Michael Amling

Michael Amling


Prominent publications by Michael Amling

KOL Index score: 13647

pQCT was evaluated for accuracy of phenotypic characterization of mouse bone in vivo. Bones (tibia, femur, spine) of 27 animals were measured ex vivo with pQCT, microCT, and histomorphometry and of 23 mice in vivo (pQCT). pQCT yielded satisfactory in vivo precision and accuracy in skeletal characterization.

INTRODUCTION: Important aspects of modern skeletal research depend on the phenotypic characterization of genetically manipulated mice, with some approaches requiring in vivo ...

Known for Microcomputed Tomography |  Bone Density |  Femur Tibia |  Peripheral Quantitative |  Computed Animals
KOL Index score: 13230

Parathyroid hormone-related peptide (PTHrP) was initially identified as a product of malignant tumors that mediates paraneoplastic hypercalcemia. It is now known that the parathyroid hormone (PTH) and PTHrP genes are evolutionarily related and that the products of these two genes share a common receptor, the PTH/PTHrP receptor. PTHrP and the PTH/PTHrP receptor are widely expressed in both adult and fetal tissues, and recent gene-targeting and disruption experiments have implicated PTHrP ...

Known for Endochondral Bone |  Parathyroid Hormone |  Targeted Overexpression |  Pthrp Chondrocytes |  Chondrocyte Differentiation
KOL Index score: 12799

In this study we analyzed the trabecular bone micro-architecture in the inferomedial and superolateral subregions of the femoral neck in a group with hip fractures and a control group of elderly women, with aim to clarify the micro-structural basis of bone fragility. Proximal femora from 29 Caucasian female cadavers were collected at Institute of Forensic Medicine in Belgrade (15 women with hip fracture: age 79.5±8.5 yrs.; and 14 women without hip fractures: age 74.1±9.3 yrs.). The ...

Known for Hip Fractures |  Trabecular Bone |  Postmenopausal Women |  Superolateral Neck |  Structural Basis
KOL Index score: 12701

Naturally occuring inactivating mutations of the Src homology 2 (SH2) domain-containing tyrosine phosphatase 1 (SHP-1) in mice give rise to the motheaten (me) phenotype. me/me mice have multiple hematopoietic abnormalities, suggesting that this phosphatase plays an important role in hematopoiesis. SHP-1 binds to and is activated by several hematopoietic surface receptors, including the colony-stimulating factor type 1 receptor. We have examined the role of SHP-1 in osteoclastogenesis and ...

Known for Tyrosine Phosphatase |  Negative Regulator |  Resorbing Activity |  Nonreceptor Type |  Mutant Mice
KOL Index score: 12547

The objective of this study was to elucidate the structure of cancellous bone and its age-related changes at different skeletal sites. Therefore, the lumbar spine, iliac crest, femur, and calcaneus of 12 age- and sex-matched skeletal healthy autopsy cases (6 females, 6 males, aged 28-84 years, mean 54 years) were removed. The following analysis includes an evaluation of the trabecular bone volume (BV/TV, %) and the trabecular interconnection (TBPf, mm-1) as well as a qualitative ...

Known for Trabecular Microarchitecture |  Iliac Crest |  Lumbar Spine |  Femoral Neck |  Aging Bone
KOL Index score: 12313

Despite an increasing use of high-resolution peripheral quantitative computed tomography (HR-pQCT) to evaluate bone morphology in vivo, there are reservations about its applicability in patients with osteoporosis and antiresorptive therapy. This study shows that HR-pQCT provides acceptable in vivo accuracy for bone volume fraction (BV/TV) in patients with osteoporosis and bisphosphonate (BP) treatment.IntroductionThe primary aim was to analyze agreement of trabecular structure between ...

Known for Trabecular Structure |  Gold Standard |  Radius Tibia |  Bone Volume Fraction |  Blandaltman Plots
KOL Index score: 12102

The axis from twenty-two cadavera was removed at autopsy and was sectioned in the sagittal plane to a thickness of one millimeter with use of a surface-stained block-grinding technique. Combined two and three-dimensional analysis included an evaluation of the volume of the trabecular bone, the trabecular interconnection, and the cortical thickness as well as qualitative investigation of the structure of the cancellous bone. The body of the axis, the base of the odontoid process, and the ...

Known for Odontoid Process |  Histomorphometric Analysis |  Trabecular Bone |  Cortical Thickness |  Autopsy Specimens
KOL Index score: 11821

Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome characterized by renal phosphate wasting, hypophosphatemia and low calcitriol levels as well as clinical symptoms like diffuse bone and muscle pain, fatigue fractures or increased fracture risk. Conventional imaging methods, however, often fail to detect the small tumors. Lately, tumor localization clearly improved by somatostatin-receptor (SSTR) imaging, such as octreotide scintigraphy or octreotide SPECT/CT. However, recent ...

Known for Tumor Localization |  68ga Dota |  Patients Tio |  Tate Pet |  Imaging Studies
KOL Index score: 11270

We recently described an unexpected high bone mass phenotype in mice lacking the Calca gene that encodes CT and alphaCGRP. Here we show that mice specifically lacking alphaCGRP expression display an osteopenia caused by a decreased bone formation. These results show that alphaCGRP is a physiological activator of bone formation and that the high bone mass phenotype of the Calca-deficient mice is caused by the absence of CT.

INTRODUCTION: Calcitonin (CT) and alpha-calcitonin gene-related ...

