• Disease
  • Framingham
  • Framingham Heart
  • Framingham Heart Study
  • Daniel L Levy

    Prominent publications by Daniel L Levy

    KOL Index score: 16459

    BACKGROUND: Relatively limited epidemiological data are available regarding the prognosis of congestive heart failure (CHF) and temporal changes in survival after its onset in a population-based setting.

    METHODS AND RESULTS: Proportional hazards models were used to evaluate the effects of selected clinical variables on survival after the onset of CHF among 652 members of the Framingham Heart Study (51% men; mean age, 70.0 +/- 10.8 years) who developed CHF between 1948 and 1988. Subjects ...

    Also Ranks for: Heart Failure |  women survival |  prognosis chf |  95 mortality |  proportional hazards
    KOL Index score: 16126

    BACKGROUND: Comprehensive long-term data on atrial fibrillation trends in men and women are scant. We aimed to provide such data through analysis of the Framingham cohort over 50 years.

    METHODS: We investigated trends in incidence, prevalence, and risk factors for atrial fibrillation and its association with stroke and mortality after onset in 9511 participants enrolled in the Framingham Heart Study between 1958 and 2007. We analysed trends within 10 year groups (1958-67, 1968-77, ...

    Also Ranks for: Atrial Fibrillation |  framingham heart study |  1000 personyears |  incidence prevalence |  stroke mortality
    KOL Index score: 15983

    Importance: Nearly half of all patients with heart failure have preserved ejection fraction (HFpEF) as opposed to reduced ejection fraction (HFrEF), yet associations of biomarkers with future heart failure subtype are incompletely understood.

    Objective: To evaluate the associations of 12 cardiovascular biomarkers with incident HFpEF vs HFrEF among adults from the general population.

    Design, Setting, and Participants: This study included 4 longitudinal community-based cohorts: the ...

    Also Ranks for: Heart Failure |  ejection fraction |  incident hfpef |  cardiovascular biomarkers |  natriuretic peptides
    KOL Index score: 15533

    BACKGROUND: The natriuretic peptides are counterregulatory hormones involved in volume homeostasis and cardiovascular remodeling. The prognostic significance of plasma natriuretic peptide levels in apparently asymptomatic persons has not been established.

    METHODS: We prospectively studied 3346 persons without heart failure. Using proportional-hazards regression, we examined the relations of plasma B-type natriuretic peptide and N-terminal pro-atrial natriuretic peptide to the risk of ...

    Also Ranks for: Cardiovascular Event |  peptide levels |  risk death |  plasma natriuretic |  heart failure
    KOL Index score: 15450

    CONTEXT: Several reports have suggested the usefulness of plasma brain natriuretic peptide (BNP) as a screening test for left ventricular hypertrophy (LVH) and systolic dysfunction (LVSD). Prior studies were limited by small sample sizes and selection bias and none compared the diagnostic performance of these peptides in men and women.

    OBJECTIVES: To examine the usefulness of natriuretic peptides for screening for elevated LV mass and LVSD in the community.


    Also Ranks for: Natriuretic Peptides |  systolic dysfunction |  community screening |  framingham heart study |  ventricular hypertrophy
    KOL Index score: 15415

    BACKGROUND: Pericardial fat has been implicated in the pathogenesis of obesity-related cardiovascular disease. Whether the associations of pericardial fat and measures of cardiac structure and function are independent of the systemic effects of obesity and visceral adiposity has not been fully explored.

    METHODS AND RESULTS: Participants from the Framingham Heart Study (n=997; 54.4% women) underwent chest and abdominal computed tomography and cardiovascular magnetic resonance imaging ...

    Also Ranks for: Pericardial Fat |  ventricular structure |  lv mass |  visceral adipose tissue |  waist circumference
    KOL Index score: 15099

    CONTEXT: Rapid time to treatment with thrombolytic therapy is associated with lower mortality in patients with acute myocardial infarction (MI). However, data on time to primary angioplasty and its relationship to mortality are inconclusive.

    OBJECTIVE: To test the hypothesis that more rapid time to reperfusion results in lower mortality in the strategy of primary angioplasty.

    DESIGN: Prospective observational study of data collected from the Second National Registry of Myocardial ...

    Also Ranks for: Balloon Time |  myocardial infarction |  relationship mortality |  primary angioplasty |  thrombolytic therapy
    KOL Index score: 14893

    BACKGROUND: Heart failure is a major public health problem. Long-term trends in the incidence of heart failure and survival after its onset in the community have not been characterized.

    METHODS: We used statistical models to assess temporal trends in the incidence of heart failure and Cox proportional-hazards regression to evaluate survival after the onset of heart failure among subjects in the Framingham Heart Study. Cases of heart failure were classified according to the date of onset: ...

