• Disease
  • Galen
  • Galen Malformations
  • Michael S B Edwards

    Prominent publications by Michael S B Edwards

    KOL Index score: 11800

    A digital video fluorescence microscopy technique was used to evaluate the distribution of hematoporphyrin derivative (HPD) in the rat intracerebral 9L gliosarcoma brain-tumor model at 4, 24, 48, and 72 hours after intravenous administration of 10 mg/kg of the drug. Compared to surrounding normal brain, there was significant preferential uptake of HPD into the tumor. In sections surveyed, fluorescence reached a maximum value by 24 hours; however, only 33% to 44% of the tumor was ...

    Also Ranks for: Hematoporphyrin Derivative |  hpd tumor |  9l gliosarcoma |  fluorescence microscopy |  normal brain
    KOL Index score: 11684

    The best operative intervention for children with arachnoid cysts remains the subject of controversy. Recent reports stress that craniotomy for cyst fenestration is associated with a low incidence of morbidity and mortality and may leave the child shunt-independent. The cases of 40 pediatric patients with arachnoid cysts treated between 1978 and 1989 are reported. Five children with mild symptoms and small cysts that remained stable on follow-up studies have not required surgical ...

    Also Ranks for: Arachnoid Cysts |  cyst fenestration |  20 patients |  infant magnetic resonance |  surgical intervention
    KOL Index score: 11532

    OBJECT: Stereotactic radiosurgery for arteriovenous malformations (AVMs) is an accepted treatment option, but few reports have been published on the results of this treatment in children. In this study the authors describe a series of pediatric patients with a minimum follow-up duration of 36 months.

    METHODS: From 1991 to 1997, 40 children (26 boys and 14 girls) with AVMs were treated with radiosurgery at the University of California at San Francisco (UCSF). Follow-up information was ...

    Also Ranks for: Stereotactic Radiosurgery |  obliteration rate |  intracranial arteriovenous |  partial response |  malformations avms
    KOL Index score: 11142

    Between February 1984 and September 1990, 60 patients with brainstem gliomas were treated with hyperfractionated radiotherapy in the Department of Radiation Oncology at the University of California, San Francisco. Forty-one children (< or = 18 years) and 19 adults were treated with 100 cGy twice daily with 4-8 hr between doses. Thirty-one patients (21 children and 10 adults) received total doses of 66-72 Gy and 29 patients (20 children and nine adults) received 74-78 Gy. Median follow-up ...

    Also Ranks for: Children Adults |  hyperfractionated radiation |  brainstem gliomas |  median followup |  thirtyone patients
    KOL Index score: 10885

    Chordomas are malignant neoplasms that typically arise in the axial spine and primarily affect adults. When chordomas arise in pediatric patients they are more likely to display unusual histological features and aggressive behavior. We noted the absence of SMARCB1/INI1 expression by immunohistochemistry in an index case of poorly differentiated chordoma of the sacrum, leading us to further examine SMARCB1/INI1 expression as well as that of brachyury, a highly specific marker of ...

    Also Ranks for: Differentiated Chordomas |  ini1 expression |  pediatric patients |  aggressive behavior |  axial spine
    KOL Index score: 10715

    Between January 1980 and January 1988, 95 evaluable patients with recurrent, unifocal, supratentorial malignant gliomas were reirradiated with high-activity iodine-125 sources implanted directly into tumor in afterloaded, removable catheters using computerized tomography-directed stereotaxy. A tumor dose of 5270-15,000 cGy was delivered at a maximum distance of 0.5 cm from the rim of the contrast-enhancing mass seen on CT scans. The median survival for the 50 patients with anaplastic ...

    Also Ranks for: Malignant Gliomas |  patients kps |  quality life |  anaplastic astrocytoma |  glioblastoma multiforme
    KOL Index score: 10180

    BACKGROUND: Successful management of pediatric arteriovenous malformations (AVMs) often requires a balanced application of embolization, surgery, and radiosurgery.

    OBJECTIVE: To describe our experience treating pediatric AVMs.

    METHODS: We analyzed 120 pediatric patients (< 18 years of age) with AVMs treated with various combinations of radiosurgery, surgery, and endovascular techniques.

    RESULTS: Between 1985 and 2009, 76 children with low Spetzler-Martin grade (1-3) and 44 with ...

    Also Ranks for: Multimodality Therapy |  arteriovenous malformations |  pediatric intracranial |  grade avms |  avm obliteration
    KOL Index score: 10014

    BACKGROUND AND PURPOSE: Chordoma and chondrosarcoma of the skull base are rare tumors with overlapping presentations and anatomic imaging features but different prognoses. We hypothesized that these tumors might be distinguished by using diffusion-weighted MR imaging.

    MATERIALS AND METHODS: We retrospectively reviewed 19 patients with pathologically confirmed chordoma or chondrosarcoma who underwent both conventional and diffusion-weighted MR imaging. Differences in distributions of ADC ...

    Also Ranks for: Skull Base |  differentiated chordoma |  diffusionweighted imaging |  signal intensity |  weighted mri
    KOL Index score: 9999

    Between March, 1983, and February, 1989, 19 infants or children with chiasmal/hypothalamic gliomas were treated with chemotherapy after either surgical or radiological diagnosis. The patients ranged in age from 15 weeks to 15.6 years (median 3.2 years) at the start of therapy. Twelve patients were treated immediately after diagnosis because of progressive symptoms, and seven received chemotherapy after either radiographic progression or clinical deterioration, including progressive ...

    Also Ranks for: Chemotherapy Patients |  hypothalamic gliomas |  therapy disease |  intracranial hypertension |  radiographic progression
    KOL Index score: 9749

    BACKGROUND AND PURPOSE: Pediatric brain tumors have diverse pathologic features, which poses diagnostic challenges. Although perfusion evaluation of adult tumors is well established, hemodynamic properties are not well characterized in children. Our goal was to apply arterial spin-labeling perfusion for various pathologic types of pediatric brain tumors and evaluate the role of arterial spin-labeling in the prediction of tumor grade.

    MATERIALS AND METHODS: Arterial spin-labeling ...

    Also Ranks for: Brain Tumors |  arterial spin |  tumor grade |  sensitivity specificity |  labeling perfusion
    KOL Index score: 9584

    PURPOSE: To evaluate the diagnosis, therapy, and survival of patients with intracranial germ-cell tumors. To define the role of prophylactic craniospinal irradiation and chemotherapy necessary to impact on survival.

    METHODS AND MATERIALS: Forty-eight patients with surgically confirmed or suspected primary intracranial germ-cell tumors treated at UCSF between 1968-1990 were reviewed. Thirty-four patients had a pathologic diagnosis, including 24 germinomas, 3 malignant teratomas, 2 ...

    Also Ranks for: Cell Tumors |  radiation therapy |  local neoplasms |  intracranial germ |  2 years


    Michael S B Edwards: Influence Statistics

    Sample of concepts for which Michael S B Edwards is among the top experts in the world.
    Concept World rank
    misonidazole neurotoxicity rats #1
    ependymomas brdu #1
    clinical experience argon #1
    drez new involvement #1
    stem cerebellar #1
    conjunction management #1
    atypical teratoma #1
    argon lesions #1
    dose 200 joules #1
    radiation test dose #1
    brain abscess treatment #1
    simple durable #1
    41±28 #1
    argon laser extent #1
    gross subtotal removal #1
    jpa patients #1
    intracerebral 9l #1
    mm focused #1
    chordomas mature teratomas #1
    pineal region biopsy #1
    lipomyelomeningocele normal #1
    21 148 months #1
    misonidazole neurotoxicity rat #1
    lis greater 10 #1
    callosotomy pediatric #1
    multicentric juvenile #1
    monitoring abscess size #1
    syringomyelia production #1
    lipomyelomeningocele patients #1
    ventriculomegaly severe #1
    jpa stable #1
    evoked potentials rats #1
    jpa neoplasms chemotherapy #1
    development endovascular embolization #1
    200 joules administration #1
    severe neurotoxicity sacrifice #1
    ependymoma choroid #1
    multicentric spread patients #1
    budr proliferative potential #1
    primary intracranial germinomas #1
    pediatric skull deformities #1
    24th injection #1
    range 40–392 #1
    meningiomas publication child #1
    ependymoma brdu #1
    findings budr #1
    greater 10 10 #1
    shunting required #1
    intramedullary spread #1
    budrpositive nuclei #1

    Key People For Galen Malformations

    Top KOLs in the world
    Pierre L Lasjaunias
    arteriovenous malformations spinal cord endovascular treatment
    Georges L Rodesch
    endovascular treatment spinal cord mechanical thrombectomy
    Karel G terBrugge
    arteriovenous malformations endovascular treatment intracranial aneurysms
    Ricardo Daniel García Mónaco
    clinical remission vascular calcifications esophageal cancer
    Hortensia Alvarez
    arteriovenous malformations endovascular treatment vascular anomalies
    Charles Milton Strother
    4d dsa intracranial aneurysms internal carotid artery

    Michael S B Edwards:Expert Impact

    Concepts for whichMichael S B Edwardshas direct influence:Galen malformations,  Radiation therapy,  Posterior fossa,  Spinal cord,  Brain stem gliomas,  Slit ventricle syndrome,  Skull base,  Galen malformation.

    Michael S B Edwards:KOL impact

    Concepts related to the work of other authors for whichfor which Michael S B Edwards has influence:Brain tumors,  Spinal cord,  Central nervous,  Radiation therapy,  Magnetic resonance,  Arachnoid cysts,  Pediatric patients.



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    Division of Pediatric Neurosurgery, Stanford University, School of Medicine, Lucile Packard Children’s Hospital, Stanford, CA, USA | Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA | Department of Neurosurgery St