Namperumalsamy Venkatesh Prajna

Namperumalsamy Venkatesh Prajna


Prominent publications by Namperumalsamy Venkatesh Prajna

KOL Index score: 14866

Objective: To compare oral voriconazole with placebo in addition to topical antifungals in the treatment of filamentous fungal keratitis.

Design, Setting, and Participants: The Mycotic Ulcer Treatment Trial II (MUTT II), a multicenter, double-masked, placebo-controlled, randomized clinical trial, was conducted in India and Nepal, with 2133 individuals screened for inclusion. Patients with smear-positive filamentous fungal ulcers and visual acuity of 20/400 (logMAR 1.3) or worse were ...

Known for Oral Voriconazole |  Fungal Keratitis |  Ulcer Treatment |  Randomized Clinical Trial |  Corneal Perforation
KOL Index score: 12875

OBJECTIVE: To characterize the susceptibility of filamentous fungi isolated from keratitis to amphotericin B, natamycin, caspofungin acetate, itraconazole, voriconazole, and posaconazole.

METHODS: Ninety isolates from fungal keratitis cases at Aravind Eye Hospital in South India were tested using macrobroth dilution for susceptibility to amphotericin B, natamycin, caspofungin, itraconazole, voriconazole, and posaconazole. The minimum inhibitory concentration (MIC) median and 90th ...

Known for Itraconazole Voriconazole |  Amphotericin Natamycin |  Fusarium Species |  Antimicrobial Susceptibility |  Filamentous Fungi
KOL Index score: 12310

OBJECTIVE: To compare topical natamycin vs voriconazole in the treatment of filamentous fungal keratitis.

METHODS: This phase 3, double-masked, multicenter trial was designed to randomize 368 patients to voriconazole (1%) or natamycin (5%), applied topically every hour while awake until reepithelialization, then 4 times daily for at least 3 weeks. Eligibility included smear-positive filamentous fungal ulcer and visual acuity of 20/40 to 20/400.

MAIN OUTCOME MEASURES: The primary outcome ...

Known for Natamycin Voriconazole |  Ulcer Treatment |  Fusarium Cases |  Visual Acuity |  Corneal Perforation
KOL Index score: 11405

OBJECTIVE: To conduct a therapeutic exploratory clinical trial comparing clinical outcomes of treatment with topical natamycin vs topical voriconazole for fungal keratitis.

METHODS: The multicenter, double-masked, clinical trial included 120 patients with fungal keratitis at Aravind Eye Hospital in India who were randomized to receive either topical natamycin or topical voriconazole and either had repeated scraping of the epithelium or not.

MAIN OUTCOME MEASURES: The primary outcome was ...

Known for Fungal Keratitis |  3 Months |  Natamycin Voriconazole |  Visual Acuity |  Scar Size
KOL Index score: 10674

OBJECTIVE: To determine the incidence of acute-onset postcataract endophthalmitis, identify risk factors, and determine clinical outcomes in a tertiary eye care center in South India.

DESIGN: Retrospective, interventional, observational case series.

PARTICIPANTS: All patients who underwent cataract extraction from January 2002 to December 2003 at Aravind Eye Hospital, Madurai.

METHODS: The records of patients with acute endophthalmitis after cataract surgery were reviewed.


Known for South India |  Postcataract Endophthalmitis |  Cataract Extraction |  Incidence Risk Factors |  Visual Outcome
KOL Index score: 10603

PURPOSE: To characterize human limbal epithelial cells based on the expression levels of nuclear protein p63 and the nucleus-to-cytoplasm (N/C) ratio.

METHODS: Limbal, peripheral, and central corneal epithelia were separated from the stroma by Dispase II and subsequently were treated with trypsin to obtain single-cell suspensions. Cytospin smears of the cell suspensions were double immunostained for p63 and then stained for any one of the markers (acidic cytokeratins [AE1], K5, K3, or ...

Known for Epithelial Cells |  Confocal Microscopy |  Limbal Epithelium |  P63 Expression |  Suppressor Proteins
KOL Index score: 10514

PURPOSE: To determine the diagnostic accuracy of in vivo confocal microscopy (IVCM) for moderate to severe microbial keratitis (MK).

DESIGN: Double-masked prospective cohort study.