    Also Ranks for: Heart Failure |  incidence survival |  term trends |  aged mortality |  rate ratio
    KOL Index score: 14854

    BACKGROUND: Previous reports have suggested that an attenuated exercise heart rate response may be associated with coronary heart disease risk and with mortality. These observations may parallel the association between reduced heart rate variability during normal activities and adverse outcome. This investigation was designed to look at the prognostic implications of exercise heart rate response in a population-based sample.

    METHODS AND RESULTS: In this prospective cohort investigation, ...

    Also Ranks for: Heart Rate |  prognostic implications |  chronotropic incompetence |  coronary disease |  response exercise
    KOL Index score: 14835

    BACKGROUND: Previous clinical studies have suggested that there is an association between mitral annular calcification and the risk of stroke, but it is unclear whether this association is independent of the traditional risk factors for stroke. We examined the relation between mitral annular calcification and the incidence of stroke in a population-based study.

    METHODS: Subjects in the Framingham Study receiving a routine examination underwent M-mode echocardiography to determine the ...

    Also Ranks for: Mitral Annular Calcification |  risk stroke |  elderly cohort |  congestive heart failure |  coronary heart disease
    KOL Index score: 14786

    BACKGROUND: Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric acid concentration and gout.

    METHODS: Genome-wide association studies were done for serum uric acid in 7699 participants in the Framingham cohort and in 4148 participants in the Rotterdam cohort. Genome-wide significant single nucleotide polymorphisms (SNPs) were replicated in white (n=11 024) and black (n=3843) individuals who took part in the ...

    Also Ranks for: Uric Acid |  genetic loci |  aric study |  snps gout |  genome wide
    KOL Index score: 14736

    CONTEXT: Vascular stiffness increases with advancing age and is a major risk factor for age-related morbidity and mortality. Vascular stiffness and blood pressure pulsatility are related; however, temporal relationships between vascular stiffening and blood pressure elevation have not been fully delineated.

    OBJECTIVE: To examine temporal relationships among vascular stiffness, central hemodynamics, microvascular function, and blood pressure progression.


    Also Ranks for: Incident Hypertension |  blood pressure |  aortic stiffness |  temporal relationships |  cfpwv fwa


    Daniel L Levy: Influence Statistics

    Sample of concepts for which Daniel L Levy is among the top experts in the world.
    Concept World rank
    wmh common variants #1
    elevated scr levels #1
    pathways cardiovascular disease #1
    hfref chd #1
    mesa fos #1
    risk hfref #1
    begindocumenth textgeneexp #1
    women low chronotropic #1
    myocardial infarction followup #1
    bnp renin #1
    fhs whi #1
    incident dementia auc #1
    olink proteins #1
    blood‐based markers #1
    coronary prognosis #1
    utilization ecg databases #1
    serum aldosterone women #1
    gal3 incident #1
    n44035 #1
    study fhs #1
    prospective analyses gal3 #1
    failure framingham #1
    antecedent cvd risk #1
    women chf #1
    cismrnaeqtls #1
    grimaa pmediation #1
    aginggip1 #1
    subjects concentric hypertrophy #1
    ventricular mass risk #1
    mitralvalve prolapse prevalence #1
    rs78701042 #1
    fibrinogen platelet aggregability #1
    gal3 cardiometabolic disease #1
    asim guidelines #1
    lv diastolic dimension #1
    echocardiographic precursors #1
    chd hfref #1
    ventricular internal dimension #1
    evpbs #1
    ckd cysc #1
    repolarization increased risk #1
    middle age survival #1
    initial myocardial #1
    obfc1 ltl #1
    pressure traits #1
    amiecg rates #1
    lowestquartile mcf #1
    normal geometry prognosis #1
    risk chf #1
    chf cvd #1

    Key People For Framingham Heart Study

    Top KOLs in the world
    William Bernard Kannel
    framingham study cardiovascular disease blood pressure
    Daniel L Levy
    framingham heart study heart failure blood pressure
    Ramachandran Srini Vasan
    heart failure cardiovascular disease blood pressure
    Martin G Larson
    framingham heart study heart failure cardiovascular disease
    Phillip A Wolf
    atrial fibrillation framingham study cardiovascular disease
    William P Castelli
    framingham study coronary heart disease hdl cholesterol

    Daniel L Levy:Expert Impact

    Concepts for whichDaniel L Levyhas direct influence:Framingham heart study,  Heart failure,  Blood pressure,  Cardiovascular disease,  Atrial fibrillation,  Framingham heart,  Ventricular mass,  Ventricular hypertrophy.

    Daniel L Levy:KOL impact

    Concepts related to the work of other authors for whichfor which Daniel L Levy has influence:Heart failure,  Atrial fibrillation,  Blood pressure,  Cardiovascular disease,  Metabolic syndrome,  Myocardial infarction,  Arterial stiffness.



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    Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.J., D.L.). | Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA