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    • Tilman T Zittel
    • Tilman T Zittel

      Tilman T Zittel

      Hudiksvall Hospital, Department of Surgery, Colorectal Section, Hudiksvall, Sweden | University Hospital for General, Visceral and Transplant Surgery, Tuebingen, Germany | ...



      KOL Resume for Tilman T Zittel


      Hudiksvall Hospital, Department of Surgery, Colorectal Section, Hudiksvall, Sweden


      University Hospital for General, Visceral and Transplant Surgery, Tuebingen, Germany


      Department of General Surgery, Eberhard-Karls-University Tuebingen, Hoppe-Seyler-Straβe 3, 72076, Tuebingen, Germany


      Department of General, Visceral and Transplantation Surgery, University Hospital, Hoppe‐Seyler‐Strasse 3, 72076 Tübingen, Germany


      From the Department of General Surgery, University Hospital Tuebingen, Tuebingen Germany


      Department of General, Visceral and Transplantation Surgery, University Hospital, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany

      Klinik f?r Allgemeine Chirurgie, Viszeral- und Transplantationschirurgie, Universit?t T?bingen(? rztlicher Direktor: Prof. Dr. Dr. h. c. H. D. Becker)


      Department of General Surgery, University Hospital, University of Tübingen, Germany


      Tübingen, Germany


      University Hospital, Department of General and Transplantation Surgery, Tübingen University, Hoppe-Seyler-Str. 3, D-72076 Tübingen, Germany e-mail: Tel.: +49-7071-2986611 Fax: +49-7071-295500, DE

      Department of General Surgery


      Chirurgische Abteilung, Universitätsklinik Tübingen, Waldhörnlestraße 22, 72072, Tübingen, Germany


      From Cure/GASTROENTERIC Biology Center, West Los Angeles Va Medical Center, And University Of California, Los Angeles, Calif., And Department Of Abdominal And Transplantation Surgery, TüBINGEN, Germany


      From University Hospital, Department of Abdominal and Transplantation Surgery, Tübingen, Germany

      Abteilung für Allgemeinchirurgie (Direktor: Prof. Dr. H. D. Becker), Chirurgische Universitätsklinik Tübingen, XX


      Department of Abdominal and Transplantation Surgery, University Hospital, Tübingen, Germany


      CURE: VA / UCLA Gastroenteric Biology Center VAMC-Wadsworth, Los Angeles, CA 90073, USA

      From the University Hospital, Department of Abdominal and Transplantation Surgery, Tübingen, Germany (TTZ, BvE, RKT, HDB)


      Center for Ulcer Research and Education, Veterans Affairs/Universityof California, Los Angeles.

      University Hospital Department of Abdominal and Transplantation Surgery Tübingen, Germany


      Department of Anatomy, School of Medicine, Los Angeles, CA USA



      Tilman T Zittel: Influence Statistics

      Sample of concepts for which Tilman T Zittel is among the top experts in the world.
      Concept World rank
      postoperative colonic ileus #1
      nt3 gastrointestinal motility #1
      3 postoperative complications #1
      gastric colonic wall #1
      nt3 gastric #1
      rats emg signals #1
      colon awake #1
      investigate postoperative ileus #1
      publication abdomen anesthetics #1
      partly mediate #1
      postoperative gastric #1
      gastrointestinal motility model #1
      postoperative inhibition #1
      nt3 motility #1
      mmc spraguedawley telemetry #1
      gastric postoperative #1
      telemetric small #1
      motility awake #1
      gastric colonic motility #1
      motility detailed #1
      ether gastrointestinal #1
      short manipulation #1
      postoperative gastric ileus #1
      investigate postoperative #1
      effects nt3 #1
      nt3 nt3 treatment #1
      motility enflurane #1
      gastrointestinal emg #1
      ileus sprague #1
      motility postoperative #1
      nt3 gastrointestinal #1
      model postoperative ileus #1
      transducers awake #1
      strain gauge transducers #1
      mediation postoperative #1
      postoperative colonic #1
      pressure abdomen anesthetics #1
      awake rats introduction #1
      model colonic motility #1
      motilityrecording #1
      fed matched #2
      metergoline vehicle #2
      metergoline increased #2
      patients standardized meal #2


      Prominent publications by Tilman T Zittel

      KOL-Index: 12462

      CCK-A receptors and neurons of the nucleus of the solitary tract (NTS) are involved in the regulation of food intake, and in rats, there is evidence for involvement of an intestinal vagal afferent pathway. Studies investigating the role of CCK-A receptors in activation of NTS neurons using highly selective CCK-A receptor agonists and antagonists have yielded conflicting data. In the present study, we investigated CCK-induced and postprandial activation of NTS neurons, together with food ...

