• Disease
  • Neuropathic
  • Neuropathic Pain
  • Claudia L Sommer

    Prominent publications by Claudia L Sommer

    KOL Index score: 16751

    Tumor necrosis factor-alpha (TNF) is implicated in the initiation of neuropathic pain. In vitro, TNF activates p38 mitogen-activated kinase. Accordingly, we investigated whether TNF activates the p38 cascade in vivo to trigger pain behavior after spinal nerve ligation (SNL). Treatment starting 2 d before SNL with the TNF antagonist etanercept (1 mg, i.p., every third day) attenuated mechanical allodynia. Treatment starting 1 or 7 d after SNL was ineffective. Similarly, intrathecal ...

    Also Ranks for: P38 Activation |  necrosis factor |  spraguedawley receptors |  drg spinal cord |  mechanical allodynia
    KOL Index score: 16428

    BACKGROUND: Fibromyalgia (FM) is a clinically well-defined chronic condition of unknown aetiology characterised by chronic widespread pain that often co-exists with sleep problems and fatigue. People often report high disability levels and poor health-related quality of life (HRQoL). Drug therapy focuses on reducing key symptoms and disability, and improving HRQoL. Anticonvulsants (antiepileptic drugs) are drugs frequently used for the treatment of chronic pain syndromes.

    OBJECTIVES: To ...

    Also Ranks for: Pregabalin Placebo |  sleep problems |  efficacy safety |  definite conclusions |  fibromyalgia fm
    KOL Index score: 15689

    Duloxetine (DLX), milnacipran (MLN), and pregabalin (PGB) are the only drugs licensed by the US Food and Drug Administration (FDA) for fibromyalgia syndrome (FMS). Evidence on the comparative benefits and harms is still accruing. The authors searched MEDLINE, SCOPUS, Cochrane Central Register of Controlled Trials, and sought unpublished data from the databases of FDA, US National Institutes for Health, and Industry through May 2009 for randomized controlled trials. Outcomes of interest ...

    Also Ranks for: Fibromyalgia Syndrome |  dlx pgb |  comparative efficacy |  duloxetine milnacipran |  randomized controlled
    KOL Index score: 15470

    BackgroundThe efficacy, tolerability and safety of opioid therapy in chronic osteoarthritis (OA) pain is under debate. We updated a Cochrane systematic review on the efficacy and safety of opioids in chronic OA pain published in 2009.MethodsWe screened MEDLINE, Scopus and the Cochrane Central Register of Controlled Trials (CENTRAL) up until October 2013, as well as reference sections of original studies and systematic reviews of randomized controlled trials (RCTs) of opioids in chronic ...

    Also Ranks for: Opioids Placebo |  terms safety |  chronic pain |  sae deaths |  opioid therapy
    KOL Index score: 13979

    Tolerance to the analgesic effects of opioids occurs after their chronic administration, a pharmacological phenomenon that has been associated with the development of abnormal pain sensitivity such as hyperalgesia. In the present study, we investigated the role of TRPV1, which is crucial for the transduction of noxious chemical and thermal stimuli, in morphine tolerance and tolerance-associated thermal hyperalgesia. After chronic morphine treatment, a marked increase in TRPV1 ...

    Also Ranks for: Morphine Tolerance |  sciatic nerve |  spinal cord |  activated protein |  spraguedawley receptors
    KOL Index score: 13961

    Background: The role of antidepressants in the management of fibromyalgia syndrome (FMS) still needs to be determined.Objective: The objective of this study was to provide a quantitative analysis (meta-analysis) of the efficacy and harms of antidepressants in the management of adult FMS patients.Data sources: The data sources used were the databases MEDLINE, SCOPUS and the Cochrane Central Register of Controlled Trials (until December 30, 2010), the reference lists of included articles, ...

    Also Ranks for: Fibromyalgia Syndrome |  pain sleep |  patients placebo |  fms life |  randomized controlled
    KOL Index score: 13627

    BackgroundThe efficacy and safety of opioid therapy in chronic neuropathic pain (CNP) is under debate. We updated a recent Cochrane systematic review on the efficacy, tolerability and safety of opioids in CNP.MethodsWe screened MEDLINE, Scopus and the Cochrane Central Register of Controlled Trials (CENTRAL) up until October 2013, as well as the reference sections of original studies and systematic reviews of randomized controlled trials (RCTs) of opioids in CNP. We included double-blind ...

