• Coronary Artery
    • William C Wijns
    • William C Wijns: Influence Statistics

      William C Wijns

      William C Wijns

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      The Lambe Institute for Translational Medicine and CURAM, National University of Ireland Galway (NUIG), Galway, Ireland | Smart Sensors Lab, Lambe Institute of Translational ...

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      William C Wijns:Expert Impact

      Concepts for whichWilliam C Wijnshas direct influence:Coronary artery,Myocardial infarction,Fractional flow reserve,Coronary angiography,Coronary artery disease,Eluting stent,Artery disease,Coronary intervention.

      William C Wijns:KOL impact

      Concepts related to the work of other authors for whichfor which William C Wijns has influence:Myocardial infarction,Coronary artery,Heart failure,Blood pressure,Atrial fibrillation,Pulmonary embolism,Chest pain.

      KOL Resume for William C Wijns


      The Lambe Institute for Translational Medicine and CURAM, National University of Ireland Galway (NUIG), Galway, Ireland


      Saolta University Healthcare Group, Galway, Ireland

      Cardiology Department, Cardiovascular Research Center Aalst, OLV Hospital, Aalst, Belgium.


      Department of Cardiology, National University of Ireland, Galway (NUIG), Galway, Ireland


      The Lambe Institute for Translational Medicine and Curam, National University of Ireland, Galway, Ireland.

      Cardiology Department, Cardiovascular Research Center Aalst, OLV Hospital, Aalst, Belgium

      Lambe Institute for Translational Medicine, Galway, Ireland


      CÚRAM, SFI Centre for Research in Medical Devices, Galway, Ireland

      The Lambe Institute for Translational Medicine and Curam Saolta University Healthcare Group.

      Cardiovascular Research Center, OLV Hospital, Aalst, Belgium


      Saolta University Healthcare Group, Galway, Ireland.

      The Lambe Institute for Translational Medicine and Curam, National University of Ireland Galway Ireland

      OLV Hospital Cardiovascular Centre Aalst Belgium

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      Sample of concepts for which William C Wijns is among the top experts in the world.
      Concept World rank
      ima coronary arteries #1
      dobutamine pa #1
      betace #1
      81±25 #1
      biophysiological responses #1
      nstruts566 #1
      aspirin america #1
      discordance angiography #1
      dissensuses #1
      plaque fragments dca #1
      regional stiffness occlusion #1
      medcor trial #1
      patients ppees #1
      stenting correlations #1
      absorbable polymer #1
      mortality hospital survivors #1
      functional significance cad #1
      dessolve trials #1
      early late control #1
      hpr mvd patients #1
      stenotic arteries dobutamine #1
      vbt svg #1
      molsidomine medcor trial #1
      disturbed vorticity #1
      73 age #1
      patient outcomes endeavour #1
      mammary artery grafts #1
      severe bicuspid tavi #1
      clinical practice pci #1
      increment restenosis #1
      ischemia qc qn #1
      ffr acute phase #1
      transatlantic patient survey #1
      ndof lpv #1
      cardiac interventions europe #1
      metal stent rate #1
      β brachytherapy #1
      reversed single string #1
      stib trial #1
      learning pawp #1
      ofr qfr #1
      diameter coronary arteries #1
      patients moderatetosevere ckd #1
      period ccta #1
      retentionenhanced catheter #1
      variables decrease #1
      myval implantation #1
      bioabsorbable coating #1
      vic dysfunctional segments #1
      computation ffrqca #1
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      Prominent publications by William C Wijns

      KOL-Index: 18633

      IMPORTANCE: Dual antiplatelet therapy after percutaneous coronary intervention (PCI) reduces ischemia but increases bleeding.

      OBJECTIVE: To develop a clinical decision tool to identify patients expected to derive benefit vs harm from continuing thienopyridine beyond 1 year after PCI.

      DESIGN, SETTING, AND PARTICIPANTS: Among 11,648 randomized DAPT Study patients from 11 countries (August 2009-May 2014), a prediction rule was derived stratifying patients into groups to distinguish ischemic ...

      Known for Prediction Rule | 1 Year | Antiplatelet Therapy | Continued Thienopyridine | Ischemia Myocardial Infarction
      KOL-Index: 18623

      OBJECTIVES: This study sought to report the final 5 years follow-up of the landmark LEADERS (Limus Eluted From A Durable Versus ERodable Stent Coating) trial.

