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    • John Dent
    • John Dent: Influence Statistics

      John Dent

      John Dent

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      Faculty of Health and Medical Sciences, The University of Adelaide, Australia. | Department of Medicine, University of Adelaide, Adelaide, SA, Australia | Department of ...

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      John Dent:Expert Impact

      Concepts for whichJohn Denthas direct influence:Reflux disease,Gastroesophageal reflux,Gastric emptying,Oesophageal reflux,Pyloric motility,Reflux oesophagitis,Sleeve sensor,Gastroesophageal reflux disease.

      John Dent:KOL impact

      Concepts related to the work of other authors for whichfor which John Dent has influence:Gastroesophageal reflux disease,Reflux esophagitis,Gastric emptying,Helicobacter pylori,Barrett esophagus,Proton pump,Patients gerd.

      KOL Resume for John Dent

      Year
      2022

      Faculty of Health and Medical Sciences, The University of Adelaide, Australia.

      2020

      Department of Medicine, University of Adelaide, Adelaide, SA, Australia

      2019

      Department of Medicine, University of Adelaide and Royal Adelaide Hospital, Adelaide, South Australia.

      2017

      Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia

      2016

      Royal Adelaide Hospital, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, SA, Australia

      2015

      Royal Adelaide Hospital and University of Adelaide, Australia

      2014

      Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia

      2013

      Department of Gastroenterology and Hepatology, Royal Adelaide Hospital and University of Adelaide, Adelaide, South Australia, Australia

      2012

      Royal Adelaide Hospital, Adelaide, South Australia, Australia

      2011

      Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, South Australia, Australia

      Nerve Gut Research Laboratory, Hanson Institute, and

      2010

      Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia

      2008

      The University of Adelaide, Nerve-Gut Research Laboratory, Department of Gastroenterology & Hepatology, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia

      2007

      Kings College, London, Gro?britannien

      Royal Adelaide Hospital, Department of Gastroenterology, Adelaide, Australia

      Dept of Gastroenterology, Sint Antonius Hospital, Nieuwegein, the Netherlands

      Dalhousie University, Halifax, Neuschottland, Kanada

      Northwestern University, Chicago, Illinois, USA

      2006

      Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, South Australia

      2005

      Departments of Surgery and Medicine, Flinders University of South Australia, Adelaide, and the Department of Gastroenterology, Royal Melbourne Hospital, Melbourne, Australia

      AstraZeneca R&D Mölndal, SE-43183, Sweden

      Section of Gastroenterology, Houston Veterans Affairs Medical Center (152), Houston, Texas, USA

      2004

      Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital; Adelaide, South Australia 5000, Australia

      2003

      Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, Australia;

      VA Palo Alto Health System, Stanford, Palo Alto, California, USA

      Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia

      2002

      Department of Gastroenterology, Hepatology, and General Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia

      Division of Medicine, Nepean Hospital, Penrith,

      Dr Margarete Fischer‐Bosch‐Institute of Clinical Pharmacology Stuttgart Germany

      2001

      Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia;

      Eberhard‐Karls Universität Dr Margarete Fischer‐Bosch‐Institut für Klinische Pharmakologie, Abteilung für Klinische Pharmakologie Tübingen

      Dentsleeve Pty Ltd Wayville

      Christchurch Hospital Department of Gastroenterology Christchurch New Zealand

      Department of Medicine, The University of Sydney, The Nepean Hospital, Penrith, Australia

      2000

      Neonatal Medicine and *Gastroenterology Unit, Women's and Children's Hospital, North Adelaide, Australia; †Unite Des Flux Digestif, Institute National de la Recherche Agronomique, St. Gilles, France; and ‡Gastrointestinal Medicine, Royal Adelaide Hospital, Adelaide, Australia

      Department of Surgery, McMaster University, Hamilton, Ontario, Canada

      Gastroenterology, and

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      Sample of concepts for which John Dent is among the top experts in the world.
      Concept World rank
      biological pressure stomach #1
      pressure pylorus #1
      premature gastric emptying #1
      secondary peristalsis mechanism #1
      phi galanin #1
      rdq internal consistency #1
      lipid absorption day #1
      transient sphincter #1
      omeprazole relapse #1
      retardation distension #1
      contractions canine pylorus #1
      40 oral baclofen #1
      40 daily esomeprazole #1
      pressure achalasia patients #1
      milk transient reductions #1
      assessment reflux #1
      gord rdq #1
      phase study omeprazole #1
      postprandial gastroesophageal #1
      74 liquid #1
      sidehole sensor #1
      azd0865 doses #1
      737823 #1
      normals infant gord #1
      omeprazole 6 #1
      sustained absence heartburn #1
      0005004 #1
      animals pylorus #1
      individuals esophageal findings #1
      surgery zenkers diverticulum #1
      fed healthy #1
      threshold ippws #1
      gastro gord #1
      emptying distension #1
      separation reflux #1
      cardia inhibits #1
      5lumen #1
      symptom evaluation #1
      acid exposure treatment #1
      common cavity episodes #1
      streak biopsies biopsies #1
      occurrence straining #1
      vater catheters #1
      complications kappa #1
      guanethidine cp96345 #1
      p005 rfe #1
      adult duodenum #1
      acidsuppressive treatment #1
      glucose infusion tlesr #1
      pressure repeated tests #1
      Sign-in to see all concepts, it's free!

