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    • Christoph C Lees
    • Christoph C Lees

      Christoph C Lees

      Department of Metabolism, Digestion and Reproduction, Institute of Reproductive and Developmental Biology, Imperial College London, Queen Charlotte's and Chelsea Hospital, ...



      KOL Resume for Christoph C Lees


      Department of Metabolism, Digestion and Reproduction, Institute of Reproductive and Developmental Biology, Imperial College London, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.

      Imperial College London and Head of Fetal Medicine, Imperial College Healthcare NHS Trust, London, UK

      Centre for Fetal Care, Queen Charlotte’s and Chelsea Hospital, London, United Kingdom


      Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Imperial College NHS Trust, London, United Kingdom.

      Women, Children and Clinical Support, Imperial College Healthcare NHS Trust, London, UK

      Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

      Imperial College Healthcare NHS Trust, London, United Kingdom


      Queen Charlotte’s and Chelsea Hospital, Imperial Healthcare NHS Trust, London, UK

      Imperial College Healthcare NHS Trust

      Department of Development and Regeneration, KU Leuven, B ‐ 3000 Leuven, Belgium


      Department of Obstetrics & Gynecology, KU Leuven, Leuven, Belgium

      Imperial College London, London, United Kingdom

      Queen Charlotte's and Chelsea Hospital, London, UK


      Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium

      Centre for Fetal Care, Queen Charlottes and Chelsea Hospital, London, UK.

      Imperial College Healthcare NHS Trust, London, UK; ; Imperial College London, Institute of Reproductive Developmental Biology, London, UK,



      Christoph C Lees: Influence Statistics

      Sample of concepts for which Christoph C Lees is among the top experts in the world.
      Concept World rank
      conventional block histology #1
      estradiol levels decrease #1
      fetal brain hifu #1
      δhpd estimated duration #1
      stv controls #1
      restriction doppler #1
      clinical new wearable #1
      maternal cardiovascular function #1
      alert bell #1
      new considerations relation #1
      063 mm conclusion #1
      rho0110 p0393 #1
      labor room accuracy #1
      rendering technology #1
      maximum minimum measurements #1
      head descent assessment #1
      epidural analgesia pregnancies #1
      sixtyfour 42 #1
      copyright isuog #1
      maternal characteristics objective #1
      pas0 3 #1
      z0055 #1
      placental vascular flow #1
      digital representation labour #1
      pulsatility cardiac #1
      tramline sign #1
      hifu sham exposures #1
      objective expression caput #1
      pas0pas3 #1
      individual fetal health #1
      pas0 pas1 #1
      perinatal postmortems parents #1
      digital ves difference #1
      low stv controls #1
      condensed abstract health #1
      questionnaire postmortem #1
      women ostensibly lowrisk #1
      trainee obstetricians #1
      involvement fetal palate #1
      differences neonatal survival #1
      ssd 096 95 #1
      targeted percutaneous biopsies #1
      vivo placental vessels #1
      obstetrics specificity ultrasonography #1
      obstetrics medical ultrasonography #1
      pregnancies uteroplacental insufficiency #1
      40 mm hpd #1
      50 35129 minutes #1
      maternal haemodynamics studies #1
      circumference umbilical #1


      Prominent publications by Christoph C Lees

      KOL-Index: 21507

      BACKGROUND: Preeclampsia and fetal growth restriction are considered to be placentally mediated disorders. The clinical manifestations are widely held to relate to gestation age at onset with early- and late-onset preeclampsia considered to be phenotypically distinct. Recent studies have reported conflicting findings in relation to cardiovascular function, and in particular cardiac output, in preeclampsia and fetal growth restriction.

      OBJECTIVE: We conducted this study to examine the ...

      Known for Fetal Growth Restriction | Cardiac Output | Preeclampsia Gestational Age | Vascular Resistance | Pregnancy Trimester
      KOL-Index: 16080

      BACKGROUND: Safe management of the second stage of labor is of great importance. Unnecessary interventions should be avoided and correct timing of interventions should be focused. Ultrasound assessment of fetal position and station has a potential to improve the precision in diagnosing and managing prolonged or arrested labors. The decision to perform vacuum delivery is traditionally based on subjective assessment by digital vaginal examination and clinical expertise and there is ...

