• Disease
  • Desmoplastic
  • Desmoplastic Malignant
  • Desmoplastic Malignant Melanoma
  • Edward Wilson Jones

    Prominent publications by Edward Wilson Jones

    KOL Index score: 10384

    Using a panel of seven cell markers, we studied the value of immunocytochemical labelling in the histological diagnosis of desmoplastic malignant melanoma. Sections from routine formalin-fixed tissue of 45 surgical specimens were obtained from 25 cases of malignant melanoma that showed well-marked desmoplastic or neurotropic features. Routinely stained sections (Haematoxylin- and -eosin and melanin stains) were compared with the following panel of seven antibodies: S-100, neuron-specific ...

    Also Ranks for: Malignant Melanoma |  25 cases |  neoplasm antigens |  s100 proteins |  factor xiiia
    KOL Index score: 8375

    AIMS: To evaluate antibodies directed against CD31 (JC70/A) and CD34 (QBEND/10 and anti-HPCA-1) more extensively in Kaposi sarcoma; to assess their value in routine diagnosis; and to compare them with the traditional endothelial cell markers Ulex europaeus agglutinin 1 (UEA-1) and factor VIII related antigen.

    METHODS: Twenty four cases of Kaposi sarcoma were studied retrospectively. All specimens had been fixed in formalin and embedded in paraffin wax. The antibodies were applied using ...

    Also Ranks for: Kaposi Sarcoma |  cd31 cd34 |  endothelial cell |  paraffin wax |  factor antigens
    KOL Index score: 7825

    Immunohistochemical studies were performed in thirty skin biopsies from patients with Kaposi's sarcoma, who did and did not have the acquired immune deficiency syndrome (AIDS). Tumour histogenesis was rigorously tested using a battery of endothelial cell markers, which included two new monoclonal antibodies, EN4 and PAL E. These are both specific for endothelial cells and can be visualised in appropriately fixed paraffin embedded tissue. Whereas EN4 labels all endothelial cells, PAL E is ...

    Also Ranks for: Kaposis Sarcoma |  endothelial cells |  patients aids |  acquired immune |  deficiency syndrome
    KOL Index score: 7359

    The histogenesis of histiocytoma (dermatofibroma) was investigated using new antibodies that demonstrate factor XIIIa (FXIIIa) positive cells and the monocyte macrophage cell series (MAC 387), in formalin fixed tissue. The distribution of S100 protein, vimentin and Ulex europaeus agglutinin I (UEA-I) were also studied. The antibody against FXIIIa labelled the normal dermal population of fixed connective tissue cells (dermal dendrocytes) emphasizing their dendritic processes; cells that ...

    Also Ranks for: Dermal Dendrocytes |  histiocytoma cutis |  s100 protein |  antibody fxiiia |  positive cells
    KOL Index score: 7171

    Twenty patients are described with an unusual form of angiomatous proliferation, which most commonly arose on the neck and upper trunk in young persons. Because of the histologic finding of small circumscribed angiomatous tufts and lobules scattered in the dermis, we suggest the term tufted angioma for this lesion. Over half the angiomas developed within the first 5 years of life, but only three patients reportedly had lesions at birth. The clinical course was variable, but most of the ...

    Also Ranks for: Tufted Angioma |  patients lesions |  kaposi sarcoma |  upper trunk |  neck neoplasms
    KOL Index score: 6717

    72 patients with angiosarcoma (AS) of the face and scalp have been analyzed with respect of various prognostic factors and the effects of different treatment regimes. This disease predominantly occurs in the elderly (age range, 56-92 years), and affects men rather more frequently than women (men: 44, women: 28). The clinical presentation varied, and included bruise-like lesions, dusky plaques, chronic edema or cellulitis, ulcerated nodules, pyoderma, and infected conditions. Due to lack ...

    Also Ranks for: Female Head |  patients lesions |  clinical presentation |  15 months |  local prognosis
    KOL Index score: 6333

    Sixteen cases of malignant melanoma which showed prominent desmoplastic and/or neurotropic features occurring throughout the tumour were compiled from the St John's Dermatology Centre histopathological archives. A further nine melanomas in which both conventional and desmoplastic melanoma were present concomitantly were also studied (three tumours with 66% desmoplastic change, two with 50%, and four with less than 50%). There were 14 males and 11 females, with a mean age of 64 years ...

