 | Claudia L Sommer |
Prominent publications by Claudia L Sommer
Tumor Necrosis Factor-α Induces Mechanical Allodynia after Spinal Nerve Ligation by Activation of p38 MAPK in Primary Sensory Neurons
[ PUBLICATION ]
Tumor necrosis factor-alpha (TNF) is implicated in the initiation of neuropathic pain. In vitro, TNF activates p38 mitogen-activated kinase. Accordingly, we investigated whether TNF activates the p38 cascade in vivo to trigger pain behavior after spinal nerve ligation (SNL). Treatment starting 2 d before SNL with the TNF antagonist etanercept (1 mg, i.p., every third day) attenuated mechanical allodynia. Treatment starting 1 or 7 d after SNL was ineffective. Similarly, intrathecal ...
| Also Ranks for: P38 Activation | necrosis factor | spraguedawley receptors | drg spinal cord | mechanical allodynia |
BACKGROUND: Fibromyalgia (FM) is a clinically well-defined chronic condition of unknown aetiology characterised by chronic widespread pain that often co-exists with sleep problems and fatigue. People often report high disability levels and poor health-related quality of life (HRQoL). Drug therapy focuses on reducing key symptoms and disability, and improving HRQoL. Anticonvulsants (antiepileptic drugs) are drugs frequently used for the treatment of chronic pain syndromes.
OBJECTIVES: To ...
| Also Ranks for: Pregabalin Placebo | sleep problems | efficacy safety | definite conclusions | fibromyalgia fm |
Comparative Efficacy and Harms of Duloxetine, Milnacipran, and Pregabalin in Fibromyalgia Syndrome
[ PUBLICATION ]
Duloxetine (DLX), milnacipran (MLN), and pregabalin (PGB) are the only drugs licensed by the US Food and Drug Administration (FDA) for fibromyalgia syndrome (FMS). Evidence on the comparative benefits and harms is still accruing. The authors searched MEDLINE, SCOPUS, Cochrane Central Register of Controlled Trials, and sought unpublished data from the databases of FDA, US National Institutes for Health, and Industry through May 2009 for randomized controlled trials. Outcomes of interest ...
| Also Ranks for: Fibromyalgia Syndrome | dlx pgb | comparative efficacy | duloxetine milnacipran | randomized controlled |
BackgroundThe efficacy, tolerability and safety of opioid therapy in chronic osteoarthritis (OA) pain is under debate. We updated a Cochrane systematic review on the efficacy and safety of opioids in chronic OA pain published in 2009.MethodsWe screened MEDLINE, Scopus and the Cochrane Central Register of Controlled Trials (CENTRAL) up until October 2013, as well as reference sections of original studies and systematic reviews of randomized controlled trials (RCTs) of opioids in chronic ...
| Also Ranks for: Opioids Placebo | terms safety | chronic pain | sae deaths | opioid therapy |
Activation of TRPV1 Contributes to Morphine Tolerance: Involvement of the Mitogen-Activated Protein Kinase Signaling Pathway
[ PUBLICATION ]
Tolerance to the analgesic effects of opioids occurs after their chronic administration, a pharmacological phenomenon that has been associated with the development of abnormal pain sensitivity such as hyperalgesia. In the present study, we investigated the role of TRPV1, which is crucial for the transduction of noxious chemical and thermal stimuli, in morphine tolerance and tolerance-associated thermal hyperalgesia. After chronic morphine treatment, a marked increase in TRPV1 ...
| Also Ranks for: Morphine Tolerance | sciatic nerve | spinal cord | activated protein | spraguedawley receptors |
Background: The role of antidepressants in the management of fibromyalgia syndrome (FMS) still needs to be determined.Objective: The objective of this study was to provide a quantitative analysis (meta-analysis) of the efficacy and harms of antidepressants in the management of adult FMS patients.Data sources: The data sources used were the databases MEDLINE, SCOPUS and the Cochrane Central Register of Controlled Trials (until December 30, 2010), the reference lists of included articles, ...