      Known for Headperineum Distance | Vacuum Delivery | Prolonged Stage | Fetal Position | Prospective Cohort Study
      KOL-Index: 16013

      BACKGROUND: Reduced fetal middle cerebral artery Doppler impedance is associated with hypoxemia in fetal growth restriction. It remains unclear as to whether this finding could be useful in timing delivery, especially in the third trimester. In this regard there is a paucity of evidence from prospective studies.

      OBJECTIVES: The aim of this study was to determine whether there is an association between middle cerebral artery Doppler impedance and its ratio with the umbilical artery in ...

      Known for Fetal Growth Restriction | Middle Cerebral | Doppler Ultrasonography | Cerebroplacental Ratio | 95 Confidence Interval
      KOL-Index: 15626

      BACKGROUND: No consensus exists for the best way to monitor and when to trigger delivery in mothers of babies with fetal growth restriction. We aimed to assess whether changes in the fetal ductus venosus Doppler waveform (DV) could be used as indications for delivery instead of cardiotocography short-term variation (STV).

      METHODS: In this prospective, European multicentre, unblinded, randomised study, we included women with singleton fetuses at 26-32 weeks of gestation who had very ...

      Known for 2 Years | Ctg Stv | Fetal Growth | Randomised Trial | Women Delivery
      KOL-Index: 15564

      OBJECTIVES: To develop a prenatal ultrasound staging system for placenta accreta spectrum (PAS) disorders in women with placenta previa and to evaluate its association with surgical outcome, placental invasion and the clinical staging system for PAS disorders proposed by the International Federation of Gynecology and Obstetrics (FIGO).

      METHODS: This was a secondary retrospective analysis of prospectively collected data from women with placenta previa. We classified women according to the ...

      Known for Placenta Previa | Pas1 Pas2 | Pas3 Women | Prenatal Ultrasound | Surgical Outcome
      KOL-Index: 15393

      OBJECTIVES: Few data exist for counseling and perinatal management of women after an antenatal diagnosis of early-onset fetal growth restriction. Yet, the consequences of preterm delivery and its attendant morbidity for both mother and baby are far reaching. The objective of this study was to describe perinatal morbidity and mortality following early-onset fetal growth restriction based on time of antenatal diagnosis and delivery.

      METHODS: We report cohort outcomes for a prospective ...

      Known for Perinatal Morbidity | Fetal Flow | Randomized Umbilical | Gestational Age Delivery | Growth Restriction
      KOL-Index: 15158

      OBJECTIVE: To investigate whether head-perineum distance (HPD) measured by transperineal ultrasound is predictive of vaginal delivery and time remaining in labor in nulliparous women with prolonged first stage of labor and to compare the predictive value with that of angle of progression (AoP).

      METHODS: This was a prospective observational study at Stavanger University Hospital, Norway and Addenbrooke's Hospital, Cambridge, UK from January 2012 to April 2013, of nulliparous women with ...

      Known for Vaginal Delivery | Hpd Aop | Sonographic Prediction | Prolonged Labor | Nulliparous Women
      KOL-Index: 14357

      OBJECTIVE: To estimate the value of screening for preeclampsia and fetal growth restriction by performing color Doppler assessment of uterine arteries at 23 weeks' gestation in predicting adverse pregnancy outcome.

      METHODS: Women with singleton pregnancies who attended routine ultrasonography at 23 weeks had color Doppler uterine artery imaging. Bilateral uterine artery notches were noted and left and right uterine artery pulsatility indices (PI) were measured. A mean PI of more than ...

      Known for Uterine Arteries | 23 Weeks | Pregnancy Complications | Color Doppler | Bilateral Notches
      KOL-Index: 14115

      BACKGROUND: The position of the placental cord insertion, its shape and cord coiling are thought to be associated with perinatal outcome. This study derives indices describing the relationship of cord insertion to the placental centre, the shape of the placenta and cord coiling in placentas from unselected term pregnancies. Further, we investigate these indices in pregnancies affected by pre-eclampsia (PET), pregnancy induced hypertension (PIH), gestational diabetes mellitus (GDM) and ...

