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    • Gabaa Receptor
    • Paul John Whiting
    • Paul John Whiting: Influence Statistics

      Paul John Whiting

      Paul John Whiting

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      ARUK-UCL Drug Discovery Institute, University College London, London, UK | ARUK Drug Discovery Institute (DDI), University College London, Cruciform Building, Gower Street, ...

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      Paul John Whiting:Expert Impact

      Concepts for whichPaul John Whitinghas direct influence:Gabaa receptor,Gabaa receptors,Rat brain,Xenopus oocytes,Acetylcholine receptor,Alpha 1,Receptors gaba,Amino acid.

      Paul John Whiting:KOL impact

      Concepts related to the work of other authors for whichfor which Paul John Whiting has influence:Gabaa receptors,Nicotinic acetylcholine,Nmda receptor,Central nervous,Stem cells,Myasthenia gravis,Xenopus oocytes.

      KOL Resume for Paul John Whiting

      Year
      2022

      ARUK-UCL Drug Discovery Institute, University College London, London, UK

      2021

      ARUK-UCL Drug Discovery Institute, University College London, London, United Kingdom

      2020

      ARUK Drug Discovery Institute (DDI), University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK

      2019

      Dementia Research Institute, UCL, London, UK

      2018

      Pfizer, Granta Park, Cambridge, UK

      2017

      AR-UK Drug Discovery Institute, Institute of Neurology, University College London, London, UK

      Pfizer Neuroscience and Pain Research Unit, Pfizer Ltd., Great Abington, Cambridge, United Kingdom

      2016

      Pfizer Neusentis, The Portway Building, Granta Park, Cambridge CB21 6GS, UK

      2015

      Pfizer Neusentis, Granta Park, Cambridge CB21 6GS, UK

      2014

      Pfizer Neusentis, Cambridge, UK.

      2012

      Neusentis, Pfizer Global Research and Development, The Portway Building, Granta Park, Great Abington, Cambridge CB21 6GS, UK

      2011

      The Neuroscience Research Centre, Merck, Sharpe and Dohme, Harlow, United Kingdom

      2007

      Merck Sharp Dohme Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR

      Pfizer Limited, Sandwich Laboratories, Sandwich, Kent, United Kingdom

      2006

      Department of Molecular and Cellular Neurosciences, Merck Sharp and Dohme, The Neuroscience Research Centre, Harlow, Essex, UK

      2005

      Merck Sharp & Dohme, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK

      2004

      Merck Sharp and Dohme, The Neuroscience Research Centre, Harlow, Essex, CM20 2QR, UK

      2003

      Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK.

      2002

      Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK

      2001

      Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK

      2000

      Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Road, CM20 2QR, Harlow, Essex, UK

      1999

      Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, United Kingdom

      1998

      Neuroscience Research Laboratories, Merck, Sharp and Dohme, Harlow, Essex CM20 2QR, UK

      1997

      Neuroscience Research Centre, Merck Sharp & Dohme Research Laboratories, Harlow, Essex CM20 2QR, United Kingdom.

      Merck, Sharpe, and Dohme Research Laboratories, Terlings Park, Harlow, Essex, U.K.

      1996

      Merck Sherp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, U.K.

      1995

      Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR

      Merck Sharpe and Dohme Research Laboratories, Harlow, Essex, UK

      1994

      Merck Sharpe and Dohme Research Laboratories, Harlow, Essex, England

      Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262.

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      Sample of concepts for which Paul John Whiting is among the top experts in the world.
      Concept World rank
      step gabaareceptor #1
      wildtype nr1 #1
      unique pharmacological #1
      loreclezole type #1
      deltasubunit receptors #1
      gabaa receptors cells #1
      tricuad #1
      fourth gamma subunit #1
      mrk alpha1beta1 epsilon #1
      functional gabagated channels #1
      mabs nicotinic achrs #1
      alpha 6containing receptors #1
      tertiary protein gabaa #1
      rna splicing basis #1
      mutation asp268ala #1
      modulators alpha1beta2gamma2s gabaa #1
      nudeloligopeptidase activity #1
      293 cells loreclezole #1
      common disease associations #1
      pentobarbitone increase #1
      epsilon mrk #1
      flunitrazepam amino #1
      human gabaa receptor #1
      large leak currents #1
      gel profile incorporation #1
      gabaa onigaba #1
      neuroendocrine mechanisms modulation #1
      1beta 1 #1
      etomidateinduced anesthesia #1
      alpha1g201 #1
      hippocampus messenger rnas #1
      reticulum nr2a #1
      cerebellum gamma #1
      alpha1h102 gaba #1
      hypothalamic hormones propofol #1
      7 tpa023 #1
      clinic publication #1
      association nr2a #1
      emotional response assay #1
      mutation allosteric modulation #1
      abolishing ifenprodil #1
      delta subunit muscle #1
      tigr alpha1beta1 #1
      β subunit cdnas #1
      expression epsilon subunit #1
      neurons nicotine oocytes #1
      slight nicotine sensitivity #1
      methylbetacarboline3carboxylate flunitrazepam #1
      human nmda nr1anr2a #1
      681 27 ic50 #1
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      Prominent publications by Paul John Whiting

      KOL-Index: 19742

      1. Human GABAA receptors containing different alpha and beta subunits with a gamma 2s subunit were expressed in Xenopus oocytes and the effects of pentobarbitone on these subunit combinations were examined by electrophysiological recording of GABA currents with the two-electrode voltage-clamp method. 2. Pentobarbitone has previously been shown to have three actions on GABAA receptors: a potentiation of GABA responses, a direct activation of GABAA receptors and, at high concentrations, a ...