    Also Ranks for: Opioids Placebo |  terms safety |  pain studies |  efficacy tolerability |  patients adverse events
    KOL Index score: 13566

    Neuropathic pain is accompanied by both positive and negative sensory signs. To explore the spectrum of sensory abnormalities, 1236 patients with a clinical diagnosis of neuropathic pain were assessed by quantitative sensory testing (QST) following the protocol of DFNS (German Research Network on Neuropathic Pain), using both thermal and mechanical nociceptive as well as non-nociceptive stimuli. Data distributions showed a systematic shift to hyperalgesia for nociceptive, and to ...

    Also Ranks for: Neuropathic Pain |  somatosensory abnormalities |  mechanical hyperalgesia |  german network |  quantitative sensory testing
    KOL Index score: 13472

    Skin biopsy has become a widely used tool to investigate small calibre sensory nerves including somatic unmyelinated intraepidermal nerve fibres (IENF), dermal myelinated nerve fibres, and autonomic nerve fibres in peripheral neuropathies and other conditions. Different techniques for tissue processing and nerve fibre evaluation have been used. In March 2004, a Task Force was set up under the auspices of the European Federation of Neurological Societies (EFNS) with the aim of developing ...

    Also Ranks for: Skin Biopsy |  efns guidelines |  peripheral neuropathies |  task force |  level recommendation
    KOL Index score: 13167

    Fibromyalgia syndrome is a clinically well-characterized chronic pain condition of high socio-economic impact. Although the pathophysiology is still unclear, there is increasing evidence for nervous system dysfunction in patients with fibromyalgia syndrome. In this case-control study we investigated function and morphology of small nerve fibres in 25 patients with fibromyalgia syndrome. Patients underwent comprehensive neurological and neurophysiological assessment. We examined small ...

    Also Ranks for: Fibromyalgia Syndrome |  small fibre |  patients depression |  painrelated evoked potentials |  quantitative sensory testing
    KOL Index score: 12795

    BACKGROUND: Data from previous studies suggest that botulinum toxin A has analgesic effects against peripheral neuropathic pain, but the quality of the evidence is low. We aimed to assess the safety and efficacy of repeated administrations of botulinum toxin A in patients with neuropathic pain.

    METHODS: We did a randomised, double-blind, placebo-controlled trial at two outpatient clinics in France (Clinical Pain Centre, Ambroise Paré Hospital, APHP, Boulogne-Billancourt, and Neurological ...

    Also Ranks for: Botulinum Toxin |  neuropathic pain |  24 weeks |  analgesic effects |  injections subcutaneous
    KOL Index score: 12557

    After nerve injury, cyclooxygenase-2 (COX-2) is upregulated in spinal cord and peripheral nerve, the latter being dependent on tumor necrosis factor-alpha (TNF). Here we asked whether COX inhibitors attenuate pain behavior induced by chronic constrictive sciatic nerve injury (CCI) or intraneural injection of TNF (2.5 pg/ml). Rats received either 0.9% saline, the nonselective COX inhibitor ibuprofen (40 mg/kg) or the selective COX-2 inhibitor celecoxib (10 or 30 mg/kg) twice daily by ...

    Also Ranks for: Pain Behavior |  spinal cord |  animal ganglia |  2 cyclooxygenase |  mechanical allodynia
    KOL Index score: 12546

    BACKGROUND: Although it has been largely demonstrated that nitric oxide synthase (NOS), a key enzyme for nitric oxide (NO) production, modulates inflammatory pain, the molecular mechanisms underlying these effects remain to be clarified. Here we asked whether cytokines, which have well-described roles in inflammatory pain, are downstream targets of NO in inflammatory pain and which of the isoforms of NOS are involved in this process.

    RESULTS: Intraperitoneal (i.p.) pretreatment with ...