Known for Bone Formation |  Mice Alphacgrp |  Calca Gene |  Alternative Splicing |  Cgrp Expression
KOL Index score: 11169

Osteonectin function in bone was investigated by infrared analysis of bones from osteonectin-null (KO) and wildtype mice (four each at 11, 17, and 36 weeks). An increase in mineral content and crystallinity in newly formed KO bone and collagen maturity at all sites was found using FTIR microspectroscopy and imaging; consistent with osteonectin's postulated role in regulating bone formation and remodeling. Mineral and matrix properties of tibias of osteonectin-null mice and their age- and ...

Known for Infrared Analysis |  Null Mice |  Mineral Matrix |  Collagen Maturity |  Bone Osteonectin
KOL Index score: 11085

Since the hematopoetic system is located within the bone marrow, it is not surprising that recent evidence has demonstrated the existence of molecular interactions between bone and immune cells. While interleukin 1 (IL-1) and IL-18, two cytokines of the IL-1 family, have been shown to regulate differentiation and activity of bone cells, the role of IL-33, another IL-1 family member, has not been addressed yet. Since we observed that the expression of IL-33 increases during osteoblast ...

Known for Bone Marrow |  Osteoclast Formation |  Cell Differentiation |  Inbred C57bl Mice |  Expression Il33
KOL Index score: 11051

Adherence and persistence to oral bisphosphonates in women with postmenopausal osteoporosis is suboptimal. In this study, patients were treated with either oral or intravenous bisphosphonates. The increased adherence and persistence observed in patients receiving intravenous medication compared with those receiving oral medication may improve health outcomes.IntroductionPoor adherence and persistence to oral medication are often observed in women with postmenopausal osteoporosis (PMO). ...

Known for Postmenopausal Osteoporosis |  Persistence Patients |  Medication Adherence |  Oral Alendronate |  Osteoporotic Fractures
KOL Index score: 11016

Inflammation has important roles in tissue regeneration, autoimmunity, and cancer. Different inflammatory stimuli can lead to bone loss by mechanisms that are not well understood. We show that skin inflammation induces bone loss in mice and humans. In psoriasis, one of the prototypic IL-17A-mediated inflammatory human skin diseases, low bone formation and bone loss correlated with increased serum IL-17A levels. Similarly, in two mouse models with chronic IL-17A-mediated skin ...

Known for Bone Loss |  Wnt Signaling |  Skin Inflammation |  Γδ Cells |  Inflammatory Conditions
KOL Index score: 10870

The molecular mechanisms controlling bone extracellular matrix (ECM) deposition by differentiated osteoblasts in postnatal life, called hereafter bone formation, are unknown. This contrasts with the growing knowledge about the genetic control of osteoblast differentiation during embryonic development. Cbfa1, a transcriptional activator of osteoblast differentiation during embryonic development, is also expressed in differentiated osteoblasts postnatally. The perinatal lethality occurring ...

Known for Bone Formation |  Differentiated Osteoblasts |  Embryonic Development |  Transgenic Mice |  Transcriptional Activity


Michael Amling: Influence Statistics

Sample of concepts for which Michael Amling is among the top experts in the world.
Concept World rank
phex bone mineralization #1
healing bone polymer #1
osteoclast activity bony #1
murine wnt1 gene #1
avg idi values #1
bisphosphonatetreated regional differences #1
ado dxa #1
relevant receptor procalcitonin #1
wnt1g177c #1
cx43 expression vivo #1
agerelated skeletal sites #1
callus vibrated animals #1
teriparatide variable effects #1
undecalcified histology #1
piezo1runx2cre mice #1
spiral control #1
specific notch2 #1
bone 2 months #1
vitamin dfortified food #1
mice col1a1krm2 #1
lv bone loss #1
vfs radiation #1
mdkdeficient mice #1
central application leptin #1
central mineralization cases #1
skeletal complications hhc #1
mdk bone #1
estrogen preclinical studies #1
ohe thyroxin #1
calcium fracturecallus mineralisation #1
pdb biopsy bone #1
distal radius aging #1
apoe physiologic role #1
fzd9 receptor #1
hypophosphatemic osteomalacia osteosclerosis #1
icrs lesions #1
progressive osteonecrosis jaws #1
expression 9 wk #1
dentine citric acid #1
odontoid process corpus #1
nsaids bmp7 #1
subdentale synchondrose #1
mice mice mlii #1
biology skeleton #1
scbth scb #1
notch2 bone #1
bone formation rodents #1
calca gene alphacgrp #1
immature fibrous bone #1
osteoblasts xlh #1

Key People For Fracture Healing

Top KOLs in the world
Thomas A Einhorn
fracture healing distraction osteogenesis bone formation
Louis Charles Gerstenfeld
fracture healing bone formation distraction osteogenesis
Peter V Giannoudis
fracture healing internal fixation compartment syndrome
Lutz Eberhardt CLAES
fracture healing intradiscal pressure cervical spine
Theodore A Miclau
fracture healing latin america bone repair
Dana T Graves
fracture healing bone loss periodontal disease

Michael Amling:Expert Impact

Concepts for whichMichael Amlinghas direct influence:Fracture healing,  Bone formation,  Bone remodeling,  Bone mass,  Bone resorption,  Bone loss,  Histomorphometric analysis,  Chondromyxoid fibroma.

Michael Amling:KOL impact

Concepts related to the work of other authors for whichfor which Michael Amling has influence:Bone formation,  Parathyroid hormone,  Osteoblast differentiation,  Fracture healing,  Gene expression,  Stem cells,  Growth plate.



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Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, 20246 Germany | Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany;, l.brylka@uke.de, (L.B.);,

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