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  • David Stephen Celermajer

    Prominent publications by David Stephen Celermajer

    KOL Index score: 15137

    BACKGROUND: Male sex is an independent risk factor for coronary artery disease. Owing to the importance of monocyte adhesion to endothelial cells in the development of atherosclerosis, we hypothesized that androgens might promote this process. We therefore studied the effects of the nonaromatizable androgen dihydrotestosterone (DHT) on human monocyte adhesion to human endothelial cells and on endothelial cell-surface expression of adhesion molecules.

    METHODS AND RESULTS: Human umbilical ...

    Also Ranks for: Cell Adhesion |  androgen exposure |  vascular endothelium |  human monocyte |  male sex
    KOL Index score: 14829

    OBJECTIVE: We sought to investigate the mechanism whereby a particular deformity of the aortic arch, an angulated Gothic shape, might lead to hypertension late after anatomically successful repair of aortic coarctation.

    METHODS: Fifty-five normotensive patients with anatomically successful repair of aortic coarctation and either a Gothic (angulated) or a Romanesque (smooth and rounded) arch were studied with magnetic resonance angiography and flow mapping in both the ascending and ...

    Also Ranks for: Aortic Arch |  ventricular mass |  coarctation repair |  magnetic resonance |  wave reflection
    KOL Index score: 13858

    OBJECTIVES: Our aim was to assess the effect of oral L-arginine on endothelial or platelet physiology in humans.

    BACKGROUND: L-Arginine is the substrate for nitric oxide synthesis, and in cholesterol-fed rabbits, oral L-arginine improves endothelium-dependent dilation, inhibits platelet aggregation and reduces atheroma. In hypercholesterolemic humans, intravenous L-arginine immediately improves endothelium-dependent dilation; however, the vascular effects of oral L-arginine in healthy ...

    Also Ranks for: Platelet Aggregation |  dependent dilation |  healthy young |  oral larginine |  plasma levels
    KOL Index score: 13519

    OBJECTIVES: This study sought to assess the effect of cigarette smoking on adhesion of human monocytes to human endothelial cells and to measure the effect of L-arginine and vitamin C supplementation on this interaction.

    BACKGROUND: Cigarette smoking has been associated with abnormal endothelial function and increased leukocyte adhesion to endothelium, both key early events in atherogenesis. Supplementation with both oral L-arginine (the physiologic substrate for nitric oxide) and ...

    Also Ranks for: Cigarette Smoking |  endothelial cells |  monocyte adhesion |  vitamin levels |  oral arginine
    KOL Index score: 13514

    OBJECTIVES: This study sought to examine whether endothelial function is impaired in the large vessels of asymptomatic young adults with insulin-dependent diabetes and whether endothelial dysfunction is related to duration or control of diabetes, small-vessel disease or other vascular risk factors.

    BACKGROUND: Endothelial dysfunction is an early event in atherosclerosis, and large-vessel atherosclerotic disease is the major cause of morbidity and mortality in diabetes.

    METHODS: We ...

    Also Ranks for: Vascular Reactivity |  dependent diabetes |  disease duration |  low density lipoprotein |  cholesterol levels
    KOL Index score: 13353

    OBJECTIVES: We sought to assess smooth muscle function in adults at risk for atherosclerosis.

    BACKGROUND: Previous studies in subjects at risk for atherosclerosis have demonstrated arterial endothelial dysfunction, with reduced vasodilator responses after pharmacologic or physiologic stimulation of endothelial nitric oxide (NO). Most have also shown a slight but nonsignificant impairment of vasodilation in response to exogenous sources of NO, such as nitroglycerin (NTG). We hypothesized ...

    Also Ranks for: Smooth Muscle |  subjects risk |  impaired endothelium |  dependent dilation |  sublingual ntg
    KOL Index score: 13330

    OBJECTIVES: We investigated the accuracy of 64-slice computed tomography (CT) angiography, as compared to invasive angiography, to evaluate reimplanted coronary arteries in children after arterial switch operation (ASO) for transposition of the great arteries (TGA).