| Also Ranks for: Fibromyalgia Syndrome | pain sleep | patients placebo | fms life | randomized controlled |
BackgroundThe efficacy and safety of opioid therapy in chronic neuropathic pain (CNP) is under debate. We updated a recent Cochrane systematic review on the efficacy, tolerability and safety of opioids in CNP.MethodsWe screened MEDLINE, Scopus and the Cochrane Central Register of Controlled Trials (CENTRAL) up until October 2013, as well as the reference sections of original studies and systematic reviews of randomized controlled trials (RCTs) of opioids in CNP. We included double-blind ...
| Also Ranks for: Opioids Placebo | terms safety | pain studies | efficacy tolerability | patients adverse events |
Neuropathic pain is accompanied by both positive and negative sensory signs. To explore the spectrum of sensory abnormalities, 1236 patients with a clinical diagnosis of neuropathic pain were assessed by quantitative sensory testing (QST) following the protocol of DFNS (German Research Network on Neuropathic Pain), using both thermal and mechanical nociceptive as well as non-nociceptive stimuli. Data distributions showed a systematic shift to hyperalgesia for nociceptive, and to ...
| Also Ranks for: Neuropathic Pain | somatosensory abnormalities | mechanical hyperalgesia | german network | quantitative sensory testing |
Skin biopsy has become a widely used tool to investigate small calibre sensory nerves including somatic unmyelinated intraepidermal nerve fibres (IENF), dermal myelinated nerve fibres, and autonomic nerve fibres in peripheral neuropathies and other conditions. Different techniques for tissue processing and nerve fibre evaluation have been used. In March 2004, a Task Force was set up under the auspices of the European Federation of Neurological Societies (EFNS) with the aim of developing ...
| Also Ranks for: Skin Biopsy | efns guidelines | peripheral neuropathies | task force | level recommendation |
Fibromyalgia syndrome is a clinically well-characterized chronic pain condition of high socio-economic impact. Although the pathophysiology is still unclear, there is increasing evidence for nervous system dysfunction in patients with fibromyalgia syndrome. In this case-control study we investigated function and morphology of small nerve fibres in 25 patients with fibromyalgia syndrome. Patients underwent comprehensive neurological and neurophysiological assessment. We examined small ...
| Also Ranks for: Fibromyalgia Syndrome | small fibre | patients depression | painrelated evoked potentials | quantitative sensory testing |
BACKGROUND: Data from previous studies suggest that botulinum toxin A has analgesic effects against peripheral neuropathic pain, but the quality of the evidence is low. We aimed to assess the safety and efficacy of repeated administrations of botulinum toxin A in patients with neuropathic pain.
METHODS: We did a randomised, double-blind, placebo-controlled trial at two outpatient clinics in France (Clinical Pain Centre, Ambroise Paré Hospital, APHP, Boulogne-Billancourt, and Neurological ...
| Also Ranks for: Botulinum Toxin | neuropathic pain | 24 weeks | analgesic effects | injections subcutaneous |
After nerve injury, cyclooxygenase-2 (COX-2) is upregulated in spinal cord and peripheral nerve, the latter being dependent on tumor necrosis factor-alpha (TNF). Here we asked whether COX inhibitors attenuate pain behavior induced by chronic constrictive sciatic nerve injury (CCI) or intraneural injection of TNF (2.5 pg/ml). Rats received either 0.9% saline, the nonselective COX inhibitor ibuprofen (40 mg/kg) or the selective COX-2 inhibitor celecoxib (10 or 30 mg/kg) twice daily by ...
| Also Ranks for: Pain Behavior | spinal cord | animal ganglia | 2 cyclooxygenase | mechanical allodynia |
Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice
[ PUBLICATION ]
BACKGROUND: Although it has been largely demonstrated that nitric oxide synthase (NOS), a key enzyme for nitric oxide (NO) production, modulates inflammatory pain, the molecular mechanisms underlying these effects remain to be clarified. Here we asked whether cytokines, which have well-described roles in inflammatory pain, are downstream targets of NO in inflammatory pain and which of the isoforms of NOS are involved in this process.
