• Disease
  • Intracranial
  • Intracranial Pressure
  • Barry M Jones

    Prominent publications by Barry M Jones

    KOL Index score: 11012

    Mutations in the fibroblast growth factor receptor 2 (FGFR2) gene have been identified in Crouzon syndrome, an autosomal dominant condition causing premature fusion of the cranial sutures (craniosynostosis). A mutation in FGFR1 has been established in several families with Pfeiffer syndrome, where craniosynostosis is associated with specific digital abnormalities. We now report point mutations in FGFR2 in seven sporadic Pfeiffer syndrome patients. Six of the seven Pfeiffer syndrome ...

    Also Ranks for: Fgfr2 Gene |  identical mutations |  crouzon syndrome |  type 2 receptors |  fibroblast growth factor
    KOL Index score: 10710

    OBJECT: Heterogeneous mutations in the fibroblast growth factor receptor 2 gene (FGFR2) cause a range of craniosynostosis syndromes. The specificity of the Apert syndrome-affected cranial phenotype reflects its narrow mutational range: 98% of cases of Apert syndrome result from an Ser252Trp or Pro253Arg mutation in the immunoglobulin-like (Ig)IIIa extracellular subdomain of FGFR2. In contrast, a broad range of mutations throughout the extracellular domain of FGFR2 causes the overlapping ...

    Also Ranks for: Fibroblast Growth Factor |  apert syndrome |  type 2 receptors |  fgfr2 fgfr3 |  p253r mutation
    KOL Index score: 10328

    OBJECT: In this study the authors investigated whether patterns of intracranial venous drainage in children with complex craniosynostosis associated with raised intracranial pressure (ICP) were abnormal and, thus, could support the theory that venous hypertension is a major contributor to raised ICP that can lead to impaired visual function or even blindness in these patients.

    METHODS: The authors analyzed the anatomy of intracranial venous drainage as demonstrated in the results of 24 ...

    Also Ranks for: Venous Drainage |  intracranial pressure |  complex craniosynostosis |  authors children |  18 patients patients
    KOL Index score: 9999

    The causative relationship between several of the syndromic forms of craniosynostosis and mutations in the fibroblast growth factor receptor (FGFR) loci is now well established. However, within the group of patients with craniosynostosis, there are several families and sporadic cases whose clinical features differ in variable degrees from the classically described syndromes of craniosynostosis. In this communication we present novel FGFR2 mutations associated with a spectrum of ...

    Also Ranks for: Fibroblast Growth Factor |  craniosynostosis mutations |  type 2 receptors |  sporadic cases |  transmembrane domain
    KOL Index score: 9826

    OBJECTIVE: Critical cellular events at the palatal medial edge epithelium (MEE) occur in unperturbed mammalian palatogenesis, the molecular control of which involves a number of growth factors including transforming growth factor beta 3 (TGF beta 3). Apert syndrome is a monogenic human disorder in which cleft palate has been significantly correlated to the fibroblast growth factor receptor (FGFR) 2-Ser252Trp mutation. We report the relative expression of these genes in human ...

    Also Ranks for: Cleft Palate |  growth factor |  palatal shelf |  tgf beta |  apert syndrome
    KOL Index score: 9373

    BACKGROUND: Raised intracranial pressure is a well-known complication of Apert syndrome. The current policy in the authors' unit is to monitor these patients and only perform surgery when raised intracranial pressure has been diagnosed. The authors present their experience with this protocol, as it allows a more accurate picture of the natural history of raised intracranial pressure in Apert syndrome.

    METHODS: The records of 24 patients, aged between 7 and 14 years, with Apert syndrome ...

    Also Ranks for: Intracranial Pressure |  apert syndrome |  patients raised |  18 months |  5 years
    KOL Index score: 9301

    OBJECTIVE: The beaten copper appearance of the cranium, as well as other cranial radiographic and computed tomographic findings in children with craniosynostosis, is often interpreted by clinicians as evidence of elevated intracranial pressure (ICP). However, a correlation between radiological findings and ICP measurements has not been previously demonstrated, and their usefulness in detecting elevated ICP has not been defined.

    METHODS: To address those issues, 123 children with ...

    Also Ranks for: Intracranial Pressure |  children craniosynostosis |  beaten copper |  computed tomographic |  elevated icp
    KOL Index score: 8952

    Craniosynostosis management partially depends on the detection and treatment of elevated intracranial pressure (ICP). Examination for papilledema is considered to be the most reliable screening method for identifying raised ICP, but its effectiveness has not been defined. One hundred and twenty-two children with craniosynostosis who underwent funduscopic examinations and then Camino ICP monitoring were studied. All eye examinations were performed by an ophthalmologist after ...

    Also Ranks for: Elevated Icp |  raised intracranial |  children craniosynostosis |  papilledema patients |  craniofacial syndromes
    KOL Index score: 8556

    Crouzon syndrome is an autosomal dominant condition causing premature fusion of the cranial sutures (craniosynostosis) and maps to chromosome 10q25–q26. We now present evidence that mutations in the fibroblast growth factor receptor 2 gene (FGFR2) cause Crouzon syndrome. We found SSCP variations in the B exon of FGFR2 in nine unrelated affected individuals as well as complete cosegregation between SSCP variation and disease in three unrelated multigenerational families. In four sporadic ...