    Also Ranks for: Malignant Melanoma |  local recurrences |  skin neoplasms |  aged 80 |  histological features
    KOL Index score: 5517

    SUMMARY.— Persistent angiomatous nodules and plaques about the ears and scalp with distinctive histological features are described. Of the 12 women and 2 men affected, 9 showed involvement of the external auditory meatus, the pinna or the retroauricular fold. Three patients presented with lesions in the occipital region and solitary nodules affecting the nasolabial fold and forehead occurred in 2 patients. Eight patients had multiple lesions with bleeding and pruritus as the main ...

    Also Ranks for: Atypical Pyogenic Granuloma |  inflammatory angiomatous nodules |  differential ear |  blood vessels |  multiple lesions
    KOL Index score: 4871

    Twenty-five cases of fibrous papule of the nose were studied by light microscopy and by immunohistochemistry using a panel of 4 cell markers. These included polyclonal antibodies against S100 protein and Factor XIII-a (FXIII-a), and 2 monoclonal antibodies, MAC 387 which labels monocyte derived macrophage cells and Ulex Europaeus Agglutinin-1 (UEA-1) a pan endothelial cell marker. An increase in the number of S100 protein positive cells, particularly in the upper dermis, was observed in ...

    Also Ranks for: Fibrous Papule |  s100 protein |  dendritic cells |  upper dermis |  skin diseases
    KOL Index score: 4231

    Multinucleate cell angiohistocytoma is a newly described benign vascular condition that usually arises on the extremities of women over the age of 40 as discrete grouped violaceous erythematous papules, often mimicking Kaposi's sarcoma. Of 10 patients, nine were women aged between 37-66 (average 51.5) years at the onset of their condition. The legs, and in particular the calves and thighs, were the commonest sites to be involved. However, in three patients the papules were confined to ...

    Also Ranks for: Multinucleate Cell |  kaposis sarcoma |  differential female histiocytoma |  kaposi skin |  small venules
    KOL Index score: 4125

    Thirteen cases of angiosarcoma of the face and scalp have been examined using immunohistochemistry and electron microscopy. Endothelial cell markers have been employed in an immunoperoxidase technique on tissue that has either been routinely processed, periodate-lysine paraformaldehyde fixed (PLP) and cold processed, or fixed in methacarn. A consistent pattern of endothelial cell labeling was only achieved in the PLP fixed tissue. In this fixative the angiosarcomas were factor VIII ...

    Also Ranks for: Hemangiosarcoma Humans |  ultrastructural examination |  factor viii |  weibelpalade bodies |  publication aged aged
    KOL Index score: 3734

    The use of monoclonal antibodies with endothelial cell specificity has prompted a search for methods of fixation which combine the morphology of paraffin-embedded tissue, with preservation of labile membrane antigens. Immunohistochemical staining using a variety of endothelial cell markers was compared in tissue fixed in formalin, methacarn, periodate lysine paraformaldehyde (PLP) and in frozen tissue. Whilst lectin-binding with Ulex europaeus agglutinin I (UEA) and localisation of ...

    Also Ranks for: Endothelial Cell |  antibodies monoclonal |  ulex europaeus |  immunohistochemical staining |  kaposis sarcoma
    KOL Index score: 3492

    This is a report of a previously undescribed type of histiocytoma distinguished clinically by its occurrence as a solitary elevated nodule often with a vascular appearance and cytologically by the presence of large angulated epithelioid cells. Nineteen lesions from 11 women and eight men have been studied. The lower limb was the commonest site for the nodules. The mean age at presentation was 42 years (range 23-63). Only one lesion recurred after attempted removal. This lesion in the ...

    Also Ranks for: Epithelioid Cell Histiocytoma |  factor xiiia |  spitz naevus |  lower limb |  immunohistochemical findings
    KOL Index score: 3382

    In an attempt to elucidate the nature of the abnormal vessels in pseudopyogenic granuloma, we performed enzyme histochemical analysis of 10 lesions and correlated them with electron microscopic findings in four lesions. The dermal vessels of pseudopyogenic granuloma possess voluminous endothelial cells demonstrating marked activity of various hydrolytic and respiratory enzymes. The alkaline phosphatase activity, however, is characteristically faint or absent. Electron microscopy reveals ...

    Also Ranks for: Pseudopyogenic Granuloma |  endothelial cells |  enzyme histochemical |  electron microscopy |  ultrastructural study
    KOL Index score: 3207

    Forty-one cases of dermatofibrosarcoma protuberans are presented. The clinical features and histopathological appearances are described. Immunohistochemical staining of thirteen cases with antisera to lysozyme, alpha 1-antichymotrypsin and S-100 protein has provided no evidence to support either a histiocytic or neuroectodermal origin for these tumours. In reviewing the literature, the histogenetic origin, differential diagnosis and malignant potential of dermatofibrosarcoma protuberans ...

    Also Ranks for: Dermatofibrosarcoma Protuberans |  differential diagnosis |  immunohistochemical staining |  thirteen cases |  alpha 1


    Edward Wilson Jones: Influence Statistics

    Sample of concepts for which Edward Wilson Jones is among the top experts in the world.
    Concept World rank
    16 tumours cases #1
    thirty skin biopsies #1
    angiosarcoma poor prognosis #1
    cell lobules angiomas #1
    voluminous endothelial cells #1
    spaces hemorrhage #1
    pal negative #1
    lesions qbend 10 #1
    hemorrhage iron deposition #1
    acquisition subnuclear zone #1
    tufted angioma lesions #1
    postcapillary venules involvement #1
    cd34 kaposi #1
    endothelium factor humans #1
    cd34 kaposi sarcoma #1
    lymphangioma‐like kaposi #1
    en4 pal #1
    desmoplastic malignant #1
    atypical lentiginous hyperplasia #1
    aids tumour #1
    pseudo atypical pyogenic #1
    plaques extremities #1
    lesions erythematous macules #1
    atypical pyogenic granuloma #1
    pal endothelial cells #1
    pseudopyogenic #1
    66 desmoplastic #1
    progressive angioma #1
    kaposis sarcoma details #1
    inflammatory angiomatous #1
    kaposis sarcoma case #1
    abnormal dermal vessels #1
    benign progressive angioma #1
    case unusual histological #1
    uea1 factor #1
    papule nose #1
    lectins scalp #1
    indirect stage method #1
    endothelial granules weibelpalade #1
    cytoplasmic vacuolation acquisition #1
    angiomatous lobules #1
    type angiosarcoma #1
    malignant melanoma tumour #1

    Key People For Desmoplastic Malignant Melanoma

    Top KOLs in the world
    Raffaele Lattes
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    John Conlev
    malignant melanoma rare variant local neoplasms
    William Orr
    washington state british columbia san juan islands
    G Richard Dickersin
    electron microscopy ultrastructural study carcinoid tumor
    Arthur J Sober
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    Richard W Sagebiel
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    Select a search phrase   desmoplastic malignant melanoma

    Edward Wilson Jones:Expert Impact

    Concepts for whichEdward Wilson Joneshas direct influence:Desmoplastic malignant melanoma,  Fibrous papule,  Malignant melanoma,  25 cases,  Kaposi sarcoma,  Pseudopyogenic granuloma,  Kaposis sarcoma,  Xanthoma disseminatum.

    Edward Wilson Jones:KOL impact

    Concepts related to the work of other authors for whichfor which Edward Wilson Jones has influence:Angiolymphoid hyperplasia,  Cutaneous angiosarcoma,  Lymphomatoid papulosis,  Tufted angioma,  Dermatofibrosarcoma protuberans,  Kaposi sarcoma,  Skin neoplasms.



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    Department of Surgery, St. Thomas'S Hospital, London, and Department of Histopathology, St. John'S Hospital for Disease of the Skin, London | Department of Dermatopathology, St John's Dermatology Centre, St Thomas' Hospital, London, UK and, | St John