Arn M. J. M. van den Maagdenberg

Arn M. J. M. van den Maagdenberg

From The Departments Of Neurology (I.d.b., A.h.s., R.z., I.v.d.s., A.m.j.m.v.d.m., M.d.f., G.m.t.), Human Genetics (A.m.j.m.v.d.m.), And Internal Medicine (E.j.p.d.k.), Leiden ...

Direct Impact

Concepts for which Arn M J M van has direct influence:

familial hemiplegic migraine
cluster headache
cortical spreading depression
p2x3 receptors
cacna1a gene
trigeminal sensory neurons
subarachnoid hemorrhage

External impact

Concepts related to the work of other authors for which Arn M J M van has influence:

breast cancer
major depression
familial hemiplegic migraine
cluster headache
subarachnoid hemorrhage
2 diabetes
asian ancestry

Prominent publications by Arn M. J. M. van den Maagdenberg

KOL-Index: 221 PURPOSE OF REVIEW: Genome-wide association studies (GWAS) have revealed over a dozen genetic factors robustly associated with the common forms of migraine. The identification of these factors, the implicated biological mechanisms, and whether they are of use in basic research and clinic practice will be discussed. RECENT FINDINGS: Several GWAS have been performed in recent years. New ...

Migraine


[ PUBLICATION ]
KOL-Index: 128 Migraine is a common, chronic, disorder that is typically characterized by recurrent disabling attacks of headache and accompanying symptoms, including aura. The aetiology is multifactorial with rare monogenic variants. Depression, epilepsy, stroke and myocardial infarction are comorbid diseases. Spreading depolarization probably causes aura and possibly also triggers trigeminal sensory ...
Known for
Moderate Severe Attacks | Depolarization | Analgesics | Cgrp Receptor Antagonists
KOL-Index: 87 Migraine and major depressive disorder (MDD) are common brain disorders that frequently co-occur. Despite epidemiological evidence that migraine and MDD share a genetic basis, their overlap at the molecular genetic level has not been thoroughly investigated. Using single-nucleotide polymorphism (SNP) and gene-based analysis of genome-wide association study (GWAS) genotype data, we found ...
KOL-Index: 73 Aarno Palotie and colleagues present results of a large genome-wide association study of migraine. They identified significant associations at 38 distinct loci and found enrichment for genes expressed in vascular and smooth muscle tissues.
Known for
Loci Migraine
KOL-Index: 65 BACKGROUND: Pathogenic variants of GNB5 encoding the β5 subunit of the guanine nucleotide-binding protein cause IDDCA syndrome, an autosomal recessive neurodevelopmental disorder associated with cognitive disability and cardiac arrhythmia, particularly severe bradycardia. METHODS: We used echocardiography and telemetric ECG recordings to investigate consequences of Gnb5 loss in mouse. ...
Known for
Pathogenic | Protein Iddca | Telemetric Ecg Recordings | Cardiac Function
KOL-Index: 61 Migraine is a common brain disorder with a large genetic component. Of the two main migraine types, migraine with aura and migraine without aura, the genetic underpinning in the former is least understood. Given the evidence from epidemiological studies in cohorts and families that the genetic contribution is highest in migraine with aura, this seems paradoxical. Various genetic approaches ...
Known for
Genome-Wide Significance | Genetic Component | Hypothesis-Free Manner | So-Called Candidate Gene Associations
KOL-Index: 60 Metabolite quantitative traits carry great promise for epidemiological studies, and their genetic background has been addressed using Genome-Wide Association Studies (GWAS). Thus far, the role of less common variants has not been exhaustively studied. Here, we set out a GWAS for metabolite quantitative traits in serum, followed by exome sequence analysis to zoom in on putative causal ...
Known for
Genes Cps1 | Linear Mixed Models | Valine | Erasmus Rucphen Erf
KOL-Index: 53 White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter ...
Known for
High-Risk | Larger Wmh-Volume | Potential | Genetically-Informed Prioritization
KOL-Index: 48 The identification of the first genes associated with idiopathic epilepsy has been an important breakthrough in the field of epilepsy research. In almost all cases these genes were found to encode components of voltage- or ligand-gated ion channels or functionally related structures. For many other idiopathic syndromes, there is linkage evidence to one or more chromosomes, but the genes have ...
Known for
Epilepsies Childhood | Voltage- Ligand-Gated Ion Channels | Genetic Idiopathic
KOL-Index: 47 BACKGROUND: Neuroinflammation has an important role in the pathophysiology of migraine, which is a complex neuro-glio-vascular disorder. The main aim of this review is to highlight findings of cortical spreading depolarization (CSD)-induced neuroinflammatory signaling in brain parenchyma from the inflammasome perspective. In addition, we discuss the limited data of the contribution of ...
Known for
Signaling Brain | Inflammatory Pain Conditions | Activation Pain | The Inflammasome

From the Departments of Neurology (I.d.B., A.H.S., R.Z., I.v.d.S., A.M.J.M.v.d.M., M.D.F., G.M.T.), Human Genetics (A.M.J.M.v.d.M.), and Internal Medicine (E.J.P.d.K.), Leiden University Medical Center, Leiden, the Netherlands; and Center for Clinica

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