      Known for Cord Coiling | Placental Shape | Gestational Age Sga | Newborn Infant | Pih Gdm
      KOL-Index: 13659

      OBJECTIVE: Few large cohort studies have reported data on maternal, fetal, perinatal and neonatal outcomes associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy. We report the outcome of infected pregnancies from a collaboration formed early during the pandemic between the investigators of two registries, the UK and Global Pregnancy and Neonatal outcomes in COVID-19 (PAN-COVID) study and the American Academy of Pediatrics (AAP) Section on ...

      Known for Neonatal Outcomes | Infection Pregnancy | Maternal Death | Preterm Delivery | Confirmed Sars
      KOL-Index: 12964

      BACKGROUND: In trichorionic pregnancies, fetal reduction from three to two lowers the risk of severe preterm delivery, but provides no advantage in survival. Similar data for dichorionic triamniotic (DCTA) triplets is not readily available.

      OBJECTIVES: To document the natural history of DCTA triplets and the effect of reduction on the risk of miscarriage and severe preterm delivery, compared with expectant management.

      SEARCH STRATEGY: Systematic search on MEDLINE, EMBASE, and the ...

      Known for Expectant Management | Fetal Reduction | 95 Dcta Triplets | Risk Miscarriage | Dichorionic Triplet Pregnancies
      KOL-Index: 12889

      OBJECTIVES: Following perinatal death, organ weights at autopsy may provide evidence of growth restriction and pulmonary hypoplasia. Whilst postmortem magnetic resonance imaging (MRI) may provide comparable information to autopsy about structural abnormalities, its ability to provide reproducible data about organ size has yet to be determined. We examined the feasibility of using postmortem MRI to provide estimates of organ size and weight.

      METHODS: Twenty-five fetuses of gestational age ...

      Known for Organ Weight | Postmortem Fetal | Magnetic Resonance | Conventional Autopsy | Brain Liver
      KOL-Index: 12598

      OBJECTIVES: To investigate whether, in women with abnormal uterine artery Doppler, platelet volume and function will identify a subgroup of women at increased risk of pre-eclampsia and intrauterine growth restriction and whether in-vitro platelet aggregation precedes the onset of clinical disease.

      DESIGN: Platelet number, volume and aggregation induced by collagen or adenosine 5'-diphosphate were evaluated in 16 non-pregnant controls, 29 pregnant women with normal uterine artery Doppler ...

      Known for Uterine Artery | Platelet Volume | Doppler Ultrasonography | Fetal Growth | Normal Pregnancy
      KOL-Index: 11096

      OBJECTIVES: In the recent TRUFFLE study, it appeared that, in pregnancies complicated by fetal growth restriction (FGR) between 26 and 32 weeks' gestation, monitoring of the fetal ductus venosus (DV) waveform combined with computed cardiotocography (CTG) to determine timing of delivery increased the chance of infant survival without neurological impairment. However, concerns with the interpretation were raised, as DV monitoring appeared to be associated with a non-significant increase in ...

      Known for 32 Weeks | Fetal Growth Restriction | Truffle Study | Adverse Outcome | Heart Rate

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      Christoph C Lees:Expert Impact

      Concepts for whichChristoph C Leeshas direct influence:Fetal growth,  Fetal growth restriction,  Doppler ultrasonography,  Gestational age,  Cardiac output,  Growth restriction,  23 weeks,  Cerebral redistribution.

      Christoph C Lees:KOL impact

      Concepts related to the work of other authors for whichfor which Christoph C Lees has influence:Gestational age,  Fetal growth,  Pregnant women,  Nitric oxide,  Uterine artery,  Prenatal diagnosis,  Vasa previa.



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      Department of Metabolism, Digestion and Reproduction, Institute of Reproductive and Developmental Biology, Imperial College London, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom. | Department of

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