    Also Ranks for: Nitric Oxide |  thermal hyperalgesia |  inflammatory pain |  synthase type |  aminoguanidine hydrochloride
    KOL Index score: 12371

    Bone-cancer-related pain is one of the most disabling factors in patients suffering from primary bone cancer or bone metastases. Recent studies point toward an important role of proinflammatory cytokines, example tumor necrosis factor-alpha (TNF), for tumor growth and bone-cancer-associated pain. Mechanisms by which TNF, through its receptor subtypes, TNF receptor 1 (TNFR1) and -2 (TNFR2), elicits altered sensation and pain behavior, are still incompletely understood. To look for a ...

    Also Ranks for: Cancer Pain |  tumor necrosis |  mouse model |  tnfr1 tnfr2 |  inbred c57bl mice
    KOL Index score: 12061

    BACKGROUND: Revision of the guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy, published in 2005, has become appropriate owing to publication of more relevant articles. Most of the new studies focused on small fiber neuropathy (SFN), a subtype of neuropathy for which the diagnosis was first developed through skin biopsy examination. This revision focuses on the use of this technique to diagnose SFN.

    METHODS: Task force members searched the Medline database ...

    Also Ranks for: Skin Biopsy |  peripheral nerve |  small fiber |  diagnosis sfn |  ienf density


    Claudia L Sommer: Influence Statistics

    Sample of concepts for which Claudia L Sommer is among the top experts in the world.
    Concept World rank
    antiamphiphysin immunoglobulin #1
    tnf il1beta mrna #1
    cgrp metabolism #1
    controls cnfl #1
    neuropathies etiologies #1
    data snl treatment #1
    palphasynuclein autonomic structures #1
    subgroup fibromyalgia patients #1
    mir103a3p fms disability #1
    diabetes cognitive factors #1
    gastrocnemius muscle tnf #1
    cncp studies #1
    fms sfn patients #1
    forms polyneuropathy #1
    controls calf #1
    415 weeks opioids #1
    nociceptor degeneration #1
    neuropathy time #1
    version fpq #1
    fpq adult #1
    50 greater disability #1
    fms skin cytokine #1
    methological #1
    pdspn #1
    caspr neurofascin #1
    nt3 epo #1
    amphiphysin clathrinmediated endocytosis #1
    mechanical hypersensitivity nociceptors #1
    22 month mice #1
    pgb fms #1
    crossed circles #1
    adult patients pain #1
    fms cnbd #1
    fd fibroblasts incubation #1
    diabetic neuropathy dnp #1
    hypoalgesia covid19 disease #1
    nsvn rage #1
    tnf fd #1
    healthy controls ienfd #1
    inos‐ #1
    skin upregulated tnf #1
    vanp chronic inflammatory #1
    notch1 kca11 #1
    c57bl mice drg #1
    mice severe hypersensitivity #1
    mp treatment nep #1
    snl baseline #1
    1973 years #1
    inflammation neuralgia animals #1
    tool nodes #1

    Key People For Neuropathic Pain

    Top KOLs in the world
    Troels Staehelin Staehelin‐Jensen
    neuropathic pain whiplash injury spinal cord
    Clifford J Woolf
    spinal cord dorsal horn neuropathic pain
    Ralf Baron
    neuropathic pain fabry disease postherpetic neuralgia
    Nadine ATTAL
    neuropathic pain botulinum toxin analgesic effects
    Gary J Bennett
    neuropathic pain spinal cord sciatic nerve
    Robert H Dworkin
    chronic pain herpes zoster postherpetic neuralgia

    Claudia L Sommer:Expert Impact

    Concepts for whichClaudia L Sommerhas direct influence:Neuropathic pain,  Fabry disease,  Fibromyalgia syndrome,  Skin biopsy,  Sciatic nerve,  Nerve injury,  Small fiber,  Skin biopsies.

    Claudia L Sommer:KOL impact

    Concepts related to the work of other authors for whichfor which Claudia L Sommer has influence:Neuropathic pain,  Fabry disease,  Chronic inflammatory,  Spinal cord,  Nerve injury,  Small fiber,  Mechanical allodynia.



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    Universitätsklinikum Würzburg, Neurologie, Würzburg, Germany | Department of Neurology, University of Würzburg, Würzburg, Germany | Neurology (N.U., C.S.), University Hospital Würzburg, Würzburg, Germany | University and University Hospital Würzburg,