Peter Francis Liddle

Peter Francis Liddle

Mrc Cyclotron Unit And Department Of Medicine (Neurology), Hammersmith Hospital Academic Unit, Department For Rehabilitation Psychiatry, Westminster And Charing Cross Medical ...

Direct Impact

Concepts for which Peter Francis Liddle has direct influence:

functional connectivity
salience network
positron emission tomography
cerebral blood flow
verbal fluency
prefrontal cortex
bipolar disorder

External impact

Concepts related to the work of other authors for which Peter Francis Liddle has influence:

repetitive transcranial magnetic stimulation
first-episode schizophrenia
severe depression
surface area
cerebral blood flow
psychotic symptoms
formal thought disorder

Prominent publications by Peter Francis Liddle

KOL-Index: 56 Schizophrenia is associated with increased levels of oxidative stress, as reflected by an increase in the concentrations of damaging reactive species and a reduction in anti-oxidant defences to combat them. Evidence has suggested that whilst not the likely primary cause of schizophrenia, increased oxidative stress may contribute to declining course and poor outcomes associated with ...
Known for
Schizophrenia Increased
KOL-Index: 53 BACKGROUND: Depression is a substantial health and economic burden. In approximately one-third of patients, depression is resistant to first-line treatment; therefore, it is essential to find alternative treatments. Transcranial magnetic stimulation (TMS) is a neuromodulatory treatment involving the application of magnetic pulses to the brain that is approved in the United Kingdom and the ...
Known for
Tbs Rtms | Tms Weighted | Depression Resistant | Transcranial
KOL-Index: 45 A reduction in the error-related negativity (ERN), a response-locked event-related potential (ERP) observed when participants commit errors during processing of stimuli, is a well-replicated cerebral abnormality in schizophrenia. However, the extent to which this abnormality reflects susceptibility to schizophrenia rather than overt change in behavioural state is unclear. As the unaffected ...
Known for
Reduced Ern Amplitudes | Overt | Ern Error | Schizophrenia Unaffected
KOL-Index: 45 BACKGROUND: Persistent formal thought disorder (FTD) is a core feature of schizophrenia. Recent cognitive and neuroimaging studies indicate a distinct mechanistic pathway underlying the persistent positive FTD (pFTD or disorganized thinking), though its structural determinants are still elusive. Using network-based cortical thickness estimates from ultra-high field 7-Tesla Magnetic Resonance ...
Known for
Cognitive Neuroimaging | Core Feature | Vertexwise Variability | Structural Correlates
KOL-Index: 32 Objective: Structural and functional abnormalities have been noted in the prefrontal cortex of individuals with neurodevelopmental disorders such as attention deficit/hyperactivity disorder (ADHD). Cortical thickness and gyrification, both of which have been reported as abnormal in the prefrontal cortex in ADHD, are thought to be modulated by genetic influences during neural development. ...
Known for
Gyrification Reduced | Genetic Influences | Carriers Allele | Inferior Frontal
KOL-Index: 31 Common and distinct neural bases of Schizophrenia (SZ) and bipolar disorder (BP) have been explored using resting-state fMRI (rs-fMRI) functional connectivity (FC). However, fMRI is an indirect measure of neural activity, which is a convolution of the hemodynamic response function (HRF) and latent neural activity. The HRF, which models neurovascular coupling, varies across the brain within ...
Known for
Connectivity Fmri | Variability False | Activity Hrf | Schizophrenia Bipolar
KOL-Index: 31 In 41 patients with schizophrenia, we used neuroanatomical information derived from structural imaging to identify patients with more severe illness, characterised by high symptom burden, low processing speed, high degree of illness persistence and lower social and occupational functional capacity. Cortical folding, but not thickness or volume, showed a high discriminatory ability in ...
Known for
Neuroanatomical | Lower Social Occupational Functional | Processing Speed
KOL-Index: 29 BACKGROUND: Several studies have found widespread structural changes affecting the grey matter at various stages of schizophrenia (the prodrome, first-episode, and the chronic stage). It is unclear which of these neuroanatomical changes are associated with a predisposition or vulnerability to develop schizophrenia rather than the appearance of the clinical features of the illness. METHODS: ...
Known for
Illness Grey | Develop Schizophrenia | Hrr Comparing | Neuroanatomical Genetic
KOL-Index: 28 Subtle disturbances of visual and motor function are known features of schizophrenia and can greatly impact quality of life; however, few studies investigate these abnormalities using simple visuomotor stimuli. In healthy people, electrophysiological data show that beta band oscillations in sensorimotor cortex decrease during movement execution (event-related beta desynchronisation (ERBD)), ...
Known for
Magnetoencephalography | Self-Paced Visuomotor Paradigm | Event-Related Beta Desynchronisation | Visual Motor Function

MRC Cyclotron Unit and Department of Medicine (Neurology), Hammersmith Hospital Academic Unit, Department for Rehabilitation Psychiatry, Westminster and Charing Cross Medical Schools, London, U.K.

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