To use an established high through-put genotyping procedure to gain an estimate of the frequency of alleles of the prion protein (PrP) gene in some common sheep breeds in New Zealand. METHODS: Using a genotyping procedure based on matrix-assisted laser desorption ionisation-time of flight (MALDI-TOF), DNA samples from 3,024 sheep from New Zealand, including breeds such as Romney, ...
Known for New Zealand | Prion Protein | Sheep Breeds | Scrapie Genotypes
KOL-Index: 5829 . Facial eczema (FE) is a hepatogenous photosensitization disease of ruminant animals, particularly in sheep which vary widely in their susceptibility to the disease. The liver damage is caused by the mycotoxin, sporidesmin. There is evidence that the toxicity of sporidesmin is due to its ability to generate 'active oxygen' species. We evaluated the catalase gene, which encodes an enzyme ...
Known for Facial Eczema | Differences Allele Frequencies | Liver Damage | Genetic Lines
KOL-Index: 5574 . Facial eczema (FE) is a secondary photosensitization disease arising from liver cirrhosis caused by the mycotoxin sporidesmin. The disease affects sheep, cattle, deer and goats, and costs the New Zealand sheep industry alone an estimated NZ$63M annually. A long-term sustainable solution to this century-old FE problem is to breed for disease-resistant animals by marker-assisted selection. ...
Known for Facial Eczema | Quantitative Trait Loci | Mycotoxin Sporidesmin | Romney Sheep
KOL-Index: 5416 . The DNA sequences of the control region of the mitochondrial genome of fifty unrelated sheep were determined in order to ascertain the extent and distribution of its variability. A consensus sequence was derived, and 1081 differences from it were observed amongst the fifty animals. Some constant groups of differences were observed that were held in common by a number of animals, which thus ...
Known for Control Region | Mitochondrial Genome | Dna Sequences | Tandem Repeats
KOL-Index: 4398 . Sporidesmin is an epidithiodioxopiperazine mycotoxin secreted by the saprophytic fungus Pithomyces chartarum. Ingestion of sporidesmin by ruminants grazing on the saprophyte infested pasture causes severe liver and bile duct damage leading to secondary photosensitisation. Zinc supplementation is used as an effective prophylaxis against sporidesmin toxicity in ruminants, however, the ...
Known for Hepg2 Cells | Zinc Cell | Lactate Dehydrogenase | Protection Sporidesmin
KOL-Index: 4167 . Romney sheep have been evaluated for resistance to facial eczema (FE) using a process which involves challenge with the FE toxin, sporidesmin, and they have been bred in selection lines for increased resistance (R) or susceptibility (S) to FE. There is evidence that sporidesmin exerts its toxic effects by generating reactive oxygen species, and protection can be afforded by a number of ...
Known for Facial Eczema | Fe Resistance | Romney Sheep | Glutathione Gsh
KOL-Index: 3525 . Facial eczema (FE) is a costly problem to New Zealand pastoral agriculture, and has a detrimental impact on animal wellbeing. Incidence and severity of the disease can be reduced by grazing management and zinc prophylaxis. An additional strategy is to breed animals that are genetically resistant to intoxication with sporidesmin, the causative mycotoxin. This review summarises research ...
Known for New Zealand | Facial Eczema | Sheep Cattle | Impact Animal
KOL-Index: 3468 . Mitochondrial DNA (mtDNA) is a widely employed molecular tool in phylogeography, in the inference of human evolutionary history, in dating the domestication of livestock and in forensic science. In humans and other vertebrates the popularity of mtDNA can be partially attributed to an assumption of strict maternal inheritance, such that there is no recombination between mitochondrial ...
Known for Mitochondrial Dna | Sequence Analysis | Genetic Variation | Inheritance Recombination
KOL-Index: 3096 . A DNA repeat element, revealed initially by digestion of horse DNA with TaqI, was cloned and characterized by Southern and in situ hybridization studies and nucleotide sequencing. The clone, e4/1, consisted of 32 tandem reiteration of a unit repeat of 21-22 bp, and produced multilocus DNA fingerprinting profiles that were useful for parentage analysis in horses. The tandem repeat element ...
Known for Dna Sequence | Situ Hybridization | Horse Chromosomes | Nucleic Acid
KOL-Index: 2371 . Long term divergent selection lines for resistance and susceptibility to two diseases of sheep were utilized to look for disease resistance QTL. The diseases were facial eczema, which is caused by a saprophytic fungus of pasture which produces toxic spores, and gastro‐intestinal parasitic nematodes. Sires derived from reciprocal crosses of the lines were mated with unrelated dams to ...
Known for Diseases Sheep | Selection Lines | Parasitic Nematodes | Resistance Susceptibility
KOL-Index: 2171 . Facial eczema (FE) is a hepato-mycotoxicosis found mainly in New Zealand sheep and cattle. When genetics was found to be a factor in FE susceptibility, resistant and susceptible selection lines of Romney sheep were established to enable further investigations of this disease trait. Using the Illumina OvineSNP50 BeadChip, we conducted a selection-sweep experiment on these FE genetic lines. ...
Known for Facial Eczema | Genetic Sheep | Illumina Ovinesnp50 Beadchip | Single Nucleotide
KOL-Index: 2027 . Pithomycotoxicosis, more commonly known as facial eczema (FE), is a liver disease that occurs predominantly in New Zealand because of its toxigenic Pithomyces chartarum strains. The first reported case was in sheep in 1887. Since the 1930s, a number of studies have been conducted in an attempt to mitigate the problems FE has on the sheep and dairy industries. The research in these studies ...
Known for Genomic Selection | New Zealand | Disease Tolerance | Array Sequence
KOL-Index: 1953 . The first ruminant multiple drug resistance gene (MDR1) has been cloned and sequenced from sheep. Sequence data revealed the sheep MDR1 gene to have high sequence and structural similarity to other characterized MDR proteins from humans and rodents. A restriction fragment length polymorphism was discovered using the EcoRI enzyme and used to map the MDR1 gene to sheep chromosome 4. Physical ...
Known for Atp Binding | Molecular Dna | Multidrug Resistance | Gene Sequence

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153 Evans Street, Dunedin 9010, New ZealandView further author information | AgResearch Invermay, Private Bag 50034, Mosgiel 9053, New Zealand | AgResearch Invermay Mosgiel New Zealand | AgResearch Ltd., New Zealand | AgResearch Molecular Biology Uni