      Known for Solitary Tract | Nts Neurons | Food Intake | Cholecystokinin Receptor | Rats Cck
      KOL-Index: 11894

      Gastrointestinal motility is strongly inhibited during peritonitis or sepsis and proinflammatory cytokines released into mesenteric lymph during an acute gastrointestinal insult mediate systemic responses. We investigated whether mesenteric lymph collected during peritonitis or sepsis inhibits gastric motility and gastric emptying. Mesenteric lymph was collected for 12 hours from three experimental groups: vehicle (saline, 1 ml, intraperitoneally [ip], control lymph), peritonitis (0.5% ...

      Known for Mesenteric Lymph | Gastric Motility | Recipient Rats | Emptying Gastrointestinal | Tumor Necrosis
      KOL-Index: 10817

      BACKGROUND: Gastrointestinal motility is frequently impaired after abdominal surgery. We investigated the effects of neostigmine on colonic motility in patients after colorectal surgery and in healthy volunteers.

      METHODS: Colonic motility was recorded by a manometry/barostat system in 12 patients after left colonic or rectal resection during baseline and after the intravenous administration of increasing doses of neostigmine on postoperative days 1, 2, and 3. In addition, colonic ...

      Known for Colonic Motility | Colorectal Surgery | Neostigmine Postoperative | Mm Hg | 12 Patients
      KOL-Index: 10773

      The purpose of the study was to determine the overall risk of a permanent stoma in patients with complicated perianal Crohn's disease, and to identify risk factors predicting stoma carriage. A total of 102 consecutive patients presented with the first manifestation of complicated perianal Crohn's disease in our outpatient department between 1992 and 1995. Ninety-seven patients (95%) could be followed up at a median of 16 years after first diagnosis of Crohn's disease. Patients were sent ...

      Known for Fecal Diversion | Perianal Crohn | Permanent Stoma | Rectal Resection | 54 Patients
      KOL-Index: 10503

      C-fos protein expression was investigated in the nucleus of the solitary tract (NTS) in response to increasing cholecystokinin (CCK) doses and food intake in rats by counting the number of c-fos protein positive cells in the NTS. C-fos protein expression in the NTS dose-dependently increased in response to CCK, the lowest effective dose being 0.1 microg/kg. The ED(50) for c-fos protein expression in the NTS in response to CCK was calculated to be 0.5 to 1.8 microg/kg, depending on the ...

      Known for Food Intake | Solitary Tract | Fos Protein | Cholecystokinin Dose | Spraguedawley Receptors
      KOL-Index: 10444

      PURPOSE: Colonic motility is crucial for the resolution of postoperative ileus. However, few data are available on postoperative colonic motility and no data on postoperative colonic tone. We aimed to characterize postoperative colonic tone and motility in patients.

      METHODS: Nineteen patients were investigated with combined barostat and manometry recordings after left colonic surgery. During surgery a combined recording catheter was placed in the colon with two barostat bags and four ...

      Known for Colonic Motility | Colorectal Surgery | Postoperative Ileus | Barostat Bag | Day 3
      KOL-Index: 10198

      BACKGROUND: Postoperative ileus influences patients well-being, hospital stay, and health cost, and postoperative inhibition of colonic motility is a major contributor to postoperative ileus. Experimental models for investigating postoperative ileus are needed. In particular, recording of postoperative colonic motility in awake rats has not been described yet.

      MATERIAL AND METHODS: Gastric, small intestinal, and colonic motility were recorded with strain gauge transducers in awake rats, ...

      Known for Awake Rats | Postoperative Ileus | Gastrointestinal Motility | Strain Gauge Transducers | Abdominal Surgery
      KOL-Index: 10049

      BACKGROUND & AIMS: Functional effects mediated via the 5-hydroxytryptamine3 receptor (5-HT3R) can be elicited from both extrinsic and intrinsic neurons innervating the gastrointestinal (GI) tract. Clinically, 5-HT3 antagonists are important in the treatment of emesis and have been used for the treatment of symptoms in functional bowel disease. The aim of the present study was to elucidate the cellular sites of 5-HT3R expression in the rat GI tract using immunohistochemistry.

      METHODS: ...

      Known for Gastrointestinal Tract | Serotonin Receptors | Interstitial Cells | 5 Ht3r | Myenteric Plexus
      KOL-Index: 9656

      Nutrients in the intestine inhibit food intake via an action on the vagal afferent pathway. The aim of the present study was to use immunochemical detection of Fos protein-like immunoreactivity (FLI) in the brainstem to trace the neuronal pathways activated by intestinal nutrients. Perfusion of the intestine of awake rats via an indwelling duodenal catheter with iso-osmotic mannitol, hydrochloric acid or casein hydrolysate had no effect on the number of FLI neurons in the nucleus of the ...