PARTICIPANTS: Consecutive patients presenting to Aravind Eye Hospital, Madurai, India, between February 2012 and February 2013 with MK (diameter ≥3 mm, excluding descemetocele, perforation, or herpetic keratitis).

METHODS: Following examination, the corneal ulcer was scanned by IVCM (HRT3/RCM, Heidelberg ...

Known for Microbial Keratitis |  Sensitivity Specificity |  Laser Scanning |  Confocal Microscopy |  Outcome Measures
KOL Index score: 10446

BACKGROUND/AIMS: To study the susceptibility of Fusarium and Aspergillus isolated from keratitis to amoxicillin, cefazolin, chloramphenicol, moxifloxacin, tobramycin and benzalkonium chloride (BAK).

METHODS: 10 isolates of Fusarium and 10 isolates of Aspergillus from cases of fungal keratitis at Aravind Eye Hospital in South India were tested using microbroth dilution for susceptibility to amoxicillin, cefazolin, chloramphenicol, moxifloxacin, tobramycin and BAK. The minimum inhibitory ...

Known for Fungal Eye Infections |  Activity Fusarium |  Sensitivity Tests |  Bacterial Agents |  Corneal Ulcer
KOL Index score: 10345

PURPOSE: Till date there is no exclusive marker for human corneal epithelial stem cells (CESCs). In this study, our strategy is to combine high expression of ABCG2, a putative SC marker with high N/C ratio to develop a specific method for identification of CESCs.

METHODS: Limbal/corneal epithelial cells (LECs/CECs) were isolated from cadaver eyes by enzymatic treatment and the cytospin smears/cryosections were immunostained for ABCG2, p63, or connexin-43 (Cx-43) and counterstained with ...

Known for Stem Cells |  Abcg2 Expression |  Corneal Epithelial |  Atp Binding |  Microscopy Fluorescence
KOL Index score: 9833

PURPOSE: To analyze the minimum inhibitory concentration (MIC) of isolates from fungal keratitis to natamycin and voriconazole and to assess the relationship between organism, MIC, and clinical outcome.

METHODS: Data were collected as part of a randomized, controlled, double-masked clinical trial. Main outcome measures included best spectacle-corrected visual acuity, infiltrate/scar size, time to reepithelialization, and perforation. Speciation and analysis of MIC to natamycin and ...

Known for Clinical Trial |  Natamycin Voriconazole |  Inhibitory Concentration |  Fungal Corneal |  Perforation Odds Ratio
KOL Index score: 9830

PURPOSE: To describe the minimum inhibitory concentration (MIC) of fungal isolates to natamycin and voriconazole, and to compare these MICs to previous ocular susceptibility studies.

DESIGN: Experimental laboratory study using isolates from a randomized clinical trial.

METHODS: The Mycotic Ulcer Treatment Trial I was a randomized, double-masked, multicenter trial comparing topical natamycin and voriconazole for fungal keratitis treatment. Susceptibility testing to natamycin and ...

Known for Natamycin Voriconazole |  Vitro Susceptibility |  Fungal Isolates |  Aspergillus Species |  Corneal Ulcer
KOL Index score: 9502

BACKGROUND: Filamentous fungi of the genera Aspergillus and Fusarium are major causes of corneal ulcers in the United States and in the developing world and result in significant visual impairment and blindness.

METHODS: RNA was extracted from 110 patients with corneal ulcers in southern India within 1 week of infection with either Fusarium solani or Aspergillus flavus, and gene expression was determined by quantitative polymerase chain reaction. Posttransplant corneas from later stage ...

Known for Aspergillus Fusarium |  Corneal Ulcers |  Filamentous Fungi |  Southern India |  Visual Impairment
KOL Index score: 9445

PURPOSE: To compare the efficacy and safety of ofloxacin 0.3% ophthalmic solution with ciprofloxacin 0.3% ophthalmic solution in patients with culture-positive bacterial keratitis.

METHODS: Patients with a microbiologic diagnosis of bacterial keratitis were included in this double-masked, parallel-group study and were randomized to treatment with either ofloxacin 0.3% or ciprofloxacin 0.3% ophthalmic solution. One drop of the study medication was instilled during the daytime according to ...

