• KOL
    • Human Plasma
    • Shaw F Chang
    • Shaw F Chang: Influence Statistics

      Shaw F Chang

      Shaw F Chang

      Departments of Pharmacokinetics and Drug Metabolism, †Clinical Research, and ‡Statistical Data Services, 3M Pharmaceuticals, St. Paul, Minnesota: and *Department of Clinical ...

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      Shaw F Chang:Expert Impact

      Concepts for whichShaw F Changhas direct influence:Human plasma,Flecainide acetate,Fluorescence detection,Beclomethasone dipropionate,New antiarrhythmic,Ultraviolet detection,Oral flecainide acetate,Atropine sulfate.

      Shaw F Chang:KOL impact

      Concepts related to the work of other authors for whichfor which Shaw F Chang has influence:Flecainide acetate,Antiarrhythmic drugs,Ventricular tachycardia,Sinus rhythm,Drug interactions,Beclomethasone dipropionate,Human plasma.

      KOL Resume for Shaw F Chang

      Year
      1997

      Departments of Pharmacokinetics and Drug Metabolism, †Clinical Research, and ‡Statistical Data Services, 3M Pharmaceuticals, St. Paul, Minnesota: and *Department of Clinical Pharmacology, Berlex Laboratories, Inc., Wayne, New Jersey, U.S.A.

      1996

      3M Pharmaceuticals, Departments of Pharmacokinetics and Drug Metabolism, Clinical Research, Statistical Data Services and Analytical Research and Development, St. Paul, MN, USA.

      1995

      Department of Drug Metabolism, 3M Pharmaceuticals, 3M Center 270-3S-05, St. Paul, MN 55144-1000, USA

      1994

      3M Pharmaceuticals Division, 3M Center, Building 270‐3S, St. Paul, MN 55144

      1993

      3M Pharmaceuticals Division, Pharmaceuticals, Dental and Disposable Products Group, Building 270–3S‐05, 3M Center, St. Paul, MN 55144

      1992

      3M Pharmaceuticals, St. Paul, Minnesota, Miami, Florida, U.S.A. *Clinical Pharmacology Associates, Inc., Miami, Florida, U.S.A.

      1990

      3M Pharmaceuticals, St. Paul, and St. George's Hospital Medical School London

      1989

      3M/Riker Laboratories, Inc. St. Paul

      University of Minnesota Medical Service, Veterans Affairs Medical Center, the Departments of Pharmacology and Medicine

      1988

      Drug Metabolism Department, 3M Riker, 3M Health Care Group, St. Paul, MN 55144 U.S.A.

      3M/Riker Laboratories, Inc St. Paul

      1986

      Riker Laboratories, Inc

      1985

      National Jewish Hospital and Research Center, Denver, Colorado; and Riker Laboratories, 3M Center, St. Paul, Minnesota, U.S.A.

      1984

      Drug Metabolism Department , Riker Laboratories, Inc. , 3M Center, Building 270-3S-05, St. Paul, Minnesota, 55144

      1983

      Drug Metabolism Department, Riker Laboratories, A Subsidiary of 3M, 3M Center, Building 270-3S, St. Paul, MN 55144 U.S.A.

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      monospan #1
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      Prominent publications by Shaw F Chang

      KOL-Index: 7014

      The antiarrhythmic efficacy and safety of oral flecainide acetate were assessed during a controlled, short-term dosage-maintenance study. Thirteen patients with chronic ventricular ectopy entered a placebo control period, and 11 with persistent, frequent (greater than 600 per 12 hours) premature ventricular complexes (PVCs) advanced to drug therapy. Of 10 patients completing a trial of different doses, nine responded completely, with a mean PVC suppression of 98,3 per cent. Repetitive ...

      Known for Ventricular Arrhythmias | Oral Flecainide Acetate | Cardiac Clinical Trials | Female Flecainide | 12 Hours
      KOL-Index: 6679

      As part of a development program to offer alternatives to chlorofluorocarbon (CFC) containing metered-dose inhalers, beclomethasone dipropionate has been formulated in a CFC-free system at three strengths: 50, 100, and 200 micrograms/actuation ex valve. To measure serum levels and dose proportionality of the beclomethasone derived from beclomethasone dipropionate, 13 mild to moderate asthmatic patients received a single dose of eight inhalations from each strength according to a ...