      Prominent publications by John Dent

      KOL-Index: 14723

      BACKGROUND AND AIMS: Transient lower oesophageal sphincter relaxations (TLOSRs) are the major cause of gastro-oesophageal reflux in normal subjects and in most patients with reflux disease. The gamma aminobutyric acid (GABA) receptor type B agonist, baclofen, is a potent inhibitor of TLOSRs in normal subjects. The aim of this study was to investigate the effect of baclofen on TLOSRs and postprandial gastro-oesophageal reflux in patients with reflux disease.

      METHODS: In 20 patients with ...

      Known for Reflux Disease | Lower Oesophageal | Agonist Baclofen | Sphincter Relaxations | Esophagogastric Junction
      KOL-Index: 14064

      OBJECTIVE: The aim of this study was to determine the accuracy of the diagnosis of gastro-oesophageal reflux disease (GORD) by the Reflux Disease Questionnaire (RDQ), family practitioners, gastroenterologists and a test of esomeprazole therapy.

      METHODS: This was a single-blind, single-arm study over 3-4 weeks from September 2005 to November 2006. Each symptom-based diagnostic assessment was made blinded to prior diagnoses. Patients were those presenting to their family practitioner with ...

      Known for Diamond Study | Proton Pump | Patients Gord | Symptombased Diagnosis | Symptom Response
      KOL-Index: 13585

      BACKGROUND: Helicobacter pylori gastritis may progress to glandular atrophy and intestinal metaplasia, conditions that predispose to gastric cancer. Profound suppression of gastric acid is associated with increased severity of H pylori gastritis. This prospective randomised study aimed to investigate whether H pylori eradication can influence gastritis and its sequelae during long term omeprazole therapy for gastro-oesophageal reflux disease (GORD).

      METHODS: A total of 231 H pylori ...

      Known for Reflux Disease | Helicobacter Pylori | Antrum Corpus | Term Omeprazole | Intestinal Metaplasia
      KOL-Index: 13480

      We have studied the response of erosive or ulcerative esophagitis to treatment with omeprazole and its subsequent relapse on cessation of therapy in 196 patients. In the first phase of the study omeprazole (20 or 40 mg daily) was compared with placebo in 64 patients. After 4 wk there was endoscopic healing in 81% (25 of 31) of omeprazole-treated patients and in only 6% (2 of 32) of placebo-treated patients. Endoscopic healing of esophagitis was accompanied by symptom relief and ...

      Known for Peptic Esophagitis | Endoscopic Healing | Patients Grade | Treatment Omeprazole | 20 40
      KOL-Index: 12829

      BACKGROUND & AIMS: Transient lower esophageal sphincter (LES) relaxations are the major mechanism of gastroesophageal reflux in normal subjects and in most patients with reflux disease. gamma-Aminobutyric acid (GABA) is an important inhibitory neurotransmitter within the central nervous system which is present in regions of the brainstem that are believed to mediate transient LES relaxations. The aim of this study was to investigate the effect of a GABA(B) agonist baclofen on ...

      Known for Gabab Agonist Baclofen | Normal Subjects | Transient Relaxations | Lower Esophageal Sphincter | Reflux Patients
      KOL-Index: 12332

      BACKGROUND: Dyspepsia and irritable bowel syndrome (IBS) are common in Western populations.

      AIM: To determine the epidemiology of dyspepsia and IBS in China.

      METHODS: A representative sample of 18 000 adults from five regions of China were asked to complete the modified Rome II questionnaire; 20% were asked to complete the 36-item Short Form Health Survey (SF-36). Participants from Shanghai were invited to provide blood samples and undergo oesophago-gastroduodenoscopy. Odds ratios (ORs) ...

      Known for Bowel Syndrome | Dyspepsia Ibs | Western Populations | Odds Ratios | Blood Samples
      KOL-Index: 11799

      There is little information about the organisation of antroduodenal contractions or pyloric motility in patients with gastroparesis. The mechanisms responsible for the acceleration of gastric emptying by cisapride in patients with gastroparesis are also poorly understood. Simultaneous manometric and scintigraphic recordings were performed in 12 patients with gastroparesis and nine healthy volunteers before and after cisapride administration. Antropyloroduodenal pressures were recorded ...