    BACKGROUND: Assessment of the integrity of reimplanted coronary arteries is crucial for long-term outcome after ASO for TGA. Noninvasive tests have limited accuracy for detecting significant coronary lesions, and invasive ...

    Also Ranks for: Coronary Angiography |  arterial switch operation |  computed tomography |  aso tga |  great arteries
    KOL Index score: 13319

    OBJECTIVES: To identify factors associated with hospital and long-term outcomes in a binational cohort of extracardiac conduit (ECC) Fontan recipients.

    METHODS: All patients who underwent an ECC Fontan procedure from 1997 to 2010 in Australia and New Zealand were identified, and perioperative, follow-up, echocardiographic and reintervention data collected. Risk factors for early and late mortality, failure and adverse outcomes were analysed.

    RESULTS: A total of 570 patients were ...

    Also Ranks for: New Zealand |  fontan procedure |  heart syndrome |  extracardiac conduit |  late outcomes
    KOL Index score: 13299

    INTRODUCTION: Pulmonary arterial hypertension is a major cause of mortality in systemic sclerosis. N-terminal pro-brain natriuretic peptide (NT-proBNP) has emerged as a candidate biomarker that may enable the early detection of systemic sclerosis-related pulmonary arterial hypertension (SSc-PAH). The objective of our study was to incorporate NT-proBNP into a screening algorithm for SSc-PAH that could potentially replace transthoracic echocardiography (TTE) as a more convenient and less ...

    Also Ranks for: Screening Algorithm |  pulmonary arterial hypertension |  systemic sclerosis |  natriuretic peptide |  sscpah pah
    KOL Index score: 13211

    OBJECTIVE: We assessed the contribution of acute aortic arch angulation and enhanced systolic pulse wave reflection to dilatation of the ascending aorta and aortic regurgitation late after the arterial switch operation for transposition of the great arteries.

    METHODS: We performed aortography, radial artery applanation tonometry, and transthoracic echocardiography in 47 children (aged 5-6 years) who underwent the arterial switch operation and in 20 matched healthy controls. The aortic ...

    Also Ranks for: Arterial Switch Operation |  great arteries |  aortic arch |  ascending aorta |  pulse pressure
    KOL Index score: 12875

    BACKGROUND: Monocyte adhesion to endothelial cells is a key early event in atherogenesis. Because L-arginine has been shown to reduce atheroma and to decrease monocyte-endothelial cell adhesion in an animal model of atherosclerosis, we studied the effects of L-arginine on human monocyte adhesion to human endothelial cells and endothelial expression of cell adhesion molecules.

    METHODS AND RESULTS: Human umbilical vein endothelial cells (HUVECs) were grown to confluence, then incubated for ...

    Also Ranks for: Monocyte Adhesion |  endothelial cells |  vascular endothelium |  arginine reduces |  key early event
    KOL Index score: 12867

    Context: Erectile function is important for life satisfaction and often impaired in men with obstructive sleep apnea (OSA). Uncontrolled studies show that treating OSA with continuous positive airway pressure (CPAP) improves erectile function. Phosphodiesterase type 5 inhibitors (e.g., vardenafil) are the first-line therapy for erectile dysfunction (ED), but may worsen OSA.

    Objective: To assess the effects of CPAP and vardenafil on ED.

    Design: Sixty-one men with moderate-to-severe OSA ...

    Also Ranks for: Erectile Dysfunction |  obstructive sleep apnea |  sexual function |  arterial stiffness |  osa cpap
    KOL Index score: 12764

    OBJECTIVES: This study was conducted to describe the incidence of ventricular arrhythmia during prospective long-term follow-up in a group of patients who had repair of tetralogy of Fallot during early childhood.

    BACKGROUND: Ventricular arrhythmia has been a common finding in patients who have undergone repair of tetralogy of Fallot in late childhood or as adults. Whether earlier repair lowers the incidence of late ventricular arrhythmia or late sudden death is unknown.