      BACKGROUND: The LEADERS trial is the first randomized study to evaluate biodegradable polymer-based drug-eluting stents (DES) against durable polymer DES.

      METHODS: The LEADERS trial was a 10-center, assessor-blind, noninferiority, "all-comers" trial (N = 1,707). All patients were centrally randomized to treatment with either ...

      Known for Durable Polymer | Stent Thrombosis | Primary Endpoint | Noninferiority Trial | Coronary Artery
      KOL-Index: 18072

      BACKGROUND: Experimental studies have shown that fractional flow reserve (defined as the ratio of maximal achievable flow in a stenotic area to normal maximal achievable flow) can be calculated from coronary pressure measurements only. The objectives of this study were to validate fractional flow reserve calculation in humans and to compare this information with that derived from quantitative coronary angiography.

      METHODS AND RESULTS: Twenty-two patients with an isolated, discrete ...

      Known for Coronary Flow | Pressure Measurements | Emission Tomography | Maximal Vasodilation | Area Stenosis
      KOL-Index: 18040

      BACKGROUND: MiStent is a drug-eluting stent with a fully absorbable polymer coating containing and embedding a microcrystalline form of sirolimus into the vessel wall. It was developed to overcome the limitation of current durable polymer drug-eluting stents eluting amorphous sirolimus. The clinical effect of MiStent sirolimus-eluting stent compared with a durable polymer drug-eluting stents has not been investigated in a large randomised trial in an all-comer population.

      METHODS: We did ...

      Known for Dessolve Iii | Durable Polymer | Percutaneous Coronary | 12 Months | Eluting Stent
      KOL-Index: 17537

      BACKGROUND: The newly developed Nobori coronary stent coated with a bioresorbable polymer, polylactic acid, and the antiproliferative agent Biolimus A9 has the potential to reduce restenosis by suppressing neointima formation.

      METHODS AND RESULTS: We conducted a randomized (2:1), controlled trial comparing the Biolimus A9-eluting stent Nobori and the paclitaxel-eluting stent Taxus Liberté, in 243 patients (153 Nobori and 90 Taxus) at 29 centers in Europe, Asia, and Australia. Patients ...

      Known for Coronary Stent | Biolimus A9 | Randomized Comparison | 9 Months | Nobori Taxus
      KOL-Index: 17235

      Aims: To determine the ranges of pre-test probability (PTP) of coronary artery disease (CAD) in which stress electrocardiogram (ECG), stress echocardiography, coronary computed tomography angiography (CCTA), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and cardiac magnetic resonance (CMR) can reclassify patients into a post-test probability that defines (>85%) or excludes (<15%) anatomically (defined by visual evaluation of invasive coronary ...

      Known for Stable Angina | Cad Ptp | Coronary Angiography | Computed Tomography | Ica Ffr
      KOL-Index: 17191

      OBJECTIVES: The aim of this study was to perform a head-to-head comparison between multi-slice computed tomography (MSCT) and myocardial perfusion imaging (MPI) in patients with an intermediate likelihood of coronary artery disease (CAD) and to compare non-invasive findings to invasive coronary angiography.

      BACKGROUND: Multi-slice computed tomography detects atherosclerosis, whereas MPI detects ischemia; how these 2 techniques compare in patients with an intermediate likelihood of CAD is ...

      Known for Myocardial Perfusion Imaging | Cad Patients | Invasive Coronary Angiography | Computed Tomography | Msct Mpi
      KOL-Index: 17143

      OBJECTIVES: The aim of this prospective multicenter study was to identify the optimal approach for simple and fast fractional flow reserve (FFR) computation from radiographic coronary angiography, called quantitative flow ratio (QFR).

      BACKGROUND: A novel, rapid computation of QFR pullbacks from 3-dimensional quantitative coronary angiography was developed recently.

      METHODS: QFR was derived from 3 flow models with: 1) fixed empiric hyperemic flow velocity (fixed-flow QFR [fQFR]); ...

      Known for Coronary Angiography | Qfr Ffr | Fractional Flow | Vasodilator Agents | Reserve Myocardial
      KOL-Index: 16683

      OBJECTIVES: The aim of this study was to investigate the impact of patient and lesion complexity on outcomes with newer-generation zotarolimus-eluting stents (ZES) and everolimus-eluting stents (EES).