      Known for Gabaa Receptor | Alpha Beta Subunits | Beta 2 | 1 Gamma | Direct Activation
      KOL-Index: 16871

      Type A gamma-aminobutyric acid (GABAA) receptors of the mammalian nervous system are a family of ligand-gated ion channels probably formed from the coassembly of different subunits (alpha 1-6, beta 1-3, gamma 1-3, delta) in the arrangement alpha beta gamma or alpha beta delta. The activation of these receptors by GABA can be modulated by a range of compounds acting at distinct allosteric sites. One such compound is the broad-spectrum anticonvulsant loreclezole, which we have recently ...

      Known for Aminobutyric Acid | Beta 2 | Modulatory Action | Receptors Gaba | Single Amino
      KOL-Index: 15433

      The effect of calcium-phospholipid-dependent protein kinase (PKC) on GABAA receptor function was examined in Xenopus oocytes expressing recombinant human GABAA receptor using two-electrode voltage-clamp measurements. Phorbol 12-myristate 13-acetate (PMA), a potent activator of PKC, inhibited GABA-gated chloride currents by approximately 72% in oocytes expressing alpha 1 beta 1 gamma 2L subunit cDNAs. Phorbol 12-monomyristate (PMM), a negative control analogue of PMA, did not alter GABAA ...

      Known for Protein Kinase | Gabaa Receptor | Gaba Responses | Activation Pkc | Xenopus Oocytes
      KOL-Index: 14972

      GABAA receptors composed of human alpha 1 beta 2 gamma 2L, alpha 1 beta 2 gamma 2S, alpha 1 beta 3 gamma 2S, alpha 6 beta 3 gamma 2S, and alpha 5 beta 3 gamma 3 subunits as well as bovine alpha 1 beta 1 gamma 2L and alpha 1 beta 1 subunits were stably expressed in mammalian L(tk-) cells and transiently expressed in Xenopus oocytes. Effects of muscimol, ethanol, flunitrazepam, and pentobarbital on receptor function were compared for the two expression systems using a 36Cl- flux assay for ...

      Known for Gabaa Receptors | Xenopus Oocytes | Expression Systems | Actions Ethanol | Cells Alpha
      KOL-Index: 14825

      1: The pharmacology of the stable cell line expressing human alpha(4)beta(3)delta GABA(A) receptor was investigated using whole-cell patch-clamp techniques. 2: alpha(4)beta(3)delta receptors exhibited increased sensitivity to GABA when compared to alpha(4)beta(3)gamma(2) receptors, with EC(50)'s of 0.50 (0.46, 0.53) microM and 2.6 (2.5, 2.6) microM respectively. Additionally, the GABA partial agonists piperidine-4-sulphonate (P4S) and 4,5,6,7-tetrahydroisothiazolo-[5,4-c]pyridin-3-ol ...

      Known for Alpha4beta3delta Receptors | Pharmacological Characterization | Thip Gaba | Expressing Human | Pharmacology Receptor
      KOL-Index: 14602

      7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) is a triazolopyridazine that binds with equivalent high (subnanomolar) affinity to the benzodiazepine binding site of recombinant human GABA(A) receptors containing an alpha1, alpha2, alpha3, or alpha5 subunit but has partial agonist efficacy at the alpha2 and alpha3 subtypes and essentially antagonist efficacy at the alpha1 and alpha5 subtypes. In rats, TPA023 gave ...

      Known for Agonist Selective | Spraguedawley Receptors | Nonsedating Anxiolytic | Rats Tpa023 | Gaba Receptor
      KOL-Index: 14081

      1. The rho 1 protein, which we previously cloned from retina, assembles as a homooligomer that transduces the binding of gamma-aminobutyric acid (GABA) into robust chloride currents. However, its insensitivity to bicuculline, pentobarbitone and benzodiazepines, all potent agents at typical GABAA receptors, suggested that it may react atypically to other GABA agonists and antagonists. 2. cDNAs for the rho 1 and the alpha 5 beta 1 receptors for GABA were expressed as homo- and ...

      Known for Xenopus Oocytes | Messenger Receptors | Rho 1 | Gaba Taca | Folded Conformation
      KOL-Index: 12931

      In situ hybridization histochemistry technique with [35S]UTP-labelled riboprobes was used to study the expression pattern of 10 GABA(A) receptor subunit messenger RNAs in the basal ganglia and motor thalamic nuclei of rhesus monkey. Human transcripts were used for the synthesis of alpha2, alpha4, beta2, beta3, gamma1 and delta subunit messenger RNA probes. Rat complementary DNAs were used for generating alpha1, alpha3, beta1 and gamma2 subunit messenger RNA probes. Nigral, pallidal and ...

      Known for Basal Ganglia | Thalamic Nuclei | Macaca Mulatta | Gabaa Receptor | Alpha1 Alpha3

      Key People For Gabaa Receptor

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      ARUK-UCL Drug Discovery Institute, University College London, London, UK | ARUK Drug Discovery Institute (DDI), University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom | UK Dementia Research Institute at Universit

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