      Known for Beclomethasone Dipropionate | Dose Proportionality | Serum Levels | Asthmatic Patients | Vaporizers Administration
      KOL-Index: 6448

      A simple, selective, sensitive, and accurate high-performance liquid chromatographic method for the quantitation of flecainide in human plasma and urine is described. The method is based on initially washing the sample with hexane followed by a single extraction with hexane. The extracted drug and internal standard are chromatographed on a Zorbax TMS column with a mobile phase consisting of acetonitrile-1% acetic acid in 0.01 M pentanesulfonate (45:55, v/v). The eluent is monitored at ...

      Known for Human Plasma | New Antiarrhythmic | Gas Chromatography | Performance Liquid | Chromatographic Method
      KOL-Index: 3587

      The possible effect of oral flecainide acetate on steady-state digoxin levels was assessed in 15 healthy men. Each volunteer received digoxin 0.25 mg daily (8 AM) for 22 consecutive days and flecainide 200 mg bid (8 AM and 8 PM) on days 11 through 15. Plasma digoxin and flecainide levels were measured by radioimmunoassay and gas-liquid chromatography methods, respectively. Flecainide levels were within the range associated with suppression of premature ventricular contractions in ...

      Known for Plasma Digoxin | New Antiarrhythmic | Vital Signs | 15 Healthy | Drug Interactions
      KOL-Index: 2995

      A simple, rapid, selective, and sensitive high-performance liquid chromatographic (HPLC) method for the monitoring of plasma flecainide levels in a therapeutic or research environment is described. The drug is first separated from plasma by a single-step extraction with hexane and then quantitated by HPLC with fluorescence detection. Two linear ranges have been established; 100–2000 ng/ml for drug monitoring in clinical management of patients and 3–300 ng/ml for pharmacokinetic studies. ...

      Known for Fluorescence Detection | Human Plasma | Performance Liquid | Drug Monitoring | Determination Flecainide
      KOL-Index: 2966

      Two three-way crossover studies were done to characterize the drug release characteristics of Monospan (3M Pharmaceuticals, St. Paul, MN) capsules, a new once-a-day theophylline formulation. In the first study, 22 healthy males received single 450-mg doses of Monospan in the presence and absence of a high-fat breakfast; the same dose of Somophyllin (Fisons, Rochester, NY) immediate-release liquid was given to fasted subjects as a reference. The second study involved 29 healthy males ...

      Known for Single Dose | Day Theophylline | Delayed Action | Dietary Fats | Dosage Forms
      KOL-Index: 2889

      A procedure of direct injection of whole plasma for the analysis of theophylline by an automated multidimensional high-performance liquid chromatographic (HPLC) technique is described. The procedure requires as little as 30 microliters of plasma sample and has a linear range of 0.25-30 micrograms/ml. Unknown plasma samples, after the addition of internal standard, are directly injected into the HPLC system. The chromatographic procedure is fully automated, thus the attention and time ...

      Known for Direct Plasma Injection | Performance Liquid | Linear Range | Day 3 | Chromatography Pressure
      KOL-Index: 2403

      The inhalation of atropine sulfate from a pressurized metered-dose inhaler was investigated in a nonrandomized four-period rising-dose study. Eight healthy, nonsmoking subjects received 1.7, 3.4, and 5.2 mg of atropine sulfate by inhalation and 1.67 mg of atropine free base (equivalent to 2 mg of atropine sulfate) by intramuscular (i.m.) injection. Serum atropine sulfate concentrations were measured over a 24-h period by gas chromatography/mass spectrometry. Mean serum concentrations ...

      Known for Atropine Sulfate | Gas Chromatography | Intramuscular Injection | Inhalation Adult | Inhaled Dose

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      Departments of Pharmacokinetics and Drug Metabolism, †Clinical Research, and ‡Statistical Data Services, 3M Pharmaceuticals, St. Paul, Minnesota: and *Department of Clinical Pharmacology, Berlex Laboratories, Inc., Wayne, New Jersey, U.S.A. | 3M Phar

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