    Also Ranks for: Fibroblast Growth Factor |  receptor 2 |  crouzon syndrome |  sporadic cases |  cranial sutures
    KOL Index score: 8133

    OBJECTIVE: To compare visual acuity, optic disc appearance, and transient pattern reversal visual evoked potentials as markers of possible visual dysfunction in children with syndromic craniosynostosis.

    METHODS: Serial visual acuity, optic disc appearance, and pattern reversal visual evoked potential data were recorded in 8 patients with syndromic craniosynostosis before and after cranial vault expansion. The pattern reversal visual evoked potentials were analyzed using linear regression ...

    Also Ranks for: Syndromic Craniosynostosis |  visual function |  patients surgery |  evoked potentials |  pattern reversal

    Endoscopic Brow Lift:

    KOL Index score: 7849

    Since the introduction of endoscopic brow lifting in the mid-1990s, it has become widely accepted as a method for rejuvenation of the upper third of the face. Despite the multitude of brow fixation techniques, there are few long-term studies providing accurate analysis of outcome. The aims of this investigation were to evaluate the long-term objective results of endoscopic brow lifting and to establish whether the technique of fixation altered the longevity of aesthetic outcome. The ...

    Also Ranks for: Endoscopic Brow Lift |  fibrin glue |  brow fixation |  2 patients |  months postoperatively
    KOL Index score: 7758

    Hematoma remains the most common complication of rhytidectomy and can lead to prolonged facial edema and skin necrosis. A number of ancillary procedures have been suggested to reduce hematoma, including dressings, drains, fibrin glue, tumescence, and adrenaline. The aim of this study was to investigate the statistical effect of these parameters on hematoma incidence in a large series of face lifts. Over an initial 6-year period, 678 consecutive face lifts were performed and included in ...

    Also Ranks for: Incidence Hematoma |  cervicofacial rhytidectomy |  fibrin glue |  common complication |  ancillary procedures
    KOL Index score: 7741

    Mutations in the fibroblast growth factor receptor (FGFR) genes 1, 2, and 3 are causal in a number of craniofacial dysostosis syndromes featuring craniosynostosis with basicranial and midfacial deformity. Great clinical variability is displayed in the pathologic phenotypes encountered. To investigate the influence of developmental genetics on clinical diversity in these syndromes, the expression of several genes implicated in their pathology was studied at sequential stages of normal ...

    Also Ranks for: Skull Base |  fibroblast growth |  fgfr2 fgfr3 |  fgfr expression |  human craniofacial


    Barry M Jones: Influence Statistics

    Sample of concepts for which Barry M Jones is among the top experts in the world.
    Concept World rank
    craniosynostosis intracranial #1
    brow lift #1
    cryotherapy ecchymosis #1
    adrenaline parameters #1
    measure jowl #1
    tumescence tumescent infiltration #1
    natural eyebrow morphology #1
    ecchymosis haematoma #1
    craniofacial service #1
    intracranial pressure 97 #1
    longevity brow #1
    anomaly apert #1
    smasbased facelift surgery #1
    procedures short scar #1
    05 drains #1
    neck 55 years #1
    postoperative bruising #1
    incidence hematoma #1
    endoscopic browlift surgery #1
    smas procedure #1
    tumescence hematoma rate #1
    hematoma statistical reduction #1
    breast enhancement macrolane #1
    operative hilotherapy #1
    scar rhytidectomy #1
    skin necrosis alopecia #1
    drains postoperative bruising #1
    craniostenosis turn #1
    infiltration comparative #1
    hilotherapy mask #1
    dressings drains #1
    brow lift morphology #1
    personal 8year quest #1
    eyebrow morphology #1
    initial 6year period #1
    specific adrenaline #1
    tumescence dissection #1
    pain smas #1
    delineate pain relief #1
    craniosynostosis intracranial pressure #1

    Key People For Intracranial Pressure

    Top KOLs in the world
    John Douglas Pickard
    intracranial pressure head injury cerebral autoregulation
    Marek Czosnyka
    intracranial pressure cerebral autoregulation traumatic brain injury
    Anthony P Marmarou
    brain edema head injury intracranial pressure
    Donald P Becker
    brain injury intracranial pressure cerebral ischemia
    Lawrence F Marshall
    head injury intracranial pressure 48 hours
    David Krishna Menon
    traumatic brain injury intracranial pressure magnetic resonance

    Barry M Jones:Expert Impact

    Concepts for whichBarry M Joneshas direct influence:Intracranial pressure,  Fibroblast growth factor,  Crouzon syndrome,  Raised intracranial pressure,  Apert syndrome,  Intracranial volume,  Cervical spine,  Brow lift.

    Barry M Jones:KOL impact

    Concepts related to the work of other authors for whichfor which Barry M Jones has influence:Crouzon syndrome,  Fibroblast growth factor,  Syndromic craniosynostosis,  Intracranial pressure,  Distraction osteogenesis,  Sagittal synostosis,  Cranial sutures.



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    London and Oxford, United Kingdom. | From the Departments of Craniofacial Surgery and Ophthalmology, Great Ormond Street Hospital, London, United Kingdom. | London and Glasgow, United Kingdom From King Edward VII Hospital and the Canniesburn Plastic