      Known for Solitary Tract | Intestinal Nutrients | Fos Protein | Awake Rats | Food Intake
      KOL-Index: 9616

      OBJECTIVE: The object of this study was to investigate the mechanisms of postoperative gastric ileus in an experimental model of abdominal surgery in anesthetized rats.

      SUMMARY BACKGROUND DATA: Sensory neurons partly mediate postoperative gastric ileus. Among other neuropeptides, sensory neurons contain calcitonin gene-related peptide (CGRP) and release CGRP in response to noxious stimulation. Because CGRP inhibits gastric motility, it was hypothesized that abdominal surgery stimulates ...

      Known for Postoperative Gastric Ileus | Abdominal Surgery | Calcitonin Gene | Gastric Motility | Sensory Neurons
      KOL-Index: 9529

      BACKGROUND: Total gastrectomy often results in early satiety and loss of body weight. Serotonin inhibits food intake, and postprandial serotonin release is increased after total gastrectomy. Serotonin might contribute to early satiety and loss of body weight after total gastrectomy.

      METHODS AND MATERIALS: Food intake and body weight were investigated with an automated recording system in gastrectomized rats 1-12 months postoperatively. Rats were treated with metergoline, a ...

      Known for Food Intake | Total Gastrectomy | Serotonin Receptor | Early Satiety | Loss Body Weight
      KOL-Index: 9303

      BACKGROUND: Studies indicate that gastrectomy might alter calcium and bone metabolism, resulting in bone disorders. No data are currently available on the prevalence of bone disorders after gastrectomy.

      METHODS: Sixty gastrectomy patients were investigated for serum parameters of calcium and bone metabolism 5 to 20 years postoperatively and compared to an age- and sex-matched healthy control population. Forty patients agreed to a radiological investigation of the spine by ...

      Known for Bone Disorders | Calcium Metabolism | Gastrectomy Patients | Vertebral Fractures | Parathyroid Hormone
      KOL-Index: 9210

      Nutrients in the intestine initiate changes in secretory and motor function of the gastrointestinal (GI) tract. The nature of the 'sensors' in the intestinal wall is not well characterized. Intestinal lipid stimulates the release of cholecystokinin (CCK) from mucosal entero-endocrine cells, and it is proposed that CCK activates CCK A receptors on vagal afferent nerve terminals. There is evidence that chylomicron components are involved in this lipid transduction pathway. The aim of the ...

      Known for Vagal Afferent | Gastric Motility | Motor Function | Cholecystokinin Receptors | Control Lymph
      KOL-Index: 9064

      BACKGROUND: Calcitonin gene-related peptide (CGRP) is a widely distributed neuropeptide contained in intrinsic and extrinsic neurons of the gastrointestinal wall that has been shown to be released by noxious stimulation, to be involved in nociception, to inhibit gastrointestinal motility, and to partly mediate postoperative gastric ileus. We hypothesized that abdominal surgery-induced release of CGRP might inhibit postoperative colonic motility and food intake.

      METHODS: Colonic transit, ...

      Known for Postoperative Colonic | Food Intake | Calcitonin Gene | Abdominal Surgery | Gastrointestinal Motility
      KOL-Index: 8506

      INTRODUCTION: The indication for surgery after conservative treatment of acute diverticulitis is still under debate. This is partly as a result of limited data on the outcome of conservative management in the long run. We therefore aimed to determine the long-term results of conservative treatment for acute diverticulitis.

      METHODS: The records of all patients treated at our institution for diverticulitis between 1985 and 1991 were reviewed (n=363, median age 64 years, range 29-93). ...

      Known for Conservative Treatment | Patients Diverticulitis | Sigmoid Colon | Term Outcome | 4 Months

      Key People For Food Intake

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      Tilman T Zittel:Expert Impact

      Concepts for whichTilman T Zittelhas direct influence:Food intake,  Awake rats,  Total gastrectomy,  Colonic motility,  Gastric motility,  Colorectal surgery,  Postoperative colonic,  Postoperative colonic motility.

      Tilman T Zittel:KOL impact

      Concepts related to the work of other authors for whichfor which Tilman T Zittel has influence:Food intake,  Postoperative ileus,  Gastrointestinal tract,  Rectal prolapse,  Gastric emptying,  Total gastrectomy,  Abdominal surgery.



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      Hudiksvall Hospital, Department of Surgery, Colorectal Section, Hudiksvall, Sweden | University Hospital for General, Visceral and Transplant Surgery, Tuebingen, Germany | Department of General, Visceral and Transplantation Surgery, University Hospit

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