      BACKGROUND: Clinical and angiographic outcomes of newer-generation stents have not been described among complex patients.

      METHODS: Patients enrolled in the RESOLUTE All Comers trial (A Randomized Comparison of a Zotarolimus-Eluting Stent With an Everolimus-Eluting Stent for Percutaneous ...

      Known for Eluting Stent | Randomized Comparison | Lesion Complexity | Zes Ees | Complex Patients
      KOL-Index: 16670

      OBJECTIVES: The aim of this study was to investigate the correlation between myocardial ischemia detected by myocardial perfusion imaging (MPI) with single-photon emission computed tomography with intracoronary pressure-derived fractional flow reserve (FFR) in patients with multivessel coronary disease at angiography.

      BACKGROUND: Myocardial perfusion imaging can underestimate the number of ischemic territories in patients with multivessel disease. However, there are limited data ...

      Known for Myocardial Perfusion | Ffr Patients | Multivessel Coronary | Fractional Flow Reserve | Illness Tomography
      KOL-Index: 16133

      OBJECTIVES: We sought to directly compare the diagnostic value of exercise-redistribution-reinjection thallium single-photon emission computed tomography (SPECT) and low dose dobutamine echocardiography for prediction of contractile recovery after revascularization.

      BACKGROUND: Both thallium SPECT and dobutamine echocardiography have been proposed to predict the reversibility of left ventricular dysfunction after revascularization. Although both techniques permit differentiation of ...

      Known for Computed Tomography | Photon Emission | Dobutamine Echocardiography | Ventricular Dysfunction Revascularization | Functional Recovery
      KOL-Index: 15917

      BACKGROUND: Even in the absence of a previous myocardial infarction, patients with coronary artery disease often present with chronic regional wall motion abnormalities that are reversible spontaneously or after coronary revascularization. In these patients, regional dysfunction has been proposed to result either from prolonged postischemic dysfunction (myocardial "stunning") or from adaptation to chronic hypoperfusion (myocardial "hibernation"). This study examines which of these two ...

      Known for Dependent Myocardium | Regional Dysfunction | Collateral Flow | Oxidative Metabolism | Coronary Revascularization Patients
      KOL-Index: 15906

      In patients with stable CAD, PCI can be considered a valuable initial mode of revascularization in all patients with objective large ischaemia in the presence of almost every lesion subset, with only one exception: chronic total occlusions that cannot be crossed. In early studies, there was a small survival advantage with CABG surgery compared with PCI without stenting. The addition of stents and newer adjunctive medications improved the outcome for PCI. The decision to recommend PCI or ...

      Known for Patients Primary Pci | Chest Pain | European Society | 3 Onset | Glycoprotein Gpiib
      KOL-Index: 15818

      BACKGROUND: Inducing both maximal and steady-state coronary hyperemia is of clinical importance to take full advantage of fractional flow reserve measurements. The present study compares different dosages and routes of administration of adenosine 5'-triphosphate (ATP), adenosine, contrast medium, and papaverine regarding their potential to achieve both maximal and steady-state hyperemia.

      METHODS AND RESULTS: In 21 patients with an isolated coronary stenosis, coronary vasodilation was ...

      Known for Intravenous Adenosine | Contrast Medium | Intracoronary Papaverine | Coronary Angiography | Fractional Flow
      KOL-Index: 15680

      BACKGROUND: Quantitative flow ratio (QFR) is a novel angiography-based method for deriving fractional flow reserve (FFR) without pressure wire or induction of hyperemia. The accuracy of QFR when assessed online in the catheterization laboratory has not been adequately examined to date.

      OBJECTIVES: The goal of this study was to assess the diagnostic performance of QFR for the diagnosis of hemodynamically significant coronary stenosis defined by FFR ≤0.80.

      METHODS: This prospective, ...

      Known for Coronary Stenosis | Flow Ratio | Diagnostic Accuracy Qfr | Based Quantitative | Online Assessment

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      The Lambe Institute for Translational Medicine and CURAM, National University of Ireland Galway (NUIG), Galway, Ireland | Smart Sensors Lab, Lambe Institute of Translational Research, National University of Ireland Galway, Galway, Ireland | Disciplin

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