    METHODS: ...

    Also Ranks for: Ventricular Arrhythmia |  early repair |  tetralogy fallot |  postoperative complications |  cardiac child child
    KOL Index score: 12751

    OBJECTIVES: Our aim was to investigate the effects of reconstituted high-density lipoprotein (rHDL) infusions on plasma high-density lipoprotein (HDL) anti-inflammatory properties and ex vivo cholesterol efflux in patients with type 2 diabetes.

    BACKGROUND: The anti-inflammatory effects of HDL contribute to protection from cardiovascular events. Individuals with type 2 diabetes are at elevated risk for cardiovascular disease, and typically have low HDL with reduced anti-inflammatory ...

    Also Ranks for: Cholesterol Efflux |  type 2 diabetes |  density lipoprotein |  inflammatory properties |  hdl rhdl
    KOL Index score: 12701

    Reduced fetal growth is associated with increased systolic blood pressure. Recently, we found an inverse association between serum ω-3 fatty acids and systolic blood pressure in young adults born with impaired fetal growth. We investigated the associations of dietary intake in childhood of the long-chain ω-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid with blood pressure parameters in children born with reduced birth weight. We analyzed data from 3457 children aged 8 to 15 ...

    Also Ranks for: Blood Pressure |  birth weight |  fatty acids |  docosahexaenoic acid |  children born


    David Stephen Celermajer: Influence Statistics

    Sample of concepts for which David Stephen Celermajer is among the top experts in the world.
    Concept World rank
    congenital humans length #1
    late outcomes arrhythmia #1
    pm25 tertile #1
    fontan procedure adolescence #1
    dilatation impaired #1
    segmental pulmonary artery #1
    55±15 #1
    trend 20 oestradiol #1
    increased plasma adma #1
    thromboembolic events year #1
    balloon fmd #1
    angiogenesis impaired angiogenesis #1
    lifestyle cardiometabolic health #1
    “atheroprotective” mediators #1
    short‐term ischaemic preconditioning #1
    almi bf #1
    heterotaxy fontan failure #1
    maintained exercise capacity #1
    increasing levels glycemia #1
    obesity⁎⁎editorials #1
    function lifestyle modification #1
    secreted levels il1β #1
    pfr pimr #1
    superfontan #1
    “atheroprotective” mediators apolipoproteina #1
    urban indigenous beta #1
    dht rhcg #1
    n4377 #1
    atorvastatin cholestyramine #1
    placebowashout #1
    segmental pulmonary arteries #1
    f378 fmd #1
    coa subjects #1
    distensibility α #1
    fontan protein #1
    bronchitis fontan procedure #1
    n18 rhte #1
    participants fontan circulation #1
    pvp sdb #1
    inappropriate shocks shocks #1
    cyanosed #1
    function male bodybuilders #1
    body fat newborns #1
    pah adulthood #1
    anzfr survival #1
    marker subclinical atherosclerosis #1
    rightheart #1
    chronic cyanosis adults #1
    nitroglycerin endothelium #1
    initial assessment attendance #1

    Key People For New Zealand

    Top KOLs in the world
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    David Stephen Celermajer:Expert Impact

    Concepts for whichDavid Stephen Celermajerhas direct influence:New zealand,  Fontan circulation,  Endothelial function,  Pulmonary hypertension,  Congenital heart disease,  Blood pressure,  Endothelial dysfunction,  Heart disease.

    David Stephen Celermajer:KOL impact

    Concepts related to the work of other authors for whichfor which David Stephen Celermajer has influence:Endothelial function,  Pulmonary hypertension,  Cardiovascular disease,  Nitric oxide,  Blood pressure,  Heart failure,  Brachial artery.



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    University of Sydney | Central Clinical School, The University of Sydney School of Medicine, Sydney, NSW, Australia | Royal Prince Alfred Hospital, The University of Sydney, Australia (D.S.C.). | Sydney Medical School, University of Sydney, Australia