Known for Bacterial Keratitis |  Ophthalmic Solutions |  Ofloxacin 03 |  Corneal Ulcer |  Primary Outcome Measure
KOL Index score: 9261

PURPOSE: To estimate the cumulative incidence of posterior capsule opacification 4 years after surgery in patients who participated in the Madurai Intraocular Lens Study and had extracapsular cataract extraction with posterior chamber intraocular lens implantation.

METHODS: In the Madurai Intraocular Lens Study, 1,700 patients with best-corrected visual acuity 20/120 or worse in the better eye had extracapsular cataract extraction with posterior chamber intraocular lens implantation, and ...

Known for Posterior Capsule Opacification |  Intraocular Lens |  Laser Capsulotomy |  Cataract Extraction |  Year Incidence
KOL Index score: 9091

PURPOSE: To determine risk factors and clinical signs that may differentiate between bacterial, fungal, and acanthamoeba keratitis among patients presenting with presumed infectious keratitis.

DESIGN: Hospital-based cross-sectional study.

METHODS: We examined the medical records of 115 patients with laboratory-proven bacterial keratitis, 115 patients with laboratory-proven fungal keratitis, and 115 patients with laboratory-proven acanthamoeba keratitis seen at Aravind Eye Hospital, ...

Known for Bacterial Keratitis |  Patients Acanthamoeba |  Medical Records |  Differential Eye Infections |  Contact Lenses


Namperumalsamy Venkatesh Prajna: Influence Statistics

Sample of concepts for which Namperumalsamy Venkatesh Prajna is among the top experts in the world.
Concept World rank
stable moxifloxacin #1
5 015 #1
greater nucleus #1
conclusions 2 #1
uninfected fellow eye #1
5 natamycin management #1
keratitis amphotericin #1
natamycin increased #1
patients fungal keratitis #1
limbal stroma #1
abcg2 putative marker #1
lscd limbal epithelium #1
tear samples tears #1
natamycin fungal #1
requiring therapeutic #1
5 natamycin #1
amphotericin keratitis #1
profile exoproteins #1
testing natamycin #1
positive fusarium #1
identifier pxd001296 #1
cescs method #1
abcg2 expression ratio #1
transplantation cultured epithelium #1
component limbal niche #1
fungal ulcer #1
subsequent exoproteome analysis #1
insect ulcer #1
lacrimal lipocalin precursor #1
infection process exoproteins #1
natamycin treated #1
cultured chromatography cefazolin #1
pooled flavus exoproteome #1
aged natamycin #1
tear proteome regulation #1
aggressive keratitis #1
005 endophthalmitis #1
slowhealing ulcers #1
cefazolin 5 #1
zag regulated #1
fusarium aspergillus spp #1
ratio 2 p63 #1
5 weeks voriconazole #1
fungal keratitis adult #1

Key People For Fungal Keratitis

Top KOLs in the world
Philip Aloysius Thomas
wistar rats cataract surgery mycotic keratitis
Prashant Garg
fungal keratitis ocular infections corneal scrapings
Savitri Sharma
fungal keratitis corneal scrapings cataract surgery
Eduardo C Alfonso
fungal keratitis contact lens visual acuity
Muthiah Srinivasan
south india bacterial keratitis corneal ulcers
Namperumalsamy Venkatesh Prajna
fungal keratitis south india oral voriconazole

Namperumalsamy Venkatesh Prajna:Expert Impact

Concepts for whichNamperumalsamy Venkatesh Prajnahas direct influence:Fungal keratitis,  South india,  Oral voriconazole,  Bacterial eye infections,  Bacterial keratitis,  Corneal perforation,  Visual acuity,  3 months.

Namperumalsamy Venkatesh Prajna:KOL impact

Concepts related to the work of other authors for whichfor which Namperumalsamy Venkatesh Prajna has influence:Fungal keratitis,  Cataract surgery,  Visual acuity,  Ocular surface,  Aspergillus fumigatus,  Stem cell,  Corneal ulcers.



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Aravind Eye Hospital, Madurai, Tamil Nadu, India | Aravind Eye Hospital, Madurai, India | Aravind Eye Hospital, Madurai, Tamil Nadu, India. | Aravind Eye Hospital, Madurai, India. | Department of Cornea and Refractive Services, Aravind Eye Hospital,

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