RESULTS: Intraperitoneal (i.p.) pretreatment with ...
| Also Ranks for: Nitric Oxide | thermal hyperalgesia | inflammatory pain | synthase type | aminoguanidine hydrochloride |
Bone-cancer-related pain is one of the most disabling factors in patients suffering from primary bone cancer or bone metastases. Recent studies point toward an important role of proinflammatory cytokines, example tumor necrosis factor-alpha (TNF), for tumor growth and bone-cancer-associated pain. Mechanisms by which TNF, through its receptor subtypes, TNF receptor 1 (TNFR1) and -2 (TNFR2), elicits altered sensation and pain behavior, are still incompletely understood. To look for a ...
| Also Ranks for: Cancer Pain | tumor necrosis | mouse model | tnfr1 tnfr2 | inbred c57bl mice |
BACKGROUND: Revision of the guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy, published in 2005, has become appropriate owing to publication of more relevant articles. Most of the new studies focused on small fiber neuropathy (SFN), a subtype of neuropathy for which the diagnosis was first developed through skin biopsy examination. This revision focuses on the use of this technique to diagnose SFN.
METHODS: Task force members searched the Medline database ...
| Also Ranks for: Skin Biopsy | peripheral nerve | small fiber | diagnosis sfn | ienf density |
Claudia L Sommer: Influence Statistics
| Concept | World rank |
|---|---|
| antiamphiphysin immunoglobulin | #1 |
| tnf il1beta mrna | #1 |
| cgrp metabolism | #1 |
| controls cnfl | #1 |
| neuropathies etiologies | #1 |
| data snl treatment | #1 |
| palphasynuclein autonomic structures | #1 |
| subgroup fibromyalgia patients | #1 |
| mir103a3p fms disability | #1 |
| diabetes cognitive factors | #1 |
| gastrocnemius muscle tnf | #1 |
| cncp studies | #1 |
| fms sfn patients | #1 |
| forms polyneuropathy | #1 |
| controls calf | #1 |
| 415 weeks opioids | #1 |
| nociceptor degeneration | #1 |
| neuropathy time | #1 |
| version fpq | #1 |
| fpq adult | #1 |
| 50 greater disability | #1 |
| fms skin cytokine | #1 |
| methological | #1 |
| pdspn | #1 |
| caspr neurofascin | #1 |
| nt3 epo | #1 |
| amphiphysin clathrinmediated endocytosis | #1 |
| mechanical hypersensitivity nociceptors | #1 |
| 22 month mice | #1 |
| pgb fms | #1 |
| crossed circles | #1 |
| adult patients pain | #1 |
| fms cnbd | #1 |
| fd fibroblasts incubation | #1 |
| diabetic neuropathy dnp | #1 |
| hypoalgesia covid19 disease | #1 |
| nsvn rage | #1 |
| tnf fd | #1 |
| healthy controls ienfd | #1 |
| inos‐ | #1 |
| skin upregulated tnf | #1 |
| vanp chronic inflammatory | #1 |
| notch1 kca11 | #1 |
| c57bl mice drg | #1 |
| mice severe hypersensitivity | #1 |
| mp treatment nep | #1 |
| snl baseline | #1 |
| 1973 years | #1 |
| inflammation neuralgia animals | #1 |
| tool nodes | #1 |
Key People For Neuropathic Pain
Claudia L Sommer:Expert Impact
Concepts for whichClaudia L Sommerhas direct influence:Neuropathic pain, Fabry disease, Fibromyalgia syndrome, Skin biopsy, Sciatic nerve, Nerve injury, Small fiber, Skin biopsies.
Claudia L Sommer:KOL impact
Concepts related to the work of other authors for whichfor which Claudia L Sommer has influence:Neuropathic pain, Fabry disease, Chronic inflammatory, Spinal cord, Nerve injury, Small fiber, Mechanical allodynia.
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