      Known for Gastric Emptying | Cisapride Patients | Pressure Waves | Gastrointestinal Motility Humans | Gastroparesis Healthy
      KOL-Index: 11361

      OBJECTIVE: To identify a body-positioning regimen that promotes gastric emptying (GE) and reduces gastroesophageal reflux (GER) by changing body position 1 hour after feeding.

      STUDY DESIGN: Ten healthy preterm infants (7 male; mean postmenstrual age, 36 weeks [range, 33 to 38 weeks]) were monitored with combined esophageal impedance-manometry. Infants were positioned in the left lateral position (LLP) or right lateral position (RLP) and then gavage-fed. After 1 hour, the position was ...

      Known for Gastric Emptying | Body Position | Premature Infant | Gastroesophageal Reflux | Rlp Llp
      KOL-Index: 11171

      BACKGROUND: There is little information on the effects of Helicobacter pylori eradication in patients with a primary diagnosis of gastro-oesophageal reflux disease (GORD). Our aim was to investigate the effect of H pylori eradication in this group of patients.

      METHODS: We did a double-blind, randomised, placebo-controlled study in 70 patients with GORD. We assigned individuals to three groups. All patients received lansoprazole 30 mg twice daily for 10 days, followed by 30 mg once daily ...

      Known for Patients Pylori | Oesophageal Reflux | Randomised Controlled Trial | Agents Anti | 8 Weeks
      KOL-Index: 11097

      BACKGROUND: The abnormally high postprandial rate of transient lower oesophageal sphincter relaxations seen in patients with reflux disease may be related to altered proximal gastric motor function. Heightened visceral sensitivity may also contribute to reporting of symptoms in these patients.

      AIMS: To assess motor function of the proximal stomach and visceral perception in reflux disease with a barostat.

      METHODS: Fasting and postprandial proximal gastric motility, sensation, and ...

      Known for Proximal Stomach | Reflux Disease | Motor Function | Symptoms Patients | Gastric Emptying
      KOL-Index: 11091

      BACKGROUND: Delivery of radiofrequency energy to the lower esophageal sphincter and gastric cardia is a new endoluminal technique proposed for the treatment of reflux disease. The mechanisms by which it achieves its effects are unclear. The study assessed the effect of radiofrequency energy delivery to the gastric cardia on the triggering of transient lower esophageal sphincter relaxations and gastroesophageal reflux in dogs.

      METHODS: In 13 dogs, esophageal motility and pH were measured ...

      Known for Gastroesophageal Reflux | Radiofrequency Energy Delivery | Gastric Cardia | Esophageal Sphincter | Transient Lower
      KOL-Index: 10853

      OBJECTIVES: A globally acceptable definition and classification of gastroesophageal reflux disease (GERD) is desirable for research and clinical practice. The aim of this initiative was to develop a consensus definition and classification that would be useful for patients, physicians, and regulatory agencies.

      METHODS: A modified Delphi process was employed to reach consensus using repeated iterative voting. A series of statements was developed by a working group of five experts after a ...

      Known for Montreal Definition | Based Consensus | Gastroesophageal Reflux Disease | Patients Physicians | Global Evidence
      KOL-Index: 10690

      The postprandial motor activity of the antrum, pylorus, and duodenum in 15 healthy volunteers was compared with the profiles of emptying of the solid and liquid components of a meal. The liquid component of the meal emptied rapidly in an exponential manner, whereas the solid remained in the fundus of the stomach until approximately 80% of the liquid had emptied and then emptied in a linear manner. The onset of solid emptying was associated with an increase in the rate of occurrence of ...

      Known for Motor Activity | Solid Emptying | Antrum Pylorus | Coordinated Contractions | Liquid Component

      Key People For Reflux Disease

      Top KOLs in the world
      #1
      John Dent
      reflux disease gastric emptying pyloric motility
      #2
      Peter James Kahrilas
      esophagogastric junction chicago classification gastroesophageal reflux disease
      #3
      Donald O Castell
      gastroesophageal reflux chest pain esophageal manometry
      #4
      Nicholas Joseph Talley
      functional dyspepsia irritable bowel syndrome emergency action
      #5
      Joel E Richter
      chest pain gastroesophageal reflux eosinophilic esophagitis
      #6
      Stuart Jon Spechler
      barrett esophagus eosinophilic esophagitis intestinal metaplasia

      Faculty of Health and Medical Sciences, The University of Adelaide, Australia. | Department of Medicine, University of Adelaide, Adelaide, SA, Australia | Department of Medicine, University of Adelaide and Royal Adelaide Hospital, Adelaide, South Aus

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